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Accueil > Annuaire > Haudry Annabelle > Projets de Recherche > Selection on noncoding DNA in Brassicaceae

Selection on noncoding DNA in Brassicaceae

Despite the central role of noncoding DNA in gene regulation and evolution, our understanding of the genomic extent and nature of selection on plant noncoding regions remains limited. Comparative genomics and population genomics are powerful approaches to analyze patterns of molecular evolution and the strength of selection of noncoding DNA. On whole genome alignments of nine Brassicaceae species recently sequenced, we identified over 90,000 conserved noncoding regions (CNSs) that show a degree of conservation across species similar to average coding exons and no evidence of expression or coding potential. Gene ontology analysis and CNSs enrichment in binding site motifs support the potential regulatory function of CNSs. Population genomic analyses in A. thaliana (selfing) and C. grandiflora (outcrossing) can be used to estimate levels of diversity and strength of the purifying selection acting on CNSs. Diversity data on those two species could be used to test how the mating system affect the efficiency of selection.

People involved : A. Haudry
Collaborators :
A. Moses, S. Wright, R. Williamson, E. Josephs (University of Toronto, Toronto, Canada)
A. Platts , M. Blanchette, T. Bureau (McGill University, Montreal, Canada)