Equipe Le Cocon

Membres

Le Cocon is both a research team and a think tank. 

Research in “Le Cocon” team focuses on two main topics: multiscale evolution on one hand (i.e., studying the evolution of genetic systems while considering different levels -nucleotides, transposable elements, genes, genomes, microbiomes, organisms, populations, species, geography-), and environmental issues on the other hand. In both cases, we rely on modeling and data analysis, using a combination of statistics and computer science.

Le Cocon is also a place to think about the responsibilities of research and researchers in the anthropocene era, and about the role of non-researcher citizens in orienting and conducting research.

Multiscale evolution

  • We have a long history of working on gene transfers. We develop new methods to detect these events in complex systems involving more than two levels (host, symbiont and parasites for example) and
  • We use horizontal transfer detection to date species trees and to infer yet unknown biodiversity (extinct and unsampled) (Sthoriz (ANR, 2018)) .
  • We have a lasting interest into convergent genomic evolution (Convergenomics - ANR, 2015)
  • We question the usual way of testing bioinformatic methods (Evoluthon - ANR, 2019)
  • We study the interaction between human populations, their lifestyles, and their gut microbiota (Microregal - ANR, 2015). We are notably interested in identifying cases of host-microbe coevolution and in better understanding transmission dynamics.

Environmental issues

  • We develop computational methods to support an agriculture that relies on ecosystemic relationships between crops, the soil, its microbiota, and wild plants and animals (Community Garden Book - Inria, 2019)
  • We develop statistical approaches to understand and predict crop yield variability with respect to meteorological conditions

Research in the anthropocene

  • We participate to the science shop (UdL), the ethics platform (UdL), Labo1.5, the open science committee, Sciences Citoyennes, the shift project
  • We organize a series of seminars to help us think about the position of scientific research in the history of the anthropocene, and about the position of scientists in the future of the anthropocene.
  • We assemble committees of citizens to investigate to what extent scientific research can be democratized.

Teaching and outreach

  • We teach at University of Lyon, University Lyon 1, INSA, Inria, ENS Lyon, we organize bioinformatics internships 
  • We regularly participate in the Fête de la Science, have contributed videos in the public transportation system in Lyon, give conferences at Université Populaire and contribute articles in general public journals.
  • We develop the software Lifemap to explore the tree of life on computers and smartphones.

 
Prospective students and postdocs are invited to apply, as we often welcome visitors for internships or research projects.

Publications

Affichage des publications 91 à 120 sur 243 au total

The transposable element environment of human genes is associated with histone and expression changes in cancer

Laura Grégoire, Annabelle A. Haudry, Emmanuelle Lerat

BMC Genomics . 17 ( 1 )

DOI: 10.1186/s12864-016-2970-1

Article dans une revue

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The inference of gene trees with species trees

Gergely Szöllősi, Eric Tannier, Vincent Daubin, Bastien Boussau

Systematic Biology . 64 ( 1 ) : e42-e62

DOI: 10.1093/sysbio/syu048

Article dans une revue

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Reconstruction of an ancestral Yersinia pestis genome and comparison with an ancient sequence

Wandrille Duchemin, Vincent Daubin, Eric Tannier

BMC Genomics . 16 ( Suppl 10 ) : S9

DOI: 10.1007/978-3-319-19048-8_16

Article dans une revue

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Sex and evolution

Pierre-Henri Gouyon, Damien De Vienne, Tatiana Giraud

Handbook of Evolutionary Thinking in the Sciences . 978-94-017-9013-0 : 499--507

Chapitre d'ouvrage

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Degeneration of the Nonrecombining Regions in the Mating-Type Chromosomes of the Anther-Smut Fungi

Eric Fontanillas, Michael E Hood, Hélène Badouin, Elsa Petit, Valérie Barbe, Jerome Gouzy...

Molecular Biology and Evolution . 32 ( 4 ) : 928-943

DOI: 10.1093/molbev/msu396

Article dans une revue

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GC-Content evolution in bacterial genomes: The biased gene conversion hypothesis expands

Florent Lassalle, Séverine Périan, Thomas Bataillon, Xavier Nesme, L. Duret, Vincent Daubin

PLoS Genetics . 11 ( 2 ) : 1-20

DOI: 10.1371/journal.pgen.1004941

Article dans une revue

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Karyotype and Gene Order Evolution from ReconstructedExtinct Ancestors Highlight Contrasts in Genome Plasticity ofModern Rosid Crops

Florent Murat, Rongzhi R. Zhang, Sébastien Guizard, Haris Gavranovic, Raphael Flores, Delphine Steinbach...

Genome Biology and Evolution . 7 ( 3 ) : 735-749

DOI: 10.1093/gbe/evv014

Article dans une revue

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Foundations of Coding: Compression, Encryption, Error-Correction

Jean-Guillaume Dumas, Jean-Louis Roch, Eric Tannier, Sébastien Varrette

978-1-118-88144-6 : 376

Ouvrage

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Ancestral gene synteny reconstruction improves extant species scaffolding

Yoann Anselmetti, Vincent Berry, Cedric Chauve, Annie Chateau, Eric Tannier, Sèverine Bérard

BMC Genomics . 16 ( Suppl 10 ) : S11

DOI: 10.1186/1471-2164-16-S10-S11

Article dans une revue

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Probabilistic modeling of the evolution of gene synteny within reconciled phylogenies

Magali Semeria, Eric Tannier, Laurent Guéguen

BMC Bioinformatics . 16 ( Suppl 14 ) : S5

DOI: 10.1186/1471-2105-16-S14-S5

Article dans une revue

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Genome-scale phylogenetic analysis finds extensive gene transfer among fungi

G.J. Szollosi, Adrián Arellano Davin, Eric Tannier, Vincent Daubin, Bastien Boussau

Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences (1934–1990) . 370 : 20140335 (11 pages)

DOI: 10.1098/rstb.2014.0335

Article dans une revue

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Phylogeny of the class Actinobacteria revisited in the light of complete genomes. The orders 'Frankiales' and Micrococcales should be split into coherent entities: proposal of Frankiales ord. nov., Geodermatophilales ord. nov., Acidothermales ord. nov. an

A. Sen, Vincent Daubin, D. Abrouk, I. Gifford, A. M. Berry, P. Normand

International Journal of Systematic and Evolutionary Microbiology . 64 ( Pt 11 ) : 3821-32

DOI: 10.1099/ijs.0.063966-0

Article dans une revue

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Counting and sampling SCJ small parsimony solutions

István Miklós, Sándor Z. Kiss, Eric Tannier

Theoretical Computer Science . 552 : 83-98

DOI: 10.1016/j.tcs.2014.07.027

Article dans une revue

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Fungal evolutionary genomics provides insight into the mechanisms of adaptive divergence in eukaryotes

Pierre P. Gladieux, Jeanne Ropars, Helene Badouin, Antoine Branca, Gabriela G. Aguileta, Damien M. de Vienne...

Molecular Ecology . 23 ( 4 ) : 753-773

DOI: 10.1111/mec.12631

Article dans une revue

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Massive gene swamping among cheese-making Penicillium fungi

Jeanne Ropars, Gabriela Aguileta, Damien M. de Vienne, Tatiana Giraud

Microbial Cell .

DOI: 10.15698/mic2014.01.135

Article dans une revue

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High Variability of Mitochondrial Gene Order among Fungi

Gabriela Aguileta, Damien M. de Vienne, Oliver N. Ross, Michael E Hood, Tatiana Giraud, Elsa Petit...

Genome Biology and Evolution . 6 ( 2 ) : 451-465

DOI: 10.1093/gbe/evu028

Article dans une revue

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Reductive genome evolution at both ends of bacterial population size spectrum

Bérénice Batut, Carole Knibbe, Gabriel Marais, Vincent Daubin

Nature Reviews Microbiology . 12 ( 12 ) : 841-850

DOI: 10.1038/nrmicro3331

Article dans une revue

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Ribosomal proteins: Toward a next generation standard for prokaryotic systematics?

Hemalatha Golaconda Ramulu, Mathieu Groussin, Emmanuel Talla, Rémi Planel, Vincent Daubin, Céline Brochier-Armanet

Molecular Phylogenetics and Evolution . 75 : 103 - 117

DOI: 10.1016/j.ympev.2014.02.013

Article dans une revue

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Single acquisition of protelomerase gave rise to speciation of a large and diverse clade within the Agrobacterium/Rhizobium supercluster characterized by the presence of a linear chromid

Martha H. Ramírez-Bahena, Ludovic Vial, Florent Lassalle, Benjamin Diel, David Chapulliot, Vincent Daubin...

Molecular Phylogenetics and Evolution . 73 : 202-207

DOI: 10.1016/j.ympev.2014.01.005

Article dans une revue

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A Bayesian Method for Analyzing Lateral Gene Transfer

Joel Sjöstrand, Ali Tofigh, Vincent Daubin, Lars Arvestad, Bengt Sennblad, Jens Lagergren

Systematic Biology . 63 ( 3 ) : 409 - 420

DOI: 10.1093/sysbio/syu007

Article dans une revue

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Evidence for Widespread Positive and Negative Selection in Coding and Conserved Noncoding Regions of Capsella grandiflora

Robert Williamson, Emily Josephs, Adrian Platts, Khaled Hazzouri, Annabelle A. Haudry, Mathieu Blanchette...

PLoS Genetics . 10 ( 9 )

DOI: 10.1371/journal.pgen.1004622

Article dans une revue

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“One code to find them all”: a perl tool to conveniently parse RepeatMasker output files

Marc Bailly-Bechet, Annabelle Haudry, Emmanuelle Lerat

Mobile DNA . 5 : 13

DOI: 10.1186/1759-8753-5-13

Article dans une revue

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Identification de complexes protéine-protéine par combinaison de classifieurs. Application à Escherichia coli

Thomas Bourquard, Damien Mathieu de Vienne, Jérôme Azé

EGC 2013 - 13eme conférence Francophone sur l'Extraction et la Gestion des Connaissances . E.24 : 419-430

Acte de congrès

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L'ADN, mémoire numérique du vivant

Vincent Daubin, Simon Penel, Eric Tannier

Pour la science . : 102-108

Article dans une revue

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Lateral Gene Transfer from the Dead.

Gergely J Szöllosi, Eric Tannier, Nicolas Lartillot, Vincent Daubin

Systematic Biology . 62 ( 3 ) : 386-397

DOI: 10.1093/sysbio/syt003

Article dans une revue

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Contrasted evolutionary constraints on secreted and non-secreted proteomes of selected Actinobacteria

Subarna Thakur, Philippe Normand, Vincent Daubin, Louis S. Tisa, Arnab Sen

BMC Genomics . 14 ( 1 )

DOI: 10.1186/1471-2164-14-474

Article dans une revue

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Lateral gene transfer, rearrangement, reconciliation

Murray Patterson, Gergely Szöllősi, Vincent Daubin, Eric Tannier

BMC Bioinformatics . 14 ( Suppl 15 ) : S4

Article dans une revue

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Théorie des Codes : compression, cryptage, correction, 2e edition

Jean-Guillaume Dumas, Jean-Louis Roch, Eric Tannier, Sébastien Varrette

9782100599110 : 384

Ouvrage

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The genome of the medieval Black Death agent (extended abstract)

Ashok Rajaraman, Eric Tannier, Cedric Chauve

Pré-publication

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