Statistiques et Modélisation pour les Sciences de la Santé
Equipe Evaluation et Modélisation des Effets Thérapeutiques
Gueyffier François
Professeur d'université - praticien hospitalier émérite
UCBL
69376 LYON cedex 08
Professor François GUEYFFIER has more than 30 years of experience in clinical pharmacology and modeling in pharmacology. He coordinated the EU-USA INDANA consortium (http://lbbe-dmz.univ-lyon1.fr/spip_indana/) for performing individual data meta-analyzes (IPDMA) of randomized controlled trials in hypertension (Italy, United Kingdom, Belgium, France, USA, China), leading to more than 20 international publications in this field. This experiment served to illustrate how the IPDMA approach could / should influence the recommendations and design of new randomized controlled trials (doi: 10.1016 / j.jclinepi.2015.05.024). He is the author of 214 publications recorded in Pubmed, 269 according to web of science, H index 36 for WoS.
He coordinated the Clinical Investigation Center (CIC) in Lyon during its first 10 years (2001-2011), as well as the working group on data management in the French CIC network. He helped to establish the requirements for data management centers in the European network ECRIN (http://www.ecrin.org). The data management platform he coordinates in Lyon is ECRIN certified in July 2016 (http://www.ecrin.org/news/two-data-centres-receive-ecrin-certification). He prepares a recertification for a larger perimeter, including almost all support services for clinical research in Lyon University Hospitals – Hospices Civils de Lyon.
He was PI of the national network for patient recruitment in the IDEAL trial (http://lbbe-dmz.univ-lyon1.fr/spip_ideal/) to identify biomarkers predictive of response to antihypertensive therapy.
He coordinated the BIMBO national consortium (http://lbbe-dmz.univ-lyon1.fr/spip_bimbo/) to help identify markers of antihypertensive drug response by combining the modeling and clinical pharmacology approach.
His team (Dr Patrice NONY and Dr Catherine CORNU) coordinated the European project PriomedChild CRESIM (https://lbbe.univ-lyon1.fr/-CRESIM-.html), to help the choice of the best experimental plan by the simulation of clinical tests.
He teaches clinical pharmacology at the Faculty of Medicine. He is co-head of a master's degree course 2 "pharmacology modeling and clinical trials", local leader of the Inter University Diploma “training clinical trial investigators”. He was in charge of organizing experts committees for HCERES, member of selection committees of local and national research projects, member of the Commission de Transparence of Haute Autorité de Santé vice-chief of the Health Data Department of the Hospices Civils de Lyon.
Publications
Affichage des publications 31 à 60 sur 170 au total
DPP-4 Inhibitors and Respiratory Infection: A Systematic Review and Meta-analysis of the Cardiovascular Outcomes Trials
Diabetes Care . 44 ( 3 ) : e36-e37
DOI: 10.2337/dc20-2018
Article dans une revue
voir la publicationNeeds for re-intervention on restored teeth in adults: a practice-based study
Clinical Oral Investigations . 26 ( 1 ) : 789-801
Article dans une revue
voir la publicationOlaparib in recurrent IDH-mutant high-grade glioma (OLAGLI).
57th Annual Meeting of the American Society of Clinical Oncology (2021 ASCO Annual Meeting) . 39 ( 15_suppl ) : 2007-2007
Acte de congrès
voir la publicationEffect of periodontal treatment on the glomerular filtration rate, reduction of inflammatory markers and mortality in patients with chronic kidney disease: A systematic review
PLoS ONE . 16 ( 1 ) : e0245619
Article dans une revue
voir la publicationClinical and laboratory characteristics of symptomatic healthcare workers with suspected COVID-19: a prospective cohort study
Scientific Reports . 11 ( 1 ) : 14977
Article dans une revue
voir la publicationEvaluation of High-Throughput SARS-CoV-2 Serological Assays in a Longitudinal Cohort of Patients with Mild COVID-19: Clinical Sensitivity, Specificity, and Association with Virus Neutralization Test
Clinical Chemistry . 67 ( 5 ) : 742-752
Article dans une revue
voir la publicationReappraisal of the efficacy of intensive glycaemic control on microvascular complications in patients with type 2 diabetes: A meta-analysis of randomised control-trials
Thérapie .
Article dans une revue
voir la publicationEvaluation of High-Throughput SARS-CoV-2 Serological Assays in a Longitudinal Cohort of Patients with Mild COVID-19: Clinical Sensitivity, Specificity, and Association with Virus Neutralization Test
Clinical Chemistry . 67 ( 5 ) : 742-752
Article dans une revue
voir la publicationExpected Evolution of COVID-19 Epidemic in France for Several Combinations of Vaccination Strategies and Barrier Measures
Vaccines . 9 ( 12 ) : 1462
Article dans une revue
voir la publicationAdapting French COVID-19 vaccination campaign duration to variant dissemination
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Rapport
voir la publicationImpact of terminating reimbursement of symptomatic slow-acting drugs in osteoarthritis in France on volume and cost of drug deliveries, assessed with administrative databases
Seminars in Arthritis and Rheumatism . 50 : 1307 - 1313
Article dans une revue
voir la publicationDynamical modeling of pro- and anti-inflammatory cytokines in the early stage of septic shock
In Silico Biology . 13 ( 3-4 ) : 101-121
DOI: 10.3233/ISB-200474
Article dans une revue
voir la publicationDrug prescription goals in primary care: a cross-sectional study
BMC Health Services Research . 20 ( 1 ) : 6
Article dans une revue
voir la publicationPrevalence of Giant Cell Arteritis Relapse in Patients Treated With Glucocorticoids: A Meta‐Analysis
Arthritis Care & Research = Arthritis Care and Research . 72 ( 6 ) : 838-849
DOI: 10.1002/acr.23901
Article dans une revue
voir la publicationAssessment of serological techniques for screening patients for COVID-19 (COVID-SER): a prospective, multicentric study
BMJ Open . 10 ( 11 ) : e041268
Article dans une revue
voir la publicationInconclusive efficacy of intervention on upper-limb function after tetraplegia: A systematic review and meta-analysis
Annals of physical and rehabilitation medicine . 63 ( 3 ) : 230-240
Article dans une revue
voir la publicationSyndrome de Klinefelter, rôle du chromosome Y dans l’espérance de vie humaine ?
36ème Congrès de la Société Française d'Endocrinologie (SFE Marseille 2020) . 81 ( 4 ) : 194
Acte de congrès
voir la publicationPublication language and the estimate of treatment effects of physical therapy on balance and postural control after stroke in meta-analyses of randomised controlled trials
PLoS ONE . 15 ( 3 ) : e0229822
Article dans une revue
voir la publicationAssociation between difference in blood pressure reduction and risk of cardiovascular events in a type 2 diabetes population: A meta-regression analysis
Diabetes Metab .
Article dans une revue
voir la publicationGLUcose COntrol Safety & Efficacy in type 2 DIabetes, a systematic review and NETwork meta-analysis
PLoS ONE . 14 ( 6 ) : e0217701
Article dans une revue
voir la publicationINN or brand name drug prescriptions: a multilevel, cross-sectional study in general practice
European Journal of Clinical Pharmacology . 75 ( 2 ) : 275-283
Article dans une revue
voir la publicationGoPerio - impact of a personalized video and an automated two-way text-messaging system in oral hygiene motivation: study protocol for a randomized controlled trial
Trials . 20 ( 1 ) : 699
Article dans une revue
voir la publicationMinoxidil versus placebo in the treatment of arterial wall hypertrophy in children with Williams Beuren Syndrome: a randomized controlled trial
BMC Pediatrics . 19 ( 1 ) : 170
Article dans une revue
voir la publicationComparison of crossover and parallel‐group designs for the identification of a binary predictive biomarker of the treatment effect
Basic and Clinical Pharmacology and Toxicology . 126 ( 1 ) : 59-64
DOI: 10.1111/bcpt.13293
Article dans une revue
voir la publicationComparison of crossover and parallel‐group designs for the identification of a binary predictive biomarker of the treatment effect
Basic and Clinical Pharmacology and Toxicology . 126 ( 1 ) : 59-64
DOI: 10.1111/bcpt.13293
Article dans une revue
voir la publicationThe contribution of genomics in the medicine of tomorrow, clinical applications and issues
Thérapie . 74 ( 1 ) : 9-15
Article dans une revue
voir la publicationDo patients with cystic fibrosis participating in clinical trials demonstrate placebo response? A meta-analysis
Journal of Cystic Fibrosis .
Article dans une revue
voir la publicationApport de la génomique dans la médecine de demain, applications cliniques et enjeux
Thérapie . 74 ( 1 ) : 1-8
Article dans une revue
voir la publicationImmune system modelling in case of a septic shock
29TH EUROPEAN SYMPOSIUM ON COMPUTER AIDED PROCESS ENGINEERING, . : 1093-1098
Chapitre d'ouvrage
voir la publicationThe limitations of observation studies for decision making regarding drugs efficacy and safety
Alternative and Complementary Therapies . 74 ( 2 ) : 181-185
Article dans une revue
voir la publication