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Janvier

le jeudi 31 janvier à 11:00

Adam Siepel (Professor, Biological Statistics & Computational Biology,Cornell University, USA)

Salle de formation du PRABI

Inference of natural selection on human transcription factor binding sites
no abstract
http://compgen.bscb.cornell.edu/~acs/
Quelques références représentatives :
• Guertin MJ*, Martins AL*, Siepel A, Lis JT. Accurate prediction of inducible transcription factor binding intensities in vivo. PLoS Genetics, 2012 ;8(3):e1002610.
• Lindblad-Toh K, Garber M, Zuk O, Lin MF, Parker BJ, et. al. (63 co-authors). A high-resolution map of evolutionary constraint in the human genome based on 29 (...)

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le jeudi 17 janvier à 11:00

Murray Patterson (LBBE)

Salle de formation du PRABI

Reconstruction of ancestral genome organization in bacteria
Background.
Recovering the structure of ancestral genomes can be formalized in terms of properties of binary matrices such as the Consecutive-Ones Property (C1P). The Linearization Problem asks to extract, from a given binary matrix, a maximum weight subset of rows that satisfies such a property. This problem is in general intractable, and in particular if the ancestral genome is expected to contain only linear chromosomes or a (...)

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le jeudi 24 janvier à 11:00

Nicolas Lartillot (Université de Montréal)

Salle de formation du PRABI

Reconstructing macroevolutionary patterns of GC-biased gene conversion in placental mammals.

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