UMR CNRS 5558 Laboratoire de Biométrie et Biologie Évolutive

Current position

Since September 2011 I have been postdoctoral fellow at LBBE, working with Dr. Fabrice Vavre in the context of the ANR project ImmunSymbArt.

The main objective of the ImmunSymbArt project is to decipher the cellular and molecular processes involved in the maintenance and control of symbiosis, with a particular emphasis on immunity. To reach that objective we develop a comparative analysis of five contrasted models of symbiosis in arthropods : nutritional symbiosis of recent origin between the weevil Sitophilus oryzae and its symbiont SOPE ; recent transition towards obligate mutualism in the association between Asobara tabida and Wolbachia that is necessary for oogenesis completion ; commensal or non-obligate mutualistic symbioses in Drosophila melanogaster and Aedes albopictus infected by Wolbachia ; and conflictual symbiosis in the crustacean isopod Armadillidium vulgare where Wolbachia induces feminization of genetic males. On each model, massive sequencing (Illumina technology) on infected and uninfected samples has been performed.

My research interest is dedicated to the identification of common and specific pathways associated with symbiosis through the biological mining of the transcriptomic dataset.

Keywords

Host-symbiont interaction (parasitism and mutualism) ; co-evolution ; invertebrate immunity ; molecular biology ; next generation sequencing ; biochemistry ; proteomics

Detailed CV

Previous position

I was PhD student at the Ecology and Evolution Interactions laboratory (UMR 5244 CNRS-UPVD) at the University of Perpignan Via Domitia (France) between October 2007 and August 2011. My PhD work was advised by Pr. Guillaume MITTA and Dr. Benjamin GOURBAL. I recieved my PhD degree in March 2011 with "mention très honorable" (.pdf in french).

My goal was to investigate the molecular basis of the compatibility polymorphism (resulting from the reciprocal antagonistic co-evolution of hosts and parasites) observed in the Biomphalaria glabrata/Schistosoma mansoni, an host-parasite interaction. The main result of this work was to demonstrate for the first time in an invertebrate host-parasite interaction that a large repertoire of parasite epitopes matched a large repertoire of host immune receptors.

Publications

MONÉ Y., RIBOU A.C., COSSEAU C., DUVAL D., MITTA G., GOURBAL B.E. (2011). An example of molecular coevolution : ROS and ROS scavenger levels in Schistosoma mansoni/Biomphalaria glabrata interaction. International Journal for Parasitology, 41 (7), 721-730. [IF = 3,819]

MONÉ Y., MITTA G., DUVAL D., GOURBAL B.E. (2010a). Effect of amphotericin B on the infection success of Schistosoma mansoni in Biomphalaria glabrata. Experimental Parasitology. 125 (2), 70-75. [IF = 1,751]

MONÉ Y., GOURBAL B.E., DUVAL D., DU PASQUIER L, KIEFFER-JAQUINOD S, MITTA G. (2010b). A large repertoire of parasite epitopes matched by a large repertoire of host immune receptors in an invertebrate host/parasite model. PloS Neglected Tropical Diseases, 4(9) : e813. [IF = 4.693]

VIDAL-DUPIOL J., ADJEROUD M., ROGER E., FOURE L., DUVAL D., MONÉ Y., FERRIER-PAGES C., TAMBUTTE E., TAMBUTTE S., ZOCCOLA D., ALLEMAND D., MITTA G. (2009). Coral bleaching under thermal stress : putative involvement of host/symbiont recognition mechanisms. BMC Physiology, 9:14. [IF non available]

ROGER E., MITTA G., MONÉ Y., BOUCHUT A., ROGNON A., GRÜNAU C., BOISSIER J, THÉRON A., GOURBAL B.E.F., (2008). Molecular determinants of compatibility polymorphism in the Biomphalaria glabrata / Schistosoma mansoni model : new candidates identified by a global comparative proteomic approach. Molecular and Biochemical Parasitology, 157 (2), 205-216. [IF = 2,733]

GUILLOU F., ROGER E., MONÉ Y., ROGNON A., GRÜNAU C., THÉRON A., MITTA G., COUSTAU C., GOURBAL B.E.F., (2007). Excretory–secretory proteome of larval Schistosoma mansoni and Echinostoma caproni, two parasites of Biomphalaria glabrata. Molecular and Biochemical Parasitology, 155 (1), 45-56. [IF = 2,733]

Talks

MONÉ Y., CARPENTIER M.C., THÉRON A., MITTA G., GOURBAL B. & VAVRE F. Parasitism, mutualism et oxidative stress. Congress of the French research group on Ecology of Intimate Interactions (REID), February, 06-08th, 2012. Rennes (France).

MONÉ Y., DUVAL D., GOURBAL B.E.F. & MITTA G. A large repertoire of parasite epitopes matched by a large repertoire of invertebrate host immune receptors in the Schistosoma mansoni / Biomphalaria glabrata model. XIIth International Congress of Parasitology (ICOPA XII), 15-20th August 2010. Melbourne (Australia).

MONÉ Y., RIBOU AC., COSSEAU C, DUVAL D, THÉRON A, MITTA G. & GOURBAL B. Reactive oxygen species (ROS) and ROS scavengers in the Biomphalaria glabrata / Schistosoma mansoni interaction. Congress of the French research group on invertebrate immunity (IMMUNINV), May 04-06th, 2011. Nice (France).

MONÉ Y., DUVAL D., GOURBAL B.E.F. & MITTA G. Study of the interactome in the host-parasite interaction Biomphalaria glabrata / Schistosoma mansoni. Congress of the French research group on invertebrate immunity (IMMUNINV), October 21-23th, 2008. Poitiers (France).

MONÉ Y., ROGER E., GRÜNAU C., GOURBAL B.E.F. & MITTA G. Molecular determinants of compatibility in Biomphalaria glabrata / Schistosoma mansoni interaction : comparative proteomics approach and S. mansoni polymorphic mucins (SmPoMuc) characterization. Congress of the French research group on invertebrate immunity (IMMUNINV), April 23-25th, 2008. Montpellier (France).

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