Statistics and Modelling for Health Sciences
Evaluation and Modeling with the Therapeutic Effects Group
Lega Jean-Christophe
Professeur d'université - praticien hospitalier
UCBL
Tel: 33 04 78 86 33 01
Mon travail est centré sur la balance bénéfice risque et le niveau de preuve de l'effet traitement des antithrombotiques et des immunosuppresseurs, en rapport avec mon activité hospitalière aux Hospices Civils de Lyon. Cette modélisation est notamment basée sur la réalisation de méta-analyse (risque de base, stratification du risque et interaction de l'effet traitement, effet des sous-populations humaines et médecine personnalisée).
La constitution de registre à partir des base de données hospitalières des HCL est aussi un axe émergent, en utilisant des approches natural language processing, pour l'estimation de la safety et l'effectiveness des thérapeutiques.
Je suis responsable de l'Equipe Modélisation et Modélisation des Effets Thérapeutiques depuis janvier 2021.
Publications
Display of 1 to 30 publications on 37 in total
Prolonged response after TPO-RA discontinuation in primary ITP: results of a prospective multicenter study
Blood .
Journal article
see the publicationImmune thrombocytopenia and pregnancy: an exposed/nonexposed cohort study
Blood . 141 ( 1 ) : 11-21
Journal article
see the publicationA call for evidence in connective tissue diseases-associated interstitial lung disease
Joint Bone Spine . 89 ( 1 ) : 105274
Journal article
see the publicationSplenectomy for primary immune thrombocytopenia revisited in the era of thrombopoietin receptor agonists: New insights for an old treatment
American Journal of Hematology . 97 ( 1 ) : 10-17
DOI: 10.1002/ajh.26378
Journal article
see the publicationManagement and Outcome of COVID-19 Positive and Negative Patients in French Emergency Departments During the First COVID-19 Outbreak: A Prospective Controlled Cohort Study
Western Journal of Emergency Medicine . 23 ( 6 ) : 897-906
Journal article
see the publicationHuman Papilloma Virus Vaccination in Patients with Rheumatic Diseases in France: A Study of Vaccination Coverage and Drivers of Vaccination
Journal of Clinical Medicine . 11 ( 14 ) : 4137
DOI: 10.3390/jcm11144137
Journal article
see the publicationPopulation designations in biomedical research: limitations and perspectives
HLA: Immune Response Genetics .
DOI: 10.1111/tan.14852
Journal article
see the publicationArterial and venous thromboembolism in COVID-19: a study-level meta-analysis
Thorax . 76 ( 10 ) : 970-979
Journal article
see the publicationAssessing the management of major bleeding events in patients treated by direct oral anticoagulant in an emergency department
Annales de Biologie Clinique . 79 ( 4 ) : 315-324
Journal article
see the publicationImmune thrombocytopenia with clinical significance in systemic lupus erythematosus: a retrospective cohort study of 90 patients.
Rheumatology .
Journal article
see the publicationEarly trajectories of skin thickening are associated with severity and mortality in systemic sclerosis
Arthritis Research and Therapy . 22 ( 1 ) : 30
Journal article
see the publicationFrench recommendations for the management of systemic necrotizing vasculitides (polyarteritis nodosa and ANCA-associated vasculitides)
Orphanet Journal of Rare Diseases . 15 ( S2 ) : 351
Journal article
see the publicationEarly-onset autoimmunity associated with SOCS1 haploinsufficiency
Nature Communications . 11 ( 1 )
Journal article
see the publicationContribution of rare and predicted pathogenic gene variants to childhood-onset lupus: a large, genetic panel analysis of British and French cohorts
The Lancet Rheumatology . 2 ( 2 ) : e99-e109
Journal article
see the publicationContribution of rare and predicted pathogenic gene variants to childhood-onset lupus: a large, genetic panel analysis of British and French cohorts
The Lancet Rheumatology . 2 ( 2 ) : e99-e109
Journal article
see the publicationSurvival and prognosis factors in systemic sclerosis data of a French multicenter cohort, systematic review, and meta-analysis of the literature
Arthritis Research and Therapy . 21 ( 1 ) : 86
Journal article
see the publicationMonogenic lupus: Dissecting heterogeneity
Autoimmunity Reviews . 18 ( 10 )
Journal article
see the publicationTreatment of idiopathic inflammatory myositis associated interstitial lung disease: A systematic review and meta-analysis
Autoimmunity Reviews . 18 ( 2 ) : 113 - 122
Journal article
see the publicationExtended anticoagulation for the secondary prevention of venous thromboembolic events: An updated network meta-analysis
PLoS ONE . 14 ( 4 ) : e0214134
Journal article
see the publicationMortality in systemic necrotizing vasculitides: A retrospective analysis of the French Vasculitis Study Group registry
Autoimmunity Reviews . 17 ( 7 ) : 653--659
Journal article
see the publicationCauses and consequences of variation in offspring body mass: meta-analyses in birds and mammals
Biol. Rev . 93 : 1 - 27
DOI: 10.1111/brv.12329
Journal article
see the publicationAdding Azathioprine to Remission-Induction Glucocorticoids for Eosinophilic Granulomatosis With Polyangiitis (Churg-Strauss), Microscopic Polyangiitis, or Polyarteritis Nodosa Without Poor Prognosis Factors
Arthritis & rheumatology . 69 ( 11 ) : 2175 - 2186
DOI: 10.1002/art.40205
Journal article
see the publicationIntravenous Immunoglobulins Improve Survival in Monoclonal Gammopathy-Associated Systemic Capillary-Leak Syndrome
The American Journal of Medicine . 130 ( 10 ) : 1219.e19 - 1219.e27
Journal article
see the publicationIsolated positive anti-SS-B autoantibodies are not related to clinical features of systemic autoimmune diseases
PLoS ONE . 12 ( 9 )
Journal article
see the publicationHeterogeneous clinical spectrum of anti-SRP myositis and importance of the methods of detection of anti-SRP autoantibodies: a multicentric study
Immunologic Research . 64 ( 3 ) : 677-686
Journal article
see the publicationTocilizumab in the treatment of mixed connective tissue disease and overlap syndrome in children
RMD Open : Rheumatic & Musculoskeletal Diseases . 2 ( 2 ) : e000271
Journal article
see the publicationIdiopathic inflammatory myopathies and the lung
European Respiratory Review . 24 ( 136 ) : 216-238
Journal article
see the publicationCharacteristics, prognosis, and outcomes of cutaneous ischemia and gangrene in systemic necrotizing vasculitides: a retrospective multicenter study
Seminars in Arthritis and Rheumatism . 43 ( 5 ) : 681--688
Journal article
see the publicationThe clinical phenotype associated with myositis-specific and associated autoantibodies: a meta-analysis revisiting the so-called antisynthetase syndrome
Autoimmunity Reviews . 13 : 883-91
Journal article
see the publicationThe clinical phenotype associated with myositis-specific and associated autoantibodies: a meta-analysis revisiting the so-called antisynthetase syndrome
Autoimmunity Reviews . 13 ( 9 ) : 883-891
Journal article
see the publication