UMR CNRS 5558 Laboratoire de Biométrie et Biologie Évolutive

article :
Auclair J, Vaissière T, Desseigne F, Lasset C, Bonadona V, Giraud S, Saurin J-C, Joly MO, Leroux D, Faivre L, Audoynaud C, Montmain G, Ruano E, Herceg Z, Puisieux A, Qinq W (2011)
Intensity-Dependent Constitutional MLHI promoter methylation leads to early onset of colorectal cancer by affecting both alleles, Genes chromosomes & cancer, vol. 50(3) pp.178-185

Bonadona V, Bonaïti B, Olschwang S, Grandjouan S, Huiart L, Longy M, Guimbaud R, Buecher B, Bignon Y J, Caron O, Colas C, Noguès C, Lejeune-Dumoulin S, Olivier-Faivre L, Polycarpe-Osaer F, Nguyen T D, Desseigne F, Saurin J-C, Berthet P, Leroux D, Duffour J, Manouvrier S, Frébourg T, Sobol H, Lasset C, Bonaïti-Pellié C (2011)
Cancer Risks Associated With Germline Mutations in MLH1 MSH2 and MSH6 Genes in Lynch Syndrome, Journal of the American medical association, vol. 305 pp.2304-2310

Bonadona V, Bonaïti B, Olschwang S, Grandjouan S, Huiart L, Longy M, Guimbaud R, Buecher B, Bignon YJ, Caron O, Colas C, Noguès C, Lejeune-Dumoulin S, Olivier-Faivre L, Polycarpe-Ozaer F, Nguyen TD, Desseigne F, Saurin J-C, Berthet P, Leroux D, Duffour J, Manouvrier S, Frébourg T, Sobol H, Lasset C, Bonaïti-Pellié C (2011)
Cancer risks associated with germline mutations in MLH1 MSH3 and MSH6 genes in Lynch Syndrome, The Journal of the American Medical Association, vol. 305(22) pp.2304-2310

El Abed R, Bourdon V, Voskoboinik I, Omri H, Ben Youssef Y, Laatiri M A, Huiart L, Eisinger F, Rabayrol L, Frenay M, Gesta P, Demange L, Dreyfus H, Bonadona V, Dugast C, Zattara H, Faivre L, Zaier M, Jemni S Y, Noguchi T, Sobol H, Soua Z (2011)
Molecular study of the perforin gene in familial hematological malignancies, Hereditary Cancer in Clinical Practice, vol. 9 pp.1-7

Julian-Reynier J, Mancini J, Mouret-Fourme E, Gauthier-Villars M, Bonadona V, Berthet P, Fricker JP, Caron O, Luporsi E, Nogues C (2011)
Cancer risk management strategies and perceptions of unaffected women 5 years after predictive genetic testing for BRCA1/2 mutations, European journal of human Genetics, vol. 19 pp.500-506

Ramus S J, Kartsonaki C, Gayther S A, Pharoah P D P, Sinilnikova O M, Beesley J, Chen X Q, McGuffog L, Healey S, Couch F J, Wang X S, Fredericksen Z, Peterlongo P, Manoukian S, Peissel B, Zaffaroni D, Roversi G, Barile M, Viel A, Allavena A, Ottini L, Papi L, Gismondi V, Capra F, Radice P, Greene M H, Mai P L, Andrulis I L, Glendon G, Ozcelik H, Thomassen M, Gerdes A M, Kruse T A, Cruger D, Jensen U B, Caligo M A, Olsson H, Kristoffersson U, Lindblom A, Arver B, Karlsson P, Askmalm M S, Borg A, Neuhausen S L, Ding Y C, Nathanson K L, Domchek S M, Jakubowska A, Lubinski J, Huzarski T, Byrski T, Gronwald J, Gorski B, Cybulski C, Debniak T, Osorio A, Duran M, Tejada M I, Benitez J, Hamann U, Rookus M A, Verhoef S, Tilanus-Linthorst M A, Vreeswijk M P, Bodmer D, Ausems M G E M, van Os T A, Asperen C J, Blok M J, Meijers-Heijboer H E J, Peock S, Cook M, Oliver C, Frost D, Dunning A M, Evans D G, Eeles R, Pichert G, Cole T, Hodgson S, Brewer C, Morrison P J, Porteous M, Kennedy M J, Rogers M T, Side L E, Donaldson A, Gregory H, Godwin A, Stoppa-Lyonnet D, Moncoutier V, Castera L, Mazoyer S, Barjhoux L, Bonadona V, Leroux D, Faivre L, Lidereau R, Nogues C, Bignon Y J, others (2011)
Genetic Variation at 9p22.2 and Ovarian Cancer Risk for BRCA1 and BRCA2 Mutation Carriers, Journal of the national cancer institute, vol. 103 pp.1-13

Banneau G, Guedj M, MacGrogan G, de Mascarel I, Velasco V, Schiappa R, Bonadona V, David A, Dugast C, Gilbert-Dussardier B, Ingster O, Vabres P, Caux F, de Reynies A, Iggo R, Sevenet N, Bonnet F, Longy M (2010)
Molecular apocrine differentiation is a common feature of breast cancer in patients with germline PTEN mutations, Breast Cancer Research, vol. 12 pp.1-13

Bonaïti B, Bonadona V, Perdry H, Andrieu N, Bonaïti-Pellié C (2010)
Estimating penetrance from multiple case families with predisposing mutations: extension of the `genotype-restricted likelihood` (GRL) method, European Journal of Human Genetics, vol. 19 pp.173-179

Bonaïti-Pellié C, Andrieu N, Arveux P, Bonadona V, Buecher B, Delpech M, Jolly D, Julian-Reynier J, Luporsi E, Noguès C, Nowak F, Olschwang S, Orsi F, Pujol P, Saurin J-C, Sinilnikova O, Stoppa-Lyonnet D, Thépot F (2009)
Oncogénétique : estimation des besoins de la population en France pour les dix ans à venir, Bulletin du Cancer, vol. 96(9) pp.875-900

Kannengiesser C, Brookes S, Del Arroyo A-G, Pham D, Bombled J, Barrois M, Mauffret O, Avril M-F, Chompret A, Lenoir GM, Sarasin A, Lasset C, Bonadona V, Peters G, Bressac-de-Paillerets B (2009)
Functional structural and genetic evaluation of 20 CDKN2A germ line mutations identified in melanoma-prone families or patients, Human Mutation, vol. 30 pp.564-574

Bougeard G, Sesboué R, Desurmont S, Berthet P, Bonadona V, Buecher B, Caron O, Colas C, Collonge-Rame M-A, Delnatte C, Dugast C, Fricker J-P, Gauthier-Villars M, Gesta P, Jonveaux P, Lasset C, Leheup B, Longy M, Nogue C (2008)
Molecular basis of the Li-Fraumeni syndrome: an update from the French LFS families, Journal of Medical Genetic, vol. 45 pp.535-538

Lesueur F, De Lichy M, Barrois M, Durand G, Bombled J, Avril M-F, Chompret A, Boitier F, Lenoir GM, Baccard M, Bachollet B, Berthet P, Bonadona V, Group French Familial Melanoma Study (2008)
The contribution of large genomic deletions at the CDKN2A locus to the burden of familial melanoma, British Journal of Cancer, vol. 99 pp.364-370

Alarcon F, Lasset C, Carayol J, Bonadona V, Perdry H, Desseigne F, Wang Q, Bonaïti-Pellié C (2007)
Estimating cancer risk in HNPCC by the GRL method, European Journal of Human Genetics, vol. 15 pp.831-836

Antoniou AC, Sinilnikova OM , Simard J , Leone M, Dumont M , Neuhausen SL, Struewing JP, Stoppa-Lyonnet D, Barjhoux L, Hughes DJ, Coupier I, Belotti M , Lasset C, Bonadona V, Bignon YJ, Rebbeck TR, Wagner T, Lynch HT, Domchek SM, Nathanson KL, Garber JE, Weitzel J, Narod SA, Tomlinson G , Olopade OI, Godwin A, Isaacs C, Jakubowska A, Lubinski J, Gronwald J, Gorski B, Byrski T, Huzarski T, Peock S, Cook M, Baynes C, Murray A, Rogers M, Daly PA, Dorkins H, Schmutzler RK, Versmold B, Engel C, Meindl A, Arnold N, Niederacher D, Deissler H, Spurdle AB, Chen X, Waddell N, Cloonan N, Kirchhoff T, Offit K, Friedman E, Kaufmann B, Laitman Y, Galore G, Rennert G, Lejbkowicz F, Raskin L, Andrulis IL, Ilyushik E, Ozcelik H, Devilee P, Vreeswijk MP, Greene MH, Prindiville SA, Osorio A, Benitez J, Zikan M, Szabo CI, Kilpivaara O, Nevanlinna H, Hamann U, Durocher F, Arason A, Couch FJ, Easton DF, Chenevix-Trench G (2007)
C Modifies Breast Cancer Risk among BRCA2 Mutation Carriers: Results from a Combined Analysis of 19 Studies, The American Society of Human Genetics, vol. 81 pp.1186-1200

Bonadona V, Dussart-Moser S, Voirin N, Sinilnikova OM, Mignotte H, Mathevet P, Bremond A , Treilleux I, Martin A, Romestaing P , Raudrant D , Rudigoz R-C, Lenoir GM , Lasset C (2007)
Prognosis of early-onset breast cancer based on BRCA1/2 mutation status in a French population-based cohort and review, Breast Cancer Research and Treatement, vol. 101 pp.233-245

Kannengiesser C, Dalle S, Leccia M-T, Avril MF, Bonadona V, Chompret A , Lasset C, Leroux D, Thomas L, Lesueur F, Lenoir G, Sarasin A, Bressac-de Paillerets B (2007)
New Founder Germline Mutations of CDKN2A in Melanoma-Prone Families and Multiple Primary Melanoma Development in a Patient Receiving Levodopa Treatment, Genes Chromosomes & Cancer, vol. 46 pp.751-760

Lasset C, Charavel M, Bonadona V (2007)
Focus Group Approach for Developing Written Patient Information in Oncogenetics, Genetic Testing, vol. 11 pp.193-197

Auclair J, Buisine MP, Navarro C, Ruano E, Montmain G, Desseigne F, Saurin JC, Lasset C, Bonadona V, Giraud S, Puisieux A, Wang Q (2006)
Systematic mRNA analysis for the effect of MLH1 and MSH2 missense and silent mutations on aberrant splicing, Human Mutation, vol. 27 pp.145-154

Casilli F, Tournier I, Sinilnikova O M, Coulet F, Soubrier F, Houdayer C, Hardouin A, Berthet P, Sobol H, Bourdon V, Muller D, Fricker JP, Capoulade-Metay C, Chompret A, Nogues C, Mazoyer S, Chappuis P, Maillet P, Philippe C, Lortholary A, Gesta P, Bézieau S, Toulas C, Gladieff L, Maugard CM, Provencher DM, Dugast C, Delvincourt C, Nguyen TD, Faivre L, Bonadona V, Frébourg T, Lidereau R, Stoppa-Lyonnet D , Tosi M (2006)
The contribution of germline rearrangements to the spectrum of BRCA2 mutations, Journal of Medical Genetics, vol. 43 pp.e49-e49

Mancini J, Nogues C, Adenis C, Berthet P, Bonadona V, Chompret A, Coupier I, Eisinger F, Fricker JP, Gauthier-Villars M, Lasset C, Lortholary A, N`Guyen TD, Vennin P, Sobol H, Stoppa-Lyonnet D, Julian-Reynier C (2006)
Impact of an information booklet on satisfaction and decision-making about BRCA genetic testing, European Journal of Cancer, vol. 42 pp.871-881

Mancini J, Nogues C, Adenis C, Berthet P, Bonadona V, Chompret A, Coupier I, Eisinger F, Fricker JP, Gauthier-Villars M, Lasset C, Lortholary A, N`Guyen TD, Vennin P, Sobol H, Stoppa-Lyonnet D, Julian-Reynier C (2006)
Patients` characteristics and rate of Internet use to obtain cancer information, Journal of public health, vol. 28 pp.235-237

Bonadona V, Sinilnikova OM, Chopin S, Antoniou AC, Mignotte H, Mathevet P, Bremond A, Martin A, Bobin JY, Romestaing P, Raudrant D, Rudigoz RC, Leone M, Chauvin F, Easton DF, Lenoir GM, Lasset C (2005)
Contribution of BRCAI and BRCA2 germ-line mutations to the incidence of breast cancer in young women: Results from a prospective population-based study in France, Genes Chromosomes & Cancer, vol. 43 pp.404-413

Sinilnikova OM, Ginolhac SM, Magnard C, Leone M, Anczukow O, Hughes D, Moreau K, Thompson D, Coutanson C, Hall J, Romestaing P, Gerard JP, Bonadona V, Lasset C, Goldgar DE, Joulin V, Venezia ND, Lenoir GM (2004)
Acetyl-CoA carboxylase alpha gene and breast cancer susceptibility, Carcinogenesis, vol. 25 pp.2417-2424

Tournier I, Bressac-de Paillerets B, Sobol H, Stoppa-Lyonnet D, Lidereau R, Barrois M, Mazoyer S, Coulet F, Hardouin A, Chompret A, Lortholary A, Chappuis P, Bourdon V, Bonadona V, Maugard C, Gilbert B, Nogues C, Frebourg T, Tosi M (2004)
Significant contribution of germline BRCA2 rearrangements in male breast cancer families, Cancer Research, vol. 64 pp.8143-8147

Bonadona V, Lasset C (2003)
Inherited predisposition to breast cancer: after the texitBRCA1 and BRCA2 genes what next?, Bulletin du Cancer, vol. 90 pp.587-594

Mignotte H, Lasset C, Bonadona V (1998)
Iatrogenic risks of endometrial carcinoma after treatment for breast cancer in a large French case-control study, European Journal of Cancer, vol. 34 pp.S46-S47