Evaluation and Modeling with the Therapeutic Effects Group

Members

EMET  presentation

The EMET team brings together doctors, pharmacists and research professors specializing in the evaluation and use of drug and non-drug therapies, around a single project built on two axes:

  • the evaluation of therapies in clinical trials or observational studies;
  • the construction of explanatory and predictive models, to better understand and therefore predict the effect of therapies, simulate their impacts at the individual and population level, and improve the innovation paradigm.

The EMET team is therefore part of two major dynamics in therapy: analysis of the level of evidence and precision medicine.
The fields of application are cardiovascular and metabolic diseases, primary care medicine, rare pediatric diseases (including genetic and autoimmune diseases), oncology and infectious diseases.
EMET members implement approaches using different mathematical models: direct comparison and network meta-analysis, pharmacokinetic/pharmacodynamic analysis, Bayesian networks and machine learning.

Education

The EMET team is specially involved in the teaching of pharmacology and therapeutics and the modeling of the treatment effect through the coordination of the Masters 2 Clinical Evaluation (EC) and Pharmacology modeling and clinical trials (PHAME), Interpretation of Therapeutic Trials (IET), Training of investigators in clinical drug trials (FIEC) and Training of clinical research assistants and clinical study technicians (FARCTEC). Teacher-researchers are also involved in the first (pharmacology), second (pharmacology / therapeutics, pharmacy) and third cycles (general medicine, pediatrics, internal medicine) in health training courses.

Society involvement

The members of the EMET team through their work and their interactions with the other components of the LBBE, National societies, governmental (HAS) or international (EMA) agencies, and the Hospices Civils de Lyon, are invested in current societal issues: rationalization of the use of health product resources, research ethics, gender equality, rationality of approaches in analyzing the diversity of human populations.

Publications

Display of 1 to 30 publications on 613 in total

A Machine Learning Algorithm to Predict the Starting Dose of Daptomycin

Florence Rivals, Sylvain Goutelle, Cyrielle Codde, Romain Garreau, Laure Ponthier, Pierre Marquet...

Clinical Pharmacokinetics . 63 ( 8 ) : 1137-1146

DOI: 10.1007/s40262-024-01405-z

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The expanded French compassionate programme for elexacaftor–tezacaftor–ivacaftor use in people with cystic fibrosis without a F508del CFTR variant: a real-world study

Pierre-Régis Burgel, Isabelle Sermet-Gaudelus, Emmanuelle Girodon, Isabelle Durieu, Véronique Houdouin, Camille Audousset...

The Lancet Respiratory Medicine . 12 ( 11 ) : 888-900

DOI: 10.1016/s2213-2600(24)00208-x

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Lumacaftor/Ivacaftor Population Pharmacokinetics in Pediatric Patients with Cystic Fibrosis: A First Step Toward Personalized Therapy

Naïm Bouazza, Saïk Urien, Frantz Foissac, Laure Choupeaux, Gabrielle Lui, Léo Froelicher Bournaud...

Clinical Pharmacokinetics . 63 ( 3 ) : 333-342

DOI: 10.1007/s40262-023-01342-3

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Long term follow-up of the STOPAGO study

Adrien Cottu, Stéphanie Guillet, Jean-François Viallard, Etienne Riviere, Stéphane Cheze, Delphine Gobert...

Blood .

DOI: 10.1182/blood.2024025707

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Comité de surveillance indépendant dans les essais cliniques : de la justification scientifique à l’organisation

Clara Locher, Silvy Laporte, Peggy Derambure, Olivier Chassany, Cécile Girault, Alix Avakiantz...

Therapies . 79 ( 1 ) : 99-110

DOI: 10.1016/j.therap.2023.10.013

Journal article

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Data Monitoring Committees and clinical trials: from scientific justification to organisation

Clara Locher, Silvy Laporte, Peggy Derambure, Olivier Chassany, Cécile Girault, Alix Avakiantz...

Therapies . 79 ( 1 ) : 111-121

DOI: 10.1016/j.therap.2023.12.002

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Estimating individualized treatment effects using an individual participant data meta-analysis

Florie Bouvier, Anna Chaimani, Etienne Peyrot, François Gueyffier, Guillaume Grenet, Raphaël Porcher

BMC Medical Research Methodology . 24 ( 1 ) : 74

DOI: 10.1186/s12874-024-02202-9

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Fondamentaux de l’évaluation des thérapeutiques, médicamenteuses et non médicamenteuses – un cadre pour l’évaluation des processus d’autoguérison

François Gueyffier, Rémy Boussageon

HEGEL - HEpato-GastroEntérologie Libérale . N° 4 ( 4 ) : 347-358

DOI: 10.3917/heg.134.0347

Journal article

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Rapid access to innovative medicinal products while ensuring relevant health technology assessment. Position of the French National Authority for Health

Antoine Vanier, Judith Fernandez, Sophie Kelley, Lise Alter, Patrick Semenzato, Corinne Alberti...

BMJ Evidence-Based Medicine . 29 ( 1 ) : 1-5

DOI: 10.1136/bmjebm-2022-112091

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Qu’est-ce qu’une thérapeutique ? Analyse conceptuelle de la notion de placebo, d’effet placebo, d’effet spécifique et de thérapeutique

Rémy Boussageon, François Gueyffier, Alain Moreau, Virgile Serrau, Widiane Ferchakhi

HEGEL - HEpato-GastroEntérologie Libérale . N° 4 ( 4 ) : 325-334

DOI: 10.3917/heg.134.0325

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Olaparib in recurrent isocitrate dehydrogenase mutant high-grade glioma: A phase 2 multicenter study of the POLA Network

Ines Esparragosa Vazquez, Marc Sanson, Olivier Chinot, Maxime Fontanilles, Romain Rivoirard, Laure Thomas-Maisonneuve...

Neuro-Oncology Advances . 6 ( 1 )

DOI: 10.1093/noajnl/vdae078

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COBRAPed cohort: Do sensitization patterns differentiate children with severe asthma from those with a milder disease?

Stéphanie Lejeune, Naïm Bouazza, Pascale Roland Nicaise, Valérie Jolaine, Léa Roditis, Christophe Marguet...

Pediatric Allergy and Immunology . 35 ( 3 ) : e14112

DOI: 10.1111/pai.14112

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Impact of COVID-19 infection on lung function and nutritional status amongst individuals with cystic fibrosis: A global cohort study

Julie Semenchuk, Yumi Naito, Susan C Charman, Siobhán B Carr, Stephanie Y Cheng, Bruce C Marshall...

Journal of Cystic Fibrosis . 23 : 815 - 822

DOI: 10.1016/j.jcf.2024.07.019

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A quick access to information on influenza burden and prevention in Lyon university hospital: A prospective QR code-based information campaign in 2022–2023

Nagham Khanafer, Sylvain Oudot, Margot Maligeay, Catherine Planckaert, Camille Mena, Nadège Trehet Mandel...

Vaccine . 42 ( 21 ) : 126160

DOI: 10.1016/j.vaccine.2024.126160

Journal article

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Taux de rémissions prolongées à l’arrêt d’un traitement par agoniste du récepteur de la thrombopoïétine au cours de la thrombopénie immunologique : suivi à long-terme de l’étude STOPAGO, cohorte prospective multicentrique

A. Cottu, S. Guillet, J.F. Viallard, E. Riviere, S. Cheze, D. Gobert...

La Revue de Médecine Interne . 45 : A109

DOI: 10.1016/j.revmed.2024.04.409

Journal article

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Risk of infections in psoriatic arthritis or axial spondyloarthritis patients treated with targeted therapies: A meta-analysis of randomized controlled trials

Milène Séauve, Mélanie Auréal, Soline Laplane, Jean-Christophe Lega, Natalia Cabrera, Fabienne Coury

Joint Bone Spine . 91 ( 3 ) : 105673

DOI: 10.1016/j.jbspin.2023.105673

Journal article

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Deaths induced by compassionate use of hydroxychloroquine during the first COVID-19 wave: an estimate

Alexiane Pradelle, Sabine Mainbourg, Steeve Provencher, Emmanuel Massy, Guillaume Grenet, Jean-Christophe Lega

Biomedicine and Pharmacotherapy . 171 : 116055

DOI: 10.1016/j.biopha.2023.116055

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Difficult‐to‐treat primary immune thrombocytopenia in adults: Prevalence and burden. Results from the CARMEN ‐France registry

Guillaume Moulis, Manuela Rueter, Aymeric Duvivier, Matthieu Mahévas, Jean‐françois Viallard, Thibault Comont...

British Journal of Haematology . 204 ( 4 ) : 1476-1482

DOI: 10.1111/bjh.19288

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Daptomycin pharmacokinetic/pharmacodynamic target in staphylococcal infections

Romain Garreau, Truong-Thanh Pham, Laurent Bourguignon, Aurélien Millet, François Parant, David Bussy...

Clinical Infectious Diseases .

DOI: 10.1093/cid/ciae018

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Pharmacokinetic Consideration of Venetoclax in Acute Myeloid Leukemia Patients: A Potential Candidate for TDM? A Short Communication

Michael Philippe, Jérôme Guitton, Sylvain Goutelle, Yann Thoma, Bertrand Favier, Nour Chtiba...

Therapeutic Drug Monitoring . 46 ( 1 ) : 127-131

DOI: 10.1097/FTD.0000000000001151

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RPEM : Randomized Monte Carlo parametric expectation maximization algorithm

Rong Chen, Alan Schumitzky, Alona Kryshchenko, Keith Nieforth, Michael Tomashevskiy, Shuhua Hu...

CPT: Pharmacometrics and Systems Pharmacology . 13 ( 5 ) : 759-780

DOI: 10.1002/psp4.13113

Journal article

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What are the available online resources targeting psychosocial burden among stroke survivors and their informal caregivers: A scoping review

Marion Delvallée, Romain Garreau, Anne Termoz, Pierre-Marie Ploteau, Laurent Derex, Anne-Marie Schott...

Digital Health . 10

DOI: 10.1177/20552076241240895

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Expositions accidentelles à des toxiques chez les enfants - Étude des données de plusieurs sources de recours aux soins entre 2014 et 2020

Christine Tournoud, Ramy Azzouz, Nathalie Beltzer, David Boels, Luc De Haro, Marion Evrard...

: 233 p.

Report

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Unlicensed/Off-Label Drug Prescriptions at Hospital Discharge in Children: An Observational Study Using Routinely Collected Health Data

Elham Jaberi, Inesse Boussaha, Xavier Dode, Guillaume Grenet, Behrouz Kassai, Kim An Nguyen

Healthcare . 12 ( 2 ) : 208

DOI: 10.3390/HEALTHCARE12020208

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Exposure to ammonia solution due to substance use: a retrospective study from the French poison centres database (2009–2018)

Aurore Czerwiec, Cecile Chevallier, Guillaume Grenet, Anne-Marie Patat, Sander de Souza, Jeanne Lichtfouse...

Clinical Toxicology . : 1-5

DOI: 10.1080/15563650.2024.2313088

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Comparison of daptomycin and glycopeptide efficacy and safety for the treatment of Gram-positive infections: a systematic review and meta-analysis

Abdelwahab Boulekbache, Fanny Maldonado, Raphael Kavafian, Tristan Ferry, Laurent Bourguignon, Sylvain Goutelle...

Journal of Antimicrobial Chemotherapy .

DOI: 10.1093/jac/dkae026

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Nirsevimab for Prevention of RSV in Term and Late-Preterm Infants

William Muller, Shabir Madhi, Beatriz Seoane Nuñez, Manuel Baca Cots, Miroslava Bosheva, Ron Dagan...

New England Journal of Medicine . 388 ( 16 ) : 1533-1534

DOI: 10.1056/NEJMc2214773

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Nirsevimab for Prevention of Hospitalizations Due to RSV in Infants

Simon Drysdale, Katrina Cathie, Florence Flamein, Markus Knuf, Andrea Collins, Helen Hill...

New England Journal of Medicine . 389 ( 26 ) : 2425-2435

DOI: 10.1056/NEJMoa2309189

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Circulating microRNAs improve bacterial infection diagnosis and overall survival prediction in acute decompensation of liver cirrhosis

Yasmina Chouik, Fanny Lebossé, Marie-Laure Plissonnier, Jean-Christophe Lega, Pierre Pradat, Teresa Antonini...

iScience . 26 ( 8 ) : 107427

DOI: 10.1016/j.isci.2023.107427

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Platelet count threshold for hemorrhage in patients with immune thrombocytopenia treated with antiplatelet agents

Natasha Ollier, Marie-Léa Piel-Julian, Matthieu Mahévas, Jean-François Viallard, Thibault Comont, Stéphane Chèze...

Blood . 142 ( 12 ) : 1099-1101

DOI: 10.1182/blood.2023020311

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