Affichage des résultats 1161 à 1180 sur 1678 au total
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Several protein isoforms can be produced from a single gene through alternative splicing. These isoforms have different protein sequences, and often diverse or even antagonistic functions. In the recent years,the use of high-throughput technologies has revealed that alternative splicing is massively deregulated in many experimental conditions. A proportion of the splicing events observed at the transcript level are also observed at the protein level. However, it is still difficult to decipher the functional consequences of these splicing variations because of the lack of functional information at the exon level. To circumvent that problem, we introduce a computational strategy that relies on the functional annotation of exons in order to predict the consequences of their inclusion or skipping.
Thèse de Pierre GARCIA le mardi 18 décembre 2018 à 14 h, amphithéâtre BU (La Doua)
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La méthode que je vais présenter résulte de 9 années de travaux et repose sur un modèle physiologique de pharmacocinétique au steady-state. Cette méthode est implémentée en grande partie dans un site académique en accès libre www.ddi-predictor dont je parlerai brièvement. Je décrirai le principe, les avantages et les limites, les approches concurrentes, les applications cliniques. -----Quantitative prediction of the variation in drug exposure, linked to the genetic polymorphism of cytochromes P450 and membrane transporters. The method I will present results from 9 years of work and is based on a physiological model of steady-state pharmacokinetics. This method is largely implemented in an open access academic site www.ddi-predictor which I will briefly discuss. I will describe the principle, the advantages and the limits, the competing approaches, the clinical applications.
Thèse de Maoulide Saindou - Mercredi 3 avril 2013 - 15h00 - Médiathèque (Faculté de Médecine Lyon Est)