UMR CNRS 5558 Laboratoire de Biométrie et Biologie Évolutive

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Anamaria Necsulea

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UMR CNRS 5558 - LBBE
"Biométrie et Biologie Evolutive"
UCB Lyon 1  - Bât. Grégor Mendel
43 bd du 11 novembre 1918
69622 VILLEURBANNE cedex

Bâtiment : Mendel 2ème étage Bureau : 211

Research themes
- +Long non-coding RNA evolution -Long non-coding RNA evolution
  
  Deciphering the mechanisms that drive the emergence of new phenotypes is a primary aim in biology. Evolutionary changes in regulatory mechanisms, which modify gene expression patterns but leave the gene products intact, are likely responsible for a large fraction of phenotypic innovations. Among the regulatory mechanisms important for phenotypic evolution, those involving non-coding RNAs are of particular interest. It was recently discovered that, in addition to protein-coding genes, mammalian genomes contain thousands of non-coding RNA genes with potential regulatory roles. Notably, long non-coding RNAs (lncRNAs, broadly defined as large RNA molecules lacking protein-coding potential) include regulatory RNAs that played key roles in mammalian evolution. Moreover, lncRNAs evolve rapidly and are largely lineage- specific, thus underlining the need to assess their roles in the emergence of lineage-specific phenotypes.