UMR CNRS 5558 Laboratoire de Biométrie et Biologie Évolutive

article :
Boussageon R, Supper I, Bejan-Angoulvant T, Kellou N, Cucherat M, Boissel J-P, Kassai B, Moreau A, Gueyffier F, Cornu C (2012)
Reappraisal of Metformin Efficacy in the Treatment of Type 2 Diabetes: A Meta-Analysis of Randomised Controlled Trials, PLoS Med, vol. 9 pp.347-351

Marchant I, Nony P, Cucherat M, Boissel J-P, Thomas SR, Bejan-Angoulvant T, Laugerotte A, Kahoul R, Gueyffier F (2011)
The Global Risk Approach Should Be Better Applied in French Hypertensive Patients: A Comparison between Simulation and Observation Studies, PLoS ONE, vol. 6(3) pp.1-7

Chapuisat G, Dronne MA, Grenier E, Hommel M, Boissel J-P (2010)
In Silico Study of the Influence of Intensity and Duration of Blood Flow Reduction on Cell Death Through Necrosis or Apoptosis During Acute Ischemic Stroke, Acta Biotheor, vol. 58 pp.171-190

Maucort-Boulch D, Baron M-H, Pommier P, Weber DC, Mizoe JE, Rochat J, Boissel J-P, Balosso J, Tsujii H, Amsallem E (2010)
Rationale for carbon ion therapy in high-grade glioma based on a review and ameta-analysis of neutron beam trials, Cancer/Radiothérapie, vol. 14(1) pp.34-41

Bajard A, Chabaud S, Pérol D, Boissel J-P, Nony P (2009)
Revisiting the level of evidence in randomized controlled clinical trials: A simulation approach, Contemporary Clinical Trials, vol. 30(5) pp.400-410

Billy F, Ribba B, Saut O, Morre-Trouilhet H, Colin T, Bresch D, Boissel J-P, Grenier E, Flandrois J-P (2009)
A pharmacologically based multiscale mathematical model of angiogenesis and its use in investigating the efficacy of a new cancer treatment strategy, Journal of Theoretical Biology, vol. 260 pp.545-562

Lelekov-Boissard T , Chapuisat G, Boissel J-P, Grenier E, Dronne MA (2009)
Exploration of beneficial and deleterious effects of inflammation in stroke: dynamics of inflammation cells, Philosophical Transactions of the Royal Society A-Mathematical Physical and engineering sciences, vol. 367 pp.4699-4716

Marchant I, Boissel J-P, Kassaï B, Bejan-Angoulvant T, Massol J, Vidal C, Amsallem E, Naudin F, Galan P, Czernichow S, Nony P, Gueyffier F (2009)
SCORE should be preferred to Framingham to predict cardiovascular death in French population, European Journal of cardiovascular prevention & rehabilitation, vol. 16(5) pp.609-615

Wang H, Boissel J-P, Nony P (2009)
Revisiting the relationship between baseline risk and risk under treatment, Emerging Themes in Epidemiology, vol. 6(1) pp.3451-3459

Boissel J-P, Cucherat M, Nonyc P, Chabaud S, Gueyffier F, Wright JM, Lièvre M, Leizorovicz A (2008)
New insights on the relation between untreated and treated outcomes for a given therapy effect model is not necessarily linear, Journal of Clinical Epidemiology, vol. 61(3) pp.301-307

Boissel J-P, Ribba B , Grenier E, Chapuisat G, Dronne MA (2008)
Modelling methodology in physiopathology, Progress in Biophysics & Molecular Biology, vol. 97 pp.28-39

Chapuisat G, Dronne MA, Grenier E, Hommel M, Gilquin H, Boissel J-P (2008)
A global phenomenological model of ischemic stroke with stress on spreading depressions, Progress in Biophysics & Molecular Biology, vol. 97 pp.4-27

Dronne MA, Grenier E , Chapuisat G, Hommel M, Boissel J-P (2008)
A modelling approach to explore some hypotheses of the failure of neuroprotective trials in ischemic stroke patients, Progress in Biophysics & Molecular Biology, vol. 97 pp.60-78

Grenier E, Dronne MA, Descombes S , Gilquin H, Jaillard A, Hommel M, Boissel J-P (2008)
A numerical study of the blocking of migraine by Rolando sulcus, Progress in Biophysics & Molecular Biology, vol. 97(1) pp.54-89

Amsallem E, Kasparian C, Cucherat M, Chabaud S, Haugh MC, Boissel J-P, Nony P (2007)
Evaluation of two evidence-based knowledge transfer interventions for physicians. A cluster randomized controlled factorial design trial: the CardioDAS study, Fundamental & Clinical Pharmacology, vol. 21 pp.631-641

Dronne MA, Grenier E, Dumont T, Hommel M, Boissel J-P (2007)
Role of astrocytes in grey matter during stroke: a modelling approach, Brain Research, vol. 1138 pp.231-242

Kassaï B, Gueyffier F, Boissel J-P (2007)
Critères intermédiaires et critères de substitution, Médecine thérapeutique, vol. 13(4) pp.279-286

Mercier C, Boissel J-P, Estève J, Iwaz J, Nony P (2007)
New tools to measure discrepancy between prescribing practices and guideline recommendations, Journal of Evaluation In Clinical Practice, vol. 13 pp.639-646

Blesius A, Chabaud S, Cucherat M, Mismetti P, Boissel J-P, Nony P (2006)
Compliance-Guided Therapy: A New Insight Into the Potential Role of Clinical Pharmacologists, Clinical Pharmacokinetics, vol. 45 pp.95-104

Boissel J-P, Pouchain D, Brodin M, Rouleau P, Barrier G, Fardeau M, Rabeharisoa V, Cathelineau G, Bricaire F, Zarifian E (2006)
Définition du panier de soins remboursables (PSR) : propositions et schéma d`applications à la prévention, Revue médicale de l`assurance maladie, vol. 37 pp.125-131

Dronne MA, Boissel J-P, Grenier E (2006)
A mathematical model of ion movements in grey matter during a stroke, Journal of Theoretical Biology, vol. 240 pp.599-615

Fouque D, Laville M, Boissel J-P (2006)
Low protein diets for chronic kidney disease in non diabetic adults, Cochrane Database of Systematic Reviews, vol. CD001892 pp.37-46

Kassaï B, Soniéb S, Shah NR, Boissel J-P (2006)
Literature search parameters marginally improved the pooled estimate accuracy for ultrasound in detecting deep venous thrombosis, Journal of Clinical Epidemiology, vol. 59 pp.710-714

Ribba B, Saut O, Colin T, Bresch D, Grenier E, Boissel J-P (2006)
A multiscale mathematical model of avascular tumor growth to investigate the therapeutic benefit of anti-invasive agents, Journal of Theoretical Biology, vol. 243 pp.532-541

Ribba B, Tracqui P, Boix J-L, Boissel J-P, Thomas SR (2006)
QxDB: A generic database to support mathematical modeling in biology, Philosophical Transactions of Royal Society Series A on `Biomathematical Modelling`, vol. 364 pp.1517-1532

Amsallem E, Kasparian C, Haddour G, Boissel J-P, Nony P (2005)
Phosphodiesterase III inhibitors for heart failure, Cochrane Database of Systematic Reviews, vol. CD002230 pp.631-641

Boissel J-P, Cucherat M, Nony P , Dronne MA, Kassaï B, Chabaud S (2005)
Modélisation numérique et simulation : nouvelles applications en pharmacologie, Thérapie, vol. 60 pp.1-15

Boissel J-P, Gueyffier F, Boutitie F, Pocock S, Fagard R (2005)
Apparent effect on blood pressure is only partly responsible for the risk reduction due to antihypertensive treatments, Fundamental & Clinical Pharmacology, vol. 19 pp.579-584

Boissel J-P, Nony P, Amsallem E, Mercier C, Estève J, Cucherat M (2005)
How to measure non-consistency of medical practices with available evidence in therapeutics: a methodological framework, Fundamental & Clinical Pharmacology, vol. 19 pp.591-596

Kassaï B, Boissel J-P, Cucherat M, Boutitie F, Gueyffier F (2005)
Treatment of high blood pressure and gain in event-free life expectancy, Vascular health and risk management, vol. 1 pp.163-169

Kassaï B, Shah NR, Leizorovicz A, Cucherat M, Gueyffier F, Boissel J-P (2005)
The true treatment benefit is unpredictable in clinical trials using surrogate outcome measured with diagnostic tests, Journal of Clinical Epidemiology, vol. 58 pp.1042-1051

Bossard N, Boissel FH, Boissel J-P (2004)
Level of evidence and therapeutic evaluation: need for more thoughts, Fundamental & Clinical Pharmacology, vol. 18 pp.365-372

Dronne MA, Boissel J-P , Grenier E , Gilquin H, Cucherat M, Hommel M, Barbier E, Bricca G (2004)
Mathematical modelling of an ischemic stroke: An integrative approach, Acta Biotheoretica, vol. 52 pp.255-272

Kassaï B, Boissel J-P, Cucherat M, Sonie S, Shah NR , Leizorovicz A (2004)
A systematic review of the accuracy of ultrasound in the diagnosis of deep venous thrombosis in asymptomatic patients, Thrombosis and Haemostasis, vol. 91 pp.655-666

Boissel J-P, Gueyffier F, Cucherat M, Bricca G (2003)
Pharmacogenetics and responders to a therapy: Theoretical background and practical problems, Clinical Chemistry and Laboratory Medicine, vol. 41 pp.564-572

Boissel J-P, Haugh M, Fardeheb M, Nony P, Gueyffier F, Strang N (2003)
How should therapeutic information be transferred to users?, Fundamental & Clinical Pharmacology, vol. 17 pp.495-503

Kassaï B, Gueyffier F, Boissel J-P, Boutitie F, Cucherat M (2003)
Absolute benefit number needed to treat and gain in life expectancy: which efficacy indices for measuring the treatment benefit?, Journal of Clinical Epidemiology, vol. 56 pp.977-982