Statistics and Modelling for Health Sciences

Evaluation and Modeling with the Therapeutic Effects Group

Gueyffier François

Professeur d'université - praticien hospitalier émérite

UCBL

Address: BP8071
69376 LYON cedex 08

Tel: 33 04 78 78 57 49 33 04 72 35 72 31

Email

Professor François GUEYFFIER has more than 30 years of experience in clinical pharmacology and modeling in pharmacology. He coordinated the EU-USA INDANA consortium (http://lbbe-dmz.univ-lyon1.fr/spip_indana/) for performing individual data meta-analyzes (IPDMA) of randomized controlled trials in hypertension (Italy, United Kingdom, Belgium, France, USA, China), leading to more than 20 international publications in this field. This experiment served to illustrate how the IPDMA approach could / should influence the recommendations and design of new randomized controlled trials (doi: 10.1016 / j.jclinepi.2015.05.024). He is the author of 214 publications recorded in Pubmed, 269 according to web of science, H index 36 for WoS.

He coordinated the Clinical Investigation Center (CIC) in Lyon during its first 10 years (2001-2011), as well as the working group on data management in the French CIC network. He helped to establish the requirements for data management centers in the European network ECRIN (http://www.ecrin.org). The data management platform he coordinates in Lyon is ECRIN certified in July 2016 (http://www.ecrin.org/news/two-data-centres-receive-ecrin-certification). He prepares a recertification for a larger perimeter, including almost all support services for clinical research in Lyon University Hospitals – Hospices Civils de Lyon.

He was PI of the national network for patient recruitment in the IDEAL trial (http://lbbe-dmz.univ-lyon1.fr/spip_ideal/) to identify biomarkers predictive of response to antihypertensive therapy.

He coordinated the BIMBO national consortium (http://lbbe-dmz.univ-lyon1.fr/spip_bimbo/) to help identify markers of antihypertensive drug response by combining the modeling and clinical pharmacology approach.

His team (Dr Patrice NONY and Dr Catherine CORNU) coordinated the European project PriomedChild CRESIM (https://lbbe.univ-lyon1.fr/-CRESIM-.html), to help the choice of the best experimental plan by the simulation of clinical tests.

He teaches clinical pharmacology at the Faculty of Medicine. He is co-head of a master's degree course 2 "pharmacology modeling and clinical trials", local leader of the Inter University Diploma “training clinical trial investigators”. He was in charge of organizing experts committees for HCERES, member of selection committees of local and national research projects, member of the Commission de Transparence of Haute Autorité de Santé vice-chief of the Health Data Department of the Hospices Civils de Lyon.

Publications

Display of 121 to 150 publications on 170 in total

Farnesoid X Receptor Targeting for Hepatitis C: Study Protocol for a Proof-of-concept Trial

C. Scholtes, P. Andre, C. Trepo, C. Cornu, Laurent Remontet, René Ecochard...

Thérapie . 67 : 423--427

DOI: 10.2515/therapie/2012058

Journal article

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Efficacy of a home-based intervention programme on the physical activity level and functional ability of older people using domestic services: A randomised study

M. Bonnefoy, F. Boutitie, Catherine Mercier, François Gueyffier, C. Carre, G. Guetemme...

Journal of Nutrition, Health & Aging . 16 : 370--377

DOI: 10.1007/s12603-011-0352-6

Journal article

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Impact of the early reduction of cyclosporine on renal function in heart transplant patients: a French randomised controlled trial.

Pascale Boissonnat, Ségolène Gaillard, Catherine Mercier, Michel Redonnet, Bernard Lelong, Marie-Françoise Mattei...

Trials . 13 ( 1 ) : 231

DOI: 10.1186/1745-6215-13-231

Journal article

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Reappraisal of metformin efficacy in the treatment of type 2 diabetes: a meta-analysis of randomised controlled trials.

Rémy Boussageon, Irène Supper, Theodora Bejan-Angoulvant, Nadir Kellou, Michel Cucherat, Jean-Pierre Boissel...

PLoS Medicine . 9 ( 4 ) : e1001204

DOI: 10.1371/journal.pmed.1001204

Journal article

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Apport de la modélisation et des populations virtuelles pour transposer les résultats des essais cliniques à la vie réelle et éclairer la décision publique

François Gueyffier, C. B. Strang, G. Berdeaux, L. R. França, P. Blin, J. Benichou...

Thérapie . 67 : 359--66

DOI: 10.2515/therapie/2012041

Journal article

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Contribution of modeling approaches and virtual populations in transposing the results of clinical trials into real life and in enlightening public health decisions

François Gueyffier, Cb. Strang, G. Berdeaux, Lr. Franca, P. Blin, J. Massol

Thérapie . 67 : 367--74

DOI: 10.2515/therapie/2012042

Journal article

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Virtual Patients and Sensitivity Analysis of the Guyton Model of Blood Pressure Regulation: Towards Individualized Models of Whole-Body Physiology

R. Moss, T. Grosse, I. Marchant, N. Lassau, François Gueyffier, S. R. Thomas

PLoS Computational Biology . 8 : e1002571

DOI: 10.1371/journal.pcbi.1002571

Journal article

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51 – Existe-t-il une surmortalité chez les femmes dépistées par mammographie ? Méta-analyse sur la mortalité non liée au cancer du sein

L. Fayolle, F. Gueyffier, S. Erpeldinger

33° Journées de la Société Française de Sénologie et de Pathologie Mammaire (SFSPM), Marseille, 2011. Cancer du sein : surdiagnostic, surtraitement. A la recherche d'un nouvel équilibre . : 339

Conference paper

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Programmed death-1 levels correlate with increased mortality nosocomial infection and immune dysfunctions in septic shock patients

C. Guignant, C. Lepage, X. Huang, H. Kherouf, L. Denis, F. Poitevin...

Critical Care . 15 ( 2 ) : R99

DOI: 10.1186/cc10112

Journal article

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Effect of intensive glucose lowering treatment on all cause mortality cardiovascular death and microvascular events in type 2 diabetes: meta-analysis of randomised controlled trials

R. Boussageon, T. Bejan-Angoulvant, M. Saadatian-Elahi, S. Lafont, C. Bergeonneau, Behrouz Kassai...

British medical journal . 343 : 1-12

DOI: 10.1136/bmj.d4169

Journal article

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Programmed death-1 levels correlate with increased mortality, nosocomial infection and immune dysfunctions in septic shock patients.

Caroline Guignant, Alain Lepape, Xin Huang, Hakim Kherouf, Laure Denis, Françoise Poitevin...

Critical Care . 15 ( 2 ) : R99

DOI: 10.1186/cc10112

Journal article

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The Global Risk Approach Should Be Better Applied in French Hypertensive Patients: A Comparison between Simulation and Observation Studies

I. Marchant, Patrice Nony, Michel Cucherat, J-P. Boissel, S.R. Thomas, T. Bejan-Angoulvant...

PLoS ONE . 6 ( 3 ) : 1-7

DOI: 10.1371/journal.pone.0017508

Journal article

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Towards personalized medicine: exploring the consequences of the effect model-based approach

Jp. Boissel, R. Kaboul, E. Amsallem, François Gueyffier, M. Haugh, F. H. Boissel

Personalized Medicine . 8 : 581-586

DOI: 10.2217/pme.11.54

Journal article

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Problématique des cibles de pression artérielle

R. Boussageon, T. Bejan-Angoulvant, François Gueyffier

Revue médicale Suisse . : 873

Journal article

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l-asparaginase loaded red blood cells in refractory or relapsing acute lymphoblastic leukaemia in children and adults: results of the GRASPALL 2005-01 randomized trial.

Carine Domenech, Xavier Thomas, Sylvie Chabaud, Andre Baruchel, François Gueyffier, Françoise Mazingue...

British Journal of Haematology . 153 ( 1 ) : 58-65

DOI: 10.1111/j.1365-2141.2011.08588.x

Journal article

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Standard requirements for GCP-compliant data management in multinational clinical trials

C. Ohmann, W. Kuchinke, S. Canham, J. Lauritsen, N. Salas, C. Schade-Brittinger...

Trials . 12 : 85

DOI: 10.1186/1745-6215-12-85

Journal article

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Blood pressure lowering in the oldest old: a step toward abandoning arbitrary blood pressure targets

François Gueyffier, M.I. Perez, Jm. Wright, I. Marchant, V.M. Musini, T. Bejan-Angoulvant

Journal of Hypertension . 29 : 171-175

Journal article

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Heterogeneity prevails: the state of clinical trial data management in Europe - results of a survey of ECRIN centres

W. Kuchinke, C. Ohmann, Q. Yang, N. Salas, J. Lauritsen, F. Gueyffier...

Trials . 11 : 79

DOI: 10.1186/1745-6215-11-79

Journal article

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Treatment of hypertension in patients 80 years and older: the lower the better? A meta-analysis of randomized controlled trials

T. Bejan-Angoulvant, M. Saadatian-Elahi, Jm. Wright, E.B. Schron, Lh. Lindholm, R. Fagard...

Journal of Hypertension . 28 : 1366-1372

Journal article

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Cognitive Therapy versus Rogerian Supportive Therapy in Borderline Personality Disorder

J. Cottraux, I. Druon Note, F. Boutitie, M. Milliery, V. Genouihlac, S.N. Yao...

Psychotherapy and Psychosomatics . 78(5) : 307-316

Journal article

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Fondements de l`évaluation des tests diagnostiques

B. Kassai, François Gueyffier, Muriel Rabilloud

Lecture critique d`article . 59 : 375-379

Journal article

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SCORE should be preferred to Framingham to predict cardiovascular death in French population

I. Marchant, J-P. Boissel, Behrouz Kassai, T. Bejan-Angoulvant, J. Massol, C. Vidal...

European Journal of Cardiovascular Prevention and Rehabilitation . 16(5) : 609-615

Journal article

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Prevention of dementia by antihypertensive drugs: how AT1-receptor-blockers and dihydropyridines better prevent dementia in hypertensive patients than thiazides and ACE-inhibitors.

Albert Fournier, Roxana Oprisiu-Fournier, Jean-Marie Serot, Olivier Godefroy, Jean-Michel Achard, Sébastien Faure...

Expert Review of Neurotherapeutics . 9 ( 9 ) : 1413-31

DOI: 10.1586/ern.09.89

Journal article

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Recueil systématique et actif des evènements indésirables médicamenteux chez les enfants admis aux urgences pédiatriques

F. Planchamp, K.-A. Nguyen, T. Vial, S. Nasri, E. Javouhey, Y. Gillet...

Archives de Pédiatrie . 16(2) : 106-111

Journal article

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Critique du modèle additif de l'essai clinique randomisé

R. Boussageon, F. Gueyffier, T. Bejan-Angoulvant, Géraldine Felden

Thérapie . 63 ( 1 ) : 29-35

Journal article

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New insights on the relation between untreated and treated outcomes for a given therapy effect model is not necessarily linear

J.-P. Boissel, Michel Cucherat, P. Nonyc, Sylvie Chabaud, François Gueyffier, Jm. Wright...

Journal of Clinical Epidemiology . 61 : 301-307

Journal article

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Meta-analysis of continuous outcomes combining individual patient data and aggregate data

Rd. Riley, Pc. Lambert, Ja. Staessen, J. Wang, François Gueyffier, L. Thijs...

Statistics in Medicine . 27(11) : 1870-1893

Journal article

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Some reflexions about double blind

R. Boussageon, François Gueyffier, A. Moreau, Y. Gansel, V. Boussageon

L'Encéphale . 34(4) : 347-351

Journal article

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Do We Need to Assess the Effect of Treatment Withdrawal? The Paradigm of Life-Long Prevention

François Gueyffier, T. Bejan-Angoulvant

Journal of the American Hearth Association . -- : 219-226

Journal article

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Critères intermédiaires et critères de substitution

Behrouz Kassai, François Gueyffier, J-P. Boissel

Médecine Thérapeutique . 13(4) : 279-286

Journal article

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