Statistics and Modelling for Health Sciences

Evaluation and Modeling with the Therapeutic Effects Group

Goutelle Sylvain

Professeur d'université - praticien hospitalier

UCBL

Address: 136 rue du Commandant Charcot
69322 Lyon cedex 05

Tel: 33 04 72 16 80 99

Email

Publications

Display of 1 to 30 publications on 116 in total

Parametric and nonparametric population pharmacokinetic analysis of fluconazole in critically ill patients and dosing simulations for Candida infections

Elodie Matusik, Olivia Vassal, Anne Conrad, Tristan Ferry, Aurélien Millet, Damien Dupont...

Antimicrobial Agents and Chemotherapy . 68 ( 11 )

DOI: 10.1128/aac.00991-24

Journal article

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Parametric and nonparametric population pharmacokinetic analysis of fluconazole in critically ill patients and dosing simulations for Candida infections

Elodie Matusik, Olivia Vassal, Anne Conrad, Tristan Ferry, Aurélien Millet, Damien Dupont...

Antimicrobial Agents and Chemotherapy . 68 ( 11 )

DOI: 10.1128/aac.00991-24

Journal article

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Comment on “Antimicrobial susceptibility of Bacteroides fragilis group organisms in Hong Kong, 2020–2021”

H. Marchandin, L. Dubreuil, Marlène Amara, Guillaume Aubin, François Caron, Vincent Cattoir...

Anaerobe . 90 : 102910

DOI: 10.1016/j.anaerobe.2024.102910

Journal article

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Daptomycin pharmacokinetic/pharmacodynamic target in staphylococcal infections

Romain Garreau, Truong-Thanh Pham, Laurent Bourguignon, Aurélien Millet, François Parant, David Bussy...

Clinical Infectious Diseases .

DOI: 10.1093/cid/ciae018

Journal article

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Pharmacokinetic Consideration of Venetoclax in Acute Myeloid Leukemia Patients: A Potential Candidate for TDM? A Short Communication

Michael Philippe, Jérôme Guitton, Sylvain Goutelle, Yann Thoma, Bertrand Favier, Nour Chtiba...

Therapeutic Drug Monitoring . 46 ( 1 ) : 127-131

DOI: 10.1097/FTD.0000000000001151

Journal article

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Comparison of daptomycin and glycopeptide efficacy and safety for the treatment of Gram-positive infections: a systematic review and meta-analysis

Abdelwahab Boulekbache, Fanny Maldonado, Raphael Kavafian, Tristan Ferry, Laurent Bourguignon, Sylvain Goutelle...

Journal of Antimicrobial Chemotherapy .

DOI: 10.1093/jac/dkae026

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AUC-based monitoring and model-informed precision dosing of vancomycin in critically ill patients: why and how?

Sylvain Goutelle, Florent Wallet, Yann Thoma, Jean-Rémi Peclard, Laurent Bourguignon, Sabine Cohen...

Anaesthesia Critical Care & Pain Medicine . 42 ( 6 ) : 101286

DOI: 10.1016/j.accpm.2023.101286

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Population Pharmacokinetics of Vancomycin in Patients Receiving Hemodialysis in a Malian and a French Center and Simulation of the Optimal Loading Dose

Balla Coulibaly, Pascal Maire, Jêrome Guitton, Solenne Pelletier, Moustapha Tangara, Gilles Aulagner...

Therapeutic Drug Monitoring . 45 ( 5 ) : 637-643

DOI: 10.1097/FTD.0000000000001065

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Evaluation of Limited Sampling Strategies for Bayesian Estimation of Daptomycin Area Under the Concentration–Time Curve: A Short Communication

Vianney Tuloup, Aurélien Millet, Alessandra Taricco, François Parant, Tristan Ferry, Sylvain Goutelle

Therapeutic Drug Monitoring . 45 ( 4 ) : 562-565

DOI: 10.1097/FTD.0000000000001070

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From Personalized to Precision Medicine in Oncology: A Model-Based Dosing Approach to Optimize Achievement of Imatinib Target Exposure

Sylvain Goutelle, Monia Guidi, Verena Gotta, Chantal Csajka, Thierry Buclin, Nicolas Widmer

Pharmaceutics . 15 ( 4 ) : 1081

DOI: 10.3390/pharmaceutics15041081

Journal article

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Suboptimal exposure to fluconazole in critically ill patients: Pharmacokinetic analysis and determinants

A.L. Bienvenu, P. Pradat, E. Matusik, V. Piriou, T. Rimmelé, F. Parant...

Infectious Diseases Now . 53 ( 2 ) : 104630

DOI: 10.1016/j.idnow.2022.10.002

Journal article

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Evaluation of Renal Impairment Influence on Metabolic Drug Clearance using a Modelling Approach

Vianney Tuloup, Sylvain Goutelle, Michel Tod, Laurent Bourguignon

Clinical Pharmacokinetics . 62 ( 2 ) : 307-319

DOI: 10.1007/s40262-022-01205-3

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Daptomycin Exposure as a Risk Factor for Daptomycin-Induced Eosinophilic Pneumonia and Muscular Toxicity

Romain Garreau, Truong-Thanh Pham, Laurent Bourguignon, Aurélien Millet, François Parant, David Bussy...

Clinical Infectious Diseases . 77 ( 10 ) : 1372-1380

DOI: 10.1093/cid/ciad386

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Defining standard and high dosages for β-lactam agents administered by intermittent, prolonged or continuous infusion: a PK/PD simulation study

Sylvain Goutelle, Vincent Jullien, Jean-Pierre Bru, Vincent Cattoir, Rémy Gauzit, Philippe Lesprit...

Journal of Antimicrobial Chemotherapy . 78 ( 11 ) : 2762–2769

DOI: 10.1093/jac/dkad300

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Cefepime Precision Dosing Tool: from Standard to Precise Dose Using Nonparametric Population Pharmacokinetics

Mohammad Alshaer, Sylvain Goutelle, Barbara Santevecchi, Bethany Shoulders, Veena Venugopalan, Kartikeya Cherabuddi...

Antimicrobial Agents and Chemotherapy . 66 ( 2 ) : e0204621

DOI: 10.1128/AAC.02046-21

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Amikacin in emergency surgery: How to dose it optimally?

Sylvain Goutelle, Guérin Fritsch, Marie Leroy, Catherine Piron, Camille Salvez, Pascal Incagnoli...

Anaesthesia Critical Care & Pain Medicine . 41 ( 1 ) : 100990

DOI: 10.1016/j.accpm.2021.100990

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Pharmacokinetic/Pharmacodynamic Simulations of Cost-Effective Dosage Regimens of Ceftolozane-Tazobactam and Ceftazidime-Avibactam in Patients with Renal Impairment

Lucile Dheyriat, Laurent Bourguignon, Thomas Perpoint, Tristan Ferry, Sylvain Goutelle

Antimicrobial Agents and Chemotherapy . 66 ( 3 ) : e0210421

DOI: 10.1128/AAC.02104-21

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Implementation assessment of a patient personalized clinical pharmacy programme (5P project) into orthogeriatric care pathway

Julie Martin, Marine Barral, Audrey Janoly Dumenil, Emmanuelle Carre, Nicolas Poletto, Sylvain Goutelle...

Journal of Clinical Pharmacy and Therapeutics . 47 ( 7 ) : 956-963

DOI: 10.1111/jcpt.13627

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Implementation and Comparison of Two Pharmacometric Tools for Model-Based Therapeutic Drug Monitoring and Precision Dosing of Daptomycin

Justine Heitzmann, Yann Thoma, Romain Bricca, Marie-Claude Gagnieu, Vincent Leclerc, Sandrine Roux...

Pharmaceutics . 14 ( 1 ) : 114

DOI: 10.3390/pharmaceutics14010114

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Implementation and Cross-Validation of a Pharmacokinetic Model for Precision Dosing of Busulfan in Hematopoietic Stem Cell Transplanted Children

Sylvain Goutelle, Yann Thoma, Roxane Buffet, Michael Philippe, Thierry Buclin, Monia Guidi...

Pharmaceutics . 14 ( 10 ) : 2107

DOI: 10.3390/pharmaceutics14102107

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Therapeutic Drug Monitoring of Antibiotic Drugs in Patients Receiving Continuous Renal Replacement Therapy or Intermittent Hemodialysis: A Critical Review

Elodie Matusik, Clément Boidin, Arnaud Friggeri, Jean-Christophe Richard, Laurent Bitker, Jason Roberts...

Therapeutic Drug Monitoring . 44 ( 1 ) : 86-102

DOI: 10.1097/FTD.0000000000000941

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Daptomycin Physiology-Based Pharmacokinetic Modeling to Predict Drug Exposure and Pharmacodynamics in Skin and Bone Tissues

Romain Garreau, Damien Montange, Antoine Grillon, François Jehl, Tristan Ferry, Laurent Bourguignon...

Clinical Pharmacokinetics . 61 ( 10 ) : 1443-1456

DOI: 10.1007/s40262-022-01168-5

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Implementation of Model-Based Dose Adjustment of Tobramycin in Adult Patients with Cystic Fibrosis

Jérémy Reverchon, Vianney Tuloup, Romain Garreau, Viviane Nave, Sabine Cohen, Philippe Reix...

Pharmaceutics . 14 ( 8 ) : 1750

DOI: 10.3390/pharmaceutics14081750

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Seventeen Cases of Daptomycin-Induced Eosinophilic Pneumonia in a Cohort of Patients Treated for Bone and Joint Infections: Proposal for a New Algorithm

Truong-Thanh Pham, Romain Garreau, Fabien Craighero, Vincent Cottin, Benoît Ben Said, Sylvain Goutelle...

Open Forum Infectious Diseases . 9 ( 11 ) : ofac577

DOI: 10.1093/ofid/ofac577

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An Investigation of O-Demethyl Tramadol/Tramadol Ratio for Cytochrome P450 2D6 Phenotyping: The CYTRAM Study

Blandine de la Gastine, Soizic Percevault, Laurent Varin, Nicolas Richard, Fabienne Fobe, Benoît Plaud...

Pharmaceutics . 14 ( 10 ) : 2177

DOI: 10.3390/pharmaceutics14102177

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Drug-related problems among older patients: Analysis of 8 years of pharmacist's interventions

F. Gervais, T. Novais, Sylvain Goutelle, M. Chappuy, S. Parat, D. Cabelguenne...

Annales Pharmaceutiques Françaises . 79 ( 5 ) : 511-521

DOI: 10.1016/j.pharma.2021.02.002

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Pharmacokinetic/Pharmacodynamic Dosage Individualization of Cefepime in Critically Ill Patients: A Case Study

Sylvain Goutelle, Lucille Jay, Clément Boidin, Sabine Cohen, Laurent Bourguignon, Nathalie Bleyzac...

Therapeutic Drug Monitoring . 43 ( 4 ) : 451-454

DOI: 10.1097/FTD.0000000000000896

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To Estimate or to Forecast? Lessons From a Comparative Analysis of Four Bayesian Fitting Methods Based on Nonparametric Models

Sylvain Goutelle, Céline Alloux, Laurent Bourguignon, Michael van Guilder, Michael Neely, Pascal Maire

Therapeutic Drug Monitoring . 43 ( 4 ) : 461-471

DOI: 10.1097/FTD.0000000000000879

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Adherence to oral antibiotic therapy in patients with bone and joint infection: A pilot study

Laure Lalande, Constance Bretagnolle, Eugénie Mabrut, Tristan Ferry, Sylvain Goutelle

Infectious Diseases Now . 51 ( 4 ) : 334-339

DOI: 10.1016/j.idnow.2020.10.007

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Pharmacokinetic/Pharmacodynamic Dosage Individualization of Suppressive Beta-Lactam Therapy Administered by Subcutaneous Route in Patients With Prosthetic Joint Infection

Sylvain Goutelle, Anne Conrad, Cécile Pouderoux, Evelyne Braun, Frédéric Laurent, Marie-Claude Gagnieu...

Frontiers in Medicine . 8 : 583086

DOI: 10.3389/fmed.2021.583086

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