Goutelle Sylvain

An Investigation of O-Demethyl Tramadol/Tramadol Ratio for Cytochrome P450 2D6 Phenotyping: The CYTRAM Study

Blandine de la Gastine, Soizic Percevault, Laurent Varin, Nicolas Richard, Fabienne Fobe, Benoît Plaud...

Pharmaceutics . 14 ( 10 ) : 2177

DOI: 10.3390/pharmaceutics14102177

2022

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Population pharmacokinetics of daptomycin in patients with bone and joint infection: minimal effect of rifampicin co-administration and confirmation of a sex difference

Romain Garreau, Romain Bricca, Marie-Claude Gagnieu, Sandrine Roux, Anne Conrad, Laurent Bourguignon...

Journal of Antimicrobial Chemotherapy . 76 ( 5 ) : 1250-1257

DOI: 10.1093/jac/dkab006

2021

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Model-Based Comparative Analysis of Rifampicin and Rifabutin Drug-Drug Interaction Profile

Vianney Tuloup, Mathilde France, Romain Garreau, Nathalie Bleyzac, Laurent Bourguignon, Michel Tod...

Antimicrobial Agents and Chemotherapy . 65 ( 9 ) : e0104321

DOI: 10.1128/AAC.01043-21

2021

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Population Pharmacokinetics and Dosing Simulation of Vancomycin Administered by Continuous Injection in Critically Ill Patient

Romain Garreau, Benoît Falquet, Lisa Mioux, Laurent Bourguignon, Tristan Ferry, Michel Tod...

Antibiotics . 10 ( 10 ) : 1228

DOI: 10.3390/antibiotics10101228

2021

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Rifampicin exposure reveals within-host Mycobacterium tuberculosis diversity in patients with delayed culture conversion

Charlotte Genestet, Elisabeth Hodille, Alexia Barbry, Jean-Luc Berland, Jonathan Hoffmann, Emilie Westeel...

PLoS Pathogens . 17 ( 6 ) : e1009643

DOI: 10.1371/journal.ppat.1009643

2021

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Amikacin Initial Dose in Critically Ill Patients: a Nonparametric Approach To Optimize A Priori Pharmacokinetic/Pharmacodynamic Target Attainments in Individual Patients

Clément Boidin, Laurent Bourguignon, Sabine Cohen, Claire Roger, Jean-Yves Lefrant, Jason A. Roberts...

Antimicrobial Agents and Chemotherapy . 63 ( 11 ) : e00993-19

DOI: 10.1128/AAC.00993-19

2019

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Pharmacokinetic variability of beta-lactams in critically ill patients: A narrative review

Clément Boidin, Parastou Moshiri, Claire Dahyot-Fizelier, Sylvain Goutelle, Sandrine Lefeuvre

Anaesthesia Critical Care & Pain Medicine .

DOI: 10.1016/j.accpm.2019.07.016

2019

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Prospective Cohort Study of the Tolerability of Prosthetic Joint Infection Empirical Antimicrobial Therapy

Claire Triffault-Fillit, Florent Valour, Ronan Guillo, Michel Tod, Sylvain Goutelle, Sébastien Lustig...

ANTIMICROB. AGENTS CHEMOTHER. . 62 ( 10 )

DOI: 10.1128/AAC.00163-18

2018

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Antituberculous drugs modulate bacterial phagolysosome avoidance and autophagy in Mycobacterium tuberculosis-infected macrophages

Charlotte Genestet, Fanny Bernard-Barret, Elisabeth Hodille, Christophe Ginevra, Florence Ader, Sylvain Goutelle...

Tuberculosis . 111 : 67-70

DOI: 10.1016/j.tube.2018.05.014

2018

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Assessing the Combined Antibacterial Effect of Isoniazid and Rifampin on Four Mycobacterium tuberculosis Strains Using In Vitro Experiments and Response-Surface Modeling

Charlotte Genestet, Florence Ader, Catherine Pichat, Gérard Lina, Oana Dumitrescu, Sylvain Goutelle

Antimicrobial Agents and Chemotherapy . 62 ( 1 )

DOI: 10.1128/AAC.01413-17

2018

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The Role of Antibiotics in Modulating Virulence in Staphylococcus aureus

Elisabeth Hodille, Warren Rose, Binh An Diep, Sylvain Goutelle, Gérard Lina, Oana Dumitrescu

Clinical Microbiology Reviews . 30 ( 4 ) : 887-917

DOI: 10.1128/CMR.00120-16

2017

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Is Trough Concentration of Vancomycin Predictive of the Area Under the Curve? A Clinical Study in Elderly Patients

A. Bel Kamel, Laurent Bourguignon, M. Marcos, M. Ducher, Sylvain Goutelle

Therapeutic Drug Monitoring . 39 : 83-87

DOI: 10.1097/FTD.0000000000000359

2017

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Implications of using the MDRD or CKD-EPI equation instead of the Cockcroft-Gault equation for estimating renal function and drug dosage adjustment in elderly patients

E. Cartet-Farnier, L. Goutelle-Audibert, P. Maire, B. de La Gastine, Sylvain Goutelle

Fundamental & Clinical Pharmacology . 31 : 110-119

DOI: 10.1111/fcp.12241

2017

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A Model for Predicting the Interindividual Variability of Drug-Drug Interactions

M. Tod, Laurent Bourguignon, N. Bleyzac, Sylvain Goutelle

AAPS Journal . 19 : 497-509

DOI: 10.1208/s12248-016-0021-0

2017

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Population pharmacokinetics of teicoplanin administered by subcutaneous or intravenous route and simulation of optimal loading dose regimen

Yoann Cazaubon, Nicolas Venisse, Olivier Mimoz, Pascal Maire, Michel Ducher, Laurent Bourguignon...

Journal of Antimicrobial Chemotherapy . 72 ( 10 ) : 2804-2812

DOI: 10.1093/jac/dkx242

2017

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Mechanisms of drug-drug interaction between rifampicin and fusidic acid

Florianne Bel, Laurent Bourguignon, Michel Tod, Tristan Ferry, Sylvain Goutelle

British Journal of Clinical Pharmacology . 83 ( 8 ) : 1862-1864

DOI: 10.1111/bcp.13277

2017

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A Nonparametric Method to Optimize Initial Drug Dosing and Attainment of a Target Exposure Interval: Concepts and Application to Busulfan in Pediatrics

M. Philippe, M. Neely, Y. Bertrand, N. Bleyzac, Sylvain Goutelle

Clinical Pharmacokinetics . 56 : 435-447

DOI: 10.1007/s40262-016-0448-6

2017

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Prevalence and Risk Factors of Drug-Associated Corrected QT Prolongation in Elderly Hospitalized Patients: Results of a Retrospective Analysis of Data Obtained Over 6 Months

O. Maison, B. de La Gastine, L. Dayot, Sylvain Goutelle

Drugs & aging . 34 : 545-553

DOI: 10.1007/s40266-017-0467-5

2017

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Quantitative Prediction of Drug Interactions Caused by CYP1A2 Inhibitors and Inducers

L. Gabriel, M. Tod, Sylvain Goutelle

Clinical Pharmacokinetics . 55 : 977-990

DOI: 10.1007/s40262-016-0371-x

2016

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Accurately Achieving Target Busulfan Exposure in Children and Adolescents With Very Limited Sampling and the BestDose Software

M. Neely, M. Philippe, T. Rushing, X. Fu, M. van Guilder, D. Bayard...

Therapeutic Drug Monitoring . 38 : 332-342

DOI: 10.1097/FTD.0000000000000276

2016

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Should busulfan therapeutic range be narrowed in pediatrics? Experience from a large cohort of hematopoietic stem cell transplant children

M. Philippe, Sylvain Goutelle, J. Guitton, X. Fonrose, C. Bergeron, Pascal Girard...

Bone Marrow Transplantation . 51 : 72-78

DOI: 10.1038/bmt.2015.218

2016

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Mathematical modeling and systems pharmacology of tuberculosis: Isoniazid as a case study

L. Lalande, Laurent Bourguignon, P. Maire, Sylvain Goutelle

Journal of Theoretical Biology . 399 : 43-52

DOI: 10.1016/j.jtbi.2016.03.038

2016

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Pharmacokinetic Variability of Daptomycin during Prolonged Therapy for Bone and Joint Infections

Sylvain Goutelle, Sandrine Roux, Marie-Claude Gagnieu, Florent Valour, Sebastien Lustig, Florence Ader...

Antimicrobial Agents and Chemotherapy . 60 ( 5 ) : pp. 3148-3151

DOI: 10.1128/AAC.02597-15

2016

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Comparison of the static in vivo approach to a physiologically based pharmacokinetic approach for metabolic drug-drug interactions prediction

M. Tod, P.B. Pierrillas, Laurent Bourguignon, Sylvain Goutelle

International Journal of Pharmacokinetics . : 1-10

2016

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Model-Based Determination of Effective Blood Concentrations of Cyclosporine for Neutrophil Response in the Treatment of Severe Aplastic Anemia in Children

M. Philippe, E. Henin, Y. Bertrand, D. Plantaz, Sylvain Goutelle, N. Bleyzac

AAPS Journal . 17 ( 5 ) : 1157-67

DOI: 10.1208/s12248-015-9779-8

2015

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Population modeling and simulation study of the pharmacokinetics and antituberculosis pharmacodynamics of isoniazid in lungs

Laure Lalande, Laurent Bourguignon, S. Bihari, P. Maire, M. Neely, R. Jelliffe...

Antimicrobial Agents and Chemotherapy . 59 ( 9 ) : 5181-5189

DOI: 10.1128/AAC.00462-15

2015

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Subcutaneous administration of levetiracetam in geriatrics

O. Maison, B. de La Gastine, L. Peter-Derex, C. Berger, Sylvain Goutelle

Revue Neurologique . 171 : 398-399

2015

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A pharmacometric pulmonary model predicting the extent and rate of distribution from plasma to epithelial lining fluid and alveolar cells-using rifampicin as an example

O. Clewe, Sylvain Goutelle, Jr. Conte, Ush. Simonsson

European Journal of Clinical Pharmacology . 71 ( 3 ) : 313-9

DOI: 10.1007/s00228-014-1798-3

2015

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Quantitative methods for prediction of the effect of cytochrome P450 gene polymorphisms on substrate drug exposure

Sylvain Goutelle, M. Tod

Clinical Pharmacokinetics . 54 : 319-20

2015

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Influence of renal function estimation on pharmacokinetic modeling of vancomycin in elderly patients

A. Glatard, Laurent Bourguignon, R. W. Jelliffe, P. Maire, M. N. Neely, Sylvain Goutelle

Antimicrobial Agents and Chemotherapy . 59 ( 6 ) : 2986-94

DOI: 10.1128/AAC.04132-14

2015

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Publications

An Investigation of O-Demethyl Tramadol/Tramadol Ratio for Cytochrome P450 2D6 Phenotyping: The CYTRAM Study

Population pharmacokinetics of daptomycin in patients with bone and joint infection: minimal effect of rifampicin co-administration and confirmation of a sex difference

Model-Based Comparative Analysis of Rifampicin and Rifabutin Drug-Drug Interaction Profile

Population Pharmacokinetics and Dosing Simulation of Vancomycin Administered by Continuous Injection in Critically Ill Patient

Rifampicin exposure reveals within-host Mycobacterium tuberculosis diversity in patients with delayed culture conversion

Amikacin Initial Dose in Critically Ill Patients: a Nonparametric Approach To Optimize A Priori Pharmacokinetic/Pharmacodynamic Target Attainments in Individual Patients

Pharmacokinetic variability of beta-lactams in critically ill patients: A narrative review

Prospective Cohort Study of the Tolerability of Prosthetic Joint Infection Empirical Antimicrobial Therapy

Antituberculous drugs modulate bacterial phagolysosome avoidance and autophagy in Mycobacterium tuberculosis-infected macrophages

Assessing the Combined Antibacterial Effect of Isoniazid and Rifampin on Four Mycobacterium tuberculosis Strains Using In Vitro Experiments and Response-Surface Modeling

The Role of Antibiotics in Modulating Virulence in Staphylococcus aureus

Is Trough Concentration of Vancomycin Predictive of the Area Under the Curve? A Clinical Study in Elderly Patients

Implications of using the MDRD or CKD-EPI equation instead of the Cockcroft-Gault equation for estimating renal function and drug dosage adjustment in elderly patients

A Model for Predicting the Interindividual Variability of Drug-Drug Interactions

Population pharmacokinetics of teicoplanin administered by subcutaneous or intravenous route and simulation of optimal loading dose regimen

Mechanisms of drug-drug interaction between rifampicin and fusidic acid

A Nonparametric Method to Optimize Initial Drug Dosing and Attainment of a Target Exposure Interval: Concepts and Application to Busulfan in Pediatrics

Prevalence and Risk Factors of Drug-Associated Corrected QT Prolongation in Elderly Hospitalized Patients: Results of a Retrospective Analysis of Data Obtained Over 6 Months

Quantitative Prediction of Drug Interactions Caused by CYP1A2 Inhibitors and Inducers

Accurately Achieving Target Busulfan Exposure in Children and Adolescents With Very Limited Sampling and the BestDose Software

Should busulfan therapeutic range be narrowed in pediatrics? Experience from a large cohort of hematopoietic stem cell transplant children

Mathematical modeling and systems pharmacology of tuberculosis: Isoniazid as a case study

Pharmacokinetic Variability of Daptomycin during Prolonged Therapy for Bone and Joint Infections

Comparison of the static in vivo approach to a physiologically based pharmacokinetic approach for metabolic drug-drug interactions prediction

Model-Based Determination of Effective Blood Concentrations of Cyclosporine for Neutrophil Response in the Treatment of Severe Aplastic Anemia in Children

Population modeling and simulation study of the pharmacokinetics and antituberculosis pharmacodynamics of isoniazid in lungs

Subcutaneous administration of levetiracetam in geriatrics

A pharmacometric pulmonary model predicting the extent and rate of distribution from plasma to epithelial lining fluid and alveolar cells-using rifampicin as an example

Quantitative methods for prediction of the effect of cytochrome P450 gene polymorphisms on substrate drug exposure

Influence of renal function estimation on pharmacokinetic modeling of vancomycin in elderly patients