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le jeudi 27 novembre à 11:00

Serena Bradde (Initiative for the Theoretical Sciences, Graduate Center at CUNY, NY)

Salle de conférence bâtiment l’Herbier

par Vincent Daubin - 27 novembre 2014

Emergence of global patterns in bacterial growth : from single cells to communities

Understanding how phenomenological behaviors observed in biological systems
emerge from molecular interactions of many individual unit and how these
interactions shape the response of living systems to a changing environment
are challenging questions which lie at the interface between multiple
disciplines. In this talk I will draw an example from the human gut
microbiome, the full consortium of microbes living in association with the
human gut. Recent developments in DNA sequencing have made it possible to
monitor how the compositions of microbial species change in time. Analysis
of healthy adults under antibiotic treatment showed that the gut microbiota
could take several weeks to recover after treatment cessation. This
suggests that the combination of inter-species and host-microbe
interactions and external perturbations could lead to hysteresis phenomena.
We investigate this possibility and propose an out of equilibrium
stochastic model able to explain this phenomenon. Our study reveals the
importance of noise-activated dynamics in the recovery from
antibiotic-perturbed states.