Statistics and Modelling for Health Sciences

Evaluation and Modeling with the Therapeutic Effects Group

Gueyffier François

Professeur d'université - praticien hospitalier émérite

UCBL

Address: BP8071
69376 LYON cedex 08

Tel: 33 04 78 78 57 49 33 04 72 35 72 31

Email

Professor François GUEYFFIER has more than 30 years of experience in clinical pharmacology and modeling in pharmacology. He coordinated the EU-USA INDANA consortium (http://lbbe-dmz.univ-lyon1.fr/spip_indana/) for performing individual data meta-analyzes (IPDMA) of randomized controlled trials in hypertension (Italy, United Kingdom, Belgium, France, USA, China), leading to more than 20 international publications in this field. This experiment served to illustrate how the IPDMA approach could / should influence the recommendations and design of new randomized controlled trials (doi: 10.1016 / j.jclinepi.2015.05.024). He is the author of 214 publications recorded in Pubmed, 269 according to web of science, H index 36 for WoS.

He coordinated the Clinical Investigation Center (CIC) in Lyon during its first 10 years (2001-2011), as well as the working group on data management in the French CIC network. He helped to establish the requirements for data management centers in the European network ECRIN (http://www.ecrin.org). The data management platform he coordinates in Lyon is ECRIN certified in July 2016 (http://www.ecrin.org/news/two-data-centres-receive-ecrin-certification). He prepares a recertification for a larger perimeter, including almost all support services for clinical research in Lyon University Hospitals – Hospices Civils de Lyon.

He was PI of the national network for patient recruitment in the IDEAL trial (http://lbbe-dmz.univ-lyon1.fr/spip_ideal/) to identify biomarkers predictive of response to antihypertensive therapy.

He coordinated the BIMBO national consortium (http://lbbe-dmz.univ-lyon1.fr/spip_bimbo/) to help identify markers of antihypertensive drug response by combining the modeling and clinical pharmacology approach.

His team (Dr Patrice NONY and Dr Catherine CORNU) coordinated the European project PriomedChild CRESIM (https://lbbe.univ-lyon1.fr/-CRESIM-.html), to help the choice of the best experimental plan by the simulation of clinical tests.

He teaches clinical pharmacology at the Faculty of Medicine. He is co-head of a master's degree course 2 "pharmacology modeling and clinical trials", local leader of the Inter University Diploma “training clinical trial investigators”. He was in charge of organizing experts committees for HCERES, member of selection committees of local and national research projects, member of the Commission de Transparence of Haute Autorité de Santé vice-chief of the Health Data Department of the Hospices Civils de Lyon.

Publications

Display of 1 to 30 publications on 101 in total

A Knowledge-Based Approach for Evaluating Impact of Therapeutic Strategies

Nadia Abchiche-Mimouni, Mike Donald Tapi Nzali, François Gueyffier

ICAART 2023 - 15th International Conference on Agents and Artificial Intelligence . 3 : 1036-1046

DOI: 10.5220/0011894300003393

Conference paper

see the publication

Projet Rebuild the Evidence Base

Hélène Vaillant-Roussel, Clara Blanchard, Thibault Menini, Elodie Charuel, Bruno Pereira, Florian Naudet...

Exercer . 34 ( 190 ) : 81-88

DOI: 10.56746/EXERCER.2023.190.81

Journal article

see the publication

Predicted Impacts of Booster, Immunity Decline, Vaccination Strategies, and Non-Pharmaceutical Interventions on COVID-19 Outcomes in France

Simon Pageaud, Anne Eyraud-Loisel, Jean-Pierre Bertoglio, Alexis Bienvenüe, Nicolas Leboisne, Catherine Pothier...

Vaccines . 10 ( 12 ) : 2033

DOI: 10.3390/vaccines10122033

Journal article

see the publication

Selected and simplified FDI criteria for assessment of restorations

Christina Maillet, Franck Decup, Emmanuelle Dantony, Jean Iwaz, Charlène Chevalier, François Gueyffier...

Journal of Dentistry . 122 : 104109

DOI: 10.1016/j.jdent.2022.104109

Journal article

see the publication

Place of a new radiological index in predicting pulp exposure before intervention for deep carious lesions

Marie-Agnès Gasqui, Matthieu Perard, Franck Decup, Paul Monsarrat, Yann-Loïg Turpin, Cyril Villat...

Oral Radiology . 38 ( 1 ) : 89-98

DOI: 10.1007/s11282-021-00530-w

Journal article

see the publication

How do they add up? The interaction between the placebo and treatment effect: A systematic review

Rémy Boussageon, Jeremy Howick, Raphael Baron, Florian Naudet, Bruno Falissard, Ghina Harika-Germaneau...

British Journal of Clinical Pharmacology .

DOI: 10.1111/bcp.15345

Journal article

see the publication

Expected Evolution of COVID-19 Epidemic in France for Several Combinations of Vaccination Strategies and Barrier Measures

Simon Pageaud, Catherine Pothier, Christophe Rigotti, Anne Eyraud-Loisel, Jean-Pierre Bertoglio, Alexis Bienvenüe...

Vaccines . 9 ( 12 ) : 1462

DOI: 10.3390/vaccines9121462

Journal article

see the publication

Inconclusive efficacy of intervention on upper-limb function after tetraplegia: A systematic review and meta-analysis

Sébastien Mateo, Julie Di Marco, Michel Cucherat, François Gueyffier, Gilles Rode

Annals of physical and rehabilitation medicine . 63 ( 3 ) : 230-240

DOI: 10.1016/j.rehab.2019.05.008

Journal article

see the publication

Publication language and the estimate of treatment effects of physical therapy on balance and postural control after stroke in meta-analyses of randomised controlled trials

Aurélien Hugues, Julie Di Marco, Isabelle Bonan, Gilles Rode, Michel Cucherat, François Gueyffier

PLoS ONE . 15 ( 3 ) : e0229822

DOI: 10.1371/journal.pone.0229822

Journal article

see the publication

The contribution of genomics in the medicine of tomorrow, clinical applications and issues

Bruno Laviolle, Patrice Denèfle, François Gueyffier, Élodie Bégué, Pascal Bilbault, Helene Esperou...

Thérapie . 74 ( 1 ) : 9-15

DOI: 10.1016/j.therap.2018.11.012

Journal article

see the publication

The limitations of observation studies for decision making regarding drugs efficacy and safety

François Gueyffier, Michel Cucherat

Alternative and Complementary Therapies . 74 ( 2 ) : 181-185

DOI: 10.1016/j.therap.2018.11.001

Journal article

see the publication

Do patients with cystic fibrosis participating in clinical trials demonstrate placebo response? A meta-analysis

Julie Coton, Ha-Hai Le, Victor Veuillet, Perrine Janiaud, Michel Cucherat, Behrouz Kassai-Koupai...

Journal of Cystic Fibrosis .

DOI: 10.1016/j.jcf.2019.02.003

Journal article

see the publication

Apport de la génomique dans la médecine de demain, applications cliniques et enjeux

Bruno Laviolle, Olivier Perche, François Gueyffier, Élodie Bégué, Pascal Bilbault, Hélène Esperou...

Thérapie . 74 ( 1 ) : 1-8

DOI: 10.1016/j.therap.2018.11.011

Journal article

see the publication

Immune system modelling in case of a septic shock

Jean Tallon, Françoise Couenne, Claire Bordes, Melaz Tayakout-Fayolle, Fabienne Venet, Guillaume Monneret...

29TH EUROPEAN SYMPOSIUM ON COMPUTER AIDED PROCESS ENGINEERING, . : 1093-1098

DOI: 10.1016/B978-0-12-818634-3.50183-1

Book chapter

see the publication

Causes and consequences of variation in offspring body mass: meta-analyses in birds and mammals

Victor Ronget, Jean-Michel Gaillard, Tim Coulson, Michael Garratt, François Gueyffier, Jean-Christophe Lega...

Biol. Rev . 93 : 1 - 27

DOI: 10.1111/brv.12329

Journal article

see the publication

Sex gap in aging and longevity: can sex chromosomes play a role?

Gabriel A.B. Marais, Jean-Michel Gaillard, Cristina Vieira, Ingrid Plotton, Damien Sanlaville, François Gueyffier...

Biology of Sex Differences . 9 ( 1 ) : 1-14

DOI: 10.1186/s13293-018-0181-y

Journal article

see the publication

Protocol of GLUcose COntrol Safety and Efficacy in type 2 DIabetes, a NETwork meta-analysis: GLUCOSE DINET protocol-Rational and design

G. Grenet, A. Lajoinie, S. Ribault, G. B. Nguyen, T. Linet, A. Metge...

Fundamental & Clinical Pharmacology . 31 ( 3 ) : 258-264

DOI: 10.1111/fcp.12263

Journal article

see the publication

Effet antalgique aigu du paracétamol en soins primaires : des preuves incomplètes

Marion Gougain, Moreau Alain, Rémy Boussageon, Gisèle Pickering, François Gueyffier

Thérapie . 72 ( 5 ) : 609 - 613

DOI: 10.1016/j.therap.2017.02.004

Journal article

see the publication

Efficiency of physical therapy on postural imbalance after stroke: study protocol for a systematic review and meta-analysis

Aurélien Hugues, Julie Di Marco, Perrine Janiaud, Y Xue, Jennifer Pires, Hooman Khademi...

BMJ Open . 7 ( 1 ) : e013348

DOI: 10.1136/bmjopen-2016-013348

Journal article

see the publication

No benefits of statins for sudden cardiac death prevention in patients with heart failure and reduced ejection fraction: A meta-analysis of randomized controlled trials

M. Al-Gobari, H.H. Le, M. Fall, François Gueyffier, B. Burnand

PLoS ONE . 12 : e0171168

DOI: 10.1371/journal.pone.0171168

Journal article

see the publication

Efficacy and safety of DPP-4 inhibitors in patients with type 2 diabetes: Meta-analysis of placebo-controlled randomized clinical trials

M. Rehman, B.V. Tudrej, J. Soustre, M. Buisson, P. Archambault, D. Pouchain...

Diabetes & Metabolism . 43 ( 1 ) : 48 - 58

DOI: 10.1016/j.diabet.2016.09.005

Journal article

see the publication

Référentiel ECRIN pour la conformité aux bonnes pratiques de gestion des données des essais cliniques multinationaux

Catherine Cornu, Anne Donche, Carine Coffre, Amélie Le Gouge, Boulkedid Rym, Isabelle Vaugier...

Thérapie .

DOI: 10.2515/therapie/2015042

Journal article

see the publication

Quality of qualitative studies centred on patients in family practice: a systematic review

Benedicte Eschalier, Stéphane Descamps, Bruno Pereira, Hélène Vaillant-Roussel, Guillaume Girard, Stéphane Boisgard...

Family Practice . 33 ( 6 ) : 580 - 587

DOI: 10.1093/fampra/cmw095

Journal article

see the publication

Antihypertensive pharmacotherapy for prevention of sudden cardiac death in hypertensive individuals

G. Taverny, Y. Mimouni, A. Ledigarcher, P. Chevalier, L. Thijs, J.M. Wright...

Cochrane database of systematic reviews (Online) . 3 : CD011745

DOI: 10.1002/14651858.CD011745.pub2

Journal article

see the publication

One-step partial or complete caries removal and bonding with antibacterial or traditional self-etch adhesives: study protocol for a randomized controlled trial

Cyril Villat, Jean-Pierre Attal, Nathalie Brulat, Franck Decup, Sophie Doméjean, Elisabeth Dursun...

Trials . 17 ( 1 ) : 404

DOI: 10.1186/s13063-016-1484-0

Journal article

see the publication

Impact of Aldosterone Antagonists on Sudden Cardiac Death Prevention in Heart Failure and Post-Myocardial Infarction Patients: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

H.-H. Le, C. El-Khatib, M. Mombled, F. Guitarian, M. Al-Gobari, M. Fall...

PLoS ONE . 11 : e0145958

DOI: 10.1371/journal.pone.0145958

Journal article

see the publication

Metformin as firstline treatment for type 2 diabetes: are we sure?

R. Boussageon, François Gueyffier, Catherine Cornu

BMJ-BRITISH MEDICAL JOURNAL . 352 : h6748

DOI: 10.1136/bmj.h6748

Journal article

see the publication

Uptake of systematic reviews and meta-analyses based on individual participant data in clinical practice guidelines: descriptive study

C. Vale, L. Rydzewska, M. Rovers, J. Emberson, François Gueyffier, L. Stewart

British medical journal . 350 : h1088

DOI: 10.1136/bmj.h1088

Journal article

see the publication

Comparison of an effect-model-law-based method versus traditional clinical practice guidelines for optimal treatment decision-making: application to statin treatment in the French population

R. Kahoul, François Gueyffier, E. Amsallem, M. Haugh, I. Marchant, F. H. Boissel...

Journal of the Royal Society Interface . 11 ( 100 ) : 20140867

DOI: 10.1098/rsif.2014.0867

Journal article

see the publication

The effect of methylphenidate on neurofibromatosis type 1: a randomised, double-blind, placebo-controlled, crossover trial

Laurence Lion-François, François Gueyffier, Catherine Mercier, Daniel Gérard, Vania Herbillon, Isabelle Kemlin...

Orphanet Journal of Rare Diseases . 9 : 142

DOI: 10.1186/s13023-014-0142-4

Journal article

see the publication