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- +Scientific interests -Scientific interests
Developping new protein substitution models in Maximum Likelihood to improve phylogenetic inferences such as phylogenetic reconstructions or ancestral sequence reconstruction. These models aim at capturing the non-homogeneity of sequence evolution in terms of amino-acid composition, either between branches or among sites. These models are implemented in C++ within the Bio++ Librairies. Using non-homogeneous models and accurate gene trees to infer ancestral sequences of protein-coding genes, to ultimately resurrect them in a wet lab. I am particularly interested in the influence of ionic and solvent environment on 3D structures and its link with sequence evolution. I am also involved in resurrection projects to study the influence of environmental temperature or duplication events in the evolution of sequence and biological functions. Using branch-heterogeneous models of sequence evolution to infer ancestral environmental conditions of life, such as optimal growth temperature and investigating its influence on genome evolution.
- +Brief resume -Brief resume 2010-2013: PhD in "Bioinformatics and Evolutionary genomics" with Manolo Gouy at LBBE (Lyon 1 University, France) 2010-2013: Teaching Assistant (64h / year) at Lyon 1 University and Ecole Normale Supérieure (ENS) de Lyon 2010: 4 month of research intership with Manolo Gouy at LBBE (Lyon 1 University, France) 2010: 4 month of research intership with Ziheng Yang at UCL (London, England) 2009: 4 month of research intership with Manolo Gouy at LBBE (Lyon 1 University, France) 2008-2010: MSc "Biosciences" at Ecole Normale Supérieure (ENS) de Lyon (Rank = 1st) 2007: 2 month of research internship with Patrick Forterre and Jacques Oberto at Paris XIII University (Orsay) 2004-2007: BSc "Fundamental Biology" at Ecole Normale Supérieure (ENS) de Lyon (Rank = 7th)
- +Talks -Talks 2012: Efficiently modeling the non-homogeneity of protein sequence evolution. Evolution meeting in Ottawa. Abstract selection for the Ernst Mayr award. 2012: Efficiently modeling the non-homogeneity of protein sequence evolution. SMBE meeting in Dublin. Abstract selection. 2011: The COaLA model : a Time Non-Homogeneous Model of Evolution Based on a Correspondence Analysis. Deep Metazoan Phylogeny meeting in Munich. Abstract selection. 2011: From Extant Molecules To Ancestral Conditions of Life : How the Adaptation to Temperature Drives the Evolution of Archaea. Archaea meeting in Paris. Abstract selection. 2010: Environmental temperature is a major determinant of evolutionary rates in Archaea SMBE meeting in Lyon. Abstract selection.
+Publications -Publications
article :
Groussin M, Boussau B, Szollosi G, Eme L, Gouy M, Brochier-Armanet C, Daubin V (2016)
Gene Acquisitions from Bacteria at the Origins of Major Archaeal Clades Are Vastly Overestimated, Molecular Biology and Evolution, vol. 33 pp.305-10.
Groussin M, Hobbs J K, Szollosi G J, Gribaldo S, Arcus V L, Gouy M (2015)
Toward more accurate ancestral protein genotype-phenotype reconstructions with the use of species tree-aware gene trees, Molecular Biology and Evolution, vol. 32 pp.13-22.
Ramulu H G, Groussin M, Talla E, Planel R, Daubin V, Brochier-Armanet C (2014)
Ribosomal proteins: Toward a next generation standard for prokaryotic systematics?, Molecular phylogenetics and evolution, vol. 75C pp.103-117.
Groussin M, Boussau B, Charles S, Blanquart S, Gouy M (2013)
The molecular signal for the adaptation to cold temperature during early life on Earth, Biology Letters, vol. 9 pp.20130608-20130608.
Groussin M, Boussau B, Gouy M (2013)
A branch-heterogeneous model of protein evolution for efficient inference of ancestral sequences, Systematic biology, vol. 62 pp.523-38.
Guéguen L, Gaillard S, Boussau B, Gouy M, Groussin M, Rochette N, Bigot T, Fournier D, Pouyet F, Cahais V, Bernard A, Scornavacca C, Nabholz B, Haudry A, Dachary L, Galtier N, Belkhir K, Dutheil J Y (2013)
Bio++: Efficient Extensible Libraries and Tools for Computational Molecular Evolution, Molecular Biology and Evolution, vol. 30 pp.1745-1750.
Groussin M, Gouy M (2011)
Adaptation to Environmental Temperature Is a Major Determinant of Molecular Evolutionary Rates in Archaea, Molecular Biology and Evolution, vol. 28 pp.2661-2674.
Groussin M, Pawlowski J, Ziheng Y (2011)
Bayesian relaxed clock estimation of divergence times in foraminifera, Molecular Phylogenetics and Evolution, vol. 61 pp.157-166.
inbook :
Groussin M, Daubin V, Gouy M, Tannier E (2016)
Ancestral Reconstruction: Theory and Practice
in: The Encyclopedia of Evolutionary Biology, , pp.70-77.
phdthesis :
Groussin M (2013)
Résurrection du passé à l’aide de modèles hétérogènes d’évolution des séquences protéiques. .
