Evaluation and Modeling with the Therapeutic Effects Group
Members
Stagiaire
UCBL
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Maîtresse de conférences - praticienne hospitalière
UCBL
Tel: 04 72 11 94 07
Maître de conférences - praticien hospitalier
UCBL
Tel: 33 04 72 32 34 87
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Professeur des universités - médecin généraliste
UCBL
Tel: 04 78 74 18 18
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Maîtresse de conférences
UCBL
Tel: 33 04 78 78 57 83
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Professeure des universités - médecin généraliste
UCBL
Tel: 04 78 77 72 86
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Professeur d'université - praticien hospitalier
UCBL
Tel: 04 72 44 81 42
Doctorante
HCL
Assistant hospitalier universitaire
UCBL
Doctorant
UCBL
Tel: 04 72 44 81 42
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Professeur d'université - praticien hospitalier
UCBL
Tel: 33 04 72 16 80 99
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Doctorante
autre
Tel: 04 72 44 81 42
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Praticien hospitalier
HCL
Tel: 04 72 44 81 42
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Professeur d'université - praticien hospitalier émérite
UCBL
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Professeur d'université - praticien hospitalier
UCBL
Tel: 04 27 85 77 32
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Professeur d'université - praticien hospitalier
UCBL
Tel: 33 04 78 86 33 01
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Maîtresse de conférences - praticienne hospitalière
UCBL
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Maître de conférences - praticien hospitalier
UCBL
Tel: 04 72 11 94 20
Doctorant
HCL
Tel: 04 72 44 81 42
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Doctorante
UCBL
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Professeur d'université - praticien hospitalier
UCBL
Tel: 33 04 72 12 94 37
Post-doc
UCBL
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Professeur d'université - praticien hospitalier émérite
UCBL
Doctorante
UCBL
Tel: 04 72 44 81 42
Stagiaire
HCL
EMET presentation
The EMET team brings together doctors, pharmacists and research professors specializing in the evaluation and use of drug and non-drug therapies, around a single project built on two axes:
- the evaluation of therapies in clinical trials or observational studies;
- the construction of explanatory and predictive models, to better understand and therefore predict the effect of therapies, simulate their impacts at the individual and population level, and improve the innovation paradigm.
The EMET team is therefore part of two major dynamics in therapy: analysis of the level of evidence and precision medicine.
The fields of application are cardiovascular and metabolic diseases, primary care medicine, rare pediatric diseases (including genetic and autoimmune diseases), oncology and infectious diseases.
EMET members implement approaches using different mathematical models: direct comparison and network meta-analysis, pharmacokinetic/pharmacodynamic analysis, Bayesian networks and machine learning.
Education
The EMET team is specially involved in the teaching of pharmacology and therapeutics and the modeling of the treatment effect through the coordination of the Masters 2 Clinical Evaluation (EC) and Pharmacology modeling and clinical trials (PHAME), Interpretation of Therapeutic Trials (IET), Training of investigators in clinical drug trials (FIEC) and Training of clinical research assistants and clinical study technicians (FARCTEC). Teacher-researchers are also involved in the first (pharmacology), second (pharmacology / therapeutics, pharmacy) and third cycles (general medicine, pediatrics, internal medicine) in health training courses.
Society involvement
The members of the EMET team through their work and their interactions with the other components of the LBBE, National societies, governmental (HAS) or international (EMA) agencies, and the Hospices Civils de Lyon, are invested in current societal issues: rationalization of the use of health product resources, research ethics, gender equality, rationality of approaches in analyzing the diversity of human populations.
Publications
Display of 61 to 90 publications on 450 in total
Trigger tools to identify adverse drug events in hospitalised children: A systematic review
Therapies . 77 ( 5 ) : 527-539
Journal article
see the publicationAgreement between a regional pharmacovigilance centre and an adjudication committee regarding adverse drug reactions on a cohort of hospitalised children
Therapies . 77 ( 4 ) : 397-404
Journal article
see the publicationSafety of Nirsevimab for RSV in Infants with Heart or Lung Disease or Prematurity
New England Journal of Medicine . 386 ( 9 ) : 892-894
DOI: 10.1056/NEJMC2112186
Journal article
see the publicationImpact of COVID-19 pandemic on antifungal consumption: a multicenter retrospective analysis
Critical Care . 26 ( 1 ) : 384
Journal article
see the publicationPaclitaxel with or without pazopanib for ovarian cancer relapsing during bevacizumab maintenance therapy: The GINECO randomized phase II TAPAZ study
Gynecologic Oncology . 166 ( 3 ) : 389-396
Journal article
see the publicationBites by Non-Native Reptiles in France: Species, Circumstances and Outcome
Toxins . 14 ( 8 ) : 570
Journal article
see the publicationAntipsychotic prescribing practices in real-life (APPREAL study): Findings from the French National Healthcare System Database (2007–2017)
Frontiers in Psychiatry . 13
Journal article
see the publicationAssociation between formal thought disorder and cannabis use: a systematic review and meta-analysis
npj Schizophrenia . 8 ( 1 ) : 78
Journal article
see the publicationLimbic Stimulation Drives Mania in STN-DBS in Parkinson Disease: A Prospective Study
Annals of Neurology . 92 ( 3 ) : 411-417
DOI: 10.1002/ana.26434
Journal article
see the publicationManagement of alcohol-related liver disease: the French Association for the Study of the Liver and the French Alcohol Society clinical guidelines
Liver International . 42 ( 6 ) : 1330-1343
DOI: 10.1111/liv.15221
Journal article
see the publicationSerum Mature BDNF Level Is Associated with Remission Following ECT in Treatment-Resistant Depression
Brain Sciences . 12
Journal article
see the publicationAssociation of Delayed Sleep/Wake Rhythm with Depression During the First COVID-19 Lockdown in France
Nature and Science of Sleep . 14 : 1545-1557
DOI: 10.2147/nss.s369859
Journal article
see the publicationTemporal trends in calls for suicide attempts to poison control centers in France during the COVID-19 pandemic: a nationwide study
European Journal of Epidemiology . 37 ( 9 ) : 901-913
Journal article
see the publicationTherapeutic Drug Monitoring of Antibiotic Drugs in Patients Receiving Continuous Renal Replacement Therapy or Intermittent Hemodialysis: A Critical Review
Therapeutic Drug Monitoring . 44 ( 1 ) : 86-102
Journal article
see the publicationA call for evidence in connective tissue diseases-associated interstitial lung disease
Joint Bone Spine . 89 ( 1 ) : 105274
Journal article
see the publicationSplenectomy for primary immune thrombocytopenia revisited in the era of thrombopoietin receptor agonists: New insights for an old treatment
American Journal of Hematology . 97 ( 1 ) : 10-17
DOI: 10.1002/ajh.26378
Journal article
see the publicationManagement and Outcome of COVID-19 Positive and Negative Patients in French Emergency Departments During the First COVID-19 Outbreak: A Prospective Controlled Cohort Study
Western Journal of Emergency Medicine . 23 ( 6 ) : 897-906
Journal article
see the publicationHuman Papilloma Virus Vaccination in Patients with Rheumatic Diseases in France: A Study of Vaccination Coverage and Drivers of Vaccination
Journal of Clinical Medicine . 11 ( 14 ) : 4137
DOI: 10.3390/jcm11144137
Journal article
see the publicationDaptomycin Physiology-Based Pharmacokinetic Modeling to Predict Drug Exposure and Pharmacodynamics in Skin and Bone Tissues
Clinical Pharmacokinetics . 61 ( 10 ) : 1443-1456
Journal article
see the publicationImplementation of Model-Based Dose Adjustment of Tobramycin in Adult Patients with Cystic Fibrosis
Pharmaceutics . 14 ( 8 ) : 1750
Journal article
see the publicationSeventeen Cases of Daptomycin-Induced Eosinophilic Pneumonia in a Cohort of Patients Treated for Bone and Joint Infections: Proposal for a New Algorithm
Open Forum Infectious Diseases . 9 ( 11 ) : ofac577
DOI: 10.1093/ofid/ofac577
Journal article
see the publicationPredicted Impacts of Booster, Immunity Decline, Vaccination Strategies, and Non-Pharmaceutical Interventions on COVID-19 Outcomes in France
Vaccines . 10 ( 12 ) : 2033
Journal article
see the publicationAn Investigation of O-Demethyl Tramadol/Tramadol Ratio for Cytochrome P450 2D6 Phenotyping: The CYTRAM Study
Pharmaceutics . 14 ( 10 ) : 2177
Journal article
see the publicationPopulation designations in biomedical research: limitations and perspectives
HLA: Immune Response Genetics .
DOI: 10.1111/tan.14852
Journal article
see the publicationSelected and simplified FDI criteria for assessment of restorations
Journal of Dentistry . 122 : 104109
Journal article
see the publicationHow do they add up? The interaction between the placebo and treatment effect: A systematic review
British Journal of Clinical Pharmacology . 88 ( 8 ) : 3638-3656
DOI: 10.1111/bcp.15345
Journal article
see the publicationPlace of a new radiological index in predicting pulp exposure before intervention for deep carious lesions
Oral Radiology . 38 ( 1 ) : 89-98
Journal article
see the publicationPrevention of venous thromboembolism in nephrotic syndrome: the quest towards precision medicine
Nephrology Dialysis Transplantation . 36 ( 7 ) : 1151-1154
DOI: 10.1093/ndt/gfaa337
Journal article
see the publicationBladder endometriosis: Preoperative MRI analysis with assessment of extension to ureteral orifices
Diagnostic and Interventional Imaging . 102 ( 4 ) : 255-263
Journal article
see the publicationDPP-4 Inhibitors and Respiratory Infection: A Systematic Review and Meta-analysis of the Cardiovascular Outcomes Trials
Diabetes Care . 44 ( 3 ) : e36-e37
DOI: 10.2337/dc20-2018
Journal article
see the publication
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