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Centre Léon Bérard Département de Santé Publique - 3ème Etage 28 rue Laennec 69373 Lyon cedex 08
- +Présentation -Présentation
Christine Lasset, MD, PhD is Assistant Professor in Public Health at Lyon 1 University in Lyon and is the leader of the “Prevention and genetic epidemiology” Unit at Léon Bérard Comprehensive Cancer Center (CLB) in Lyon. This unit is part of CNRS UMR 5558 “Biometry and Evolutive Biology” at Lyon 1 University.
C. Lasset is actively implicated in the cancer genetics clinic of the CLB where she provides genetic counselling. She is involved in the establishment of national guidelines for the management of individuals affected by such familial cancers.
Her main research program is in the field of hereditary cancer. The first axis concerns the evaluation of cancer risk in germline mutation carriers using genetic epidemiology methods and is developed in collaboration with Valérie Bonadona, MD, PhD. The second axis concerns the early detection of cancer in high-risk populations, such as MRI breast cancer screening in female BRCA mutation carriers.
Her team is also interested in cancer prevention in the general population and participates in different programs such as the evaluation of the impact of HPV vaccination in the population of the Rhône-Alpes region.
Christine Lasset also heads the Public Health Department of the CLB which is involved in the medical evaluation of cancer treatments or screening and maintains the hospital-based clinical and biological database of the CLB for breast cancer, colorectal cancer and some hematologic malignancies.
Christine Lasset is an author of 120 articles published in international journals with peer-review committees.
+Publications -Publications
article :
Boyault S, Drouet Y, Navarro C, Bachelot T, Lasset C, Treilleux I, Tabone E, Puisieux A, Wang Q (2012)
Mutational characterization of individual breast tumors: TP53 and PI3K pathway genes are frequently and distinctively mutated in different subtypes, Breast Cancer Res Treat, vol. 132 pp.29-39
Eisinger F, Fabre R, Lasset C, Stoppa-Lyonnet D, Julian-Reynier C, Nogues C (2012)
Spontaneous disclosure of BRCA1/2 genetic test results to employers: a French prospective study, European Journal of Human Genetics, vol. pp.1-3
Julian-Reynier C, Fabre R, Coupier I, Stoppa-Lyonnet D, Lasset C, Caron O, Mouret-Fourme E, Berthet P, Faivre L, Frenay M, Gesta P, Gladieff L, Bouhnik A-D, Protière C, Noguès C (2012)
BRCA1/2 carriers: their childbearing plans and theoretical intentions about having preimplantation genetic diagnosis and prenatal diagnosis, Genetics in Medicine, vol. pp.5579-5592
Maheu C, Apostolidis T, Petri-Cal A, Mouret-Fourme E, Gauthier-Villars M, Lasset C, Berthet P, Fricker J-P, Caron O, Luporsi E, Gladieff L, Noguès C, Julian-Reynier C (2012)
French women’s breast self-examination practices with time after undergoing BRCA1/2 genetic testing, Familial Cancer, vol. pp.317-330
Antoniou A C, Kartsonaki C, Olga S, Lasset C, al et (2011)
Common alleles at 6q25.1 and 1p11.2 are associated with breast cancer risk for BRCA1 and BRCA2 mutation carriers, Human Molecular Genetics, vol. 20 pp.3304-3321
Auclair J, Vaissière T, Desseigne F, Lasset C, Bonadona V, Giraud S, Saurin J-C, Joly MO, Leroux D, Faivre L, Audoynaud C, Montmain G, Ruano E, Herceg Z, Puisieux A, Qinq W (2011)
Intensity-Dependent Constitutional MLHI promoter methylation leads to early onset of colorectal cancer by affecting both alleles, Genes chromosomes & cancer, vol. 50(3) pp.178-185
Bonadona V, Bonaïti B, Olschwang S, Grandjouan S, Huiart L, Longy M, Guimbaud R, Buecher B, Bignon Y J, Caron O, Colas C, Noguès C, Lejeune-Dumoulin S, Olivier-Faivre L, Polycarpe-Osaer F, Nguyen T D, Desseigne F, Saurin J-C, Berthet P, Leroux D, Duffour J, Manouvrier S, Frébourg T, Sobol H, Lasset C, Bonaïti-Pellié C (2011)
Cancer Risks Associated With Germline Mutations in MLH1 MSH2 and MSH6 Genes in Lynch Syndrome, Journal of the American medical association, vol. 305 pp.2304-2310
Bonadona V, Bonaïti B, Olschwang S, Grandjouan S, Huiart L, Longy M, Guimbaud R, Buecher B, Bignon YJ, Caron O, Colas C, Noguès C, Lejeune-Dumoulin S, Olivier-Faivre L, Polycarpe-Ozaer F, Nguyen TD, Desseigne F, Saurin J-C, Berthet P, Leroux D, Duffour J, Manouvrier S, Frébourg T, Sobol H, Lasset C, Bonaïti-Pellié C (2011)
Cancer risks associated with germline mutations in MLH1 MSH3 and MSH6 genes in Lynch Syndrome, The Journal of the American Medical Association, vol. 305(22) pp.2304-2310
Coissieux M-M, Tomsic J, Castets M, Hampel H, Tuupanen S, Andrieu N, Comeras I, Drouet Y, Lasset C, Liyanarachchi S, Mazelin L, Puisieux A, Saurin J-C, Scoazec J-Y, Wang Q, Aaltonen L, Tanner S M, De la Chapelle A, Bernet A, Mehlen P (2011)
Variants in the Netrin-1 Receptor UNC5C Prevent Apoptosis and Increase Risk of Familial Colorectal Cancer, GASTROENTEROLOGY, vol. 141 pp.2039-2046
Dorval M, Noguès C, Berthet P, Chiquette J, Gauthier-Villars M, Lasset C, Picard C, Plante M, Simard J, Julian-Reynier J (2011)
Breast and ovarian cancer screening of non-carriers from BRCA1/2 mutation-positive families: 2-year follow-up of cohorts from France and Quebec, European journal of human Genetics, vol. 19(5) pp.494-499
Lecarpentier J, Noguès C, Mouret-Fourme E, Stoppa-Lyonnet D, Lasset C, Caron O, Fricker J-P, Gladieff L, Faivre F, Sobol H, Gesta P, Frenay M, Luporsi E, Coupier I, GENEPSO, Lidereau R, Andrieu N (2011)
Variation in breast cancer risk with mutation position smoking alcohol and chest X-ray history in the French National BRCA1/2 carrier cohort (GENEPSO), Breast Cancer Res Treat, vol. 130 pp.927-938
Lutringer-Magnin D, Kalecinski J, Barone G, Borne H, Regnier V, Vanhems P, Chauvin F, Lasset C (2011)
Invasive aspergillosis: an important risk factor on the short- and long-term survival of acute myeloid leukemia (AML) patients, Gynécologie Obstétrique & Fertilité, vol. pp.1-7
Lutringer-Magnin D, Kalecinski J, Barone G, Leocmach Y, Regnier V, Jacquard AC, Soubeyrand B, Vanhems P, Chauvin F, Lasset C (2011)
Human papillomavirus (HPV) vaccination: Perception and practice among French general practitioners in the year since licensing, Vaccine, vol. pp.1-7
Spurdle A B, Marquart L, McGuffog L, Healey Sue, Sinilnikova O, Wan F, Chen X, Beesley J, Singer C F, Dressler A-C, Gschwantler-Kaulich D, Blum J L, Tung N, Weitzel J, Lynch H, Garber J, Easton D F, Peock S, Margaret C, Clare T O, Frost D, Conroy D, Evans D G, Laloo F, Eeles R, Izatt L, Davidson R, Chu C, Eccles D, Selkirk C G, Daly M, Isaacs C, Stoppa-Lyonnet D, Sinilnikova O M, Buecher B, Belotti M, Mazoyer S, Barjhoux L, Verny-Pierre C, Lasset C, Dreyfus B, Pujol P, Collonge-Rame M-A, Rookus M A, Verhoef S, Kriege M, Hoogerbrugge N, Ausems M G E M, van Os T A, Wijnen J, Devilee P, Meijers-Heijboer H E J, Blok M J, T Heikkinen, Nevanlinna H, Jakubowska A, Lubinski J, Huzarski T, Byrski T, Durocher F, Couch F J, Lindor N M, Wang X, Thomassen M, Domchek S, Nathanson K, Caligo M A, Jernstrom H, Liljegren A, Ehrencrona H, Karlsson P, Ganz P A, Olopade O I, Tomlinson G, Neuhausen S, Antoniou A, Chenevix-Trench G, Rebbeck T R (2011)
Common Genetic Variation at BARD1 Is Not Associated with Breast Cancer Risk in BRCA1 or BRCA2 Mutation Carriers, Cancer Epidemiol Biomarkers Prev, vol. 20 pp.1032-1038
Antoniou A, Wang X, Fredericksen Z, McGuffog L, Tarrell R, Sinilnikova O, Healey S, Morrison J, Kartsonaki C, Lesnick T, Ghoussanini M, Barrowdale D, Embrace, Peock S, Cook M, Oliver C, Frost D, Eccles D, Evans G, Eeles R, Izatt L, Chu C, Douglas F, Paterson J, Stoppa-Lyonnet D, Houdayer C, Mazoyer S, Giraud S, Lasset C (2010)
A locus on 19p13 modifies risk of breast cancer in BRCA1 mutation carriers and is associated with hormone receptor-negative breast cancer in the general population, Nature Genetics, vol. 42(10) pp.885-895
Combes J-D, Grelier G, Laversanne M, Voirin N, Chabaud S, Ecochard R, Lasset C (2009)
Contribution of cell culture RNA extraction and reverse transcription to the measurement error in quantitative reverse transcription polymerase chain reaction-based gene expression quantification, Analytical Biochemistry, vol. 393(1) pp.29-35
Grelier G, Voirin N, Ay A-S, Cox DG, Chabaud S, Treilleux I, Léon-Goddard S, Rimokh R, Mikaelian I, Venoux C, Puisieux A, Lasset C, Moyret-Lalle C (2009)
Prognostic value of Dicer expression in human breast cancers and association with the mesenchymal phenotype, British Journal of Cancer, vol. 101(4) pp.673-683
Kannengiesser C, Brookes S, Del Arroyo A-G, Pham D, Bombled J, Barrois M, Mauffret O, Avril M-F, Chompret A, Lenoir GM, Sarasin A, Lasset C, Bonadona V, Peters G, Bressac-de-Paillerets B (2009)
Functional structural and genetic evaluation of 20 CDKN2A germ line mutations identified in melanoma-prone families or patients, Human Mutation, vol. 30 pp.564-574
Metzger M-H, Lasset C (2009)
Etudes de cohorte et études pronostiques, La revue du praticien, vol. 59 pp.535-538
Bougeard G, Sesboué R, Desurmont S, Berthet P, Bonadona V, Buecher B, Caron O, Colas C, Collonge-Rame M-A, Delnatte C, Dugast C, Fricker J-P, Gauthier-Villars M, Gesta P, Jonveaux P, Lasset C, Leheup B, Longy M, Nogue C (2008)
Molecular basis of the Li-Fraumeni syndrome: an update from the French LFS families, Journal of Medical Genetic, vol. 45 pp.535-538
Alarcon F, Lasset C, Carayol J, Bonadona V, Perdry H, Desseigne F, Wang Q, Bonaïti-Pellié C (2007)
Estimating cancer risk in HNPCC by the GRL method, European Journal of Human Genetics, vol. 15 pp.831-836
Antoniou AC, Sinilnikova OM , Simard J , Leone M, Dumont M , Neuhausen SL, Struewing JP, Stoppa-Lyonnet D, Barjhoux L, Hughes DJ, Coupier I, Belotti M , Lasset C, Bonadona V, Bignon YJ, Rebbeck TR, Wagner T, Lynch HT, Domchek SM, Nathanson KL, Garber JE, Weitzel J, Narod SA, Tomlinson G , Olopade OI, Godwin A, Isaacs C, Jakubowska A, Lubinski J, Gronwald J, Gorski B, Byrski T, Huzarski T, Peock S, Cook M, Baynes C, Murray A, Rogers M, Daly PA, Dorkins H, Schmutzler RK, Versmold B, Engel C, Meindl A, Arnold N, Niederacher D, Deissler H, Spurdle AB, Chen X, Waddell N, Cloonan N, Kirchhoff T, Offit K, Friedman E, Kaufmann B, Laitman Y, Galore G, Rennert G, Lejbkowicz F, Raskin L, Andrulis IL, Ilyushik E, Ozcelik H, Devilee P, Vreeswijk MP, Greene MH, Prindiville SA, Osorio A, Benitez J, Zikan M, Szabo CI, Kilpivaara O, Nevanlinna H, Hamann U, Durocher F, Arason A, Couch FJ, Easton DF, Chenevix-Trench G (2007)
C Modifies Breast Cancer Risk among BRCA2 Mutation Carriers: Results from a Combined Analysis of 19 Studies, The American Society of Human Genetics, vol. 81 pp.1186-1200
Auclair J, Leroux D, Desseigne F, Lasset C, Saurin JC, Joly MO, Pinson S, Li Xu X, Montmain G, Ruano E, Navarro C, Puisieux A, Wang Q (2007)
Novel biallelic mutations in MSH6 and PMS2 genes: gene conversion as a likely cause of PMS2 gene inactivation, Human Mutation, vol. 28 pp.1084-1090
Bonadona V, Dussart-Moser S, Voirin N, Sinilnikova OM, Mignotte H, Mathevet P, Bremond A , Treilleux I, Martin A, Romestaing P , Raudrant D , Rudigoz R-C, Lenoir GM , Lasset C (2007)
Prognosis of early-onset breast cancer based on BRCA1/2 mutation status in a French population-based cohort and review, Breast Cancer Research and Treatement, vol. 101 pp.233-245
Kannengiesser C, Dalle S, Leccia M-T, Avril MF, Bonadona V, Chompret A , Lasset C, Leroux D, Thomas L, Lesueur F, Lenoir G, Sarasin A, Bressac-de Paillerets B (2007)
New Founder Germline Mutations of CDKN2A in Melanoma-Prone Families and Multiple Primary Melanoma Development in a Patient Receiving Levodopa Treatment, Genes Chromosomes & Cancer, vol. 46 pp.751-760
Lasset C, Charavel M, Bonadona V (2007)
Focus Group Approach for Developing Written Patient Information in Oncogenetics, Genetic Testing, vol. 11 pp.193-197
Vanhems P, Pires-Cronenberger S, Lasset C (2007)
Sporadic and epidemic community legionellosis: two faces of the same illness, European Respiratory Journal, vol. 30 pp.813-813
You B, Blandin S, Gérinière L, Lasset C, Souquet P-J (2007)
Mésothéliomes familiaux : une composante génétique associée aux risques environnementaux ?, Bulletin du Cancer, vol. 94 pp.705-710
Auclair J, Buisine MP, Navarro C, Ruano E, Montmain G, Desseigne F, Saurin JC, Lasset C, Bonadona V, Giraud S, Puisieux A, Wang Q (2006)
Systematic mRNA analysis for the effect of MLH1 and MSH2 missense and silent mutations on aberrant splicing, Human Mutation, vol. 27 pp.145-154
Mancini J, Nogues C, Adenis C, Berthet P, Bonadona V, Chompret A, Coupier I, Eisinger F, Fricker JP, Gauthier-Villars M, Lasset C, Lortholary A, N`Guyen TD, Vennin P, Sobol H, Stoppa-Lyonnet D, Julian-Reynier C (2006)
Impact of an information booklet on satisfaction and decision-making about BRCA genetic testing, European Journal of Cancer, vol. 42 pp.871-881
Mancini J, Nogues C, Adenis C, Berthet P, Bonadona V, Chompret A, Coupier I, Eisinger F, Fricker JP, Gauthier-Villars M, Lasset C, Lortholary A, N`Guyen TD, Vennin P, Sobol H, Stoppa-Lyonnet D, Julian-Reynier C (2006)
Patients` characteristics and rate of Internet use to obtain cancer information, Journal of public health, vol. 28 pp.235-237
Olschwang S, Bonaiti-Pellie C, Feingold J, Frebourg T, Grandjouan S, Lasset C, Laurent-Puig P, Lecuru F, Millat B, Sobol H, Thomas G, Eisinger F (2006)
Identification and management of HNPCC syndrome (hereditary non polyposis colon cancer) hereditary predisposition to colorectal and endometrial adenocarcinomas, Pathologie Biologie, vol. 54 pp.215-229
Bonadona V, Sinilnikova OM, Chopin S, Antoniou AC, Mignotte H, Mathevet P, Bremond A, Martin A, Bobin JY, Romestaing P, Raudrant D, Rudigoz RC, Leone M, Chauvin F, Easton DF, Lenoir GM, Lasset C (2005)
Contribution of BRCAI and BRCA2 germ-line mutations to the incidence of breast cancer in young women: Results from a prospective population-based study in France, Genes Chromosomes & Cancer, vol. 43 pp.404-413
Hughes DJ, Ginolhac SM, Coupier I, Barjhoux L, Gaborieau V, Bressac-de-Paillerets B, Chompret A, Bignon YJ, Uhrhammer N, Lasset C, Giraud S, Sobol H, Hardouin A, Berthet P, Peyrat JP, Fournier J, Nogues C, Lidereau R, Muller D, Fricker JP, Longy M, Toulas C, Guimbaud R, Yannoukakos D, Mazoyer S, Lynch HT, Lenoir GM, Goldgar DE, Stoppa-Lyonnet D, Sinilnikova OM (2005)
Breast cancer risk in BRCA1 and BRCA2 mutation carriers and polyglutamine repeat length in the AIB1 gene, International Journal of Cancer, vol. 117 pp.230-233
Hughes DJ, Ginolhac SM, Coupier I, Corbex M, Bressac-de-Paillerets B, Chompret A, Bignon YJ, Uhrhammer N, Lasset C, Giraud S, Hardouin A, Berthet P, Peyrat J-P, Fournier J, Nogues C, Lidereau R, Muller D, Fricker J-P, Longy M, Toulas C, Guimbaud R, Maugard C, Olschwang S, Yannoukakos D, Durocher F, Moisan A-M, Simard J, Mazoyer S, Lynch HT, Szabo C, Lenoir GM, Goldgar DE, Stoppa-Lyonnet D, Sinilnikova OM (2005)
Common BRCA2 Variants and Modification of Breast and Ovarian Cancer Risk in BRCA1 Mutation Carriers, Cancer Epidemiology Biomarkers & Prevention, vol. 14 pp.265-267
Negrier S, Gomez F, Douillard J-Y, Ravaud A, Chevreau C, Buclon M, Perol D, Lasset C, Escudier B (2005)
Prognostic factors of response or failure of treatment in patients with metastatic renal carcinomas treated by cytokines: a report from the Groupe Français d’Immunothérapie, World journal of Urology, vol. 23 pp.161-165
Olschwang S, Bonaïti C, Feingold J, Frébourg T, Grandjouan S, Lasset C, Laurent-Puig P, Lecuru F, Millat B, Sobol H, Thomas G, Eisinger F (2005)
HNPCC syndrome (Hereditary Non Polyposis Colon Cancer): identification and management, Revue de Medecine Interne, vol. 26 pp.106-118
Negrier S , Perol D , Menetrier-Caux C , Escudier B , Pallardy M, Ravaud A , Douillard J-Y, Chevreau C, Lasset C , Blay J-Y (2004)
Interleukin-6 Interleukin-10 and Vascular Endothelial Growth Factor in Metastatic Renal Cell Carcinoma: Prognostic Value of Interleukin-6—From the Groupe Français d’Immunothérapie, Journal of clinical oncology, vol. 22(12) pp.2371-2378
Olschwang S, Bonaiti C, Feingold J, Frebourg T, Grandjouan S, Lasset C, Laurent-Puig P, Lecuru F, Millat B, Sobol H, Thomas G, Eisinger F (2004)
Identification and management of HNPCC syndrome (hereditary non polyposis colon cancer) hereditary predisposition to colorectal and endometrial adenocarcinomas, Bulletin du Cancer, vol. 91 pp.303-315
Sinilnikova OM, Ginolhac SM, Magnard C, Leone M, Anczukow O, Hughes D, Moreau K, Thompson D, Coutanson C, Hall J, Romestaing P, Gerard JP, Bonadona V, Lasset C, Goldgar DE, Joulin V, Venezia ND, Lenoir GM (2004)
Acetyl-CoA carboxylase alpha gene and breast cancer susceptibility, Carcinogenesis, vol. 25 pp.2417-2424
Bonadona V, Lasset C (2003)
Inherited predisposition to breast cancer: after the texitBRCA1 and BRCA2 genes what next?, Bulletin du Cancer, vol. 90 pp.587-594
Ginolhac SM, Gad S, Corbex M, Bressac-de-Paillerets B, Chompret A, Bignon YJ, Peyrat JP, Fournier J, Lasset C, Giraud S, Muller D, Fricker JP, Hardouin A, Berthet P, Maugard C, Nogues C, Lidereau R, Longy M, Olschwang S, Toulas C, Guimbaud R, Yannoukakos D, Szabo C, Durocher F, Moisan AM, Simard J, Mazoyer S, Lynch HT, Goldgar D, Stoppa-Lyonnet D, Lenoir GM, Sinilnikova OM (2003)
BRCA1 wild-type allele modifies risk of ovarian cancer in carriers of BRCA1 germ-line mutations, Cancer Epidemiology Biomarkers & Prevention, vol. 2 pp.90-95
Bonadona V, Saltel P, Desseigne f, Mignotte h, Saurin J-C, Wang Q, Sinilnikova O, Giraud S, Freyer G, Plauchu H, Puisieux A, Lasset C (2002)
Cancer Patients Who Experienced Diagnostic Genetic Testing for Cancer Susceptibility: Reactions and Behavior after the Disclosure of a Positive Test Result, Cancer Epidemiology Biomarkers & Prevention, vol. 11 pp.97-104
Auroy S, Avril MF, Chompret A, Pham D, Goldstein AM, Bianchi-Scarra G, Frebourg T, Joly P, Spatz A, Rubino C, Demenais F, Bressac-de Paillerets B, Berard F, Blanc JF, Boitier F, Bonnetblanc JM, Caux F, Cesarini JP, Chevrant-Breton J, Demange L, Esteve E, Frenay M, Grange F, Guillot B, d’Incan M, Lasset C, Le Corvaisier-Pieto C, Longy M, Michel JL, Saiag P, Sassolas B, Triller R, Vabres P (2001)
Sporadic multiple primary melanoma cases: CDKN2A germline mutations with a founder effect, Genes Chromosomes & Cancer, vol. 32 pp.195-202
Wang Q, Lasset C, Desseigne F, Frappaz D, Bergeron C, Navarro C, Ruano E, Puisieux A (1999)
Neurofibromatosis and early onset of cancers in hMLH1-deficient children, Cancer Research, vol. 59 pp.294-297
Mignotte H, Lasset C, Bonadona V (1998)
Iatrogenic risks of endometrial carcinoma after treatment for breast cancer in a large French case-control study, European Journal of Cancer, vol. 34 pp.S46-S47
Rimokh R, Berger F, Bastard C, Klein B, French M, Archimbaud E, Rouault J P, Santa Lucia B, Duret L, Vuillaume M (1994)
Rearrangement of CCND1 (BCL1/PRAD1) 3` untranslated region in mantle-cell lymphomas and t(11q13)-associated leukemias, Blood, vol. 83 pp.3689-3696
