Evaluation and Modeling with the Therapeutic Effects Group

Members

EMET  presentation

The EMET team brings together doctors, pharmacists and research professors specializing in the evaluation and use of drug and non-drug therapies, around a single project built on two axes:

  • the evaluation of therapies in clinical trials or observational studies;
  • the construction of explanatory and predictive models, to better understand and therefore predict the effect of therapies, simulate their impacts at the individual and population level, and improve the innovation paradigm.

The EMET team is therefore part of two major dynamics in therapy: analysis of the level of evidence and precision medicine.
The fields of application are cardiovascular and metabolic diseases, primary care medicine, rare pediatric diseases (including genetic and autoimmune diseases), oncology and infectious diseases.
EMET members implement approaches using different mathematical models: direct comparison and network meta-analysis, pharmacokinetic/pharmacodynamic analysis, Bayesian networks and machine learning.

Education

The EMET team is specially involved in the teaching of pharmacology and therapeutics and the modeling of the treatment effect through the coordination of the Masters 2 Clinical Evaluation (EC) and Pharmacology modeling and clinical trials (PHAME), Interpretation of Therapeutic Trials (IET), Training of investigators in clinical drug trials (FIEC) and Training of clinical research assistants and clinical study technicians (FARCTEC). Teacher-researchers are also involved in the first (pharmacology), second (pharmacology / therapeutics, pharmacy) and third cycles (general medicine, pediatrics, internal medicine) in health training courses.

Society involvement

The members of the EMET team through their work and their interactions with the other components of the LBBE, National societies, governmental (HAS) or international (EMA) agencies, and the Hospices Civils de Lyon, are invested in current societal issues: rationalization of the use of health product resources, research ethics, gender equality, rationality of approaches in analyzing the diversity of human populations.

Publications

Display of 61 to 90 publications on 613 in total

Daptomycin Exposure as a Risk Factor for Daptomycin-Induced Eosinophilic Pneumonia and Muscular Toxicity

Romain Garreau, Truong-Thanh Pham, Laurent Bourguignon, Aurélien Millet, François Parant, David Bussy...

Clinical Infectious Diseases . 77 ( 10 ) : 1372-1380

DOI: 10.1093/cid/ciad386

Journal article

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Strengthening Reporting of Neonatal Trials

James Webbe, Ami Baba, Nancy Butcher, Craig Rodrigues, Emma Stallwood, Katherine Goren...

Pediatrics . 152 ( 3 )

DOI: 10.1542/PEDS.2022-060765

Journal article

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Heterogeneity and Gaps in Reporting Primary Outcomes From Neonatal Trials

Ami Baba, James Webbe, Nancy Butcher, Craig Rodrigues, Emma Stallwood, Katherine Goren...

Pediatrics . 152 ( 3 )

DOI: 10.1542/PEDS.2022-060751

Journal article

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Safety of Re-dosing Nirsevimab Prior to RSV Season 2 in Children With Heart or Lung Disease

Joseph Domachowske, Yue Chang, Victoria Atanasova, Fernando Cabañas, Kenji Furuno, Irfana Banu...

Journal of the Pediatric Infectious Diseases Society . 12 ( 8 ) : 477-480

DOI: 10.1093/JPIDS/PIAD052

Journal article

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Efficacy of nirsevimab against respiratory syncytial virus lower respiratory tract infections in preterm and term infants, and pharmacokinetic extrapolation to infants with congenital heart disease and chronic lung disease: a pooled analysis of randomised

Eric Simões, Shabir Madhi, William Muller, Victoria Atanasova, Miroslava Bosheva, Fernando Cabañas...

The Lancet Child & Adolescent Health . 7 ( 3 ) : 180-189

DOI: 10.1016/S2352-4642(22)00321-2

Journal article

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Avis de l'Anses relatif à l’évaluation du triphénylphosphate (TPP) (EC No 204-112-2 ; CAS No 115-86-6) dans le cadre de l’évaluation des substances sous REACH

Sakina Mhaouty-Kodja, René Habert, Sylvie Babajko, Isabelle Beau, Nicolas J. Cabaton, Marie-Chantal Canivenc-Lavier...

: 12 p.

Report

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Theratyping cystic fibrosis patients to guide elexacaftor/tezacaftor/ivacaftor out-of-label prescription

Elise Dreano, Pierre Régis Burgel, Aurelie Hatton, Naim Bouazza, Benoit Chevalier, Julie Macey...

European Respiratory Journal . 62 ( 4 ) : 2300110

DOI: 10.1183/13993003.00110-2023

Journal article

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Clinical problems in rare interstitial lung diseases

Camille Fletcher, Alice Hadchouel, Caroline Thumerelle, Manon Fleury, Nouha Jedidi, Myriam Benhamida...

European Respiratory Society .

Poster

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Prolonged response after TPO-RA discontinuation in primary ITP: results of a prospective multicenter study

Stephanie Guillet, Etienne Crickx, Imane Azzaoui, Pascal Chappert, Emmanuelle Boutin, Jean-François Viallard...

Blood .

DOI: 10.1182/blood.2022018665

Journal article

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Immune thrombocytopenia and pregnancy: an exposed/nonexposed cohort study

Stéphanie Guillet, Valentine Loustau, Emmanuelle Boutin, Anissa Zarour, Thibault Comont, Odile Souchaud-Debouverie...

Blood . 141 ( 1 ) : 11-21

DOI: 10.1182/blood.2022017277

Journal article

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Preuves de bénéfice et décision thérapeutique : enquête auprès de médecins généralistes sur la prescription d’hydroxychloroquine pour traiter la Covid-19

Remy de Castro, Michelle Johnson, Florian Naudet, Denis Pouchain, François Gueyffier, Laurent Letrilliart...

Exercer . 34 ( 195 ) : 298-304

DOI: 10.56746/EXERCER.2023.195.298

Journal article

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Outcomes of pregnancies with preterm premature rupture of membranes occurring before 24 weeks of gestation: An 11‐year observational study

Helene Gauthier-Moulinier, Daouda Ndour, Muriel Rabilloud, Kim‐an Nguyen

International Journal of Gynecology and Obstetrics . 162 ( 2 ) : 590-595

DOI: 10.1002/ijgo.14700

Journal article

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Defining standard and high dosages for β-lactam agents administered by intermittent, prolonged or continuous infusion: a PK/PD simulation study

Sylvain Goutelle, Vincent Jullien, Jean-Pierre Bru, Vincent Cattoir, Rémy Gauzit, Philippe Lesprit...

Journal of Antimicrobial Chemotherapy . 78 ( 11 ) : 2762–2769

DOI: 10.1093/jac/dkad300

Journal article

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A Knowledge-Based Approach for Evaluating Impact of Therapeutic Strategies

Nadia Abchiche-Mimouni, Mike Donald Tapi Nzali, François Gueyffier

ICAART 2023 - 15th International Conference on Agents and Artificial Intelligence . 3 : 1036-1046

DOI: 10.5220/0011894300003393

Conference paper

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Projet Rebuild the Evidence Base

Hélène Vaillant-Roussel, Clara Blanchard, Thibault Menini, Elodie Charuel, Bruno Pereira, Florian Naudet...

Exercer . 34 ( 190 ) : 81-88

DOI: 10.56746/EXERCER.2023.190.81

Journal article

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Population designations in biomedical research: limitations and perspectives

Caroline Gombault, Guillaume Grenet, Laure Ségurel, Laurent Duret, François Gueyffier, Pascal Cathébras...

HLA: Immune Response Genetics . 101 ( 1 ) : 3-15

DOI: 10.1111/tan.14852

Journal article

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Replacing liquid with solid dosage forms in pediatric practice: Feasibility and economic impact from a hospital-based study

Rama Arab, Behrouz Kassai, Roubi Kilo, Catherine Cornu, Elisabete Gomes, Tristan Dagonneau...

Therapies . 77 ( 4 ) : 445-452

DOI: 10.1016/J.THERAP.2021.12.013

Journal article

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Nirsevimab for Prevention of RSV in Healthy Late-Preterm and Term Infants

Laura Hammitt, Ron Dagan, Yuan Yuan, Manuel Baca Cots, Miroslava Bosheva, Shabir Madhi...

New England Journal of Medicine . 386 ( 9 ) : 837-846

DOI: 10.1056/NEJMoa2110275

Journal article

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Intravenous Immunoglobulins Tapering and Withdrawal in Systemic Capillary Leak Syndrome (Clarkson Disease)

Quentin Moyon, Marc Pineton de Chambrun, Marie Gousseff, Alexis Mathian, Miguel Hie, Geoffrey Urbanski...

Journal of Allergy and Clinical Immunology: In Practice . 10 ( 11 ) : 2889-2895

DOI: 10.1016/j.jaip.2022.07.006

Journal article

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Immune thrombocytopenia with clinical significance in systemic lupus erythematosus: a retrospective cohort study of 90 patients

Mickaël Roussotte, Mathieu Gerfaud-Valentin, Arnaud Hot, Sylvain Audia, Bernard Bonnotte, Thomas Thibault...

Rheumatology . 61 ( 9 ) : 3627-3639

DOI: 10.1093/rheumatology/keab925

Journal article

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The consequences of COVID-19 pandemic on patients with monoclonal gammopathy–associated systemic capillary leak syndrome (Clarkson disease)

Marc Pineton de Chambrun, Quentin Moyon, Stanislas Faguer, Geoffrey Urbanski, Alexis Mathian, Noémie Zucman...

Journal of Allergy and Clinical Immunology: In Practice . 10 ( 2 ) : 626-629

DOI: 10.1016/j.jaip.2021.11.023

Journal article

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Quelle place pour l’automatisation intelligente et l’intelligence artificielle pour préserver et renforcer l’expertise en vigilance devant l’augmentation des déclarations ?

Antoine Pariente, Joelle Micallef, Amir Lahouegue, Mathieu Molimard, Marine Auffret, Laurent Chouchana...

Therapies . 78 ( 1 ) : 115-129

DOI: 10.1016/j.therap.2022.11.003

Journal article

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Estimating individualized treatment effects using individual participant data meta-analysis

Florie Brion Bouvier, Anna Chaimani, François Gueyffier, Guillaume Grenet, Raphaël Porcher

Preprint

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A randomized controlled phase III study comparing hadrontherapy with carbon ions versus conventional radiotherapy – including photon and proton therapy – for the treatment of radioresistant tumors: the ETOILE trial

Jacques Balosso, Olivia Febvey-Combes, Annie Iung, Hélène Lozano, Abdoulkader Alloh, Catherine Cornu...

BMC Cancer . 22 ( 1 ) : 575

DOI: 10.1186/s12885-022-09564-7

Journal article

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Machine-Learning Exploration of Exposure-Effect Relationships of Cisplatin in Head and Neck Cancer Patients

Céleste Cauvin, Laurent Bourguignon, Laure Carriat, Abel Mence, Pauline Ghipponi, Sébastien Salas...

Pharmaceutics . 14 ( 11 ) : 2509

DOI: 10.3390/pharmaceutics14112509

Journal article

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SGLT2 inhibitors in type 2 diabetes: a systematic review and meta-analysis of cardiovascular outcome trials balancing their risks and benefits

Elisa Marilly, Judith Cottin, Natalia Cabrera, Catherine Cornu, Rémy Boussageon, Philippe Moulin...

Diabetologia . 65 : 2000-2010

DOI: 10.1007/s00125-022-05773-8

Journal article

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Indirect Comparison of Glucocorticoid-Sparing Agents for Remission Maintenance in Giant Cell Arteritis: A Network Meta-analysis

Sabine Mainbourg, Axel Tabary, Michel Cucherat, François Gueyffier, Hervé Lobbes, Marie Aussedat...

Mayo Clinic Proceedings . 97 ( 10 ) : 1824-1835

DOI: 10.1016/j.mayocp.2022.03.010

Journal article

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Screening for hypertension-mediated organ damage and aetiology: still of value after 65 years of age?

Delphine Thiolliere, Brahim Harbaoui, Claire Falandry, Marc Bonnefoy, Jean-Christophe Lega, Pierre Lantelme...

Journal of Geriatric Cardiology . 19 ( 11 ) : 791-801

DOI: 10.11909/j.issn.1671-5411.2022.11.005

Journal article

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Réponse sérologique après vaccination contre le coronavirus chez les patients atteints de rhumatisme inflammatoire chronique traités par DMARDs : étude de cohorte et revue systématique avec méta-analyse

Maxime Auroux, Benjamin Laurent, Baptiste Coste, Emmanuel Massy, Alexandre Mercier, Isabelle Durieu...

Revue du Rhumatisme . 89 ( 5 ) : 435-446

DOI: 10.1016/j.rhum.2022.07.002

Journal article

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Immune thrombocytopenia with clinical significance in systemic lupus erythematosus: a retrospective cohort study of 90 patients

Mickaël Roussotte, Mathieu Gerfaud-Valentin, Arnaud Hot, Sylvain Audia, Bernard Bonnotte, Thomas Thibault...

Rheumatology . 61 ( 9 ) : 3627-3639

DOI: 10.1093/rheumatology/keab925

Journal article

see the publication

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