Evaluation and Modeling with the Therapeutic Effects Group
Members
Stagiaire
UCBL
Maîtresse de conférences - praticienne hospitalière
UCBL
Tel: 04 72 11 94 07
Maître de conférences - praticien hospitalier
UCBL
Tel: 33 04 72 32 34 87
Professeur des universités - médecin généraliste
UCBL
Tel: 04 78 74 18 18
Maîtresse de conférences
UCBL
Tel: 33 04 78 78 57 83
Professeure des universités - médecin généraliste
UCBL
Tel: 04 78 77 72 86
Professeur d'université - praticien hospitalier
UCBL
Tel: 04 72 44 81 42
Doctorante
HCL
Assistant hospitalier universitaire
UCBL
Doctorant
UCBL
Tel: 04 72 44 81 42
Professeur d'université - praticien hospitalier
UCBL
Tel: 33 04 72 16 80 99
Doctorante
autre
Tel: 04 72 44 81 42
Praticien hospitalier
HCL
Tel: 04 72 44 81 42
Professeur d'université - praticien hospitalier émérite
UCBL
Professeur d'université - praticien hospitalier
UCBL
Tel: 04 27 85 77 32
Professeur d'université - praticien hospitalier
UCBL
Tel: 33 04 78 86 33 01
Maîtresse de conférences - praticienne hospitalière
UCBL
Maître de conférences - praticien hospitalier
UCBL
Tel: 04 72 11 94 20
Doctorant
HCL
Tel: 04 72 44 81 42
Doctorante
UCBL
Professeur d'université - praticien hospitalier
UCBL
Tel: 33 04 72 12 94 37
Post-doc
UCBL
Professeur d'université - praticien hospitalier émérite
UCBL
Doctorante
UCBL
Tel: 04 72 44 81 42
Stagiaire
HCL
EMET presentation
The EMET team brings together doctors, pharmacists and research professors specializing in the evaluation and use of drug and non-drug therapies, around a single project built on two axes:
- the evaluation of therapies in clinical trials or observational studies;
- the construction of explanatory and predictive models, to better understand and therefore predict the effect of therapies, simulate their impacts at the individual and population level, and improve the innovation paradigm.
The EMET team is therefore part of two major dynamics in therapy: analysis of the level of evidence and precision medicine.
The fields of application are cardiovascular and metabolic diseases, primary care medicine, rare pediatric diseases (including genetic and autoimmune diseases), oncology and infectious diseases.
EMET members implement approaches using different mathematical models: direct comparison and network meta-analysis, pharmacokinetic/pharmacodynamic analysis, Bayesian networks and machine learning.
Education
The EMET team is specially involved in the teaching of pharmacology and therapeutics and the modeling of the treatment effect through the coordination of the Masters 2 Clinical Evaluation (EC) and Pharmacology modeling and clinical trials (PHAME), Interpretation of Therapeutic Trials (IET), Training of investigators in clinical drug trials (FIEC) and Training of clinical research assistants and clinical study technicians (FARCTEC). Teacher-researchers are also involved in the first (pharmacology), second (pharmacology / therapeutics, pharmacy) and third cycles (general medicine, pediatrics, internal medicine) in health training courses.
Society involvement
The members of the EMET team through their work and their interactions with the other components of the LBBE, National societies, governmental (HAS) or international (EMA) agencies, and the Hospices Civils de Lyon, are invested in current societal issues: rationalization of the use of health product resources, research ethics, gender equality, rationality of approaches in analyzing the diversity of human populations.
Publications
Display of 1 to 30 publications on 450 in total
Daptomycin pharmacokinetic/pharmacodynamic target in staphylococcal infections
Clinical Infectious Diseases .
DOI: 10.1093/cid/ciae018
Journal article
see the publicationPharmacokinetic Consideration of Venetoclax in Acute Myeloid Leukemia Patients: A Potential Candidate for TDM? A Short Communication
Therapeutic Drug Monitoring . 46 ( 1 ) : 127-131
Journal article
see the publicationRPEM : Randomized Monte Carlo parametric expectation maximization algorithm
CPT: Pharmacometrics and Systems Pharmacology . 13 ( 5 ) : 759-780
DOI: 10.1002/psp4.13113
Journal article
see the publicationWhat are the available online resources targeting psychosocial burden among stroke survivors and their informal caregivers: A scoping review
Digital Health . 10
Journal article
see the publicationExpositions accidentelles à des toxiques chez les enfants - Étude des données de plusieurs sources de recours aux soins entre 2014 et 2020
: 233 p.
Report
see the publicationUnlicensed/Off-Label Drug Prescriptions at Hospital Discharge in Children: An Observational Study Using Routinely Collected Health Data
Healthcare . 12 ( 2 ) : 208
Journal article
see the publicationExposure to ammonia solution due to substance use: a retrospective study from the French poison centres database (2009–2018)
Clinical Toxicology . : 1-5
Journal article
see the publicationNeurodevelopmental outcomes after prenatal exposure to lamotrigine monotherapy in women with epilepsy: a systematic review and meta-analysis
BMC Pregnancy and Childbirth . 24 ( 1 ) : 103
Journal article
see the publicationComparison of daptomycin and glycopeptide efficacy and safety for the treatment of Gram-positive infections: a systematic review and meta-analysis
Journal of Antimicrobial Chemotherapy .
DOI: 10.1093/jac/dkae026
Journal article
see the publicationTreatment strategy for acquired pure red cell aplasia: a systematic review and meta-analysis
Blood Advances . 7 ( 21 ) : 6451-6465
Journal article
see the publicationPlatelet count threshold for hemorrhage in patients with immune thrombocytopenia treated with antiplatelet agents
Blood . 142 ( 12 ) : 1099-1101
Journal article
see the publicationProlonged response after TPO-RA discontinuation in primary ITP: results of a prospective multicenter study
Blood .
Journal article
see the publicationImmune thrombocytopenia and pregnancy: an exposed/nonexposed cohort study
Blood . 141 ( 1 ) : 11-21
Journal article
see the publicationAUC-based monitoring and model-informed precision dosing of vancomycin in critically ill patients: why and how?
Anaesthesia Critical Care & Pain Medicine . 42 ( 6 ) : 101286
Journal article
see the publicationPopulation Pharmacokinetics of Vancomycin in Patients Receiving Hemodialysis in a Malian and a French Center and Simulation of the Optimal Loading Dose
Therapeutic Drug Monitoring . 45 ( 5 ) : 637-643
Journal article
see the publicationEvaluation of Limited Sampling Strategies for Bayesian Estimation of Daptomycin Area Under the Concentration–Time Curve: A Short Communication
Therapeutic Drug Monitoring . 45 ( 4 ) : 562-565
Journal article
see the publicationFrom Personalized to Precision Medicine in Oncology: A Model-Based Dosing Approach to Optimize Achievement of Imatinib Target Exposure
Pharmaceutics . 15 ( 4 ) : 1081
Journal article
see the publicationSuboptimal exposure to fluconazole in critically ill patients: Pharmacokinetic analysis and determinants
Infectious Diseases Now . 53 ( 2 ) : 104630
Journal article
see the publicationEvaluation of Renal Impairment Influence on Metabolic Drug Clearance using a Modelling Approach
Clinical Pharmacokinetics . 62 ( 2 ) : 307-319
Journal article
see the publicationDaptomycin Exposure as a Risk Factor for Daptomycin-Induced Eosinophilic Pneumonia and Muscular Toxicity
Clinical Infectious Diseases . 77 ( 10 ) : 1372-1380
DOI: 10.1093/cid/ciad386
Journal article
see the publicationStrengthening Reporting of Neonatal Trials
Pediatrics . 152 ( 3 )
Journal article
see the publicationHeterogeneity and Gaps in Reporting Primary Outcomes From Neonatal Trials
Pediatrics . 152 ( 3 )
Journal article
see the publicationSafety of Re-dosing Nirsevimab Prior to RSV Season 2 in Children With Heart or Lung Disease
Journal of the Pediatric Infectious Diseases Society . 12 ( 8 ) : 477-480
Journal article
see the publicationEfficacy of nirsevimab against respiratory syncytial virus lower respiratory tract infections in preterm and term infants, and pharmacokinetic extrapolation to infants with congenital heart disease and chronic lung disease: a pooled analysis of randomised
The Lancet Child & Adolescent Health . 7 ( 3 ) : 180-189
Journal article
see the publicationTherapeutic Drug Monitoring and Pharmacogenetic Testing as Guides to Psychotropic Drug Dose Adjustment: An Observational Study
Pharmaceuticals . 17 ( 1 ) : 21
DOI: 10.3390/ph17010021
Journal article
see the publicationAvis de l'Anses relatif à l’évaluation du triphénylphosphate (TPP) (EC No 204-112-2 ; CAS No 115-86-6) dans le cadre de l’évaluation des substances sous REACH
: 12 p.
Report
see the publicationOptions chirurgicales et instrumentales pour la rhinite chronique : une revue systématique avec méta-analyse PRISMA
Annales françaises d'Oto-rhino-laryngologie et de Pathologie Cervico-faciale . 140 ( 6 ) : 279-289
Journal article
see the publicationSurgical and instrumental options for chronic rhinitis: A systematic review and PRISMA meta-analysis
European Annals of Otorhinolaryngology, Head and Neck Diseases . 140 ( 6 ) : 279-287
Journal article
see the publicationSurgical and instrumental options for chronic rhinitis: A systematic review and PRISMA meta-analysis
European Annals of Otorhinolaryngology, Head and Neck Diseases . 140 ( 6 ) : 279-287
Journal article
see the publicationAssociation between cannabis use and symptom dimensions in schizophrenia spectrum disorders: an individual participant data meta-analysis on 3053 individuals
EClinicalMedicine . 64 ( 6 ) : 102199
Journal article
see the publication
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