The software package HiFiX implements the novel algorithm for HIgh FIdelity Clustering of Sequences.
To tackle the challenge of finding proteins families, we model the all-against-all comparison between proteins by a similarity network. HiFiX combines network topology analysis where sequence similarity is seen as a social relationship, multiple alignment quality measurement and model selection theory.
HiFiX supports multiprocessing and is therefore fast enough to be used in practice on large amounts of data.
HiFiX is already included in the experimental pipeline for HOGENOM.