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Fitness Landscapes & Dynamics of Adaptation: what can we infer from patterns of phenotypic and molecular evolution?

Thomas Bataillon

universite d'Aarhus, DK

The distribution of fitness effect of new mutations is central to many questions in evolutionary biology such as: what type of genetic variation enables sustained evolution, does adaptation to a given environment entails systematically a cost in different environments, what forces maintain phenotypic and molecular variation we observe in extant populations, etc. Fitness landscapes link the (phenotypic) effect of a new mutation and its fitness consequences. I will present recent work geared at inferring distribution of fitness effects and more broadly the properties of fitness landscapes underlying adaptation. I will consider empirical data bearing both on phenotypic evolution in experimental populations and patterns of molecular variation in natural populations.