Evaluation and Modeling with the Therapeutic Effects Group

Members

EMET  presentation

The EMET team brings together doctors, pharmacists and research professors specializing in the evaluation and use of drug and non-drug therapies, around a single project built on two axes:

  • the evaluation of therapies in clinical trials or observational studies;
  • the construction of explanatory and predictive models, to better understand and therefore predict the effect of therapies, simulate their impacts at the individual and population level, and improve the innovation paradigm.

The EMET team is therefore part of two major dynamics in therapy: analysis of the level of evidence and precision medicine.
The fields of application are cardiovascular and metabolic diseases, primary care medicine, rare pediatric diseases (including genetic and autoimmune diseases), oncology and infectious diseases.
EMET members implement approaches using different mathematical models: direct comparison and network meta-analysis, pharmacokinetic/pharmacodynamic analysis, Bayesian networks and machine learning.

Education

The EMET team is specially involved in the teaching of pharmacology and therapeutics and the modeling of the treatment effect through the coordination of the Masters 2 Clinical Evaluation (EC) and Pharmacology modeling and clinical trials (PHAME), Interpretation of Therapeutic Trials (IET), Training of investigators in clinical drug trials (FIEC) and Training of clinical research assistants and clinical study technicians (FARCTEC). Teacher-researchers are also involved in the first (pharmacology), second (pharmacology / therapeutics, pharmacy) and third cycles (general medicine, pediatrics, internal medicine) in health training courses.

Society involvement

The members of the EMET team through their work and their interactions with the other components of the LBBE, National societies, governmental (HAS) or international (EMA) agencies, and the Hospices Civils de Lyon, are invested in current societal issues: rationalization of the use of health product resources, research ethics, gender equality, rationality of approaches in analyzing the diversity of human populations.

Publications

Display of 61 to 90 publications on 626 in total

Treatment strategy for acquired pure red cell aplasia: a systematic review and meta-analysis

Hervé Lobbes, Jean-Christophe Lega, Guillaume Le Guenno, Marc Ruivard, Sabine Mainbourg

Blood Advances . 7 ( 21 ) : 6451-6465

DOI: 10.1182/bloodadvances.2023010587

Journal article

see the publication

Platelet count threshold for hemorrhage in patients with immune thrombocytopenia treated with antiplatelet agents

Natasha Ollier, Marie-Léa Piel-Julian, Matthieu Mahévas, Jean-François Viallard, Thibault Comont, Stéphane Chèze...

Blood . 142 ( 12 ) : 1099-1101

DOI: 10.1182/blood.2023020311

Journal article

see the publication

Prolonged response after TPO-RA discontinuation in primary ITP: results of a prospective multicenter study

Stephanie Guillet, Etienne Crickx, Imane Azzaoui, Pascal Chappert, Emmanuelle Boutin, Jean-François Viallard...

Blood .

DOI: 10.1182/blood.2022018665

Journal article

see the publication

Immune thrombocytopenia and pregnancy: an exposed/nonexposed cohort study

Stéphanie Guillet, Valentine Loustau, Emmanuelle Boutin, Anissa Zarour, Thibault Comont, Odile Souchaud-Debouverie...

Blood . 141 ( 1 ) : 11-21

DOI: 10.1182/blood.2022017277

Journal article

see the publication

AUC-based monitoring and model-informed precision dosing of vancomycin in critically ill patients: why and how?

Sylvain Goutelle, Florent Wallet, Yann Thoma, Jean-Rémi Peclard, Laurent Bourguignon, Sabine Cohen...

Anaesthesia Critical Care & Pain Medicine . 42 ( 6 ) : 101286

DOI: 10.1016/j.accpm.2023.101286

Journal article

see the publication

Population Pharmacokinetics of Vancomycin in Patients Receiving Hemodialysis in a Malian and a French Center and Simulation of the Optimal Loading Dose

Balla Coulibaly, Pascal Maire, Jêrome Guitton, Solenne Pelletier, Moustapha Tangara, Gilles Aulagner...

Therapeutic Drug Monitoring . 45 ( 5 ) : 637-643

DOI: 10.1097/FTD.0000000000001065

Journal article

see the publication

Evaluation of Limited Sampling Strategies for Bayesian Estimation of Daptomycin Area Under the Concentration–Time Curve: A Short Communication

Vianney Tuloup, Aurélien Millet, Alessandra Taricco, François Parant, Tristan Ferry, Sylvain Goutelle

Therapeutic Drug Monitoring . 45 ( 4 ) : 562-565

DOI: 10.1097/FTD.0000000000001070

Journal article

see the publication

From Personalized to Precision Medicine in Oncology: A Model-Based Dosing Approach to Optimize Achievement of Imatinib Target Exposure

Sylvain Goutelle, Monia Guidi, Verena Gotta, Chantal Csajka, Thierry Buclin, Nicolas Widmer

Pharmaceutics . 15 ( 4 ) : 1081

DOI: 10.3390/pharmaceutics15041081

Journal article

see the publication

Suboptimal exposure to fluconazole in critically ill patients: Pharmacokinetic analysis and determinants

A.L. Bienvenu, P. Pradat, E. Matusik, V. Piriou, T. Rimmelé, F. Parant...

Infectious Diseases Now . 53 ( 2 ) : 104630

DOI: 10.1016/j.idnow.2022.10.002

Journal article

see the publication

Evaluation of Renal Impairment Influence on Metabolic Drug Clearance using a Modelling Approach

Vianney Tuloup, Sylvain Goutelle, Michel Tod, Laurent Bourguignon

Clinical Pharmacokinetics . 62 ( 2 ) : 307-319

DOI: 10.1007/s40262-022-01205-3

Journal article

see the publication

Granulocyte-macrophage colony-stimulating factor (GM-CSF) in patients presenting sepsis-induced immunosuppression: The GRID randomized controlled trial

Charles-Hervé Vacheron, Alain Lepape, Fabienne Venet, Guillaume Monneret, Francois Gueyffier, Florent Boutitie...

Journal of Critical Care . 78 : 154330

DOI: 10.1016/j.jcrc.2023.154330

Journal article

see the publication

Daptomycin Exposure as a Risk Factor for Daptomycin-Induced Eosinophilic Pneumonia and Muscular Toxicity

Romain Garreau, Truong-Thanh Pham, Laurent Bourguignon, Aurélien Millet, François Parant, David Bussy...

Clinical Infectious Diseases . 77 ( 10 ) : 1372-1380

DOI: 10.1093/cid/ciad386

Journal article

see the publication

Strengthening Reporting of Neonatal Trials

James Webbe, Ami Baba, Nancy Butcher, Craig Rodrigues, Emma Stallwood, Katherine Goren...

Pediatrics . 152 ( 3 )

DOI: 10.1542/PEDS.2022-060765

Journal article

see the publication

Heterogeneity and Gaps in Reporting Primary Outcomes From Neonatal Trials

Ami Baba, James Webbe, Nancy Butcher, Craig Rodrigues, Emma Stallwood, Katherine Goren...

Pediatrics . 152 ( 3 )

DOI: 10.1542/PEDS.2022-060751

Journal article

see the publication

Safety of Re-dosing Nirsevimab Prior to RSV Season 2 in Children With Heart or Lung Disease

Joseph Domachowske, Yue Chang, Victoria Atanasova, Fernando Cabañas, Kenji Furuno, Irfana Banu...

Journal of the Pediatric Infectious Diseases Society . 12 ( 8 ) : 477-480

DOI: 10.1093/JPIDS/PIAD052

Journal article

see the publication

Efficacy of nirsevimab against respiratory syncytial virus lower respiratory tract infections in preterm and term infants, and pharmacokinetic extrapolation to infants with congenital heart disease and chronic lung disease: a pooled analysis of randomised

Eric Simões, Shabir Madhi, William Muller, Victoria Atanasova, Miroslava Bosheva, Fernando Cabañas...

The Lancet Child & Adolescent Health . 7 ( 3 ) : 180-189

DOI: 10.1016/S2352-4642(22)00321-2

Journal article

see the publication

Avis de l'Anses relatif à l’évaluation du triphénylphosphate (TPP) (EC No 204-112-2 ; CAS No 115-86-6) dans le cadre de l’évaluation des substances sous REACH

Sakina Mhaouty-Kodja, René Habert, Sylvie Babajko, Isabelle Beau, Nicolas J. Cabaton, Marie-Chantal Canivenc-Lavier...

: 12 p.

Report

see the publication

Theratyping cystic fibrosis patients to guide elexacaftor/tezacaftor/ivacaftor out-of-label prescription

Elise Dreano, Pierre Régis Burgel, Aurelie Hatton, Naim Bouazza, Benoit Chevalier, Julie Macey...

European Respiratory Journal . 62 ( 4 ) : 2300110

DOI: 10.1183/13993003.00110-2023

Journal article

see the publication

Clinical problems in rare interstitial lung diseases

Camille Fletcher, Alice Hadchouel, Caroline Thumerelle, Manon Fleury, Nouha Jedidi, Myriam Benhamida...

European Respiratory Society .

Poster

see the publication

Prolonged response after TPO-RA discontinuation in primary ITP: results of a prospective multicenter study

Stephanie Guillet, Etienne Crickx, Imane Azzaoui, Pascal Chappert, Emmanuelle Boutin, Jean-François Viallard...

Blood .

DOI: 10.1182/blood.2022018665

Journal article

see the publication

Immune thrombocytopenia and pregnancy: an exposed/nonexposed cohort study

Stéphanie Guillet, Valentine Loustau, Emmanuelle Boutin, Anissa Zarour, Thibault Comont, Odile Souchaud-Debouverie...

Blood . 141 ( 1 ) : 11-21

DOI: 10.1182/blood.2022017277

Journal article

see the publication

Preuves de bénéfice et décision thérapeutique : enquête auprès de médecins généralistes sur la prescription d’hydroxychloroquine pour traiter la Covid-19

Remy de Castro, Michelle Johnson, Florian Naudet, Denis Pouchain, François Gueyffier, Laurent Letrilliart...

Exercer . 34 ( 195 ) : 298-304

DOI: 10.56746/EXERCER.2023.195.298

Journal article

see the publication

Outcomes of pregnancies with preterm premature rupture of membranes occurring before 24 weeks of gestation: An 11‐year observational study

Helene Gauthier-Moulinier, Daouda Ndour, Muriel Rabilloud, Kim‐an Nguyen

International Journal of Gynecology and Obstetrics . 162 ( 2 ) : 590-595

DOI: 10.1002/ijgo.14700

Journal article

see the publication

Defining standard and high dosages for β-lactam agents administered by intermittent, prolonged or continuous infusion: a PK/PD simulation study

Sylvain Goutelle, Vincent Jullien, Jean-Pierre Bru, Vincent Cattoir, Rémy Gauzit, Philippe Lesprit...

Journal of Antimicrobial Chemotherapy . 78 ( 11 ) : 2762–2769

DOI: 10.1093/jac/dkad300

Journal article

see the publication

A Knowledge-Based Approach for Evaluating Impact of Therapeutic Strategies

Nadia Abchiche-Mimouni, Mike Donald Tapi Nzali, François Gueyffier

ICAART 2023 - 15th International Conference on Agents and Artificial Intelligence . 3 : 1036-1046

DOI: 10.5220/0011894300003393

Conference paper

see the publication

Projet Rebuild the Evidence Base

Hélène Vaillant-Roussel, Clara Blanchard, Thibault Menini, Elodie Charuel, Bruno Pereira, Florian Naudet...

Exercer . 34 ( 190 ) : 81-88

DOI: 10.56746/EXERCER.2023.190.81

Journal article

see the publication

Population designations in biomedical research: limitations and perspectives

Caroline Gombault, Guillaume Grenet, Laure Ségurel, Laurent Duret, François Gueyffier, Pascal Cathébras...

HLA: Immune Response Genetics . 101 ( 1 ) : 3-15

DOI: 10.1111/tan.14852

Journal article

see the publication

Replacing liquid with solid dosage forms in pediatric practice: Feasibility and economic impact from a hospital-based study

Rama Arab, Behrouz Kassai, Roubi Kilo, Catherine Cornu, Elisabete Gomes, Tristan Dagonneau...

Therapies . 77 ( 4 ) : 445-452

DOI: 10.1016/J.THERAP.2021.12.013

Journal article

see the publication

Nirsevimab for Prevention of RSV in Healthy Late-Preterm and Term Infants

Laura Hammitt, Ron Dagan, Yuan Yuan, Manuel Baca Cots, Miroslava Bosheva, Shabir Madhi...

New England Journal of Medicine . 386 ( 9 ) : 837-846

DOI: 10.1056/NEJMoa2110275

Journal article

see the publication

Immune thrombocytopenia with clinical significance in systemic lupus erythematosus: a retrospective cohort study of 90 patients

Mickaël Roussotte, Mathieu Gerfaud-Valentin, Arnaud Hot, Sylvain Audia, Bernard Bonnotte, Thomas Thibault...

Rheumatology . 61 ( 9 ) : 3627-3639

DOI: 10.1093/rheumatology/keab925

Journal article

see the publication

You also, comment on this article

Choose an avatar
(Will not be posted on the site)
(Will not be posted on the site)