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Viral evolution

Dengue virus evolution

In collaboration with Marlène Dreux, I have started a project to annotate the Dengue virus genome through experimental evolution and bioinformatics.
Dengue virus transmits to humans through mosquito bites. Yet, very little is known about how Dengue virus interacts with its mosquito host. The goal of this project is to use experimental evolution to identify the sites in the viral genome that interact with the machinery of the mosquito cell. To this end, we will assemble and estimate the fitness of several viral genomes.