Statistiques et Modélisation pour les Sciences de la Santé

The Role of Antibiotics in Modulating Virulence in Staphylococcus aureus

Elisabeth Hodille, Warren Rose, Binh An Diep, Sylvain Goutelle, Gérard Lina, Oana Dumitrescu

Clinical Microbiology Reviews . 30 ( 4 ) : 887-917

DOI: 10.1128/CMR.00120-16

2017

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Is Trough Concentration of Vancomycin Predictive of the Area Under the Curve? A Clinical Study in Elderly Patients

A. Bel Kamel, Laurent Bourguignon, M. Marcos, M. Ducher, Sylvain Goutelle

Therapeutic Drug Monitoring . 39 : 83-87

DOI: 10.1097/FTD.0000000000000359

2017

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Implications of using the MDRD or CKD-EPI equation instead of the Cockcroft-Gault equation for estimating renal function and drug dosage adjustment in elderly patients

E. Cartet-Farnier, L. Goutelle-Audibert, P. Maire, B. de La Gastine, Sylvain Goutelle

Fundamental & Clinical Pharmacology . 31 : 110-119

DOI: 10.1111/fcp.12241

2017

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A Model for Predicting the Interindividual Variability of Drug-Drug Interactions

M. Tod, Laurent Bourguignon, N. Bleyzac, Sylvain Goutelle

AAPS Journal . 19 : 497-509

DOI: 10.1208/s12248-016-0021-0

2017

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Dynamics of Ebola RNA Persistence in Semen: A Report From the Postebogui Cohort in Guinea

Fabien Subtil, Charlotte Delaunay, Alpha Kabinet Keita, Mamadou Saliou Sow, Abdoulaye Touré, Sandrine Leroy...

Clinical Infectious Diseases . 64 ( 12 ) : 1788 - 1790

DOI: 10.1093/cid/cix210

2017

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Cementless lateralized stems in primary THA: Mid-term survival and risk factors for failure in 172 stems

Cyril Courtin, Anthony Viste, Fabien Subtil, Olivier Catin, Romain Desmarchelier, Michel-Henri Fessy

Orthopaedics & Traumatology: Surgery & Research . 103 ( 1 ) : pp. 15-19

DOI: 10.1016/j.otsr.2016.10.011

2017

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Vancomycin treatment is a risk factor for vancomycin-nonsusceptible Staphylococcus capitis sepsis in preterm neonates

Marine Butin, Jean-Philippe Rasigade, F. Subtil, Patricia Martins-Simões, C. Pralong, A.-M. Freydière...

Clinical Microbiology and Infection . 23 ( 11 ) : 839-844

DOI: 10.1016/j.cmi.2017.03.022

2017

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Ibrutinib in very elderly patients with relapsed/refractory chronic lymphocytic leukemia: A real-world experience of 71 patients treated in France: A study from the French Innovative Leukemia Organization (FILO) group

Sophie Michallet, Arnaud Campidelli, Helene Lequeu, Marie-Sarah Dilhuydy, Olivier Tournilhac, Luc-Matthieu Fornecker...

American Journal of Hematology . 92 ( 6 ) : E105 - E107

DOI: 10.1002/ajh.24715

2017

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Evaluation of haemodialysis as a protective technique for preventing high daily dose amikacin nephrotoxicity: an experimental study in an ovine model.

Céline Pouzot Pouzot-Névoret, Mathieu Magnin, Jean-Yves Ayoub, Laurent Bourguignon, Pascal Maire, Damien Wertz...

International Journal of Antimicrobial Agents .

DOI: 10.1016/j.ijantimicag.2017.03.029

2017

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Restricted mean survival time over 15 years for patients starting renal replacement therapy

Cécile Couchoud, Emmanuelle Dantony, Mad-Hélénie Elsensohn, Emmanuel Villar, Cécile Vigneau, Olivier Moranne...

Nephrology Dialysis Transplantation . 32 ( Suppl.2 ) : ii60-ii67

DOI: 10.1093/ndt/gfw386

2017

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Reproducibility of in vivo magnetic resonance imaging T 1 rho and T 2 relaxation time measurements of hip cartilage at 3.0T in healthy volunteers

Angeline Nemeth, Lucy Di Marco, Florent Boutitie, Michael Sdika, Denis Grenier, Muriel Rabilloud...

Journal of Magnetic Resonance Imaging . 47 ( 4 ) : 1022-1033

DOI: 10.1002/jmri.25799

2017

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Efficacy and safety of DPP-4 inhibitors in patients with type 2 diabetes: Meta-analysis of placebo-controlled randomized clinical trials

M. Rehman, B.V. Tudrej, J. Soustre, M. Buisson, P. Archambault, D. Pouchain...

Diabetes & Metabolism . 43 ( 1 ) : 48 - 58

DOI: 10.1016/j.diabet.2016.09.005

2017

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No benefits of statins for sudden cardiac death prevention in patients with heart failure and reduced ejection fraction: A meta-analysis of randomized controlled trials

M. Al-Gobari, H.H. Le, M. Fall, François Gueyffier, B. Burnand

PLoS ONE . 12 : e0171168

DOI: 10.1371/journal.pone.0171168

2017

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Population pharmacokinetics of teicoplanin administered by subcutaneous or intravenous route and simulation of optimal loading dose regimen

Yoann Cazaubon, Nicolas Venisse, Olivier Mimoz, Pascal Maire, Michel Ducher, Laurent Bourguignon...

Journal of Antimicrobial Chemotherapy . 72 ( 10 ) : 2804-2812

DOI: 10.1093/jac/dkx242

2017

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Mechanisms of drug-drug interaction between rifampicin and fusidic acid

Florianne Bel, Laurent Bourguignon, Michel Tod, Tristan Ferry, Sylvain Goutelle

British Journal of Clinical Pharmacology . 83 ( 8 ) : 1862-1864

DOI: 10.1111/bcp.13277

2017

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A Nonparametric Method to Optimize Initial Drug Dosing and Attainment of a Target Exposure Interval: Concepts and Application to Busulfan in Pediatrics

M. Philippe, M. Neely, Y. Bertrand, N. Bleyzac, Sylvain Goutelle

Clinical Pharmacokinetics . 56 : 435-447

DOI: 10.1007/s40262-016-0448-6

2017

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Prevalence and Risk Factors of Drug-Associated Corrected QT Prolongation in Elderly Hospitalized Patients: Results of a Retrospective Analysis of Data Obtained Over 6 Months

O. Maison, B. de La Gastine, L. Dayot, Sylvain Goutelle

Drugs & aging . 34 : 545-553

DOI: 10.1007/s40266-017-0467-5

2017

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Mathematical model of T-cell lymphoblastic lymphoma: disease, treatment, cure or relapse of a virtual cohort of patients

Nathalie Eymard, Vitaly Volpert, Polina Kurbatova, Nikolai Bessonov, Kayode Ogungbenro, Leon Aarons...

Mathematical Medicine and Biology .

DOI: 10.1093/imammb/dqw019

2017

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Phone-based safety monitoring of the first year of baclofen treatment for alcohol use disorder: the baclophone cohort study protocol

Benjamin Rolland, Marine Auffret, Julien Labreuche, Maryse Lapeyre-Mestre, Malek Dib, Aomar Kemkem...

Expert Opinion on Drug Safety . 16 ( 2 ) : 125-132

DOI: 10.1080/14740338.2017.1270939

2016

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Proactive Regional Pharmacovigilance System Versus National Spontaneous Reporting for Collecting Safety Data on Concerning Off-Label Prescribing Practices: An Example with Baclofen and Alcohol Dependence in France

Marine Auffret, Julien Labreuche, Alain Duhamel, Sylvie Deheul, Olivier Cottencin, Regis Bordet...

Drug Safety . 40 : 257-262

DOI: 10.1007/s40264-016-0489-7

2016

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A Novel Analog Reasoning Paradigm: New Insights in Intellectually Disabled Patients

Aurore Curie, Amandine Brun, Anne Cheylus, Anne Reboul, Tatjana Nazir, Gérald Bussy...

PLoS ONE . 11 ( 2 ) : e0149717

DOI: 10.1371/journal.pone.0149717

2016

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ADHD in childhood epilepsy: Clinical determinants of severity and of the response to methylphenidate

S. Rheims, V. Herbillon, N. Villeneuve, S. Auvin, S. Napuri, C. Cances...

Epilepsia . 57 : 1069-77

DOI: 10.1111/epi.13420

2016

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Safety study of Ciprofloxacin in newborn mice

T. Bourgeois, Al. Delezoide, W. Zhao, F. Guimiot, H. Adle-Biassette, E. Durand...

Regulatory Toxicology and Pharmacology . 74 : 161-169

DOI: 10.1016/j.yrtph.2015.11.002

2016

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Prise en compte de la technologie dans la quantification des biomarqueurs

C. Mercier, A. Klich, C. Truntzer, Vincent Picaud, J.F. Giovannelli, P. Ducoroy...

EPICLIN 2016 - 10ème conférence francophone d'épidémiologie clinique and 23e journées des statisticiens des centres de Lutte contre le cancer .

2016

Acte de congrès

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Efficacy and safety of insulin in type 2 diabetes: meta-analysis of randomised controlled trials

S. Erpeldinger, M. B. Rehman, C. Berkhout, C. Pigache, Y. Zerbib, F. Regnault...

BMC Endocrine Disorders . 16 : 39

DOI: 10.1186/s12902-016-0120-z

2016

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Factors associated with changes in exposure to anticholinergic and sedative medications in elderly hospitalized patients: multicentre longitudinal study

V. Dauphinot, R. Faure, L. Bourguignon, Sylvain Goutelle, P. Krolak-Salmon, C. Mouchoux

European Journal of Neurology . 24 ( 3 ) : 483-490

DOI: 10.1111/ene.13228

2016

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Pharmacokinetics of Vancomycin in Elderly Patients Aged over 80 Years

Laurent Bourguignon, Yoann Cazaubon, Guillaume Debeurme, Constance Loue, Michel Ducher, Sylvain Goutelle

Antimicrobial Agents and Chemotherapy . 60 ( 8 ) : 4563-4567

DOI: 10.1128/AAC.00303-16

2016

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Improved outcome of children transplanted for high-risk leukemia by using a new strategy of cyclosporine-based GVHD prophylaxis

N Bleyzac, D Cuzzubbo, C Rénard, N Garnier, V Dubois, C Domenech...

Bone Marrow Transplantation . 51 ( 5 ) : 698-704

DOI: 10.1038/bmt.2015.350

2016

Article dans une revue

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Pharmacokinetic and Analytical Issues in Busulfan Area Under the Curve Estimation and Simulation

Michael Philippe, Nathalie Bleyzac, Sylvain Goutelle

Biology of Blood and Marrow Transplantation . 22 ( 1 ) : 185

DOI: 10.1016/j.bbmt.2015.09.022

2016

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Sarcoidosis-related mortality in France: a multiple-cause-of-death analysis

Y. Jamilloux, Delphine Maucort-Boulch, S. Kerever, M. Gerfaud-Valentin, C. Broussolle, M. Eb...

European Respiratory Journal . 48 : 1700-1709

DOI: 10.1183/13993003.00457-2016

2016

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Statistiques et Modélisation pour les Sciences de la Santé

Equipe Biostatistiques Santé

Equipe Evaluation et Modélisation des Effets Thérapeutiques

Publications

The Role of Antibiotics in Modulating Virulence in Staphylococcus aureus

Is Trough Concentration of Vancomycin Predictive of the Area Under the Curve? A Clinical Study in Elderly Patients

Implications of using the MDRD or CKD-EPI equation instead of the Cockcroft-Gault equation for estimating renal function and drug dosage adjustment in elderly patients

A Model for Predicting the Interindividual Variability of Drug-Drug Interactions

Dynamics of Ebola RNA Persistence in Semen: A Report From the Postebogui Cohort in Guinea

Cementless lateralized stems in primary THA: Mid-term survival and risk factors for failure in 172 stems

Vancomycin treatment is a risk factor for vancomycin-nonsusceptible Staphylococcus capitis sepsis in preterm neonates

Ibrutinib in very elderly patients with relapsed/refractory chronic lymphocytic leukemia: A real-world experience of 71 patients treated in France: A study from the French Innovative Leukemia Organization (FILO) group

Evaluation of haemodialysis as a protective technique for preventing high daily dose amikacin nephrotoxicity: an experimental study in an ovine model.

Restricted mean survival time over 15 years for patients starting renal replacement therapy

Reproducibility of in vivo magnetic resonance imaging T 1 rho and T 2 relaxation time measurements of hip cartilage at 3.0T in healthy volunteers

Efficacy and safety of DPP-4 inhibitors in patients with type 2 diabetes: Meta-analysis of placebo-controlled randomized clinical trials

No benefits of statins for sudden cardiac death prevention in patients with heart failure and reduced ejection fraction: A meta-analysis of randomized controlled trials

Population pharmacokinetics of teicoplanin administered by subcutaneous or intravenous route and simulation of optimal loading dose regimen

Mechanisms of drug-drug interaction between rifampicin and fusidic acid

A Nonparametric Method to Optimize Initial Drug Dosing and Attainment of a Target Exposure Interval: Concepts and Application to Busulfan in Pediatrics

Prevalence and Risk Factors of Drug-Associated Corrected QT Prolongation in Elderly Hospitalized Patients: Results of a Retrospective Analysis of Data Obtained Over 6 Months

Mathematical model of T-cell lymphoblastic lymphoma: disease, treatment, cure or relapse of a virtual cohort of patients

Phone-based safety monitoring of the first year of baclofen treatment for alcohol use disorder: the baclophone cohort study protocol

Proactive Regional Pharmacovigilance System Versus National Spontaneous Reporting for Collecting Safety Data on Concerning Off-Label Prescribing Practices: An Example with Baclofen and Alcohol Dependence in France

A Novel Analog Reasoning Paradigm: New Insights in Intellectually Disabled Patients

ADHD in childhood epilepsy: Clinical determinants of severity and of the response to methylphenidate

Safety study of Ciprofloxacin in newborn mice

Prise en compte de la technologie dans la quantification des biomarqueurs

Efficacy and safety of insulin in type 2 diabetes: meta-analysis of randomised controlled trials

Factors associated with changes in exposure to anticholinergic and sedative medications in elderly hospitalized patients: multicentre longitudinal study

Pharmacokinetics of Vancomycin in Elderly Patients Aged over 80 Years

Improved outcome of children transplanted for high-risk leukemia by using a new strategy of cyclosporine-based GVHD prophylaxis

Pharmacokinetic and Analytical Issues in Busulfan Area Under the Curve Estimation and Simulation

Sarcoidosis-related mortality in France: a multiple-cause-of-death analysis

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