The EMET team brings together doctors, pharmacists and research professors specializing in the evaluation and use of drug and non-drug therapies, around a single project built on two axes:
- the evaluation of therapies in clinical trials or observational studies;
- the construction of explanatory and predictive models, to better understand and therefore predict the effect of therapies, simulate their impacts at the individual and population level, and improve the innovation paradigm.
The EMET team is therefore part of two major dynamics in therapy: analysis of the level of evidence and precision medicine.
The fields of application are cardiovascular and metabolic diseases, primary care medicine, rare pediatric diseases (including genetic and autoimmune diseases), oncology and infectious diseases.
EMET members implement approaches using different mathematical models: direct comparison and network meta-analysis, pharmacokinetic/pharmacodynamic analysis, Bayesian networks and machine learning.
The EMET team is specially involved in the teaching of pharmacology and therapeutics and the modeling of the treatment effect through the coordination of the Masters 2 Clinical Evaluation (EC) and Pharmacology modeling and clinical trials (PHAME), Interpretation of Therapeutic Trials (IET), Training of investigators in clinical drug trials (FIEC) and Training of clinical research assistants and clinical study technicians (FARCTEC). Teacher-researchers are also involved in the first (pharmacology), second (pharmacology / therapeutics, pharmacy) and third cycles (general medicine, pediatrics, internal medicine) in health training courses.
The members of the EMET team through their work and their interactions with the other components of the LBBE, National societies, governmental (HAS) or international (EMA) agencies, and the Hospices Civils de Lyon, are invested in current societal issues: rationalization of the use of health product resources, research ethics, gender equality, rationality of approaches in analyzing the diversity of human populations.
Display of 1 to 30 publications on 184 in total
Place of a new radiological index in predicting pulp exposure before intervention for deep carious lesions
Oral Radiology .
Publication language and the estimate of treatment effects of physical therapy on balance and postural control after stroke in meta-analyses of randomised controlled trials
PLoS ONE . 15 ( 3 ) : e0229822
Clomiphene citrate and neural tube defects: a meta‐analysis of controlled observational studies
BJOG: An International Journal of Obstetrics and Gynaecology .
Extended anticoagulation for the secondary prevention of venous thromboembolic events: An updated network meta-analysis
PLoS ONE . 14 ( 4 ) : e0214134
Amikacin Initial Dose in Critically Ill Patients: a Nonparametric Approach To Optimize A Priori Pharmacokinetic/Pharmacodynamic Target Attainments in Individual Patients
Antimicrobial Agents and Chemotherapy . 63 ( 11 ) : e00993-19
Pharmacokinetic variability of beta-lactams in critically ill patients: A narrative review
Anaesthesia Critical Care & Pain Medicine .
GLUcose COntrol Safety & Efficacy in type 2 DIabetes, a systematic review and NETwork meta-analysis
PLoS ONE . 14 ( 6 ) : e0217701
The limitations of observation studies for decision making regarding drugs efficacy and safety
Alternative and Complementary Therapies . 74 ( 2 ) : 181-185
Do patients with cystic fibrosis participating in clinical trials demonstrate placebo response? A meta-analysis
Journal of Cystic Fibrosis .
Apport de la génomique dans la médecine de demain, applications cliniques et enjeux
Thérapie . 74 ( 1 ) : 1-8
The contribution of genomics in the medicine of tomorrow, clinical applications and issues
Thérapie . 74 ( 1 ) : 9-15
Immune system modelling in case of a septic shock
29TH EUROPEAN SYMPOSIUM ON COMPUTER AIDED PROCESS ENGINEERING, . : 1093-1098
Stereo-electroencephalography-guided radiofrequency thermocoagulation in patients with focal epilepsy: A systematic review and meta-analysis
Epilepsia . 59 ( 12 ) : 2296-2304
The efficacy of early versus delayed P2Y12 inhibition in percutaneous coronary intervention for ST-elevation myocardial infarction: a systematic review and meta-analysis
EuroIntervention . 14 ( 1 ) : 78-85
Determinants of amikacin first peak concentration in critically ill patients
Fundamental and Clinical Pharmacology .
Antituberculous drugs modulate bacterial phagolysosome avoidance and autophagy in Mycobacterium tuberculosis-infected macrophages
Tuberculosis . 111 : 67-70
Prospective Cohort Study of the Tolerability of Prosthetic Joint Infection Empirical Antimicrobial Therapy
ANTIMICROB. AGENTS CHEMOTHER. . 62 ( 10 )
Assessing the Combined Antibacterial Effect of Isoniazid and Rifampin on Four Mycobacterium tuberculosis Strains Using In Vitro Experiments and Response-Surface Modeling
Antimicrobial Agents and Chemotherapy . 62 ( 1 )
Sex gap in aging and longevity: can sex chromosomes play a role?
Biology of Sex Differences . 9 ( 1 ) : 1-14
Causes and consequences of variation in offspring body mass: meta-analyses in birds and mammals
Biol. Rev . 93 : 1 - 27
Les résultats faux positifs ou quelle est la probabilité que le traitement soit efficace quand p < 0,05 ?
Alternative and Complementary Therapies . 72 ( 4 ) : 421-426
Assessment of clinically relevant bleeding as a surrogate outcome for major bleeding: validation by meta-analysis of randomized controlled trials
Journal of Thrombosis and Haemostasis . 15 ( 8 ) : 1547-1558
Challenges for Small Biopharmaceutical Companies
New England Journal of Medicine . 376 ( 17 ) : 1697-1698
Evaluation of haemodialysis as a protective technique for preventing high daily dose amikacin nephrotoxicity: an experimental study in an ovine model.
International Journal of Antimicrobial Agents .
Population pharmacokinetics of teicoplanin administered by subcutaneous or intravenous route and simulation of optimal loading dose regimen
Journal of Antimicrobial Chemotherapy . 72 ( 10 ) : 2804-2812
Mechanisms of drug-drug interaction between rifampicin and fusidic acid
British Journal of Clinical Pharmacology . 83 ( 8 ) : 1862-1864
Prevalence and Risk Factors of Drug-Associated Corrected QT Prolongation in Elderly Hospitalized Patients: Results of a Retrospective Analysis of Data Obtained Over 6 Months
Drugs & aging . 34 : 545-553
Is Trough Concentration of Vancomycin Predictive of the Area Under the Curve? A Clinical Study in Elderly Patients
Therapeutic Drug Monitoring . 39 : 83-87
A Model for Predicting the Interindividual Variability of Drug-Drug Interactions
AAPS Journal . 19 : 497-509
The Role of Antibiotics in Modulating Virulence in Staphylococcus aureus
Clinical Microbiology Reviews . 30 ( 4 ) : 887-917