Statistics and Modelling for Health Sciences
Evaluation and Modeling with the Therapeutic Effects Group
Gueyffier François
Professeur d'université - praticien hospitalier émérite
UCBL
Professor François GUEYFFIER has more than 30 years of experience in clinical pharmacology and modeling in pharmacology. He coordinated the EU-USA INDANA consortium (http://lbbe-dmz.univ-lyon1.fr/spip_indana/) for performing individual data meta-analyzes (IPDMA) of randomized controlled trials in hypertension (Italy, United Kingdom, Belgium, France, USA, China), leading to more than 20 international publications in this field. This experiment served to illustrate how the IPDMA approach could / should influence the recommendations and design of new randomized controlled trials (doi: 10.1016 / j.jclinepi.2015.05.024). He is the author of 214 publications recorded in Pubmed, 269 according to web of science, H index 36 for WoS.
He coordinated the Clinical Investigation Center (CIC) in Lyon during its first 10 years (2001-2011), as well as the working group on data management in the French CIC network. He helped to establish the requirements for data management centers in the European network ECRIN (http://www.ecrin.org). The data management platform he coordinates in Lyon is ECRIN certified in July 2016 (http://www.ecrin.org/news/two-data-centres-receive-ecrin-certification). He prepares a recertification for a larger perimeter, including almost all support services for clinical research in Lyon University Hospitals – Hospices Civils de Lyon.
He was PI of the national network for patient recruitment in the IDEAL trial (http://lbbe-dmz.univ-lyon1.fr/spip_ideal/) to identify biomarkers predictive of response to antihypertensive therapy.
He coordinated the BIMBO national consortium (http://lbbe-dmz.univ-lyon1.fr/spip_bimbo/) to help identify markers of antihypertensive drug response by combining the modeling and clinical pharmacology approach.
His team (Dr Patrice NONY and Dr Catherine CORNU) coordinated the European project PriomedChild CRESIM (https://lbbe.univ-lyon1.fr/-CRESIM-.html), to help the choice of the best experimental plan by the simulation of clinical tests.
He teaches clinical pharmacology at the Faculty of Medicine. He is co-head of a master's degree course 2 "pharmacology modeling and clinical trials", local leader of the Inter University Diploma “training clinical trial investigators”. He was in charge of organizing experts committees for HCERES, member of selection committees of local and national research projects, member of the Commission de Transparence of Haute Autorité de Santé vice-chief of the Health Data Department of the Hospices Civils de Lyon.
Publications
Display of 61 to 90 publications on 102 in total
Virtual Patients and Sensitivity Analysis of the Guyton Model of Blood Pressure Regulation: Towards Individualized Models of Whole-Body Physiology
PLoS Computational Biology . 8 : e1002571
Journal article
see the publicationEfficacy of a home-based intervention programme on the physical activity level and functional ability of older people using domestic services: A randomised study
Journal of Nutrition, Health & Aging . 16 : 370--377
Journal article
see the publicationImpact of the early reduction of cyclosporine on renal function in heart transplant patients: a French randomised controlled trial.
Trials . 13 ( 1 ) : 231
Journal article
see the publicationProgrammed death-1 levels correlate with increased mortality, nosocomial infection and immune dysfunctions in septic shock patients.
Critical Care . 15 ( 2 ) : R99
DOI: 10.1186/cc10112
Journal article
see the publicationThe Global Risk Approach Should Be Better Applied in French Hypertensive Patients: A Comparison between Simulation and Observation Studies
PLoS ONE . 6 ( 3 ) : 1-7
Journal article
see the publicationProgrammed death-1 levels correlate with increased mortality nosocomial infection and immune dysfunctions in septic shock patients
Critical Care . 15 ( 2 ) : R99
DOI: 10.1186/cc10112
Journal article
see the publicationEffect of intensive glucose lowering treatment on all cause mortality cardiovascular death and microvascular events in type 2 diabetes: meta-analysis of randomised controlled trials
British medical journal . 343 : 1-12
DOI: 10.1136/bmj.d4169
Journal article
see the publicationTowards personalized medicine: exploring the consequences of the effect model-based approach
Personalized Medicine . 8 : 581-586
DOI: 10.2217/pme.11.54
Journal article
see the publicationProblématique des cibles de pression artérielle
Revue médicale Suisse . : 873
Journal article
see the publicationBlood pressure lowering in the oldest old: a step toward abandoning arbitrary blood pressure targets
Journal of Hypertension . 29 : 171-175
Journal article
see the publicationl-asparaginase loaded red blood cells in refractory or relapsing acute lymphoblastic leukaemia in children and adults: results of the GRASPALL 2005-01 randomized trial.
British Journal of Haematology . 153 ( 1 ) : 58-65
Journal article
see the publicationStandard requirements for GCP-compliant data management in multinational clinical trials
Trials . 12 : 85
Journal article
see the publicationTreatment of hypertension in patients 80 years and older: the lower the better? A meta-analysis of randomized controlled trials
Journal of Hypertension . 28 : 1366-1372
Journal article
see the publicationCognitive Therapy versus Rogerian Supportive Therapy in Borderline Personality Disorder
Psychotherapy and Psychosomatics . 78(5) : 307-316
Journal article
see the publicationPrevention of dementia by antihypertensive drugs: how AT1-receptor-blockers and dihydropyridines better prevent dementia in hypertensive patients than thiazides and ACE-inhibitors.
Expert Review of Neurotherapeutics . 9 ( 9 ) : 1413-31
DOI: 10.1586/ern.09.89
Journal article
see the publicationRecueil systématique et actif des evènements indésirables médicamenteux chez les enfants admis aux urgences pédiatriques
Archives de Pédiatrie . 16(2) : 106-111
Journal article
see the publicationFondements de l`évaluation des tests diagnostiques
Lecture critique d`article . 59 : 375-379
Journal article
see the publicationSCORE should be preferred to Framingham to predict cardiovascular death in French population
European Journal of Cardiovascular Prevention and Rehabilitation . 16(5) : 609-615
Journal article
see the publicationNew insights on the relation between untreated and treated outcomes for a given therapy effect model is not necessarily linear
Journal of Clinical Epidemiology . 61 : 301-307
Journal article
see the publicationMeta-analysis of continuous outcomes combining individual patient data and aggregate data
Statistics in Medicine . 27(11) : 1870-1893
Journal article
see the publicationSome reflexions about double blind
L'Encéphale . 34(4) : 347-351
Journal article
see the publicationDo We Need to Assess the Effect of Treatment Withdrawal? The Paradigm of Life-Long Prevention
Journal of the American Hearth Association . -- : 219-226
Journal article
see the publicationCritères intermédiaires et critères de substitution
Médecine Thérapeutique . 13(4) : 279-286
Journal article
see the publicationDoes a change in angiotensin-II-formation caused by antihypertensive drugs affect the risk of stroke ? A meta-analysis of trials according to treatment with potentially different effects on angiotensin-II
Journal of Hypertension . 25 : 1543-1553
Journal article
see the publicationSevere myoclonic epilepsy in infancy: A systematic review and a meta-analysis of individual patient data
Epilepsia . 48 : 1-6
Journal article
see the publicationPersisting low monocyte human leukocyte antigen-DR expression predicts mortality in septic shock
Intensive Care Medicine . 32 : 1175-1183
Journal article
see the publicationCardiovascular Risk Stratification in Decision Support Systems: A Probabilistic Approach. Application to pHealth
2006 Computers in Cardiology .
Conference paper
see the publicationThe lower the better: Does simplicity lead to absurdity?
Editorial comment . 24(3) : 431-433
Journal article
see the publicationSafety of computerized drug management: a case report
British Journal of Clinical Pharmacology . 63 : 245-246
Journal article
see the publication