Evaluation and Modeling with the Therapeutic Effects Group

Members

EMET  presentation

The EMET team brings together doctors, pharmacists and research professors specializing in the evaluation and use of drug and non-drug therapies, around a single project built on two axes:

  • the evaluation of therapies in clinical trials or observational studies;
  • the construction of explanatory and predictive models, to better understand and therefore predict the effect of therapies, simulate their impacts at the individual and population level, and improve the innovation paradigm.

The EMET team is therefore part of two major dynamics in therapy: analysis of the level of evidence and precision medicine.
The fields of application are cardiovascular and metabolic diseases, primary care medicine, rare pediatric diseases (including genetic and autoimmune diseases), oncology and infectious diseases.
EMET members implement approaches using different mathematical models: direct comparison and network meta-analysis, pharmacokinetic/pharmacodynamic analysis, Bayesian networks and machine learning.

Education

The EMET team is specially involved in the teaching of pharmacology and therapeutics and the modeling of the treatment effect through the coordination of the Masters 2 Clinical Evaluation (EC) and Pharmacology modeling and clinical trials (PHAME), Interpretation of Therapeutic Trials (IET), Training of investigators in clinical drug trials (FIEC) and Training of clinical research assistants and clinical study technicians (FARCTEC). Teacher-researchers are also involved in the first (pharmacology), second (pharmacology / therapeutics, pharmacy) and third cycles (general medicine, pediatrics, internal medicine) in health training courses.

Society involvement

The members of the EMET team through their work and their interactions with the other components of the LBBE, National societies, governmental (HAS) or international (EMA) agencies, and the Hospices Civils de Lyon, are invested in current societal issues: rationalization of the use of health product resources, research ethics, gender equality, rationality of approaches in analyzing the diversity of human populations.

Publications

Display of 1 to 30 publications on 634 in total

Self-reported health effects after one year from a viper bite: A prospective study from France

Gaël Le Roux, Emilie Morin, Guillaume Grenet, Corinne Schmitt, Alexis d'Escatha, Sébastien Larréché

Toxicon . 261 : 108360

DOI: 10.1016/j.toxicon.2025.108360

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Efficacy of Ruxolitinib in Severe Pediatric Intra‐Alveolar Hemorrhages Unrelated to COPA Mutations

Anaïs Le, Thomas Perrin, David Drummond, Philippe Reix, Brigitte Bader-Meunier, Gillian Rice...

Pediatric Pulmonology . 60 ( 1 ) : e27481

DOI: 10.1002/ppul.27481

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French protocol for the diagnosis and management of giant cell arteritis

Hubert de Boysson, Valérie Devauchelle-Pensec, Christian Agard, Marc André, Boris Bienvenu, Bernard Bonnotte...

La Revue de Médecine Interne . 46 ( 1 ) : 12-31

DOI: 10.1016/j.revmed.2024.10.011

Journal article

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Parametric and nonparametric population pharmacokinetic analysis of fluconazole in critically ill patients and dosing simulations for Candida infections

Elodie Matusik, Olivia Vassal, Anne Conrad, Tristan Ferry, Aurélien Millet, Damien Dupont...

Antimicrobial Agents and Chemotherapy . 68 ( 11 )

DOI: 10.1128/aac.00991-24

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Preoperative 11C-Methionine PET-MRI in Pediatric Infratentorial Tumors

Pierre-Aurélien Beuriat, Anthime Flaus, Aurélie Portefaix, Alexandru Szathmari, Marc Janier, Marc Hermier...

Clinical Nuclear Medicine . 49 ( 5 ) : 381-386

DOI: 10.1097/RLU.0000000000005174

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A revisited version of the disputatio for pharmacological training: An educational study

Louise Carton, Perle Totoson, Edouard-Jules Laforgue, Jean-Marc Pelerin, Thomas Portier-Feunteun, Sabine Mainbourg...

Therapies . 79 ( 4 ) : 435-441

DOI: 10.1016/j.therap.2023.10.016

Journal article

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Parametric and nonparametric population pharmacokinetic analysis of fluconazole in critically ill patients and dosing simulations for Candida infections

Elodie Matusik, Olivia Vassal, Anne Conrad, Tristan Ferry, Aurélien Millet, Damien Dupont...

Antimicrobial Agents and Chemotherapy . 68 ( 11 )

DOI: 10.1128/aac.00991-24

Journal article

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Comment on “Antimicrobial susceptibility of Bacteroides fragilis group organisms in Hong Kong, 2020–2021”

H. Marchandin, L. Dubreuil, Marlène Amara, Guillaume Aubin, François Caron, Vincent Cattoir...

Anaerobe . 90 : 102910

DOI: 10.1016/j.anaerobe.2024.102910

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Factors of late respiratory support or oxygen weaning in infants with bronchopulmonary dysplasia

Alma Garcia-Anton, Lélia Dreyfus, Aurélie Portefaix, Florent Baudin, Franck Plaisant, Thomas Loppinet...

Pediatric Pulmonology .

DOI: 10.1002/ppul.27367

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Efficacy and tolerance of intravenous methylprednisolone pulses in children with severe bronchopulmonary dysplasia requiring respiratory support

Josseline Reynaud, Lélia Dreyfus, Laurianne Coutier, Marine Butin, Isabelle Godbert, Florent Baudin...

Pediatric Pulmonology .

DOI: 10.1002/ppul.27344

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Use of sodium-glucose cotransporter-2 inhibitors in France: Analysis of French nationwide health insurance database

Sibylle de Germay, Elodie Pambrun, Antoine Pariente, Guillaume Grenet, Julien Bezin, Jean-Luc Faillie

Diabetes, Obesity and Metabolism .

DOI: 10.1111/dom.15472

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A Machine Learning Algorithm to Predict the Starting Dose of Daptomycin

Florence Rivals, Sylvain Goutelle, Cyrielle Codde, Romain Garreau, Laure Ponthier, Pierre Marquet...

Clinical Pharmacokinetics . 63 ( 8 ) : 1137-1146

DOI: 10.1007/s40262-024-01405-z

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The expanded French compassionate programme for elexacaftor–tezacaftor–ivacaftor use in people with cystic fibrosis without a F508del CFTR variant: a real-world study

Pierre-Régis Burgel, Isabelle Sermet-Gaudelus, Emmanuelle Girodon, Isabelle Durieu, Véronique Houdouin, Camille Audousset...

The Lancet Respiratory Medicine . 12 ( 11 ) : 888-900

DOI: 10.1016/s2213-2600(24)00208-x

Journal article

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Lumacaftor/Ivacaftor Population Pharmacokinetics in Pediatric Patients with Cystic Fibrosis: A First Step Toward Personalized Therapy

Naïm Bouazza, Saïk Urien, Frantz Foissac, Laure Choupeaux, Gabrielle Lui, Léo Froelicher Bournaud...

Clinical Pharmacokinetics . 63 ( 3 ) : 333-342

DOI: 10.1007/s40262-023-01342-3

Journal article

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Long term follow-up of the STOPAGO study

Adrien Cottu, Stéphanie Guillet, Jean-François Viallard, Etienne Riviere, Stéphane Cheze, Delphine Gobert...

Blood .

DOI: 10.1182/blood.2024025707

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Comité de surveillance indépendant dans les essais cliniques : de la justification scientifique à l’organisation

Clara Locher, Silvy Laporte, Peggy Derambure, Olivier Chassany, Cécile Girault, Alix Avakiantz...

Therapies . 79 ( 1 ) : 99-110

DOI: 10.1016/j.therap.2023.10.013

Journal article

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Data Monitoring Committees and clinical trials: from scientific justification to organisation

Clara Locher, Silvy Laporte, Peggy Derambure, Olivier Chassany, Cécile Girault, Alix Avakiantz...

Therapies . 79 ( 1 ) : 111-121

DOI: 10.1016/j.therap.2023.12.002

Journal article

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Estimating individualized treatment effects using an individual participant data meta-analysis

Florie Bouvier, Anna Chaimani, Etienne Peyrot, François Gueyffier, Guillaume Grenet, Raphaël Porcher

BMC Medical Research Methodology . 24 ( 1 ) : 74

DOI: 10.1186/s12874-024-02202-9

Journal article

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Fondamentaux de l’évaluation des thérapeutiques, médicamenteuses et non médicamenteuses – un cadre pour l’évaluation des processus d’autoguérison

François Gueyffier, Rémy Boussageon

HEGEL - HEpato-GastroEntérologie Libérale . N° 4 ( 4 ) : 347-358

DOI: 10.3917/heg.134.0347

Journal article

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Rapid access to innovative medicinal products while ensuring relevant health technology assessment. Position of the French National Authority for Health

Antoine Vanier, Judith Fernandez, Sophie Kelley, Lise Alter, Patrick Semenzato, Corinne Alberti...

BMJ Evidence-Based Medicine . 29 ( 1 ) : 1-5

DOI: 10.1136/bmjebm-2022-112091

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Qu’est-ce qu’une thérapeutique ? Analyse conceptuelle de la notion de placebo, d’effet placebo, d’effet spécifique et de thérapeutique

Rémy Boussageon, François Gueyffier, Alain Moreau, Virgile Serrau, Widiane Ferchakhi

HEGEL - HEpato-GastroEntérologie Libérale . N° 4 ( 4 ) : 325-334

DOI: 10.3917/heg.134.0325

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Olaparib in recurrent isocitrate dehydrogenase mutant high-grade glioma: A phase 2 multicenter study of the POLA Network

Ines Esparragosa Vazquez, Marc Sanson, Olivier Chinot, Maxime Fontanilles, Romain Rivoirard, Laure Thomas-Maisonneuve...

Neuro-Oncology Advances . 6 ( 1 )

DOI: 10.1093/noajnl/vdae078

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COBRAPed cohort: Do sensitization patterns differentiate children with severe asthma from those with a milder disease?

Stéphanie Lejeune, Naïm Bouazza, Pascale Roland Nicaise, Valérie Jolaine, Léa Roditis, Christophe Marguet...

Pediatric Allergy and Immunology . 35 ( 3 ) : e14112

DOI: 10.1111/pai.14112

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Impact of COVID-19 infection on lung function and nutritional status amongst individuals with cystic fibrosis: A global cohort study

Julie Semenchuk, Yumi Naito, Susan C Charman, Siobhán B Carr, Stephanie Y Cheng, Bruce C Marshall...

Journal of Cystic Fibrosis . 23 : 815 - 822

DOI: 10.1016/j.jcf.2024.07.019

Journal article

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A quick access to information on influenza burden and prevention in Lyon university hospital: A prospective QR code-based information campaign in 2022–2023

Nagham Khanafer, Sylvain Oudot, Margot Maligeay, Catherine Planckaert, Camille Mena, Nadège Trehet Mandel...

Vaccine . 42 ( 21 ) : 126160

DOI: 10.1016/j.vaccine.2024.126160

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Taux de rémissions prolongées à l’arrêt d’un traitement par agoniste du récepteur de la thrombopoïétine au cours de la thrombopénie immunologique : suivi à long-terme de l’étude STOPAGO, cohorte prospective multicentrique

A. Cottu, S. Guillet, J.F. Viallard, E. Riviere, S. Cheze, D. Gobert...

La Revue de Médecine Interne . 45 : A109

DOI: 10.1016/j.revmed.2024.04.409

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Risk of infections in psoriatic arthritis or axial spondyloarthritis patients treated with targeted therapies: A meta-analysis of randomized controlled trials

Milène Séauve, Mélanie Auréal, Soline Laplane, Jean-Christophe Lega, Natalia Cabrera, Fabienne Coury

Joint Bone Spine . 91 ( 3 ) : 105673

DOI: 10.1016/j.jbspin.2023.105673

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Deaths induced by compassionate use of hydroxychloroquine during the first COVID-19 wave: an estimate

Alexiane Pradelle, Sabine Mainbourg, Steeve Provencher, Emmanuel Massy, Guillaume Grenet, Jean-Christophe Lega

Biomedicine and Pharmacotherapy . 171 : 116055

DOI: 10.1016/j.biopha.2023.116055

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Difficult‐to‐treat primary immune thrombocytopenia in adults: Prevalence and burden. Results from the CARMEN ‐France registry

Guillaume Moulis, Manuela Rueter, Aymeric Duvivier, Matthieu Mahévas, Jean‐françois Viallard, Thibault Comont...

British Journal of Haematology . 204 ( 4 ) : 1476-1482

DOI: 10.1111/bjh.19288

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Daptomycin pharmacokinetic/pharmacodynamic target in staphylococcal infections

Romain Garreau, Truong-Thanh Pham, Laurent Bourguignon, Aurélien Millet, François Parant, David Bussy...

Clinical Infectious Diseases .

DOI: 10.1093/cid/ciae018

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