Evaluation and Modeling with the Therapeutic Effects Group

Members

Tod Michel

Professeur d'université - praticien hospitalier émérite

UCBL

Email

EMET  presentation

The EMET team brings together doctors, pharmacists and research professors specializing in the evaluation and use of drug and non-drug therapies, around a single project built on two axes:

  • the evaluation of therapies in clinical trials or observational studies;
  • the construction of explanatory and predictive models, to better understand and therefore predict the effect of therapies, simulate their impacts at the individual and population level, and improve the innovation paradigm.

The EMET team is therefore part of two major dynamics in therapy: analysis of the level of evidence and precision medicine.
The fields of application are cardiovascular and metabolic diseases, primary care medicine, rare pediatric diseases (including genetic and autoimmune diseases), oncology and infectious diseases.
EMET members implement approaches using different mathematical models: direct comparison and network meta-analysis, pharmacokinetic/pharmacodynamic analysis, Bayesian networks and machine learning.

Education

The EMET team is specially involved in the teaching of pharmacology and therapeutics and the modeling of the treatment effect through the coordination of the Masters 2 Clinical Evaluation (EC) and Pharmacology modeling and clinical trials (PHAME), Interpretation of Therapeutic Trials (IET), Training of investigators in clinical drug trials (FIEC) and Training of clinical research assistants and clinical study technicians (FARCTEC). Teacher-researchers are also involved in the first (pharmacology), second (pharmacology / therapeutics, pharmacy) and third cycles (general medicine, pediatrics, internal medicine) in health training courses.

Society involvement

The members of the EMET team through their work and their interactions with the other components of the LBBE, National societies, governmental (HAS) or international (EMA) agencies, and the Hospices Civils de Lyon, are invested in current societal issues: rationalization of the use of health product resources, research ethics, gender equality, rationality of approaches in analyzing the diversity of human populations.

Publications

Display of 1 to 30 publications on 169 in total

Defining standard and high dosages for β-lactam agents administered by intermittent, prolonged or continuous infusion: a PK/PD simulation study

Sylvain Goutelle, Vincent Jullien, Jean-Pierre Bru, Vincent Cattoir, Rémy Gauzit, Philippe Lesprit...

Journal of Antimicrobial Chemotherapy . 78 ( 11 ) : 2762–2769

DOI: 10.1093/jac/dkad300

Journal article

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A Knowledge-Based Approach for Evaluating Impact of Therapeutic Strategies

Nadia Abchiche-Mimouni, Mike Donald Tapi Nzali, François Gueyffier

ICAART 2023 - 15th International Conference on Agents and Artificial Intelligence . 3 : 1036-1046

DOI: 10.5220/0011894300003393

Conference paper

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Projet Rebuild the Evidence Base

Hélène Vaillant-Roussel, Clara Blanchard, Thibault Menini, Elodie Charuel, Bruno Pereira, Florian Naudet...

Exercer . 34 ( 190 ) : 81-88

DOI: 10.56746/EXERCER.2023.190.81

Journal article

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Machine-Learning Exploration of Exposure-Effect Relationships of Cisplatin in Head and Neck Cancer Patients

Céleste Cauvin, Laurent Bourguignon, Laure Carriat, Pauline Ghipponi, Abel Mence, Sébastien Salas...

Pharmaceutics . 14 ( 11 ) : 2509

DOI: 10.3390/pharmaceutics14112509

Journal article

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Daptomycin Physiology-Based Pharmacokinetic Modeling to Predict Drug Exposure and Pharmacodynamics in Skin and Bone Tissues

Romain Garreau, Damien Montange, Antoine Grillon, François Jehl, Tristan Ferry, Laurent Bourguignon...

Clinical Pharmacokinetics . 61 ( 10 ) : 1443-1456

DOI: 10.1007/s40262-022-01168-5

Journal article

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Implementation of Model-Based Dose Adjustment of Tobramycin in Adult Patients with Cystic Fibrosis

Jérémy Reverchon, Vianney Tuloup, Romain Garreau, Viviane Nave, Sabine Cohen, Philippe Reix...

Pharmaceutics . 14 ( 8 ) : 1750

DOI: 10.3390/pharmaceutics14081750

Journal article

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Seventeen Cases of Daptomycin-Induced Eosinophilic Pneumonia in a Cohort of Patients Treated for Bone and Joint Infections: Proposal for a New Algorithm

Truong-Thanh Pham, Romain Garreau, Fabien Craighero, Vincent Cottin, Benoît Ben Said, Sylvain Goutelle...

Open Forum Infectious Diseases . 9 ( 11 ) : ofac577

DOI: 10.1093/ofid/ofac577

Journal article

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Predicted Impacts of Booster, Immunity Decline, Vaccination Strategies, and Non-Pharmaceutical Interventions on COVID-19 Outcomes in France

Simon Pageaud, Anne Eyraud-Loisel, Jean-Pierre Bertoglio, Alexis Bienvenüe, Nicolas Leboisne, Catherine Pothier...

Vaccines . 10 ( 12 ) : 2033

DOI: 10.3390/vaccines10122033

Journal article

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An Investigation of O-Demethyl Tramadol/Tramadol Ratio for Cytochrome P450 2D6 Phenotyping: The CYTRAM Study

Blandine de la Gastine, Soizic Percevault, Laurent Varin, Nicolas Richard, Fabienne Fobe, Benoît Plaud...

Pharmaceutics . 14 ( 10 ) : 2177

DOI: 10.3390/pharmaceutics14102177

Journal article

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Selected and simplified FDI criteria for assessment of restorations

Christina Maillet, Franck Decup, Emmanuelle Dantony, Jean Iwaz, Charlène Chevalier, François Gueyffier...

Journal of Dentistry . 122 : 104109

DOI: 10.1016/j.jdent.2022.104109

Journal article

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How do they add up? The interaction between the placebo and treatment effect: A systematic review

Rémy Boussageon, Jeremy Howick, Raphael Baron, Florian Naudet, Bruno Falissard, Ghina Harika-Germaneau...

British Journal of Clinical Pharmacology .

DOI: 10.1111/bcp.15345

Journal article

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Place of a new radiological index in predicting pulp exposure before intervention for deep carious lesions

Marie-Agnès Gasqui, Matthieu Perard, Franck Decup, Paul Monsarrat, Yann-Loïg Turpin, Cyril Villat...

Oral Radiology . 38 ( 1 ) : 89-98

DOI: 10.1007/s11282-021-00530-w

Journal article

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Population pharmacokinetics of daptomycin in patients with bone and joint infection: minimal effect of rifampicin co-administration and confirmation of a sex difference

Romain Garreau, Romain Bricca, Marie-Claude Gagnieu, Sandrine Roux, Anne Conrad, Laurent Bourguignon...

Journal of Antimicrobial Chemotherapy . 76 ( 5 ) : 1250-1257

DOI: 10.1093/jac/dkab006

Journal article

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Model-Based Comparative Analysis of Rifampicin and Rifabutin Drug-Drug Interaction Profile

Vianney Tuloup, Mathilde France, Romain Garreau, Nathalie Bleyzac, Laurent Bourguignon, Michel Tod...

Antimicrobial Agents and Chemotherapy . 65 ( 9 ) : e0104321

DOI: 10.1128/AAC.01043-21

Journal article

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Expected Evolution of COVID-19 Epidemic in France for Several Combinations of Vaccination Strategies and Barrier Measures

Simon Pageaud, Catherine Pothier, Christophe Rigotti, Anne Eyraud-Loisel, Jean-Pierre Bertoglio, Alexis Bienvenüe...

Vaccines . 9 ( 12 ) : 1462

DOI: 10.3390/vaccines9121462

Journal article

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Population Pharmacokinetics and Dosing Simulation of Vancomycin Administered by Continuous Injection in Critically Ill Patient

Romain Garreau, Benoît Falquet, Lisa Mioux, Laurent Bourguignon, Tristan Ferry, Michel Tod...

Antibiotics . 10 ( 10 ) : 1228

DOI: 10.3390/antibiotics10101228

Journal article

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Rifampicin exposure reveals within-host Mycobacterium tuberculosis diversity in patients with delayed culture conversion

Charlotte Genestet, Elisabeth Hodille, Alexia Barbry, Jean-Luc Berland, Jonathan Hoffmann, Emilie Westeel...

PLoS Pathogens . 17 ( 6 ) : e1009643

DOI: 10.1371/journal.ppat.1009643

Journal article

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Inconclusive efficacy of intervention on upper-limb function after tetraplegia: A systematic review and meta-analysis

Sébastien Mateo, Julie Di Marco, Michel Cucherat, François Gueyffier, Gilles Rode

Annals of physical and rehabilitation medicine . 63 ( 3 ) : 230-240

DOI: 10.1016/j.rehab.2019.05.008

Journal article

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Publication language and the estimate of treatment effects of physical therapy on balance and postural control after stroke in meta-analyses of randomised controlled trials

Aurélien Hugues, Julie Di Marco, Isabelle Bonan, Gilles Rode, Michel Cucherat, François Gueyffier

PLoS ONE . 15 ( 3 ) : e0229822

DOI: 10.1371/journal.pone.0229822

Journal article

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The contribution of genomics in the medicine of tomorrow, clinical applications and issues

Bruno Laviolle, Patrice Denèfle, François Gueyffier, Élodie Bégué, Pascal Bilbault, Helene Esperou...

Thérapie . 74 ( 1 ) : 9-15

DOI: 10.1016/j.therap.2018.11.012

Journal article

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Amikacin Initial Dose in Critically Ill Patients: a Nonparametric Approach To Optimize A Priori Pharmacokinetic/Pharmacodynamic Target Attainments in Individual Patients

Clément Boidin, Laurent Bourguignon, Sabine Cohen, Claire Roger, Jean-Yves Lefrant, Jason A. Roberts...

Antimicrobial Agents and Chemotherapy . 63 ( 11 ) : e00993-19

DOI: 10.1128/AAC.00993-19

Journal article

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Pharmacokinetic variability of beta-lactams in critically ill patients: A narrative review

Clément Boidin, Parastou Moshiri, Claire Dahyot-Fizelier, Sylvain Goutelle, Sandrine Lefeuvre

Anaesthesia Critical Care & Pain Medicine .

DOI: 10.1016/j.accpm.2019.07.016

Journal article

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The limitations of observation studies for decision making regarding drugs efficacy and safety

François Gueyffier, Michel Cucherat

Alternative and Complementary Therapies . 74 ( 2 ) : 181-185

DOI: 10.1016/j.therap.2018.11.001

Journal article

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Do patients with cystic fibrosis participating in clinical trials demonstrate placebo response? A meta-analysis

Julie Coton, Ha-Hai Le, Victor Veuillet, Perrine Janiaud, Michel Cucherat, Behrouz Kassai-Koupai...

Journal of Cystic Fibrosis .

DOI: 10.1016/j.jcf.2019.02.003

Journal article

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Apport de la génomique dans la médecine de demain, applications cliniques et enjeux

Bruno Laviolle, Olivier Perche, François Gueyffier, Élodie Bégué, Pascal Bilbault, Hélène Esperou...

Thérapie . 74 ( 1 ) : 1-8

DOI: 10.1016/j.therap.2018.11.011

Journal article

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Immune system modelling in case of a septic shock

Jean Tallon, Françoise Couenne, Claire Bordes, Melaz Tayakout-Fayolle, Fabienne Venet, Guillaume Monneret...

29TH EUROPEAN SYMPOSIUM ON COMPUTER AIDED PROCESS ENGINEERING, . : 1093-1098

DOI: 10.1016/B978-0-12-818634-3.50183-1

Book chapter

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Causes and consequences of variation in offspring body mass: meta-analyses in birds and mammals

Victor Ronget, Jean-Michel Gaillard, Tim Coulson, Michael Garratt, François Gueyffier, Jean-Christophe Lega...

Biol. Rev . 93 : 1 - 27

DOI: 10.1111/brv.12329

Journal article

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Prospective Cohort Study of the Tolerability of Prosthetic Joint Infection Empirical Antimicrobial Therapy

Claire Triffault-Fillit, Florent Valour, Ronan Guillo, Michel Tod, Sylvain Goutelle, Sébastien Lustig...

ANTIMICROB. AGENTS CHEMOTHER. . 62 ( 10 )

DOI: 10.1128/AAC.00163-18

Journal article

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Antituberculous drugs modulate bacterial phagolysosome avoidance and autophagy in Mycobacterium tuberculosis-infected macrophages

Charlotte Genestet, Fanny Bernard-Barret, Elisabeth Hodille, Christophe Ginevra, Florence Ader, Sylvain Goutelle...

Tuberculosis . 111 : 67-70

DOI: 10.1016/j.tube.2018.05.014

Journal article

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Determinants of amikacin first peak concentration in critically ill patients

Clément Boidin, Sophie Jenck, Laurent Bourguignon, Sejad Torkmani, Aurore Roussey-Jean, Stanislas Ledochowski...

Fundamental & Clinical Pharmacology .

DOI: 10.1111/fcp.12374

Journal article

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