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UMR CNRS 5558 - LBBE "Biométrie et Biologie Évolutive" UCB Lyon 1 - Bât. Grégor Mendel 43 bd du 11 novembre 1918 69622 VILLEURBANNE cedex
- Thèmes de recherche
- +Thèmes de recherche -Thèmes de recherche
Mon objectif au sein du laboratoire de « Biométrie et Biologie Evolutive », mais plus particulièrement dans l’équipe « Transposable Elements, Evolution and Populations » est d’apporter une approche bioinformatique afin d’étudier le rôle fonctionnel des éléments transposables au sein des génomes pour comprendre comment ces génomes évoluent.
- +CV -CV
Depuis 2010
Habilitation à diriger des recherchesDepuis 2005
Chargée de Recherche CNRS 1ère classe2004-2005
Post-Doctorante (lab. Biométrie et Biologie Evolutive, Université Lyon 1, financement de la Fondation pour la Recherche Médicale)2002-2004
Chercheur associé, Dep "Ecology and Evolutionary Biology", Université d’Arizona (Tucson, USA)2001-2002
ATER - Université Lyon 11998-2001
Thèse en bioinformatique soutenue le 26 octobre 2001, mention très honorable1997-1998
DEA Analyse de Génomes et Modélisation Moléculaire - Université Paris VII
+Publications -Publications
article :
Modolo L, Picard F, Lerat E (2014)
A new genome-wide method to track horizontally transferred sequences: application to Drosophila, Genome biology and evolution, vol. 6 pp.416-32, DOI.
Mey A, Acloque H, Lerat E, Gounel S, Tribollet V, Blanc S, Curton D, Birot A-M, Nieto A, Samarut J (2012)
The endogenous retrovirus ENS-1 provides active binding sites for transcription factors in embryonic stem cells that specify extra embryonic tissue, Retrovirology, vol. 9 pp.21-21, DOI.
Vieira C, Fablet M, Lerat E, Boulesteix M, Rebollo R, Burlet N, Akkouche A, Hubert B, Mortada H, Biemont C (2012)
A comparative analysis of the amounts and dynamics of transposable elements in natural populations of Drosophila melanogaster and Drosophila simulans, Journal of Environmental Radioactivity, vol. 113 pp.83-86.
Lerat E, Burlet N, Biemont C, Vieira C (2011)
Comparative analysis of transposable elements in the melanogaster subgroup sequenced genomes, Gene, vol. 473 pp.100-109, DOI.
Mortada H, Vieira C, Lerat E (2010)
Genes Devoid of Full-Length Transposable Element Insertions are Involved in Development and in the Regulation of Transcription in Human and Closely Related Species, Journal of Molecular Evolution, vol. 71 pp.180-191, DOI.
Deloger M, Cavalli FMG, Lerat E, Biémont C, Sagot M-F, Vieira C (2009)
Identification of expressed transposable element insertions in the sequenced genome of Drosophila melanogaster, Gene, vol. 439 pp.55-62.
Fablet M, Lerat E, Rebollo R, Horard B, Burlet N, Martinez S, Brasset E, Gilson E, Vaury C, Vieira C (2009)
Genomic environment influences the dynamics of the tirant LTR retrotransposon in Drosophila, FASEB Journal, vol. 23 pp.54-62, DOI.
Granzotto A, Lopes FR, Lerat E, Vieira C, Carareto CMA (2009)
The evolutionary dynamics of the Helena retrotransposon revealed by sequenced Drosophila genomes, BMC Evolutionary Biology, vol. 9(174) pp.95-148, DOI.
Lerat E (2009)
Identifying repeats and transposable elements in sequenced genomes: how to find your way through the dense forest of programs, Heredity, vol. 104 pp.520-533.
Vieira C, Fablet M, Lerat E (2009)
Infra- and Transspecific Clues to Understanding the Dynamics of Transposable Elements, Genome Dyn Stab, vol. pp.115-123, DOI.
Rebollo R, Lerat E, Lopez Kleine L, Biémont C, Vieira C (2008)
Losing helena: The extinction of a drosophila line-like element, BMC Genomics, vol. 9 pp.1-11.
Lerat E, Birot AM, Samarut J, Mey A (2007)
Maintenance in the Chicken Genome of the Retroviral-like cENS Gene Family Specifically Expressed in Early Embryos, Journal of Molecular Evolution, vol. 65 pp.215-227.
Lerat E, Sémon M (2007)
Influence of the transposable element neighborhood on human gene expression in normal and tumor tissues, Gene, vol. 396 pp.303-311.
Lerat E, Daubin V, Ochman H, Moran NA (2005)
Evolutionary origins of genomic repertoires in bacteria, PLoS Biology, vol. 3 pp.0807-0814.
Lerat E, Ochman H (2005)
Recognizing the pseudogenes in bacterial genomes, Nucleic Acids Research, vol. 33 pp.3125-3132.
Ochman H, Daubin V, Lerat E (2005)
A bunch of fun-guys: the whole-genome view of yeast evolution, Trends in Genetics, vol. 21 pp.1-3.
Ochman H, Lerat E, Daubin V (2005)
Examining bacterial species under the specter of gene transfer and exchange, Proceedings of The National Academy of Sciences of The United States of America, vol. 102 pp.6595-6599.
Edvardsen R, Lerat E, Maeland AD, Flat M, Tewari R, Jensen MF, Lehrach H, Reinhardt R, Seo H-C, Chourrout D (2004)
Hypervariable and highly divergent intron/exon organizations in the chordate Oikopleura dioica, Journal of Molecular Biology, vol. 59 pp.448-457.
Lerat E, Moran NA (2004)
The evolutionary history of quorum-sensing in bacteria, Molecular Biology and Evolution, vol. 21 pp.903-913.
Lerat E, Ochman H (2004)
$Psi$-$Phi$: Exploring the outer limits of bacterial pseudogenes, Genome Research, vol. 14 pp.2273-2278.
Daubin V, Lerat E, Perrière G (2003)
The source of laterally transferred genes in bacterial genomes, Genome Biology, vol. 4 pp.R57.1-R57.12.
Lerat E, Daubin V, Moran NA (2003)
From gene trees to organismal phylogeny in prokaryotes: the case of the gamma-Proteobacteria, PLoS Biology, vol. 1 pp.101-109.
Lerat E, Rizzon C, Biémont C (2003)
Sequence divergence within transposable element families in the Drosophila melanogaster genome, Genome Research, vol. 13 pp.1889-1896.
Lerat E, Capy P, Biémont C (2002)
Codon usage by transposable elements and their host genes in five species, Journal of Molecular Evolution, vol. 54 pp.625-637.
Lerat E, Capy P, Biémont C (2002)
The relative abundance of dinucleotides in transposable elements in five species, Molecular Biology and Evolution, vol. 19 pp.964-967.
Lerat E, Biémont C, Capy P (2000)
Codon usage and the origin of P elements, Molecular Biology and Evolution, vol. 17 pp.467-468.
Lerat E, Brunet F, Bazin C, Capy P (1999)
Is the evolution of transposable elements modular?, Genetica, vol. 107 pp.15-25.
Lerat E, Capy P (1999)
Retrotransposons and retroviruses: analysis of the envelope gene, Molecular Biology and Evolution, vol. 16 pp.1198-1207.
inbook :
Modolo L, Lerat E (2013)
Identification and Analysis of Transposable Elements in Genomic Sequences, , vol. pp.813-819.
Earnest-DeYoung JV, Lerat E, Moret BME (2004)
Reversing gene erosion: Reconstructing ancestral bacterial genomes from gene-content and order data, , vol. 3240 pp.1-13.
phdthesis :
Lerat E (2010)
HDR - Evolution of eukaryotic genomes and the impact of transposable elements .
Lerat E (2001)
Comparaison de séquences d`éléments transposables et de gènes d`hôtes chez cinq espèces : A. Thaliana C. Elegans D. Melanogaster H. Sapiens S. Cerevisiae .
