Statistics and Modelling for Health Sciences
Evaluation and Modeling with the Therapeutic Effects Group
Gueyffier François
Professeur d'université - praticien hospitalier émérite
UCBL
Professor François GUEYFFIER has more than 30 years of experience in clinical pharmacology and modeling in pharmacology. He coordinated the EU-USA INDANA consortium (http://lbbe-dmz.univ-lyon1.fr/spip_indana/) for performing individual data meta-analyzes (IPDMA) of randomized controlled trials in hypertension (Italy, United Kingdom, Belgium, France, USA, China), leading to more than 20 international publications in this field. This experiment served to illustrate how the IPDMA approach could / should influence the recommendations and design of new randomized controlled trials (doi: 10.1016 / j.jclinepi.2015.05.024). He is the author of 214 publications recorded in Pubmed, 269 according to web of science, H index 36 for WoS.
He coordinated the Clinical Investigation Center (CIC) in Lyon during its first 10 years (2001-2011), as well as the working group on data management in the French CIC network. He helped to establish the requirements for data management centers in the European network ECRIN (http://www.ecrin.org). The data management platform he coordinates in Lyon is ECRIN certified in July 2016 (http://www.ecrin.org/news/two-data-centres-receive-ecrin-certification). He prepares a recertification for a larger perimeter, including almost all support services for clinical research in Lyon University Hospitals – Hospices Civils de Lyon.
He was PI of the national network for patient recruitment in the IDEAL trial (http://lbbe-dmz.univ-lyon1.fr/spip_ideal/) to identify biomarkers predictive of response to antihypertensive therapy.
He coordinated the BIMBO national consortium (http://lbbe-dmz.univ-lyon1.fr/spip_bimbo/) to help identify markers of antihypertensive drug response by combining the modeling and clinical pharmacology approach.
His team (Dr Patrice NONY and Dr Catherine CORNU) coordinated the European project PriomedChild CRESIM (https://lbbe.univ-lyon1.fr/-CRESIM-.html), to help the choice of the best experimental plan by the simulation of clinical tests.
He teaches clinical pharmacology at the Faculty of Medicine. He is co-head of a master's degree course 2 "pharmacology modeling and clinical trials", local leader of the Inter University Diploma “training clinical trial investigators”. He was in charge of organizing experts committees for HCERES, member of selection committees of local and national research projects, member of the Commission de Transparence of Haute Autorité de Santé vice-chief of the Health Data Department of the Hospices Civils de Lyon.
Publications
Display of 31 to 60 publications on 102 in total
Tranexamic acid for epistaxis in hereditary hemorrhagic telangiectasia patients: a European cross-over controlled trial in a rare disease
Journal of Thrombosis and Haemostasis . 12 : 1494-502
DOI: 10.1111/jth.12654
Journal article
see the publicationImproving risk prediction performance for a better guidelines application
Journal of Hypertension . 32 : 1192-1193
Journal article
see the publicationComparison of an effect-model-law-based method versus traditional clinical practice guidelines for optimal treatment decision-making: application to statin treatment in the French population
Journal of the Royal Society Interface . 11 ( 100 ) : 20140867
Journal article
see the publicationThe effect of methylphenidate on neurofibromatosis type 1: a randomised, double-blind, placebo-controlled, crossover trial
Orphanet Journal of Rare Diseases . 9 : 142
Journal article
see the publicationImpact of the reduction of calcineurin inhibitors on renal function in heart transplant patients: a systematic review and meta-analysis
British Journal of Clinical Pharmacology . 78 ( 1 ) : 24-32
DOI: 10.1111/bcp.12289
Journal article
see the publicationCardiovascular Events and Bleeding Risk Associated With Intravitreal Antivascular Endothelial Growth Factor Monoclonal Antibodies: Systematic Review and Meta-analysis
JAMA Ophthalmology . 132 ( 11 ) : 1317-26
Journal article
see the publicationGuidelines for Managing High Blood Pressure
Journal of the American Medical Association . 312 ( 3 ) : 293-294
Journal article
see the publicationMultivariate meta-analysis using individual participant data
Research Synthesis Methods . 6 ( 2 ) : 157-174
DOI: 10.1002/jrsm.1129
Journal article
see the publicationRevising the ECRIN standard requirements for information technology and data management in clinical trials.
Trials . 14 ( 1 ) : 97
Journal article
see the publicationPharmacoepidemiology studies: what levels of evidence and how can they be reached?
Thérapie . 68 ( 4 ) : 241-52
Journal article
see the publicationÉtudes pharmaco-épidémiologiques : quels niveaux de preuve et comment les atteindre ?
Thérapie . 68 : 241--246
Journal article
see the publicationIs there excess mortality in women screened with mammography: a meta-analysis of non-breast cancer mortality
Trials . 14 ( 1 )
Journal article
see the publicationAre concomitant treatments confounding factors in randomized controlled trials on intensive blood-glucose control in type 2 diabetes? a systematic review
BMC Medical Research Methodology . 13 ( 1 ) : 107
Journal article
see the publicationHeart rate: a prognostic factor and therapeutic target in chronic heart failure. The distinct roles of drugs with heart rate-lowering properties
European Journal of Heart Failure . 16 ( 1 ) : 76-85
Journal article
see the publicationBeta-blockers for the prevention of sudden cardiac death in heart failure patients: a meta-analysis of randomized controlled trials
BMC Cardiovascular Disorders . 13 : 52
Journal article
see the publicationAnti-Trypanosoma cruzi cross-reactive antibodies detected at high rate in non-exposed individuals living in non-endemic regions: seroprevalence and association to other viral serologies.
PLoS ONE . 8 ( 9 ) : e74493
Journal article
see the publicationClinically Relevant Efficacy of Insulin Therapy in Patients with Type 2 Diabetes
Thérapie . 68 : 415--7
Journal article
see the publicationCorrespondance à propos de l\textquoterightarticle \guillemotleft Objectifs glycémiques dans la prise en charge du diabète de type 2 \guillemotright
La Presse Médicale . 42 : 1284--1286
Journal article
see the publicationExpected impact of a public health intervention in the presence of synergistic risk factors
Journal of Clinical Epidemiology . 66 : 445-52
Journal article
see the publicationEssais cliniques institutionnels : quel monitoring ?
Pharmacologie clinique . 68 : 135-141
Journal article
see the publicationOseltamivir-zanamivir bitherapy compared to oseltamivir monotherapy in the treatment of pandemic 2009 influenza A(H1N1) influenza virus infections
Antiviral Research . 96 : 130--137
Journal article
see the publicationModeling the impact of cardiovascular prevention strategies: toward better information for public health decisions
Journal of Hypertension . 30 : 51--2
Journal article
see the publicationPharmacotherapy for mild hypertension (Review)
Cochrane Database of Systematic Reviews . : 1--28
Journal article
see the publicationIndividual patient data meta-analysis of survival data using Poisson regression models.
BMC Medical Research Methodology . 12 ( 1 ) : 34
Journal article
see the publicationThe IDEAL Study : Towards Personalized Drug Treatment of Hypertension
Thérapie . 67 : 195--204
Journal article
see the publicationFarnesoid X Receptor Targeting for Hepatitis C: Study Protocol for a Proof-of-concept Trial
Thérapie . 67 : 423--427
Journal article
see the publicationContribution of modeling approaches and virtual populations in transposing the results of clinical trials into real life and in enlightening public health decisions
Thérapie . 67 : 367--74
Journal article
see the publicationVirtual Patients and Sensitivity Analysis of the Guyton Model of Blood Pressure Regulation: Towards Individualized Models of Whole-Body Physiology
PLoS Computational Biology . 8 : e1002571
Journal article
see the publicationEfficacy of a home-based intervention programme on the physical activity level and functional ability of older people using domestic services: A randomised study
Journal of Nutrition, Health & Aging . 16 : 370--377
Journal article
see the publication