Statistiques et Modélisation pour les Sciences de la Santé
Equipe Evaluation et Modélisation des Effets Thérapeutiques
Gueyffier François
Professeur d'université - praticien hospitalier émérite
UCBL
69376 LYON cedex 08
Professor François GUEYFFIER has more than 30 years of experience in clinical pharmacology and modeling in pharmacology. He coordinated the EU-USA INDANA consortium (http://lbbe-dmz.univ-lyon1.fr/spip_indana/) for performing individual data meta-analyzes (IPDMA) of randomized controlled trials in hypertension (Italy, United Kingdom, Belgium, France, USA, China), leading to more than 20 international publications in this field. This experiment served to illustrate how the IPDMA approach could / should influence the recommendations and design of new randomized controlled trials (doi: 10.1016 / j.jclinepi.2015.05.024). He is the author of 214 publications recorded in Pubmed, 269 according to web of science, H index 36 for WoS.
He coordinated the Clinical Investigation Center (CIC) in Lyon during its first 10 years (2001-2011), as well as the working group on data management in the French CIC network. He helped to establish the requirements for data management centers in the European network ECRIN (http://www.ecrin.org). The data management platform he coordinates in Lyon is ECRIN certified in July 2016 (http://www.ecrin.org/news/two-data-centres-receive-ecrin-certification). He prepares a recertification for a larger perimeter, including almost all support services for clinical research in Lyon University Hospitals – Hospices Civils de Lyon.
He was PI of the national network for patient recruitment in the IDEAL trial (http://lbbe-dmz.univ-lyon1.fr/spip_ideal/) to identify biomarkers predictive of response to antihypertensive therapy.
He coordinated the BIMBO national consortium (http://lbbe-dmz.univ-lyon1.fr/spip_bimbo/) to help identify markers of antihypertensive drug response by combining the modeling and clinical pharmacology approach.
His team (Dr Patrice NONY and Dr Catherine CORNU) coordinated the European project PriomedChild CRESIM (https://lbbe.univ-lyon1.fr/-CRESIM-.html), to help the choice of the best experimental plan by the simulation of clinical tests.
He teaches clinical pharmacology at the Faculty of Medicine. He is co-head of a master's degree course 2 "pharmacology modeling and clinical trials", local leader of the Inter University Diploma “training clinical trial investigators”. He was in charge of organizing experts committees for HCERES, member of selection committees of local and national research projects, member of the Commission de Transparence of Haute Autorité de Santé vice-chief of the Health Data Department of the Hospices Civils de Lyon.
Publications
Affichage des publications 61 à 90 sur 170 au total
Causes and consequences of variation in offspring body mass: meta-analyses in birds and mammals
Biol. Rev . 93 : 1 - 27
DOI: 10.1111/brv.12329
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voir la publicationSex gap in aging and longevity: can sex chromosomes play a role?
Biology of Sex Differences . 9 ( 1 ) : 1-14
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voir la publicationA sudden death risk score specifically for hypertension
Journal of Hypertension . 35 ( 11 ) : 2178-2184
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voir la publicationProtocol of GLUcose COntrol Safety and Efficacy in type 2 DIabetes, a NETwork meta-analysis: GLUCOSE DINET protocol-Rational and design
Fundamental & Clinical Pharmacology . 31 ( 3 ) : 258-264
DOI: 10.1111/fcp.12263
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voir la publicationEffet antalgique aigu du paracétamol en soins primaires : des preuves incomplètes
Thérapie . 72 ( 5 ) : 609 - 613
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voir la publicationEfficiency of physical therapy on postural imbalance after stroke: study protocol for a systematic review and meta-analysis
BMJ Open . 7 ( 1 ) : e013348
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voir la publicationEfficacy and safety of DPP-4 inhibitors in patients with type 2 diabetes: Meta-analysis of placebo-controlled randomized clinical trials
Diabetes & Metabolism . 43 ( 1 ) : 48 - 58
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voir la publicationNo benefits of statins for sudden cardiac death prevention in patients with heart failure and reduced ejection fraction: A meta-analysis of randomized controlled trials
PLoS ONE . 12 : e0171168
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voir la publicationEfficacy and safety of insulin in type 2 diabetes: meta-analysis of randomised controlled trials
BMC Endocrine Disorders . 16 : 39
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voir la publicationQuality of qualitative studies centred on patients in family practice: a systematic review
Family Practice . 33 ( 6 ) : 580 - 587
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voir la publicationRéférentiel ECRIN pour la conformité aux bonnes pratiques de gestion des données des essais cliniques multinationaux
Thérapie .
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voir la publicationAntihypertensive pharmacotherapy for prevention of sudden cardiac death in hypertensive individuals
Cochrane database of systematic reviews (Online) . 3 : CD011745
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voir la publicationOne-step partial or complete caries removal and bonding with antibacterial or traditional self-etch adhesives: study protocol for a randomized controlled trial
Trials . 17 ( 1 ) : 404
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voir la publicationImpact of Aldosterone Antagonists on Sudden Cardiac Death Prevention in Heart Failure and Post-Myocardial Infarction Patients: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
PLoS ONE . 11 : e0145958
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voir la publicationMetformin as firstline treatment for type 2 diabetes: are we sure?
BMJ-BRITISH MEDICAL JOURNAL . 352 : h6748
DOI: 10.1136/bmj.h6748
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voir la publicationIs HbA a valid surrogate for macrovascular and microvascular complications in type 2 diabetes?
Diabetes & Metabolism . 41 : 195-201
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voir la publicationCan we identify response markers to antihypertensive drugs? First results from the Ideal Trial
Journal of human hypertension . 29 ( 1 ) : 22-27
DOI: 10.1038/jhh.2014.29
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voir la publicationUptake of systematic reviews and meta-analyses based on individual participant data in clinical practice guidelines: descriptive study
British medical journal . 350 : h1088
DOI: 10.1136/bmj.h1088
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voir la publicationDifferent treatment benefits were estimated by clinical trials performed in adults compared with those performed in children
Journal of Clinical Epidemiology . 68 : 1221-1231
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voir la publicationIs legacy a myth or a reality? We should know, and we do not
Journal of Hypertension . 33 : 2207-9
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voir la publicationHigh Risk versus Proportional Benefit: Modelling Equitable Strategies in Cardiovascular Prevention
PLoS ONE . 10 ( 11 ) : e0140793
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voir la publicationEffects of pharmacological treatments on micro- and macrovascular complications of type 2 diabetes: What is the level of evidence?
Diabetes & Metabolism . 40 : 169-75
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voir la publicationTranexamic acid for epistaxis in hereditary hemorrhagic telangiectasia patients: a European cross-over controlled trial in a rare disease
Journal of Thrombosis and Haemostasis . 12 : 1494-502
DOI: 10.1111/jth.12654
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voir la publicationImproving risk prediction performance for a better guidelines application
Journal of Hypertension . 32 : 1192-1193
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voir la publicationComparison of an effect-model-law-based method versus traditional clinical practice guidelines for optimal treatment decision-making: application to statin treatment in the French population
Journal of the Royal Society Interface . 11 ( 100 ) : 20140867
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voir la publicationThe effect of methylphenidate on neurofibromatosis type 1: a randomised, double-blind, placebo-controlled, crossover trial
Orphanet Journal of Rare Diseases . 9 : 142
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voir la publicationImpact of the reduction of calcineurin inhibitors on renal function in heart transplant patients: a systematic review and meta-analysis
British Journal of Clinical Pharmacology . 78 ( 1 ) : 24-32
DOI: 10.1111/bcp.12289
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voir la publicationMultivariate meta-analysis using individual participant data
Research Synthesis Methods . 6 ( 2 ) : 157-174
DOI: 10.1002/jrsm.1129
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voir la publicationCan we identify response markers to antihypertensive drugs? First results from the Ideal Trial.
Journal of Human Hypertension . : doi: 10.1038/jhh.2014.29
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voir la publicationCardiovascular Events and Bleeding Risk Associated With Intravitreal Antivascular Endothelial Growth Factor Monoclonal Antibodies: Systematic Review and Meta-analysis
JAMA Ophthalmology . 132 ( 11 ) : 1317-26
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