Research Projects
Trois thématiques dont les approches se chevauchent sont développées au sein de l’équipe.
Contrats de recherche
Les membres de l’équipe ont des contrats de recherche avec la FRM, l’ANR, le CNRS et l’IUF.
Epigenetics and genome stability : how the environment affects transposable element stability.
We study genome stability through the diversity of the epigenetic pathways controlling TEs, in normal conditions and when the environment changes. We use fresh Drosophila samples coming from temperate (France) and tropical (Brasil) areas, that are submitted to various environmental stress. We then characterize TE content and activity as well as epigenetic regulation using NGS technologies.
People involved : C. Vieira, M. Fablet, J. Salces-Ortiz, B. Fraga Menezes
Funding : Fondation pour la Recherche Médicale
Endogenous Retroviruses and Immunity
We want to investigate the interplay between the host immune responses to arbovirus (Arthropod Borne virus) infections and the TE and Endogenous Retroviruses (ERV) genomic control mechanisms (RNA interference : piRNA and siRNA pathways) using Drosophila as an in vivo model system. To this end, we will take advantage of the natural variability existing between and within species for ERVs (copy numbers, activities, and control by the piRNA pathway).
People involved : M. Fablet, C. Terzian, F. Arnaud
Funding : Labex ECOFECT
