Showing results 701 to 720 on 1245 in total
These de Janice Kielbassa - mardi 12 octobre 2010 - Amphi Ampère
Merci de me confirmer votre présence par mail à mariethe.chaumeil@chu-lyon.fr
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Thèse de Micheline Guisérix - Mercredi 1er juillet 2009 à 14h00 - Amphi du CNRS
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Population-level effects of chemicals, for example pesticides, depend not only on exposure and toxicity but also on ecological factors. It is impossible to fully address these factors empirically. Mechanistic effect models, for example ecological models, can solve this problem. They can be used to extrapolate results from single species tests and higher tier tests to the population level and larger scales. Currently, however, there is no common framework that would allow developing such models and assessing their quality in a coherent way. The EU-funded project CREAM ("Mechanistic Effect Models for Ecological Risk Assessments of Chemicals") aims at developing and establishing such a framework. CREAM will not only focus on what Good Modelling Practice is but also on how it can be developed and established. CREAM's central approach will be to use a common framework for documenting the modelling process, dubbed TRACE (Transparent Comprehensive Modelling) documentation. TRACE provides a common structure for organizing and, at the same time, documenting the modelling process on a day-to-day basis. I will demonstrate the use of TRACE using example models. Finally, I will discuss a main further challeng of ecological modelling for chemical risk assessment: the agreement on practical but meaningful population-level endpoints.See the two regional speakers on the SEMOVI web page : http://www.cgmc.univ-lyon1.fr/Semovi/
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Habilitation à diriger des recherches de Marie Hélène Metzger - Jeudi 10 mai 2012 - 14h00 - Rockefeller
Thèse de Yoann Blangero le 13 septembre 2019 à 14 h, salle des thèses Rockefeller
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We study a poorly characterized bacterial gender of the Planctomycetes phylum, Gemmata obscuriglobus. Planctomycetes are major players in the global nitrogen and carbon cycles and are uniquely capable of anaerobic ammonium oxidation (a globally important nitrogen transformation). Within that phylum, the bacteria of the gender Gemmata are particularly interesting due to their complex intracellular membranous organization that is sustained by proteins showing similarity to the eukaryotic equivalent ones and their capability to internalize fully folded proteins in a process reminiscent of eukaryotic endocytosis (Lohnienne et al., 2010).We use a combination of computational, molecular biology, and electron-microscopy to first, decipher the peculiar biology of the Planctomycetes and second, to understand their contribution to eukaryotic origin. Computationally, we use structure to push the limits of sequence homology detection. Amongst other tools, we use protein architecture correlation to detect potential relationship between distantly related proteins (Santarella-Mellwig et al. PLoS Biol. 2010).
Thèse de Susan Higashi le mercredi 26 novembre 2014 à 14 h 30 - amphithéâtre bâtiment Paul Dirac (Doua)
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Thèse de Laura URBINI le lundi 23 octobre 2017 à 10 h, salle Fontannes bâtiment Darwin D (La Doua)
Le registre du Rhône, qui fête cette année ses 20 ans, recense l'ensemble des victimes des accidents de la route corporels survenus dans le département du Rhône. Pour chacune des victimes étant passées par les services de soins hospitaliers, un bilan lésionnel complet est connu, selon la classification AIS (Abbreviated Injury Scale). L'objectif de ce travail est de décrire ces tableaux lésionnels, et notamment les associations privilégiées entre les différentes lésions. D'autre part, la question de la spécificité des associations en fonction du type d'usager (automobiliste, motard, cycliste ou piéton typiquement) sera également abordée. Après avoir rappelé les principes généraux des modèles graphiques binaires et de l'estimation pénalisée, nous montrerons comment le choix d'une pénalité adaptée permet de répondre à l'ensemble de ces questions sur les données du Registre du Rhône.Contact : Mme Mariethé CHAUMEIL Inscription gratuite mais obligatoire avant LUNDI 02 novembre 2015 Courriel : mariethe.chaumeil@chu-lyon.fr