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Statistics and Modelling for Health Sciences
Evaluation and Modeling with the Therapeutic Effects Group
Lega Jean-Christophe
Professeur d'université - praticien hospitalier
UCBL
Tel: 33 04 78 86 33 01
Mon travail est centré sur la balance bénéfice risque et le niveau de preuve de l'effet traitement des antithrombotiques et des immunosuppresseurs, en rapport avec mon activité hospitalière aux Hospices Civils de Lyon. Cette modélisation est notamment basée sur la réalisation de méta-analyse (risque de base, stratification du risque et interaction de l'effet traitement, effet des sous-populations humaines et médecine personnalisée).
La constitution de registre à partir des base de données hospitalières des HCL est aussi un axe émergent, en utilisant des approches natural language processing, pour l'estimation de la safety et l'effectiveness des thérapeutiques.
Je suis responsable de l'Equipe Modélisation et Modélisation des Effets Thérapeutiques depuis janvier 2021.
Publications
Display of 31 to 47 publications on 47 in total
Causes and consequences of variation in offspring body mass: meta-analyses in birds and mammals
Biol. Rev . 93 : 1 - 27
DOI: 10.1111/brv.12329
Journal article
see the publicationAdding Azathioprine to Remission-Induction Glucocorticoids for Eosinophilic Granulomatosis With Polyangiitis (Churg-Strauss), Microscopic Polyangiitis, or Polyarteritis Nodosa Without Poor Prognosis Factors
Arthritis & rheumatology . 69 ( 11 ) : 2175 - 2186
DOI: 10.1002/art.40205
Journal article
see the publicationIntravenous Immunoglobulins Improve Survival in Monoclonal Gammopathy-Associated Systemic Capillary-Leak Syndrome
The American Journal of Medicine . 130 ( 10 ) : 1219.e19 - 1219.e27
Journal article
see the publicationIsolated positive anti-SS-B autoantibodies are not related to clinical features of systemic autoimmune diseases
PLoS ONE . 12 ( 9 )
Journal article
see the publicationHeterogeneous clinical spectrum of anti-SRP myositis and importance of the methods of detection of anti-SRP autoantibodies: a multicentric study
Immunologic Research . 64 ( 3 ) : 677-686
Journal article
see the publicationTocilizumab in the treatment of mixed connective tissue disease and overlap syndrome in children
RMD Open : Rheumatic & Musculoskeletal Diseases . 2 ( 2 ) : e000271
Journal article
see the publicationIdiopathic inflammatory myopathies and the lung
European Respiratory Review . 24 ( 136 ) : 216-238
Journal article
see the publicationConsistency of safety profile of new oral anticoagulants in patients with renal failure
Journal of Thrombosis and Haemostasis . 12 ( 2 ) : 337-43
DOI: 10.1111/jth.12486
Journal article
see the publicationCharacteristics, prognosis, and outcomes of cutaneous ischemia and gangrene in systemic necrotizing vasculitides: a retrospective multicenter study
Seminars in Arthritis and Rheumatism . 43 ( 5 ) : 681--688
Journal article
see the publicationThe clinical phenotype associated with myositis-specific and associated autoantibodies: a meta-analysis revisiting the so-called antisynthetase syndrome
Autoimmunity Reviews . 13 : 883-91
Journal article
see the publicationThe clinical phenotype associated with myositis-specific and associated autoantibodies: a meta-analysis revisiting the so-called antisynthetase syndrome
Autoimmunity Reviews . 13 ( 9 ) : 883-891
Journal article
see the publicationRisk of venous and arterial thrombosis according to type of antiphospholipid antibodies in adults without systemic lupus erythematosus: a systematic review and meta-analysis
Autoimmunity Reviews . 13 : 595-608
Journal article
see the publicationConsistency of Safety and Efficacy of New Oral Anticoagulants across Subgroups of Patients with Atrial Fibrillation
PLoS ONE . 9 ( 3 ) : e91398
Journal article
see the publicationMutations in CECR1 associated with a neutrophil signature in peripheral blood
Pediatric Rheumatology . 12 : 44
Journal article
see the publicationPrognostic value of troponins in sepsis: a meta-analysis
Intensive Care Medicine . 39 : 1181-9
Journal article
see the publicationPrésentation pulmonaire inhabituelle d’une histiocytose à cellules de Langerhans systémique
La Revue de Médecine Interne . 29 ( 8 ) : 669-672
Journal article
see the publicationWhen to stop in the quest of formes frustes of connective tissue disease ?
Clinical Rheumatology . 26 ( 4 ) : 615-616
Journal article
see the publication