Statistics and Modelling for Health Sciences

Evaluation and Modeling with the Therapeutic Effects Group

Goutelle Sylvain

Professeur d'université - praticien hospitalier

UCBL

Address: 136 rue du Commandant Charcot
69322 Lyon cedex 05

Tel: 33 04 72 16 80 99

Email

Publications

Display of 31 to 59 publications on 59 in total

Subcutaneous administration of levetiracetam in geriatrics

O. Maison, B. de La Gastine, L. Peter-Derex, C. Berger, Sylvain Goutelle

Revue Neurologique . 171 : 398-399

Journal article

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A pharmacometric pulmonary model predicting the extent and rate of distribution from plasma to epithelial lining fluid and alveolar cells-using rifampicin as an example

O. Clewe, Sylvain Goutelle, Jr. Conte, Ush. Simonsson

European Journal of Clinical Pharmacology . 71 ( 3 ) : 313-9

DOI: 10.1007/s00228-014-1798-3

Journal article

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Quantitative methods for prediction of the effect of cytochrome P450 gene polymorphisms on substrate drug exposure

Sylvain Goutelle, M. Tod

Clinical Pharmacokinetics . 54 : 319-20

Journal article

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Model-Based Determination of Effective Blood Concentrations of Cyclosporine for Neutrophil Response in the Treatment of Severe Aplastic Anemia in Children

M. Philippe, E. Henin, Y. Bertrand, D. Plantaz, Sylvain Goutelle, N. Bleyzac

AAPS Journal . 17 ( 5 ) : 1157-67

DOI: 10.1208/s12248-015-9779-8

Journal article

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Population modeling and simulation study of the pharmacokinetics and antituberculosis pharmacodynamics of isoniazid in lungs

Laure Lalande, Laurent Bourguignon, S. Bihari, P. Maire, M. Neely, R. Jelliffe...

Antimicrobial Agents and Chemotherapy . 59 ( 9 ) : 5181-5189

DOI: 10.1128/AAC.00462-15

Journal article

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Influence of renal function estimation on pharmacokinetic modeling of vancomycin in elderly patients

A. Glatard, Laurent Bourguignon, R. W. Jelliffe, P. Maire, M. N. Neely, Sylvain Goutelle

Antimicrobial Agents and Chemotherapy . 59 ( 6 ) : 2986-94

DOI: 10.1128/AAC.04132-14

Journal article

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A Prediction Model of Drug Exposure in Cirrhotic Patients According to Child-Pugh Classification

J. Steelandt, E. Jean-Bart, Sylvain Goutelle, M. Tod

Clinical Pharmacokinetics . 54 : 1245-58

DOI: 10.1007/s40262-015-0288-9

Journal article

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The Case for Using Higher Doses of First Line Anti-Tuberculosis Drugs to Optimize Efficacy

Sylvain Goutelle, Laurent Bourguignon, P. Maire, R. W. Jelliffe, M. Neely

Current Pharmaceutical Design . 20 : 6191-6206

Journal article

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Pharmacokinetic Drug Interaction Between Cyclosporine and Imatinib in Bone Marrow Transplant Children and Model-Based Reappraisal of Imatinib Drug Interaction Profile

Nathalie Bleyzac, K. Kebaili, V. Mialou, Y. Bertrand, Sylvain Goutelle

Therapeutic Drug Monitoring . 36 : 724-729

Journal article

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Pharmacokinetic drug-drug interaction of calcium channel blockers with cyclosporine in hematopoietic stem cell transplant children

E. Bernard, Sylvain Goutelle, Y. Bertrand, Nathalie Bleyzac

The Annals of Pharmacotherapy . 48 : 1580-4

DOI: 10.1177/1060028014550644

Journal article

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Determinants of torsades de pointes in older patients with drug-associated long QT syndrome: a case-control study

Sylvain Goutelle, E. Sidolle, M. Ducher, J. Caron, Q. Timour, Patrice Nony...

Drugs & aging . 31 : 601-9

Journal article

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Exposure to anticholinergic and sedative drugs, risk of falls, and mortality: an elderly inpatient, multicenter cohort

V. Dauphinot, R. Faure, S. Omrani, Sylvain Goutelle, Laurent Bourguignon, P. Krolak-Salmon...

Journal of clinical psychopharmacology . 34 : 565-70

DOI: 10.1097/JCP.0000000000000195

Journal article

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Pharmacokinetic-pharmacodynamic modeling of unboosted Atazanavir in a cohort of stable HIV-infected patients.

Sylvain Goutelle, Thomas Baudry, Marie-Claude Gagnieu, André Boibieux, Jean-Michel Livrozet, Dominique Peyramond...

Antimicrobial Agents and Chemotherapy . 57 ( 1 ) : 517-23

DOI: 10.1128/AAC.01822-12

Journal article

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Comparison of Four Renal Function Estimation Equations for Pharmacokinetic Modeling of Gentamicin in Geriatric Patients

N. Charhon, M.N. Neely, Laurent Bourguignon, P. Maire, R.W. Jelliffe, Sylvain Goutelle

Antimicrobial Agents and Chemotherapy . 56 ( 4 ) : 1862-1869

DOI: 10.1128/AAC.05634-11

Journal article

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Prescriptions analysis by clinical pharmacists in the post-operative period: a 4-year prospective study.

B. Charpiat, Sylvain Goutelle, M. Schoeffler, F. Aubrun, J.-P. Viale, C. Ducerf...

Acta Anaesthesiologica Scandinavica . 56 ( 8 ) : 1047-51

DOI: 10.1111/j.1399-6576.2011.02644.x

Journal article

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Probable Drug Interaction Between Intravenous Ciprofloxacin and Mycophenolate Mofetil in a Bone Marrow Transplant Recipient

Sylvain Goutelle, V. Mialou, A. Gouraud, F. Parant, N. Bleyzac

Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy . 31(1) : 36-40

Journal article

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Mathematical modeling of pulmonary tuberculosis therapy: insights from a prototype model with rifampin

Sylvain Goutelle, Laurent Bourguignon, Roger W. Jelliffe, John E. Conte, Pascal Maire

Journal of Theoretical Biology .

DOI: 10.1016/j.jtbi.2011.05.013

Journal article

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Mathematical modeling of pulmonary tuberculosis therapy: Insights from a prototype model with rifampin

Sylvain Goutelle, Laurent Bourguignon, R-W. Jelliffe, J.E. Conte, P. Maire

Journal of Theoretical Biology . 282 ( 1 ) : 80-92

DOI: 10.1016/j.jtbi.2011.05.013

Journal article

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Genotype-Based Quantitative Prediction of Drug Exposure for Drugs Metabolized by CYP2D6

Michel Tod, Sylvain Goutelle, M.C. Gagnieu, Working Group The Genophar Ii

Clinical Pharmacology and Therapeutics . 90 : 582-587

Journal article

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Quantitative prediction of cytochrome P450(CYP) 2D6-Mediated drug interactions

Michel Tod, Sylvain Goutelle, F. Clavel-Grabit, G. Nicolas, B. Charpiat

Clinical Pharmacokinetics . 50(8) : 519-530

Journal article

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Intrapulmonary Pharmacokinetics and Pharmacodynamics of Micafungin in Adult Lung Transplant Patients

T. Walsh, Sylvain Goutelle, R.-W. Jelliffe, J.A. Golden, E.A. Little, C. Devoe...

Antimicrobial Agents and Chemotherapy . 54 ( 8 ) : 3451-3459

DOI: 10.1128/AAC.01647-09

Journal article

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Oral Voriconazole Dose in children: One size does not fit all

Sylvain Goutelle, R. Larcher, C. Padoin, V. Mialou, N. Bleyzac

Clinical Infectious Diseases . 51 ( 7 ) : 870-870

DOI: 10.1086/656293

Journal article

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Variabilité pharmacocinétique intra-individuelle et traitement antibiotique prolongé

Laurent Bourguignon, Sylvain Goutelle, Julie Burdin de Saint Martin, Anne Guillermet, P. Bouniot, Pascal Maire...

Médecine et Maladies Infectieuses . 2859 : 38-41

DOI: 10.1016/j.medmal.2009.03.003

Journal article

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Population Modeling and Monte Carlo Simulation Study of the Pharmacokinetics and Antituberculosis Pharmacodynamics of Rifampin in Lungs

Sylvain Goutelle, Laurent Bourguignon, P. Maire, M. van Guilder, J.-D. Conte, R.-W. Jelliffe

Antimicrobial Agents and Chemotherapy . 53(7) : 2974-2981

Journal article

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Evaluation of various gentamicin dosage regimens in geriatric patients: a simulation study

Laurent Bourguignon, Sylvain Goutelle, J. Burdin de Saint Martin, P. Maire, M. Ducher

Fundamental & Clinical Pharmacology . -- : 1-5

Journal article

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Modification of Diet in Renal Disease and Modified Cockcroft-Gault Formulas in Predicting Aminoglycoside Elimination

Sylvain Goutelle, Laurent Bourguignon, M. Ducher, P. Maire

The Annals of Pharmacotherapy . 43 : 1143-1146

Journal article

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Pharmacocinétique de l'amikacine chez l'adulte : une hétérogénéité qui remet en cause le calcul de la dose basé sur le poids

Laurent Bourguignon, Sylvain Goutelle, C. Gérard, A. Guillermet, J. Burdin de Saint Martin, P. Maire...

Thérapie . 64 ( 1 ) : 189-194

Journal article

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The Hill equation: a review of its capabilities in pharmacological modelling

Sylvain Goutelle, M. Maurinc, F. Rougier, X. Barbaut, Laurent Bourguignon, M. Ducher...

Fundamental & Clinical Pharmacology . 22 : 633-648

Journal article

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Pharmacocinétique de la teicoplanine chez le sujet âgé : construction d'un modèle pour le suivi thérapeutique

Laurent Bourguignon, Sylvain Goutelle, P. Bouniot, A. Guillermet, J. Burdin de Saint-Martin, P. Maire...

Journal de Pharmacie Clinique . 27 ( 3 ) : 189-194

Journal article

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