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Annelyse Thevenin

Salle de l’herbier, 9 rue Raphaël Dubois

par Vincent Daubin - 23 octobre 2013

Organization of genes along genome during evolution.

The organization of genes along a genome is not random. There exists
various proofs of specific rearrangements such that operon for
procaryote organisms.

In the goal to better understand how this organization can explain the
correlation between chromosomic mutation in cancer, we studied the
organization of co-functional genes on the human genome (pathways,
protein complexes, RNAt, etc). Using statistics, we observed significant
concentrations (or dispersions) for sets of co-functioning genes. We
evaluated the organization of these sets of genes through three aspects :
number of chromosomes involved, genomic distance, spatial
intra-chromosomic distance. This organization seems to depend on the
functional category (FunCat) of each set of genes. From this results, we
start to work on the evolution of these concentrations and dispersions
among various species.

Moreover, in order to observe some (dis)similarities between genomes, it
is necessary to define realistic models and measures. We have
implemented models (based of graph theory and mathematic programming) to
compute in particular common adjacencies between genomes. These models
take into account increasingly biologic information despite the
complexity of the studied problems.