Statistiques et Modélisation pour les Sciences de la Santé
Equipe Evaluation et Modélisation des Effets Thérapeutiques
Gueyffier François
Professeur d'université - praticien hospitalier émérite
UCBL
69376 LYON cedex 08
Professor François GUEYFFIER has more than 30 years of experience in clinical pharmacology and modeling in pharmacology. He coordinated the EU-USA INDANA consortium (http://lbbe-dmz.univ-lyon1.fr/spip_indana/) for performing individual data meta-analyzes (IPDMA) of randomized controlled trials in hypertension (Italy, United Kingdom, Belgium, France, USA, China), leading to more than 20 international publications in this field. This experiment served to illustrate how the IPDMA approach could / should influence the recommendations and design of new randomized controlled trials (doi: 10.1016 / j.jclinepi.2015.05.024). He is the author of 214 publications recorded in Pubmed, 269 according to web of science, H index 36 for WoS.
He coordinated the Clinical Investigation Center (CIC) in Lyon during its first 10 years (2001-2011), as well as the working group on data management in the French CIC network. He helped to establish the requirements for data management centers in the European network ECRIN (http://www.ecrin.org). The data management platform he coordinates in Lyon is ECRIN certified in July 2016 (http://www.ecrin.org/news/two-data-centres-receive-ecrin-certification). He prepares a recertification for a larger perimeter, including almost all support services for clinical research in Lyon University Hospitals – Hospices Civils de Lyon.
He was PI of the national network for patient recruitment in the IDEAL trial (http://lbbe-dmz.univ-lyon1.fr/spip_ideal/) to identify biomarkers predictive of response to antihypertensive therapy.
He coordinated the BIMBO national consortium (http://lbbe-dmz.univ-lyon1.fr/spip_bimbo/) to help identify markers of antihypertensive drug response by combining the modeling and clinical pharmacology approach.
His team (Dr Patrice NONY and Dr Catherine CORNU) coordinated the European project PriomedChild CRESIM (https://lbbe.univ-lyon1.fr/-CRESIM-.html), to help the choice of the best experimental plan by the simulation of clinical tests.
He teaches clinical pharmacology at the Faculty of Medicine. He is co-head of a master's degree course 2 "pharmacology modeling and clinical trials", local leader of the Inter University Diploma “training clinical trial investigators”. He was in charge of organizing experts committees for HCERES, member of selection committees of local and national research projects, member of the Commission de Transparence of Haute Autorité de Santé vice-chief of the Health Data Department of the Hospices Civils de Lyon.
Publications
Affichage des publications 31 à 60 sur 102 au total
The effect of methylphenidate on neurofibromatosis type 1: a randomised, double-blind, placebo-controlled, crossover trial
Orphanet Journal of Rare Diseases . 9 : 142
Article dans une revue
voir la publicationEffects of pharmacological treatments on micro- and macrovascular complications of type 2 diabetes: What is the level of evidence?
Diabetes & Metabolism . 40 : 169-75
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voir la publicationTranexamic acid for epistaxis in hereditary hemorrhagic telangiectasia patients: a European cross-over controlled trial in a rare disease
Journal of Thrombosis and Haemostasis . 12 : 1494-502
DOI: 10.1111/jth.12654
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voir la publicationImproving risk prediction performance for a better guidelines application
Journal of Hypertension . 32 : 1192-1193
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voir la publicationImpact of the reduction of calcineurin inhibitors on renal function in heart transplant patients: a systematic review and meta-analysis
British Journal of Clinical Pharmacology . 78 ( 1 ) : 24-32
DOI: 10.1111/bcp.12289
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voir la publicationCardiovascular Events and Bleeding Risk Associated With Intravitreal Antivascular Endothelial Growth Factor Monoclonal Antibodies: Systematic Review and Meta-analysis
JAMA Ophthalmology . 132 ( 11 ) : 1317-26
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voir la publicationGuidelines for Managing High Blood Pressure
Journal of the American Medical Association . 312 ( 3 ) : 293-294
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voir la publicationMultivariate meta-analysis using individual participant data
Research Synthesis Methods . 6 ( 2 ) : 157-174
DOI: 10.1002/jrsm.1129
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voir la publicationRevising the ECRIN standard requirements for information technology and data management in clinical trials.
Trials . 14 ( 1 ) : 97
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voir la publicationPharmacoepidemiology studies: what levels of evidence and how can they be reached?
Thérapie . 68 ( 4 ) : 241-52
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voir la publicationAre concomitant treatments confounding factors in randomized controlled trials on intensive blood-glucose control in type 2 diabetes? a systematic review
BMC Medical Research Methodology . 13 ( 1 ) : 107
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voir la publicationÉtudes pharmaco-épidémiologiques : quels niveaux de preuve et comment les atteindre ?
Thérapie . 68 : 241--246
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voir la publicationIs there excess mortality in women screened with mammography: a meta-analysis of non-breast cancer mortality
Trials . 14 ( 1 )
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voir la publicationCorrespondance à propos de l\textquoterightarticle \guillemotleft Objectifs glycémiques dans la prise en charge du diabète de type 2 \guillemotright
La Presse Médicale . 42 : 1284--1286
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voir la publicationExpected impact of a public health intervention in the presence of synergistic risk factors
Journal of Clinical Epidemiology . 66 : 445-52
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voir la publicationEssais cliniques institutionnels : quel monitoring ?
Pharmacologie clinique . 68 : 135-141
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voir la publicationHeart rate: a prognostic factor and therapeutic target in chronic heart failure. The distinct roles of drugs with heart rate-lowering properties
European Journal of Heart Failure . 16 ( 1 ) : 76-85
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voir la publicationBeta-blockers for the prevention of sudden cardiac death in heart failure patients: a meta-analysis of randomized controlled trials
BMC Cardiovascular Disorders . 13 : 52
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voir la publicationAnti-Trypanosoma cruzi cross-reactive antibodies detected at high rate in non-exposed individuals living in non-endemic regions: seroprevalence and association to other viral serologies.
PLoS ONE . 8 ( 9 ) : e74493
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voir la publicationClinically Relevant Efficacy of Insulin Therapy in Patients with Type 2 Diabetes
Thérapie . 68 : 415--7
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voir la publicationTraitement anti-hypertenseur et tabac
Médecine . : 157--162
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voir la publicationThe IDEAL Study : Towards Personalized Drug Treatment of Hypertension
Thérapie . 67 : 195--204
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voir la publicationFarnesoid X Receptor Targeting for Hepatitis C: Study Protocol for a Proof-of-concept Trial
Thérapie . 67 : 423--427
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voir la publicationOseltamivir-zanamivir bitherapy compared to oseltamivir monotherapy in the treatment of pandemic 2009 influenza A(H1N1) influenza virus infections
Antiviral Research . 96 : 130--137
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voir la publicationModeling the impact of cardiovascular prevention strategies: toward better information for public health decisions
Journal of Hypertension . 30 : 51--2
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voir la publicationPharmacotherapy for mild hypertension (Review)
Cochrane Database of Systematic Reviews . : 1--28
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voir la publicationIndividual patient data meta-analysis of survival data using Poisson regression models.
BMC Medical Research Methodology . 12 ( 1 ) : 34
Article dans une revue
voir la publicationReappraisal of metformin efficacy in the treatment of type 2 diabetes: a meta-analysis of randomised controlled trials.
PLoS Medicine . 9 ( 4 ) : e1001204
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voir la publicationApport de la modélisation et des populations virtuelles pour transposer les résultats des essais cliniques à la vie réelle et éclairer la décision publique
Thérapie . 67 : 359--66
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voir la publicationContribution of modeling approaches and virtual populations in transposing the results of clinical trials into real life and in enlightening public health decisions
Thérapie . 67 : 367--74
Article dans une revue
voir la publication