Evaluation and Modeling with the Therapeutic Effects Group

Members

EMET  presentation

The EMET team brings together doctors, pharmacists and research professors specializing in the evaluation and use of drug and non-drug therapies, around a single project built on two axes:

  • the evaluation of therapies in clinical trials or observational studies;
  • the construction of explanatory and predictive models, to better understand and therefore predict the effect of therapies, simulate their impacts at the individual and population level, and improve the innovation paradigm.

The EMET team is therefore part of two major dynamics in therapy: analysis of the level of evidence and precision medicine.
The fields of application are cardiovascular and metabolic diseases, primary care medicine, rare pediatric diseases (including genetic and autoimmune diseases), oncology and infectious diseases.
EMET members implement approaches using different mathematical models: direct comparison and network meta-analysis, pharmacokinetic/pharmacodynamic analysis, Bayesian networks and machine learning.

Education

The EMET team is specially involved in the teaching of pharmacology and therapeutics and the modeling of the treatment effect through the coordination of the Masters 2 Clinical Evaluation (EC) and Pharmacology modeling and clinical trials (PHAME), Interpretation of Therapeutic Trials (IET), Training of investigators in clinical drug trials (FIEC) and Training of clinical research assistants and clinical study technicians (FARCTEC). Teacher-researchers are also involved in the first (pharmacology), second (pharmacology / therapeutics, pharmacy) and third cycles (general medicine, pediatrics, internal medicine) in health training courses.

Society involvement

The members of the EMET team through their work and their interactions with the other components of the LBBE, National societies, governmental (HAS) or international (EMA) agencies, and the Hospices Civils de Lyon, are invested in current societal issues: rationalization of the use of health product resources, research ethics, gender equality, rationality of approaches in analyzing the diversity of human populations.

Publications

Display of 1 to 30 publications on 656 in total

Intravenous administration of antibiotics by prolonged and continuous infusion

Clément Ourghanlian, Elise D’huart, Pascale Longuet, Matthieu Boisson, Fabrice Bruneel, Delphine Cabelguenne...

Infectious Diseases Now . 55 ( 1 ) : 105018

DOI: 10.1016/j.idnow.2024.105018

Journal article

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Newborn Screening for Cystic Fibrosis Is Associated With the Lowest Healthcare Costs: A 10‐Year Observational Follow‐Up Study in France

Erika Guyot, Floriane Deygas, Manon Belhassen, Marjorie Berard, Eric van Ganse, Isabelle Sermet-Gaudelus...

Pediatric Pulmonology . 60 ( 5 ) : e71134

DOI: 10.1002/ppul.71134

Journal article

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How publication bias overestimates the risk of atypical femoral fracture and osteonecrosis of the jaw associated with bisphosphonate use: A meta-epidemiological study

Arthur Gougeon, Maëlys Granal, Emmanuel Massy, François Gueyffier, Jean-Christophe Lega, Audrey Lajoinie...

Joint Bone Spine . 92 ( 4 ) : 105871

DOI: 10.1016/j.jbspin.2025.105871

Journal article

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Publication bias in pharmacogenetics of statin-associated muscle symptoms: A meta-epidemiological study

A. Gougeon, I. Aribi, S. Guernouche, J.C. Lega, J.M. Wright, C. Verstuyft...

Atherosclerosis . 400 : 118624

DOI: 10.1016/j.atherosclerosis.2024.118624

Journal article

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Blood pressure lowering efficacy of dual glucose-dependent insulinotropic polypeptide/glucagon-like peptide-1 (GIP/GLP-1) receptor agonists compared to glucagon-like peptide-1 (GLP-1) receptor agonists

Guillaume Grenet, Arthur Gougeon, Douglas Salzwedel, Ciprian Jauca, James Wright

Cochrane database of systematic reviews (Online) . 2025 ( 4 )

DOI: 10.1002/14651858.CD016144

Journal article

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JRJC 2024 - Journées de Rencontres Jeunes Chercheurs. Book of Proceedings

Thomas Strebler, Antonio Uras, Louis D'Eramo, Ragansu Chakkappai, Arthur Lafarge, Théo Cuisset...

JRJC 2024 - Journées de Rencontres Jeunes Chercheurs .

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Self-reported health effects after one year from a viper bite: A prospective study from France

Gaël Le Roux, Emilie Morin, Guillaume Grenet, Corinne Schmitt, Alexis d'Escatha, Sébastien Larréché

Toxicon . 261 : 108360

DOI: 10.1016/j.toxicon.2025.108360

Journal article

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Efficacy of Ruxolitinib in Severe Pediatric Intra‐Alveolar Hemorrhages Unrelated to COPA Mutations

Anaïs Le, Thomas Perrin, David Drummond, Philippe Reix, Brigitte Bader-Meunier, Gillian Rice...

Pediatric Pulmonology . 60 ( 1 ) : e27481

DOI: 10.1002/ppul.27481

Journal article

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French protocol for the diagnosis and management of giant cell arteritis

Hubert de Boysson, Valérie Devauchelle-Pensec, Christian Agard, Marc André, Boris Bienvenu, Bernard Bonnotte...

La Revue de Médecine Interne . 46 ( 1 ) : 12-31

DOI: 10.1016/j.revmed.2024.10.011

Journal article

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Optimizing antibiotic prophylaxis in obese patients undergoing surgery: Weight-based dosing on the rocks?

Sylvain Goutelle, Matthieu Boisson

Anaesthesia Critical Care & Pain Medicine . 43 ( 5 ) : 101412

DOI: 10.1016/j.accpm.2024.101412

Journal article

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Trends in medications for autoimmune disorders during pregnancy and factors for their discontinuation: a population-based study

Sabine Mainbourg, Odile Sheehy, Jessica Gorgui, Evelyne Vinet, Anick Bérard

BMC Pregnancy and Childbirth . 24 ( 1 ) : 765

DOI: 10.1186/s12884-024-06932-y

Journal article

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Synergistic effect between denosumab and immune checkpoint inhibitors (ICI)? A retrospective study of 268 patients with ICI and bone metastases

E. Mabrut, S. Mainbourg, J. Peron, D. Maillet, S. Dalle, C. Fontaine Delaruelle...

Journal of Bone Oncology . 48 : 100634

DOI: 10.1016/j.jbo.2024.100634

Journal article

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Mepolizumab and benralizumab in patients with severe asthma and a history of eosinophilic granulomatosis with polyangiitis

Charlene Desaintjean, Kaïs Ahmad, Julie Traclet, Mathieu Gerfaud-Valentin, Cecile-Audrey Durel, Jean-Charles Glerant...

Frontiers in Medicine . 11 : 1341310

DOI: 10.3389/fmed.2024.1341310

Journal article

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Parametric and nonparametric population pharmacokinetic analysis of fluconazole in critically ill patients and dosing simulations for Candida infections

Elodie Matusik, Olivia Vassal, Anne Conrad, Tristan Ferry, Aurélien Millet, Damien Dupont...

Antimicrobial Agents and Chemotherapy . 68 ( 11 )

DOI: 10.1128/aac.00991-24

Journal article

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Preoperative 11C-Methionine PET-MRI in Pediatric Infratentorial Tumors

Pierre-Aurélien Beuriat, Anthime Flaus, Aurélie Portefaix, Alexandru Szathmari, Marc Janier, Marc Hermier...

Clinical Nuclear Medicine . 49 ( 5 ) : 381-386

DOI: 10.1097/RLU.0000000000005174

Journal article

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A revisited version of the disputatio for pharmacological training: An educational study

Louise Carton, Perle Totoson, Edouard-Jules Laforgue, Jean-Marc Pelerin, Thomas Portier-Feunteun, Sabine Mainbourg...

Therapies . 79 ( 4 ) : 435-441

DOI: 10.1016/j.therap.2023.10.016

Journal article

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Parametric and nonparametric population pharmacokinetic analysis of fluconazole in critically ill patients and dosing simulations for Candida infections

Elodie Matusik, Olivia Vassal, Anne Conrad, Tristan Ferry, Aurélien Millet, Damien Dupont...

Antimicrobial Agents and Chemotherapy . 68 ( 11 )

DOI: 10.1128/aac.00991-24

Journal article

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Comment on “Antimicrobial susceptibility of Bacteroides fragilis group organisms in Hong Kong, 2020–2021”

H. Marchandin, L. Dubreuil, Marlène Amara, Guillaume Aubin, François Caron, Vincent Cattoir...

Anaerobe . 90 : 102910

DOI: 10.1016/j.anaerobe.2024.102910

Journal article

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Factors of late respiratory support or oxygen weaning in infants with bronchopulmonary dysplasia

Alma Garcia-Anton, Lélia Dreyfus, Aurélie Portefaix, Florent Baudin, Franck Plaisant, Thomas Loppinet...

Pediatric Pulmonology .

DOI: 10.1002/ppul.27367

Journal article

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Efficacy and tolerance of intravenous methylprednisolone pulses in children with severe bronchopulmonary dysplasia requiring respiratory support

Josseline Reynaud, Lélia Dreyfus, Laurianne Coutier, Marine Butin, Isabelle Godbert, Florent Baudin...

Pediatric Pulmonology .

DOI: 10.1002/ppul.27344

Journal article

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Use of sodium-glucose cotransporter-2 inhibitors in France: Analysis of French nationwide health insurance database

Sibylle de Germay, Elodie Pambrun, Antoine Pariente, Guillaume Grenet, Julien Bezin, Jean-Luc Faillie

Diabetes, Obesity and Metabolism .

DOI: 10.1111/dom.15472

Journal article

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A Machine Learning Algorithm to Predict the Starting Dose of Daptomycin

Florence Rivals, Sylvain Goutelle, Cyrielle Codde, Romain Garreau, Laure Ponthier, Pierre Marquet...

Clinical Pharmacokinetics . 63 ( 8 ) : 1137-1146

DOI: 10.1007/s40262-024-01405-z

Journal article

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The expanded French compassionate programme for elexacaftor–tezacaftor–ivacaftor use in people with cystic fibrosis without a F508del CFTR variant: a real-world study

Pierre-Régis Burgel, Isabelle Sermet-Gaudelus, Emmanuelle Girodon, Isabelle Durieu, Véronique Houdouin, Camille Audousset...

The Lancet Respiratory Medicine . 12 ( 11 ) : 888-900

DOI: 10.1016/s2213-2600(24)00208-x

Journal article

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Lumacaftor/Ivacaftor Population Pharmacokinetics in Pediatric Patients with Cystic Fibrosis: A First Step Toward Personalized Therapy

Naïm Bouazza, Saïk Urien, Frantz Foissac, Laure Choupeaux, Gabrielle Lui, Léo Froelicher Bournaud...

Clinical Pharmacokinetics . 63 ( 3 ) : 333-342

DOI: 10.1007/s40262-023-01342-3

Journal article

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Long term follow-up of the STOPAGO study

Adrien Cottu, Stéphanie Guillet, Jean-François Viallard, Etienne Riviere, Stéphane Cheze, Delphine Gobert...

Blood .

DOI: 10.1182/blood.2024025707

Journal article

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Comité de surveillance indépendant dans les essais cliniques : de la justification scientifique à l’organisation

Clara Locher, Silvy Laporte, Peggy Derambure, Olivier Chassany, Cécile Girault, Alix Avakiantz...

Therapies . 79 ( 1 ) : 99-110

DOI: 10.1016/j.therap.2023.10.013

Journal article

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Data Monitoring Committees and clinical trials: from scientific justification to organisation

Clara Locher, Silvy Laporte, Peggy Derambure, Olivier Chassany, Cécile Girault, Alix Avakiantz...

Therapies . 79 ( 1 ) : 111-121

DOI: 10.1016/j.therap.2023.12.002

Journal article

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Estimating individualized treatment effects using an individual participant data meta-analysis

Florie Bouvier, Anna Chaimani, Etienne Peyrot, François Gueyffier, Guillaume Grenet, Raphaël Porcher

BMC Medical Research Methodology . 24 ( 1 ) : 74

DOI: 10.1186/s12874-024-02202-9

Journal article

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Fondamentaux de l’évaluation des thérapeutiques, médicamenteuses et non médicamenteuses – un cadre pour l’évaluation des processus d’autoguérison

François Gueyffier, Rémy Boussageon

HEGEL - HEpato-GastroEntérologie Libérale . N° 4 ( 4 ) : 347-358

DOI: 10.3917/heg.134.0347

Journal article

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Rapid access to innovative medicinal products while ensuring relevant health technology assessment. Position of the French National Authority for Health

Antoine Vanier, Judith Fernandez, Sophie Kelley, Lise Alter, Patrick Semenzato, Corinne Alberti...

BMJ Evidence-Based Medicine . 29 ( 1 ) : 1-5

DOI: 10.1136/bmjebm-2022-112091

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