Predictive Modelling and Ecotoxicology Group
Members
Professeur des universités
UCBL
Tel: 33 04 72 43 29 00
Doctorante
CNRS
Ingénieure d'études CDD
UCBL
Maître de conférences
UCBL
Tel: 33 04 72 44 80 51
Research activities of team MEPS team aim at proposing integrated mathematical and statistical modelling approaches to predict the effects of environmental disturbances at different levels of biological organisation. We are also interested in their functional and evolutionary consequences whether on individual fitness, population, community and/or ecosystem dynamics. In order to build generic enough models with a high predictive power, team MEPS is particularly interested in understanding the functioning of the complex systems under consideration, and not only a very refined description of them. Thus, our models always respect the parsimony principl, ensuring that they remain sufficiently simple with limited "black box" effects. Particular attention is also paid to the robustness, and therefore the generalizability, of the knowledge produced through these models, with the final goal of improving the overall acceptability of modelling approaches in support of decision-making for environmental risk assessment.
Reducing the complexity of systems in order to produce relevant and generic enough models must not preclude having solid mathematical foundations, so that these models remain useful tools for understanding the mechanisms underlying disturbance processes and effects observed on tissues, organisms, populations, communities and/or ecosystems. Such mechanistic models must also include the temporal dimension, which is essential when we are talking about dynamic processes as for realistic exposure scenarios to several environmental pressures. At the same time, complementary criteria of short- and long-term effects must be taken into account to address issues such as remediation and restoration of some specific environments as well as the potential of providing a dynamical and integrative prediction of effects over several generations.
In this context, team MEPS is today focused on the following topics:
- The development of mechanistic models based on physiological, namely physiologically based toxicokinetic-toxicodynamic (PBTKTD) models, in the perspective of providing predictive and diagnostic tools for the environmental quality;
- The plasticity of individual responses to one (or a combination of) stress factor(s) (e.g. contamination and/or global warming) and the effects of adaptation phenomena on the long-term dynamics of populations;
- The prediction of the species sensitivity distribution within communities when exposed to chemical contaminants by integrating inter-species variability on various biological parameters of interest and not only on a critical effect concentration;
- The development and the maintenance of the MOSAIC web platform (MOdeling and StAtistical tools for ecotoxICology, http://mosaic.univ-lyon1.fr) which freely and in a user-friendly way provides a collection of tools for data analysis and modelling in the field of ecotoxicology.
Publications
Display of 31 to 60 publications on 190 in total
A critical review of effect modeling for ecological risk assessment of plant protection products
Environmental Science and Pollution Research . 29 : 43448-43500
Journal article
see the publicationRecent advances in the development of the comet assay on the hemocytes of zebra mussels and its application in field studies for evaluating environmental genotoxicity
International Comet Assay Workshop - 14th annual meeting .
Conference paper
see the publicationPredicting characterization factors of chemical substances from a set of molecular descriptors based on machine learning algorithms
Peer Community In Ecotoxicology and Environmental Chemistry . : 100001
Other publication
see the publicationTaking full advantage of modelling to better assess environmental risk due to xenobiotics
Environmental Science and Pollution Research .
Journal article
see the publicationGeneric Solving of One-compartment Toxicokinetic Models
Journal of Exploratory Research in Pharmacology .
Journal article
see the publicationKeeping modelling notebooks with TRACE: Good for you and good for environmental research and management support
Environmental Modelling & Software . 136 : 104932
Journal article
see the publicationOne and multi-compartments toxico-kinetic modeling to understand metals’ organotropism and fate in Gammarus fossarum
Environment International . 156 : 106625
Journal article
see the publicationThe added value of Bayesian inference for estimating biotransformation rates of organic contaminants in aquatic invertebrates
Aquatic Toxicology . 234 : 105811
Journal article
see the publicationAccumulation-depuration data collection in support of toxicokinetic modelling
Preprint
see the publicationHow to account for the uncertainty from standard toxicity tests in species sensitivity distributions: An example in non-target plants
PLoS ONE .
Journal article
see the publicationApplication of General Unified Threshold Models of Survival Models for Regulatory Aquatic Pesticide Risk Assessment Illustrated with an Example for the Insecticide Chlorpyrifos
Integrated Environmental Assessment and Management . 17 ( 1 ) : 243-258
DOI: 10.1002/ieam.4327
Journal article
see the publicationIn Situ Reproductive Bioassay with Caged Gammarus fossarum (Crustacea): Part 1—Gauging the Confounding Influence of Temperature and Water Hardness
Environmental Toxicology and Chemistry . 39 ( 3 ) : 667-677
DOI: 10.1002/etc.4655
Journal article
see the publicationIn Situ Reproductive Bioassay with Caged Gammarus fossarum (Crustacea): Part 2—Evaluating the Relevance of Using a Molt Cycle Temperature‐Dependent Model as a Reference to Assess Toxicity in Freshwater Monitoring
Environmental Toxicology and Chemistry . 39 ( 3 ) : 678-691
DOI: 10.1002/etc.4656
Journal article
see the publicationModèles de croissance des micro-organismes, in Micro-organismes & biodiversité
Textes et documents pour la classe . 1130 : 60-63
Journal article
see the publicationRecommendations to address uncertainties in environmental risk assessment using toxicokinetic-toxicodynamic models
Scientific Reports . 9 ( 1 )
Journal article
see the publicationA Bayesian framework for estimating parameters of a generic toxicokinetic model for the bioaccumulation of organic chemicals by benthic invertebrates: Proof of concept with PCB153 and two freshwater species
Ecotoxicology and Environmental Safety . 180 : 33-42
Journal article
see the publicationScientific Opinion on the state of the art of Toxicokinetic/Toxicodynamic (TKTD) effect models for regulatory risk assessment of pesticides for aquatic organisms
EFSA Journal . 16 ( 8 )
Journal article
see the publicationFit Reduced GUTS Models Online: From Theory to Practice
Integrated Environmental Assessment and Management . 14 ( 5 ) : 625-630
DOI: 10.1002/ieam.4061
Journal article
see the publicationNew Insights to Compare and Choose TKTD Models for Survival Based on an Interlaboratory Study for Lymnaea stagnalis Exposed to Cd
Environmental Science and Technology . 52 ( 3 ) : 1582-1590
Journal article
see the publicationMOSAIC: a web-interface for statistical analyses in ecotoxicology
Environmental Science and Pollution Research . 25 ( 12 ) : 11295-11302
Journal article
see the publicationMOSAIC : une plate-forme web pour l’analyse statistique des données d’écotoxicologie. Fiche Thématique N°13
: 4 p.
tRophicPosition , an r package for the Bayesian estimation of trophic position from consumer stable isotope ratios
Methods in Ecology and Evolution . 9 ( 6 ) : 1592-1599
Journal article
see the publicationCombined effect of temperature and ammonia on molecular response and survival of the freshwater crustacean Gammarus pulex
Ecotoxicology and Environmental Safety . 137 : 42-48
Journal article
see the publicationDe la bioaccumulation aux effets écotoxicologiques : comment modéliser le cycle de vie de Gammarus fossarum pour prédire et évaluer l’impact d’une contamination sur les populations d’une espèce sentinelle en biosurveillance ?
Colloque 2016 de la Société Française d'Ecotoxicologie Fondamentale et Appliquée . : 56
Conference paper
see the publicationCombined effect of temperature and ammonia on the freshwater crustacean Gammarus pulex
SETAC Europe 26th Annual Meeting .
Conference paper
see the publicationModelling survival: exposure pattern, species sensitivity and uncertainty
Scientific Reports . 6 : 29178
DOI: 10.1038/srep29178
Journal article
see the publicationCombined effect of temperature and ammonia on the freshwater crustacean Gammarus pulex
SETAC Europe 26th Annual Meeting .
Poster
see the publicationMechanistic modelling of daphnid-algae dynamics within a laboratory microcosm
Ecological Modelling . 320 : 213–230
Journal article
see the publicationEcophysiological responses of Gammarus pulex to the combined effects of temperature and ammonia
26th Annual Meeting SETAC Europe .
Poster
see the publication