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UMR CNRS 5558 - LBBE "Biométrie et Biologie Evolutive" UCB Lyon 1 - Bât. Grégor Mendel 43 bd du 11 novembre 1918 69622 VILLEURBANNE cedex
- Research themes
- +Long non-coding RNA evolution -Long non-coding RNA evolution
Deciphering the mechanisms that drive the emergence of new phenotypes is a primary aim in biology. Evolutionary changes in regulatory mechanisms, which modify gene expression patterns but leave the gene products intact, are likely responsible for a large fraction of phenotypic innovations. Among the regulatory mechanisms important for phenotypic evolution, those involving non-coding RNAs are of particular interest. It was recently discovered that, in addition to protein-coding genes, mammalian genomes contain thousands of non-coding RNA genes with potential regulatory roles. Notably, long non-coding RNAs (lncRNAs, broadly defined as large RNA molecules lacking protein-coding potential) include regulatory RNAs that played key roles in mammalian evolution. Moreover, lncRNAs evolve rapidly and are largely lineage- specific, thus underlining the need to assess their roles in the emergence of lineage-specific phenotypes.
+Publications -Publications
article :
Boldanova T, Suslov A, Heim MH, Necsulea A (2017)
Transcriptional response to hepatitis C virus infection and interferon-alpha treatment in the human liver, EMBO Molecular Medicine, vol. 9 pp.816-834.
Saudemont B, Popa A, Parmley JL, Rocher V, Blugeon C, Necsulea A, Meyer E, Duret L (2017)
The fitness cost of mis-splicing is the main determinant of alternative splicing patterns, Genome biology, vol. 18 pp.208-208.
Amandio AR, Necsulea A, Joye E, Mascrez B, Duboule D (2016)
Hotair Is Dispensible for Mouse Development, PLoS Genetics, vol. 12 pp.e1006232-e1006232.
Beccari L, Yakushiji-Kaminatsui N, Woltering J M, Necsulea A, Lonfat N, Rodriguez-Carballo E, Mascrez B, Yamamoto S, Kuroiwa A, Duboule D (2016)
A role for HOX13 proteins in the regulatory switch between TADs at the HoxD locus, Genes & development, vol. 30 pp.1172-86.
Schep R, Necsulea A, Rodriguez-Carballo E, Guerreiro I, Andrey G, Nguyen Huynh TH, Marcet V, Zakany J, Duboule D, Beccari L (2016)
Control of Hoxd gene transcription in the mammary bud by hijacking a preexisting regulatory landscape, Proceedings of the National Academy of Sciences of the United States of America, vol. 113 pp.e7720-e7729.
Wiberg RA, Halligan DL, Ness RW, Necsulea A, Kaessmann H, Keightley PD (2015)
Assessing Recent Selection and Functionality at Long Noncoding RNA Loci in the Mouse Genome, Genome Biology and Evolution, vol. 7 pp.2432-44.
Barabote RD, Xie G, Leu DH, Normand P, Necsulea A, Daubin V, Médigue C, Adney WS, Xu XC, Lapidus A, Paralez RE, Detter C, Pujic P, Bruce D, Lavire C, Challacombe JF, Brettin TS, Berry AM (2009)
Complete genome of the cellulolytic thermophile Acidothermus cellulolyticus 11B provides insights into its ecophysiological and evolutionary adaptations, Genome Research, vol. 19(6) pp.1033-1043.
Boussau B, Blanquart S, Necsulea A, Lartillot N, Gouy M (2008)
Parallel adaptations to high temperatures in the Archaean eon, Nature, vol. 456 pp.942-945.
