
Statistics and Modelling for Health Sciences
Evaluation and Modeling with the Therapeutic Effects Group
Gueyffier François
Professeur d'université - praticien hospitalier émérite
UCBL
Professor François GUEYFFIER has more than 30 years of experience in clinical pharmacology and modeling in pharmacology. He coordinated the EU-USA INDANA consortium (http://lbbe-dmz.univ-lyon1.fr/spip_indana/) for performing individual data meta-analyzes (IPDMA) of randomized controlled trials in hypertension (Italy, United Kingdom, Belgium, France, USA, China), leading to more than 20 international publications in this field. This experiment served to illustrate how the IPDMA approach could / should influence the recommendations and design of new randomized controlled trials (doi: 10.1016 / j.jclinepi.2015.05.024). He is the author of 214 publications recorded in Pubmed, 269 according to web of science, H index 36 for WoS.
He coordinated the Clinical Investigation Center (CIC) in Lyon during its first 10 years (2001-2011), as well as the working group on data management in the French CIC network. He helped to establish the requirements for data management centers in the European network ECRIN (http://www.ecrin.org). The data management platform he coordinates in Lyon is ECRIN certified in July 2016 (http://www.ecrin.org/news/two-data-centres-receive-ecrin-certification). He prepares a recertification for a larger perimeter, including almost all support services for clinical research in Lyon University Hospitals – Hospices Civils de Lyon.
He was PI of the national network for patient recruitment in the IDEAL trial (http://lbbe-dmz.univ-lyon1.fr/spip_ideal/) to identify biomarkers predictive of response to antihypertensive therapy.
He coordinated the BIMBO national consortium (http://lbbe-dmz.univ-lyon1.fr/spip_bimbo/) to help identify markers of antihypertensive drug response by combining the modeling and clinical pharmacology approach.
His team (Dr Patrice NONY and Dr Catherine CORNU) coordinated the European project PriomedChild CRESIM (https://lbbe.univ-lyon1.fr/-CRESIM-.html), to help the choice of the best experimental plan by the simulation of clinical tests.
He teaches clinical pharmacology at the Faculty of Medicine. He is co-head of a master's degree course 2 "pharmacology modeling and clinical trials", local leader of the Inter University Diploma “training clinical trial investigators”. He was in charge of organizing experts committees for HCERES, member of selection committees of local and national research projects, member of the Commission de Transparence of Haute Autorité de Santé vice-chief of the Health Data Department of the Hospices Civils de Lyon.
Publications
Display of 1 to 30 publications on 101 in total
A Knowledge-Based Approach for Evaluating Impact of Therapeutic Strategies
ICAART 2023 - 15th International Conference on Agents and Artificial Intelligence . 3 : 1036-1046
Conference paper
see the publicationPredicted Impacts of Booster, Immunity Decline, Vaccination Strategies, and Non-Pharmaceutical Interventions on COVID-19 Outcomes in France
Vaccines . 10 ( 12 ) : 2033
Journal article
see the publicationSelected and simplified FDI criteria for assessment of restorations
Journal of Dentistry . 122 : 104109
Journal article
see the publicationPlace of a new radiological index in predicting pulp exposure before intervention for deep carious lesions
Oral Radiology . 38 ( 1 ) : 89-98
Journal article
see the publicationHow do they add up? The interaction between the placebo and treatment effect: A systematic review
British Journal of Clinical Pharmacology .
DOI: 10.1111/bcp.15345
Journal article
see the publicationExpected Evolution of COVID-19 Epidemic in France for Several Combinations of Vaccination Strategies and Barrier Measures
Vaccines . 9 ( 12 ) : 1462
Journal article
see the publicationInconclusive efficacy of intervention on upper-limb function after tetraplegia: A systematic review and meta-analysis
Annals of physical and rehabilitation medicine . 63 ( 3 ) : 230-240
Journal article
see the publicationPublication language and the estimate of treatment effects of physical therapy on balance and postural control after stroke in meta-analyses of randomised controlled trials
PLoS ONE . 15 ( 3 ) : e0229822
Journal article
see the publicationThe contribution of genomics in the medicine of tomorrow, clinical applications and issues
Thérapie . 74 ( 1 ) : 9-15
Journal article
see the publicationThe limitations of observation studies for decision making regarding drugs efficacy and safety
Alternative and Complementary Therapies . 74 ( 2 ) : 181-185
Journal article
see the publicationDo patients with cystic fibrosis participating in clinical trials demonstrate placebo response? A meta-analysis
Journal of Cystic Fibrosis .
Journal article
see the publicationApport de la génomique dans la médecine de demain, applications cliniques et enjeux
Thérapie . 74 ( 1 ) : 1-8
Journal article
see the publicationImmune system modelling in case of a septic shock
29TH EUROPEAN SYMPOSIUM ON COMPUTER AIDED PROCESS ENGINEERING, . : 1093-1098
Book chapter
see the publicationCauses and consequences of variation in offspring body mass: meta-analyses in birds and mammals
Biol. Rev . 93 : 1 - 27
DOI: 10.1111/brv.12329
Journal article
see the publicationSex gap in aging and longevity: can sex chromosomes play a role?
Biology of Sex Differences . 9 ( 1 ) : 1-14
Journal article
see the publicationProtocol of GLUcose COntrol Safety and Efficacy in type 2 DIabetes, a NETwork meta-analysis: GLUCOSE DINET protocol-Rational and design
Fundamental & Clinical Pharmacology . 31 ( 3 ) : 258-264
DOI: 10.1111/fcp.12263
Journal article
see the publicationEffet antalgique aigu du paracétamol en soins primaires : des preuves incomplètes
Thérapie . 72 ( 5 ) : 609 - 613
Journal article
see the publicationEfficiency of physical therapy on postural imbalance after stroke: study protocol for a systematic review and meta-analysis
BMJ Open . 7 ( 1 ) : e013348
Journal article
see the publicationNo benefits of statins for sudden cardiac death prevention in patients with heart failure and reduced ejection fraction: A meta-analysis of randomized controlled trials
PLoS ONE . 12 : e0171168
Journal article
see the publicationEfficacy and safety of DPP-4 inhibitors in patients with type 2 diabetes: Meta-analysis of placebo-controlled randomized clinical trials
Diabetes & Metabolism . 43 ( 1 ) : 48 - 58
Journal article
see the publicationRéférentiel ECRIN pour la conformité aux bonnes pratiques de gestion des données des essais cliniques multinationaux
Thérapie .
Journal article
see the publicationQuality of qualitative studies centred on patients in family practice: a systematic review
Family Practice . 33 ( 6 ) : 580 - 587
Journal article
see the publicationAntihypertensive pharmacotherapy for prevention of sudden cardiac death in hypertensive individuals
Cochrane database of systematic reviews (Online) . 3 : CD011745
Journal article
see the publicationOne-step partial or complete caries removal and bonding with antibacterial or traditional self-etch adhesives: study protocol for a randomized controlled trial
Trials . 17 ( 1 ) : 404
Journal article
see the publicationImpact of Aldosterone Antagonists on Sudden Cardiac Death Prevention in Heart Failure and Post-Myocardial Infarction Patients: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
PLoS ONE . 11 : e0145958
Journal article
see the publicationMetformin as firstline treatment for type 2 diabetes: are we sure?
BMJ-BRITISH MEDICAL JOURNAL . 352 : h6748
DOI: 10.1136/bmj.h6748
Journal article
see the publicationUptake of systematic reviews and meta-analyses based on individual participant data in clinical practice guidelines: descriptive study
British medical journal . 350 : h1088
DOI: 10.1136/bmj.h1088
Journal article
see the publicationComparison of an effect-model-law-based method versus traditional clinical practice guidelines for optimal treatment decision-making: application to statin treatment in the French population
Journal of the Royal Society Interface . 11 ( 100 ) : 20140867
Journal article
see the publicationThe effect of methylphenidate on neurofibromatosis type 1: a randomised, double-blind, placebo-controlled, crossover trial
Orphanet Journal of Rare Diseases . 9 : 142
Journal article
see the publication