Statistics and Modelling for Health Sciences

Evaluation and Modeling with the Therapeutic Effects Group

Goutelle Sylvain

Professeur d'université - praticien hospitalier

UCBL

Address: 136 rue du Commandant Charcot
69322 Lyon cedex 05

Tel: 33 04 72 16 80 99

Email

Publications

Display of 1 to 30 publications on 113 in total

Daptomycin pharmacokinetic/pharmacodynamic target in staphylococcal infections

Romain Garreau, Truong-Thanh Pham, Laurent Bourguignon, Aurélien Millet, François Parant, David Bussy...

Clinical Infectious Diseases .

DOI: 10.1093/cid/ciae018

Journal article

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Pharmacokinetic Consideration of Venetoclax in Acute Myeloid Leukemia Patients: A Potential Candidate for TDM? A Short Communication

Michael Philippe, Jérôme Guitton, Sylvain Goutelle, Yann Thoma, Bertrand Favier, Nour Chtiba...

Therapeutic Drug Monitoring . 46 ( 1 ) : 127-131

DOI: 10.1097/FTD.0000000000001151

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Comparison of daptomycin and glycopeptide efficacy and safety for the treatment of Gram-positive infections: a systematic review and meta-analysis

Abdelwahab Boulekbache, Fanny Maldonado, Raphael Kavafian, Tristan Ferry, Laurent Bourguignon, Sylvain Goutelle...

Journal of Antimicrobial Chemotherapy .

DOI: 10.1093/jac/dkae026

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AUC-based monitoring and model-informed precision dosing of vancomycin in critically ill patients: why and how?

Sylvain Goutelle, Florent Wallet, Yann Thoma, Jean-Rémi Peclard, Laurent Bourguignon, Sabine Cohen...

Anaesthesia Critical Care & Pain Medicine . 42 ( 6 ) : 101286

DOI: 10.1016/j.accpm.2023.101286

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Population Pharmacokinetics of Vancomycin in Patients Receiving Hemodialysis in a Malian and a French Center and Simulation of the Optimal Loading Dose

Balla Coulibaly, Pascal Maire, Jêrome Guitton, Solenne Pelletier, Moustapha Tangara, Gilles Aulagner...

Therapeutic Drug Monitoring . 45 ( 5 ) : 637-643

DOI: 10.1097/FTD.0000000000001065

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Evaluation of Limited Sampling Strategies for Bayesian Estimation of Daptomycin Area Under the Concentration–Time Curve: A Short Communication

Vianney Tuloup, Aurélien Millet, Alessandra Taricco, François Parant, Tristan Ferry, Sylvain Goutelle

Therapeutic Drug Monitoring . 45 ( 4 ) : 562-565

DOI: 10.1097/FTD.0000000000001070

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From Personalized to Precision Medicine in Oncology: A Model-Based Dosing Approach to Optimize Achievement of Imatinib Target Exposure

Sylvain Goutelle, Monia Guidi, Verena Gotta, Chantal Csajka, Thierry Buclin, Nicolas Widmer

Pharmaceutics . 15 ( 4 ) : 1081

DOI: 10.3390/pharmaceutics15041081

Journal article

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Suboptimal exposure to fluconazole in critically ill patients: Pharmacokinetic analysis and determinants

A.L. Bienvenu, P. Pradat, E. Matusik, V. Piriou, T. Rimmelé, F. Parant...

Infectious Diseases Now . 53 ( 2 ) : 104630

DOI: 10.1016/j.idnow.2022.10.002

Journal article

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Evaluation of Renal Impairment Influence on Metabolic Drug Clearance using a Modelling Approach

Vianney Tuloup, Sylvain Goutelle, Michel Tod, Laurent Bourguignon

Clinical Pharmacokinetics . 62 ( 2 ) : 307-319

DOI: 10.1007/s40262-022-01205-3

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Daptomycin Exposure as a Risk Factor for Daptomycin-Induced Eosinophilic Pneumonia and Muscular Toxicity

Romain Garreau, Truong-Thanh Pham, Laurent Bourguignon, Aurélien Millet, François Parant, David Bussy...

Clinical Infectious Diseases . 77 ( 10 ) : 1372-1380

DOI: 10.1093/cid/ciad386

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Defining standard and high dosages for β-lactam agents administered by intermittent, prolonged or continuous infusion: a PK/PD simulation study

Sylvain Goutelle, Vincent Jullien, Jean-Pierre Bru, Vincent Cattoir, Rémy Gauzit, Philippe Lesprit...

Journal of Antimicrobial Chemotherapy . 78 ( 11 ) : 2762–2769

DOI: 10.1093/jac/dkad300

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Cefepime Precision Dosing Tool: from Standard to Precise Dose Using Nonparametric Population Pharmacokinetics

Mohammad Alshaer, Sylvain Goutelle, Barbara Santevecchi, Bethany Shoulders, Veena Venugopalan, Kartikeya Cherabuddi...

Antimicrobial Agents and Chemotherapy . 66 ( 2 ) : e0204621

DOI: 10.1128/AAC.02046-21

Journal article

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Amikacin in emergency surgery: How to dose it optimally?

Sylvain Goutelle, Guérin Fritsch, Marie Leroy, Catherine Piron, Camille Salvez, Pascal Incagnoli...

Anaesthesia Critical Care & Pain Medicine . 41 ( 1 ) : 100990

DOI: 10.1016/j.accpm.2021.100990

Journal article

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Implementation assessment of a patient personalized clinical pharmacy programme (5P project) into orthogeriatric care pathway

Julie Martin, Marine Barral, Audrey Janoly Dumenil, Emmanuelle Carre, Nicolas Poletto, Sylvain Goutelle...

Journal of Clinical Pharmacy and Therapeutics . 47 ( 7 ) : 956-963

DOI: 10.1111/jcpt.13627

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Implementation and Comparison of Two Pharmacometric Tools for Model-Based Therapeutic Drug Monitoring and Precision Dosing of Daptomycin

Justine Heitzmann, Yann Thoma, Romain Bricca, Marie-Claude Gagnieu, Vincent Leclerc, Sandrine Roux...

Pharmaceutics . 14 ( 1 ) : 114

DOI: 10.3390/pharmaceutics14010114

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Implementation and Cross-Validation of a Pharmacokinetic Model for Precision Dosing of Busulfan in Hematopoietic Stem Cell Transplanted Children

Sylvain Goutelle, Yann Thoma, Roxane Buffet, Michael Philippe, Thierry Buclin, Monia Guidi...

Pharmaceutics . 14 ( 10 ) : 2107

DOI: 10.3390/pharmaceutics14102107

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Pharmacokinetic/Pharmacodynamic Simulations of Cost-Effective Dosage Regimens of Ceftolozane-Tazobactam and Ceftazidime-Avibactam in Patients with Renal Impairment

Lucile Dheyriat, Laurent Bourguignon, Thomas Perpoint, Tristan Ferry, Sylvain Goutelle

Antimicrobial Agents and Chemotherapy . 66 ( 3 ) : e0210421

DOI: 10.1128/AAC.02104-21

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Therapeutic Drug Monitoring of Antibiotic Drugs in Patients Receiving Continuous Renal Replacement Therapy or Intermittent Hemodialysis: A Critical Review

Elodie Matusik, Clément Boidin, Arnaud Friggeri, Jean-Christophe Richard, Laurent Bitker, Jason Roberts...

Therapeutic Drug Monitoring . 44 ( 1 ) : 86-102

DOI: 10.1097/FTD.0000000000000941

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Daptomycin Physiology-Based Pharmacokinetic Modeling to Predict Drug Exposure and Pharmacodynamics in Skin and Bone Tissues

Romain Garreau, Damien Montange, Antoine Grillon, François Jehl, Tristan Ferry, Laurent Bourguignon...

Clinical Pharmacokinetics . 61 ( 10 ) : 1443-1456

DOI: 10.1007/s40262-022-01168-5

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Implementation of Model-Based Dose Adjustment of Tobramycin in Adult Patients with Cystic Fibrosis

Jérémy Reverchon, Vianney Tuloup, Romain Garreau, Viviane Nave, Sabine Cohen, Philippe Reix...

Pharmaceutics . 14 ( 8 ) : 1750

DOI: 10.3390/pharmaceutics14081750

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Seventeen Cases of Daptomycin-Induced Eosinophilic Pneumonia in a Cohort of Patients Treated for Bone and Joint Infections: Proposal for a New Algorithm

Truong-Thanh Pham, Romain Garreau, Fabien Craighero, Vincent Cottin, Benoît Ben Said, Sylvain Goutelle...

Open Forum Infectious Diseases . 9 ( 11 ) : ofac577

DOI: 10.1093/ofid/ofac577

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An Investigation of O-Demethyl Tramadol/Tramadol Ratio for Cytochrome P450 2D6 Phenotyping: The CYTRAM Study

Blandine de la Gastine, Soizic Percevault, Laurent Varin, Nicolas Richard, Fabienne Fobe, Benoît Plaud...

Pharmaceutics . 14 ( 10 ) : 2177

DOI: 10.3390/pharmaceutics14102177

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Pharmacokinetic/Pharmacodynamic Dosage Individualization of Cefepime in Critically Ill Patients: A Case Study

Sylvain Goutelle, Lucille Jay, Clément Boidin, Sabine Cohen, Laurent Bourguignon, Nathalie Bleyzac...

Therapeutic Drug Monitoring . 43 ( 4 ) : 451-454

DOI: 10.1097/FTD.0000000000000896

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To Estimate or to Forecast? Lessons From a Comparative Analysis of Four Bayesian Fitting Methods Based on Nonparametric Models

Sylvain Goutelle, Céline Alloux, Laurent Bourguignon, Michael van Guilder, Michael Neely, Pascal Maire

Therapeutic Drug Monitoring . 43 ( 4 ) : 461-471

DOI: 10.1097/FTD.0000000000000879

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Adherence to oral antibiotic therapy in patients with bone and joint infection: A pilot study

Laure Lalande, Constance Bretagnolle, Eugénie Mabrut, Tristan Ferry, Sylvain Goutelle

Infectious Diseases Now . 51 ( 4 ) : 334-339

DOI: 10.1016/j.idnow.2020.10.007

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Pharmacokinetic/Pharmacodynamic Dosage Individualization of Suppressive Beta-Lactam Therapy Administered by Subcutaneous Route in Patients With Prosthetic Joint Infection

Sylvain Goutelle, Anne Conrad, Cécile Pouderoux, Evelyne Braun, Frédéric Laurent, Marie-Claude Gagnieu...

Frontiers in Medicine . 8 : 583086

DOI: 10.3389/fmed.2021.583086

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Parametric and Nonparametric Methods in Population Pharmacokinetics: Experts’ Discussion on Use, Strengths, and Limitations

Sylvain Goutelle, Jean-Baptiste Woillard, Thierry Buclin, Laurent Bourguignon, Walter Yamada, Chantal Csajka...

Journal of Clinical Pharmacology . 62 ( 2 ) : 158-170

DOI: 10.1002/jcph.1993

Journal article

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Pharmacogenetic-guided glimepiride therapy in type-2 diabetes mellitus: a cost-effectiveness study

Cécile Fokoun, Hassan Serrier, Hugo Rabier, Sylvain Goutelle, Michel Tod, Laurent Bourguignon

Pharmacogenomics Journal . 21 ( 5 ) : 559-565

DOI: 10.1038/s41397-021-00232-w

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Estimating renal function when adjusting the dosage of antibiotics: Facts and fables

Sylvain Goutelle, N. Bleyzac, L. Mioux, B. de la Gastine, L. Bourguignon

Infectious Diseases Now . 51 ( 7 ) : 635-637

DOI: 10.1016/j.idnow.2021.01.012

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Population Pharmacokinetic Modeling and Dosing Simulations of Tobramycin in Pediatric Patients with Cystic Fibrosis

Antonin Praet, Laurent Bourguignon, Florence Vetele, Valentine Bréant, Charlotte Genestet, Oana Dumitrescu...

Antimicrobial Agents and Chemotherapy . 65 ( 10 ) : e0073721

DOI: 10.1128/AAC.00737-21

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