Professor François GUEYFFIER has more than 30 years of experience in clinical pharmacology and modeling in pharmacology. He coordinated the EU-USA INDANA consortium (http://lbbe-dmz.univ-lyon1.fr/spip_indana/) for performing individual data meta-analyzes (IPDMA) of randomized controlled trials in hypertension (Italy, United Kingdom, Belgium, France, USA, China), leading to more than 20 international publications in this field. This experiment served to illustrate how the IPDMA approach could / should influence the recommendations and design of new randomized controlled trials (doi: 10.1016 / j.jclinepi.2015.05.024). He is the author of 214 publications recorded in Pubmed, 269 according to web of science, H index 36 for WoS.
He coordinated the Clinical Investigation Center (CIC) in Lyon during its first 10 years (2001-2011), as well as the working group on data management in the French CIC network. He helped to establish the requirements for data management centers in the European network ECRIN (http://www.ecrin.org). The data management platform he coordinates in Lyon is ECRIN certified in July 2016 (http://www.ecrin.org/news/two-data-centres-receive-ecrin-certification). He prepares a recertification for a larger perimeter, including almost all support services for clinical research in Lyon University Hospitals – Hospices Civils de Lyon.
He was PI of the national network for patient recruitment in the IDEAL trial (http://lbbe-dmz.univ-lyon1.fr/spip_ideal/) to identify biomarkers predictive of response to antihypertensive therapy.
He coordinated the BIMBO national consortium (http://lbbe-dmz.univ-lyon1.fr/spip_bimbo/) to help identify markers of antihypertensive drug response by combining the modeling and clinical pharmacology approach.
His team (Dr Patrice NONY and Dr Catherine CORNU) coordinated the European project PriomedChild CRESIM (https://lbbe.univ-lyon1.fr/-CRESIM-.html), to help the choice of the best experimental plan by the simulation of clinical tests.
He teaches clinical pharmacology at the Faculty of Medicine. He is co-head of a master's degree course 2 "pharmacology modeling and clinical trials", local leader of the Inter University Diploma “training clinical trial investigators”. He was in charge of organizing experts committees for HCERES, member of selection committees of local and national research projects, member of the Commission de Transparence of Haute Autorité de Santé vice-chief of the Health Data Department of the Hospices Civils de Lyon.
Display of 1 to 30 publications on 96 in total
Selected and simplified FDI criteria for assessment of restorations
Journal of Dentistry . : 104109
How do they add up? The interaction between the placebo and treatment effect: A systematic review
British Journal of Clinical Pharmacology .
Place of a new radiological index in predicting pulp exposure before intervention for deep carious lesions
Oral Radiology .
Expected Evolution of COVID-19 Epidemic in France for Several Combinations of Vaccination Strategies and Barrier Measures
Vaccines . 9 ( 12 ) : 1462
Publication language and the estimate of treatment effects of physical therapy on balance and postural control after stroke in meta-analyses of randomised controlled trials
PLoS ONE . 15 ( 3 ) : e0229822
The contribution of genomics in the medicine of tomorrow, clinical applications and issues
Thérapie . 74 ( 1 ) : 9-15
The limitations of observation studies for decision making regarding drugs efficacy and safety
Alternative and Complementary Therapies . 74 ( 2 ) : 181-185
Do patients with cystic fibrosis participating in clinical trials demonstrate placebo response? A meta-analysis
Journal of Cystic Fibrosis .
Apport de la génomique dans la médecine de demain, applications cliniques et enjeux
Thérapie . 74 ( 1 ) : 1-8
Immune system modelling in case of a septic shock
29TH EUROPEAN SYMPOSIUM ON COMPUTER AIDED PROCESS ENGINEERING, . : 1093-1098
Causes and consequences of variation in offspring body mass: meta-analyses in birds and mammals
Biol. Rev . 93 : 1 - 27
Sex gap in aging and longevity: can sex chromosomes play a role?
Biology of Sex Differences . 9 ( 1 ) : 1-14
Effet antalgique aigu du paracétamol en soins primaires : des preuves incomplètes
Thérapie . 72 ( 5 ) : 609 - 613
Efficiency of physical therapy on postural imbalance after stroke: study protocol for a systematic review and meta-analysis
BMJ Open . 7 ( 1 ) : e013348
No benefits of statins for sudden cardiac death prevention in patients with heart failure and reduced ejection fraction: A meta-analysis of randomized controlled trials
PLoS ONE . 12 : e0171168
Efficacy and safety of DPP-4 inhibitors in patients with type 2 diabetes: Meta-analysis of placebo-controlled randomized clinical trials
Diabetes and Metabolism . 43 ( 1 ) : 48 - 58
Référentiel ECRIN pour la conformité aux bonnes pratiques de gestion des données des essais cliniques multinationaux
Quality of qualitative studies centred on patients in family practice: a systematic review
Family Practice . 33 ( 6 ) : 580 - 587
Antihypertensive pharmacotherapy for prevention of sudden cardiac death in hypertensive individuals
Cochrane database of systematic reviews (Online) . 3 : CD011745
One-step partial or complete caries removal and bonding with antibacterial or traditional self-etch adhesives: study protocol for a randomized controlled trial
Trials . 17 ( 1 ) : 404
Impact of Aldosterone Antagonists on Sudden Cardiac Death Prevention in Heart Failure and Post-Myocardial Infarction Patients: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
PLoS ONE . 11 : e0145958
Metformin as firstline treatment for type 2 diabetes: are we sure?
BMJ-BRITISH MEDICAL JOURNAL . 352 : h6748
Uptake of systematic reviews and meta-analyses based on individual participant data in clinical practice guidelines: descriptive study
British medical journal . 350 : h1088
Comparison of an effect-model-law-based method versus traditional clinical practice guidelines for optimal treatment decision-making: application to statin treatment in the French population
Journal of the Royal Society Interface . 11 ( 100 ) : 20140867
The effect of methylphenidate on neurofibromatosis type 1: a randomised, double-blind, placebo-controlled, crossover trial
Orphanet Journal of Rare Diseases . 9 : 142
Effects of pharmacological treatments on micro- and macrovascular complications of type 2 diabetes: What is the level of evidence?
Diabetes and Metabolism . 40 : 169-75
Tranexamic acid for epistaxis in hereditary hemorrhagic telangiectasia patients: a European cross-over controlled trial in a rare disease
Journal of thrombosis and haemostasis . 12 : 1494-502
Improving risk prediction performance for a better guidelines application
Journal of Hypertension . 32 : 1192-1193
Impact of the reduction of calcineurin inhibitors on renal function in heart transplant patients: a systematic review and meta-analysis
British Journal of Clinical Pharmacology . 78 ( 1 ) : 24-32
Cardiovascular Events and Bleeding Risk Associated With Intravitreal Antivascular Endothelial Growth Factor Monoclonal Antibodies: Systematic Review and Meta-analysis
JAMA Ophthalmology . 132 ( 11 ) : 1317-26