Statistics and Modelling for Health Sciences

Evaluation and Modeling with the Therapeutic Effects Group

Gueyffier François

Professeur d'université - praticien hospitalier émérite

UCBL

Address: BP8071
69376 LYON cedex 08

Tel: 33 04 78 78 57 49 33 04 72 35 72 31

Email

Professor François GUEYFFIER has more than 30 years of experience in clinical pharmacology and modeling in pharmacology. He coordinated the EU-USA INDANA consortium (http://lbbe-dmz.univ-lyon1.fr/spip_indana/) for performing individual data meta-analyzes (IPDMA) of randomized controlled trials in hypertension (Italy, United Kingdom, Belgium, France, USA, China), leading to more than 20 international publications in this field. This experiment served to illustrate how the IPDMA approach could / should influence the recommendations and design of new randomized controlled trials (doi: 10.1016 / j.jclinepi.2015.05.024). He is the author of 214 publications recorded in Pubmed, 269 according to web of science, H index 36 for WoS.

He coordinated the Clinical Investigation Center (CIC) in Lyon during its first 10 years (2001-2011), as well as the working group on data management in the French CIC network. He helped to establish the requirements for data management centers in the European network ECRIN (http://www.ecrin.org). The data management platform he coordinates in Lyon is ECRIN certified in July 2016 (http://www.ecrin.org/news/two-data-centres-receive-ecrin-certification). He prepares a recertification for a larger perimeter, including almost all support services for clinical research in Lyon University Hospitals – Hospices Civils de Lyon.

He was PI of the national network for patient recruitment in the IDEAL trial (http://lbbe-dmz.univ-lyon1.fr/spip_ideal/) to identify biomarkers predictive of response to antihypertensive therapy.

He coordinated the BIMBO national consortium (http://lbbe-dmz.univ-lyon1.fr/spip_bimbo/) to help identify markers of antihypertensive drug response by combining the modeling and clinical pharmacology approach.

His team (Dr Patrice NONY and Dr Catherine CORNU) coordinated the European project PriomedChild CRESIM (https://lbbe.univ-lyon1.fr/-CRESIM-.html), to help the choice of the best experimental plan by the simulation of clinical tests.

He teaches clinical pharmacology at the Faculty of Medicine. He is co-head of a master's degree course 2 "pharmacology modeling and clinical trials", local leader of the Inter University Diploma “training clinical trial investigators”. He was in charge of organizing experts committees for HCERES, member of selection committees of local and national research projects, member of the Commission de Transparence of Haute Autorité de Santé vice-chief of the Health Data Department of the Hospices Civils de Lyon.

Publications

Display of 91 to 120 publications on 170 in total

Can we identify response markers to antihypertensive drugs? First results from the Ideal Trial.

Gueyffier F., Subtil F., Bejan-Angoulvant T., Yves Zerbib, Baguet Jp, Boivin Jm...

Journal of Human Hypertension . : doi: 10.1038/jhh.2014.29

Journal article

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L\textquoterighteffet placebo chez l\textquoterightenfant est méconnu et peu étudié

B. Kassai, H. Gheit, R. Boussageon, F. Gueyffier

La Lettre du Pharmacologue . 27 : 17--20

Journal article

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Information et participation active des patients à l\textquoterightaide d\textquoterightune brochure interactive lors de la prescription d\textquoterightantihypertenseurs en soins primaires

M. Keriel-Gascou, A. Badet-Phan, Ma. Le Pogam, S. Figon, L. Letrilliart, F. Gueyffier...

Santé Publique . 25 : 193--201

Journal article

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Meta-analysis of randomised trials with a continuous outcome according to baseline imbalance and availability of individual participant data

Richard Riley, Iram Kauser, Martin Bland, Lutgarde Thijs, Jan Staessen, Jiguang Wang...

Statistics in Medicine . 32 ( 16 ) : 2747-2766

DOI: 10.1002/sim.5726

Journal article

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Are we using blood pressure-lowering drugs appropriately? Perhaps now is the time for a change

François Gueyffier, J. Wright

Journal of human hypertension . 28 : 68-70

DOI: 10.1038/jhh.2013.79

Journal article

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Physicians' knowledge and practice of lung cancer screening: a cross-sectional survey comparing general practitioners, thoracic oncologists, and pulmonologists in France

S. Couraud, N. Girard, S. Erpeldinger, François Gueyffier, G. Devouassoux, G. Llorca...

Clinical Lung Cancer . 14 : 574-80

DOI: 10.1016/j.cllc.2013.05.003

Journal article

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Biomarker-guided therapies in heart failure: a forum for unified strategies

M. Fiuzat, C. M. O'Connor, François Gueyffier, A. M. Mascette, N. L. Geller, A. Mebazaa...

Journal of Cardiac Failure . 19 : 592-9

DOI: 10.1016/j.cardfail.2013.05.012

Journal article

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Impaired baroreflex sensitivity and the risks of new-onset ambulatory hypertension, in an elderly population-based study

V. Dauphinot, M. P. Kossovsky, François Gueyffier, V. Pichot, P. Gosse, F. Roche...

International Journal of Cardiology . 168 : 4010-4

DOI: 10.1016/j.ijcard.2013.06.080

Journal article

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Impact of Genetic Polymorphism on Drug-Drug Interactions Mediated by Cytochromes: A General Approach

M. Tod, C. Nkoud-Mongo, François Gueyffier

AAPS journal . 15 : 1242--1252

DOI: 10.1208/s12248-013-9530-2

Journal article

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Quantitative Prediction of the Impact of Drug Interactions and Genetic Polymorphisms on Cytochrome P450 2C9 Substrate Exposure

Anne-Charlotte Castellan, M. Tod, François Gueyffier, M. Audars, F. Cambriels, Berouz Kassai...

Clinical Pharmacokinetics . 52 : 199-209

DOI: 10.1007/s40262-013-0031-3

Journal article

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Revising the ECRIN standard requirements for information technology and data management in clinical trials.

Christian Ohmann, Steve Canham, Catherine Cornu, Jochen Dress, François Gueyffier, Wolfgang Kuchinke...

Trials . 14 ( 1 ) : 97

DOI: 10.1186/1745-6215-14-97

Journal article

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Pharmacoepidemiology studies: what levels of evidence and how can they be reached?

Maryse Lapeyre-Mestre, Claudine Sapède, Nicholas Moore, Pascal Bilbault, Patrick Blin, Damien Chopy...

Thérapie . 68 ( 4 ) : 241-52

DOI: 10.2515/therapie/2013038

Journal article

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Are concomitant treatments confounding factors in randomized controlled trials on intensive blood-glucose control in type 2 diabetes? a systematic review

Rémy Boussageon, Irène Supper, Sylvie Erpeldinger, Michel Cucherat, Theodora Bejan-Angoulvant, Behrouz Kassai...

BMC Medical Research Methodology . 13 ( 1 ) : 107

Journal article

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Études pharmaco-épidémiologiques : quels niveaux de preuve et comment les atteindre ?

M. Lapeyre-Mestre, C. Sapède, N. Moore, P. Bilbault, P. Blin, D. Chopy...

Thérapie . 68 : 241--246

DOI: 10.2515/therapie/2013037

Journal article

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Is there excess mortality in women screened with mammography: a meta-analysis of non-breast cancer mortality

Sylvie Erpeldinger, Laure Fayolle, Rémy Boussageon, Marie Flori, Xavier Lainé, Moreau Alain...

Trials . 14 ( 1 )

DOI: 10.1186/1745-6215-14-368

Journal article

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Beta-blockers for the prevention of sudden cardiac death in heart failure patients: a meta-analysis of randomized controlled trials

M. Al-Gobari, C. El Khatib, F. Pillon, François Gueyffier

BMC Cardiovascular Disorders . 13 : 52

DOI: 10.1186/1471-2261-13-52

Journal article

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Anti-Trypanosoma cruzi cross-reactive antibodies detected at high rate in non-exposed individuals living in non-endemic regions: seroprevalence and association to other viral serologies.

Esber S Saba, Lucie Gueyffier, Marie-Laure Dichtel-Danjoy, Bruno Pozzetto, Thomas Bourlet, François Gueyffier...

PLoS ONE . 8 ( 9 ) : e74493

DOI: 10.1371/journal.pone.0074493

Journal article

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Clinically Relevant Efficacy of Insulin Therapy in Patients with Type 2 Diabetes

R. Boussageon, J. M. Gamble, François Gueyffier, C. Cornu

Thérapie . 68 : 415--7

DOI: 10.2515/therapie/2013063

Journal article

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Correspondance à propos de l\textquoterightarticle \guillemotleft Objectifs glycémiques dans la prise en charge du diabète de type 2 \guillemotright

R. Boussageon, François Gueyffier, C. Cornu

La Presse Médicale . 42 : 1284--1286

DOI: 10.1016/j.lpm.2013.04.005

Journal article

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Expected impact of a public health intervention in the presence of synergistic risk factors

Hadrien Charvat, François Gueyffier, Aurélien Belot, Pascal Roy

Journal of Clinical Epidemiology . 66 : 445-52

DOI: 10.1016/j.jclinepi.2012.11.004

Journal article

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Essais cliniques institutionnels : quel monitoring ?

C. Cornu, C. Binquet, C. Thalamas, C. Vigouroux, S. Gaillard, T. Ginhoux...

Pharmacologie clinique . 68 : 135-141

DOI: 10.2515/therapie/2013032

Journal article

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Heart rate: a prognostic factor and therapeutic target in chronic heart failure. The distinct roles of drugs with heart rate-lowering properties

D. Dobre, J. S. Borer, K. Fox, K. Swedberg, K. F. Adams, J. G. Cleland...

European Journal of Heart Failure . 16 ( 1 ) : 76-85

DOI: 10.1093/eurjhf/hft129

Journal article

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Approche individu-centrée pour l'exploration de stratégies de prescription médicale - un exemple dans l'hypertension artérielle

Nadia Abchiche-Mimouni, Monique Rousset, F. Gueyffier

Proc. de la 6ème Conférence Francophone d'Épidémiologie Clinique, 19èmes Journées des Statisticiens des Centres de Lutte contre le Cancer ( EPICLIN 2012) . : (elec. proc)

Conference paper

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Virtual reality exposure therapy versus cognitive behavior therapy for panic disorder with agoraphobia: a randomized comparison study

A. Pelissolo, M. Zaoui, G. Aguayo, S. Nan Yao, S. Roche, René Ecochard...

Journal of CyberTherapy & Rehabilitation . 5 : 35-43

Journal article

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Individual patient data meta-analysis of survival data using Poisson regression models.

Michael Crowther, Richard Riley, Jan Staessen, Jiguang Wang, Francois Gueyffier, Paul Lambert

BMC Medical Research Methodology . 12 ( 1 ) : 34

DOI: 10.1186/1471-2288-12-34

Journal article

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The IDEAL Study : Towards Personalized Drug Treatment of Hypertension

T. Bejan-Angoulvant, J-P. Baguet, S. Erpeldinger, J-M. Boivin, A. Mercier, G. Leftheriotis...

Thérapie . 67 : 195--204

DOI: 10.2515/therapie/2012031

Journal article

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Farnesoid X Receptor Targeting for Hepatitis C: Study Protocol for a Proof-of-concept Trial

C. Scholtes, P. Andre, C. Trepo, C. Cornu, Laurent Remontet, René Ecochard...

Thérapie . 67 : 423--427

DOI: 10.2515/therapie/2012058

Journal article

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Oseltamivir-zanamivir bitherapy compared to oseltamivir monotherapy in the treatment of pandemic 2009 influenza A(H1N1) influenza virus infections

V. Escuret, C. Cornu, F. Boutitie, V. Ernouf, A. Mosnier, M. Bouscambert-Duchamp...

Antiviral Research . 96 : 130--137

DOI: 10.1016/j.antiviral.2012.08.002

Journal article

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Modeling the impact of cardiovascular prevention strategies: toward better information for public health decisions

François Gueyffier, I. Marchant, B. Carlberg

Journal of Hypertension . 30 : 51--2

DOI: 10.1097/HJH.0b013e32834e089d

Journal article

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