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Accueil > Annuaire > Haudry Annabelle > Projets de Recherche > Influence of TEs on histone marks changes associated with tumor in human

Influence of TEs on histone marks changes associated with tumor in human



Transposable elements (TEs) are particularly abundant in the human genome as they constitute 40% of its sequence. We have previously shown that the presence of TEs in the vicinity of genes may affect their expression under different conditions. One question is whether this effect is related to epigenetic changes, specifically post-translational modifications of histones, which are known to be involved in gene regulation. Using Chip-seq data informing on histone marks for the entire genome in different tissues (cancerous and healthy) and the complete annotation of the human genome, it is possible to look for links between the presence of TEs and specific histone changes. This project aims to identify potential (i) associations between TE families and particular histone marks, (ii) tissue-specific histone modifications, (iii) differences in histone modifications associated to the cancerous state of a given tissue.

People involved :
E. Lerat, L. Gregoire, A. Haudry