Evaluation and Modeling with the Therapeutic Effects Group

Members

EMET  presentation

The EMET team brings together doctors, pharmacists and research professors specializing in the evaluation and use of drug and non-drug therapies, around a single project built on two axes:

  • the evaluation of therapies in clinical trials or observational studies;
  • the construction of explanatory and predictive models, to better understand and therefore predict the effect of therapies, simulate their impacts at the individual and population level, and improve the innovation paradigm.

The EMET team is therefore part of two major dynamics in therapy: analysis of the level of evidence and precision medicine.
The fields of application are cardiovascular and metabolic diseases, primary care medicine, rare pediatric diseases (including genetic and autoimmune diseases), oncology and infectious diseases.
EMET members implement approaches using different mathematical models: direct comparison and network meta-analysis, pharmacokinetic/pharmacodynamic analysis, Bayesian networks and machine learning.

Education

The EMET team is specially involved in the teaching of pharmacology and therapeutics and the modeling of the treatment effect through the coordination of the Masters 2 Clinical Evaluation (EC) and Pharmacology modeling and clinical trials (PHAME), Interpretation of Therapeutic Trials (IET), Training of investigators in clinical drug trials (FIEC) and Training of clinical research assistants and clinical study technicians (FARCTEC). Teacher-researchers are also involved in the first (pharmacology), second (pharmacology / therapeutics, pharmacy) and third cycles (general medicine, pediatrics, internal medicine) in health training courses.

Society involvement

The members of the EMET team through their work and their interactions with the other components of the LBBE, National societies, governmental (HAS) or international (EMA) agencies, and the Hospices Civils de Lyon, are invested in current societal issues: rationalization of the use of health product resources, research ethics, gender equality, rationality of approaches in analyzing the diversity of human populations.

Publications

Display of 121 to 150 publications on 613 in total

Implementation of Model-Based Dose Adjustment of Tobramycin in Adult Patients with Cystic Fibrosis

Jérémy Reverchon, Vianney Tuloup, Romain Garreau, Viviane Nave, Sabine Cohen, Philippe Reix...

Pharmaceutics . 14 ( 8 ) : 1750

DOI: 10.3390/pharmaceutics14081750

Journal article

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Seventeen Cases of Daptomycin-Induced Eosinophilic Pneumonia in a Cohort of Patients Treated for Bone and Joint Infections: Proposal for a New Algorithm

Truong-Thanh Pham, Romain Garreau, Fabien Craighero, Vincent Cottin, Benoît Ben Said, Sylvain Goutelle...

Open Forum Infectious Diseases . 9 ( 11 ) : ofac577

DOI: 10.1093/ofid/ofac577

Journal article

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Predicted Impacts of Booster, Immunity Decline, Vaccination Strategies, and Non-Pharmaceutical Interventions on COVID-19 Outcomes in France

Simon Pageaud, Anne Eyraud-Loisel, Jean-Pierre Bertoglio, Alexis Bienvenüe, Nicolas Leboisne, Catherine Pothier...

Vaccines . 10 ( 12 ) : 2033

DOI: 10.3390/vaccines10122033

Journal article

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An Investigation of O-Demethyl Tramadol/Tramadol Ratio for Cytochrome P450 2D6 Phenotyping: The CYTRAM Study

Blandine de la Gastine, Soizic Percevault, Laurent Varin, Nicolas Richard, Fabienne Fobe, Benoît Plaud...

Pharmaceutics . 14 ( 10 ) : 2177

DOI: 10.3390/pharmaceutics14102177

Journal article

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Selected and simplified FDI criteria for assessment of restorations

Christina Maillet, Franck Decup, Emmanuelle Dantony, Jean Iwaz, Charlène Chevalier, François Gueyffier...

Journal of Dentistry . 122 : 104109

DOI: 10.1016/j.jdent.2022.104109

Journal article

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How do they add up? The interaction between the placebo and treatment effect: A systematic review

Rémy Boussageon, Jeremy Howick, Raphael Baron, Florian Naudet, Bruno Falissard, Ghina Harika-Germaneau...

British Journal of Clinical Pharmacology . 88 ( 8 ) : 3638-3656

DOI: 10.1111/bcp.15345

Journal article

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Place of a new radiological index in predicting pulp exposure before intervention for deep carious lesions

Marie-Agnès Gasqui, Matthieu Perard, Franck Decup, Paul Monsarrat, Yann-Loïg Turpin, Cyril Villat...

Oral Radiology . 38 ( 1 ) : 89-98

DOI: 10.1007/s11282-021-00530-w

Journal article

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Characteristics and risk factors for poor outcome in patients with systemic vasculitis involving the gastrointestinal tract

Ségolène Gendreau, Raphael Porcher, Benjamin Thoreau, Romain Paule, François Maurier, Tiphaine Goulenok...

Seminars in Arthritis and Rheumatism . 51 ( 2 ) : 436-441

DOI: 10.1016/j.semarthrit.2021.03.002

Journal article

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Paraneoplastic polyarteritis nodosa in a patient with cutaneous T-cell lymphoma

Inès Chircop, Amélie Boespflug, Antoine Cini, Jean Christophe Lega, Stéphane Dalle

The Lancet Haematology . 8 ( 3 ) : e240

DOI: 10.1016/S2352-3026(20)30393-8

Journal article

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Olaparib in recurrent IDH-mutant high-grade glioma (OLAGLI)

François Ducray, Marc Sanson, Olivier Chinot, Maxime Fontanilles, Romain Rivoirard, Laure Thomas-Maisonneuve...

57th Annual Meeting of the American Society of Clinical Oncology (2021 ASCO Annual Meeting) . 39 ( 15S ) : 2007

Conference paper

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Arterial and venous thromboembolism in COVID-19: a study-level meta-analysis

Boun Kim Tan, Sabine Mainbourg, Arnaud Friggeri, Laurent Bertoletti, Marion Douplat, Yesim Dargaud...

Thorax . 76 ( 10 ) : 970-979

DOI: 10.1136/thoraxjnl-2020-215383

Journal article

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Twice- or Once-Daily Dosing of Direct Oral Anticoagulants, a systematic review and meta-analysis

S. Mainbourg, M. Cucherat, S. Provencher, L. Bertoletti, P. Nony, F. Gueyffier...

Thrombosis Research . 197 : 24 - 32

DOI: 10.1016/j.thromres.2020.10.011

Journal article

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Twice- or Once-Daily Dosing of Direct Oral Anticoagulants, a systematic review and meta-analysis

S. Mainbourg, M. Cucherat, S. Provencher, L. Bertoletti, P. Nony, F. Gueyffier...

Thrombosis Research . 197 : 24-32

DOI: 10.1016/j.thromres.2020.10.011

Journal article

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Inflammation of Unknown Origin: Evaluation and Prognosis of 57 Cases

Suzanne Béra, Yvan Jamilloux, Mathieu Gerfaud-Valentin, Stéphane Durupt, Raphaèle Nove-Josserand, Jean-Christophe Lega...

Journal of Clinical Medicine . 11 ( 1 ) : 32

DOI: 10.3390/jcm11010032

Journal article

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Risk Factors for Venous Thromboembolism in Severe COVID-19: A Study-Level Meta-Analysis of 21 Studies

Hervé Lobbes, Sabine Mainbourg, Vicky Mai, Marion Douplat, Steeve Provencher, Jean-Christophe Lega

International Journal of Environmental Research and Public Health . 18 ( 24 ) : 12944

DOI: 10.3390/ijerph182412944

Journal article

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Venous thromboembolism in COVID-19 compared to non-COVID-19 cohorts: A systematic review with meta-analysis

Vicky Mai, Boun Kim Tan, Sabine Mainbourg, François Potus, Michel Cucherat, Jean-Christophe Lega...

Vascular Pharmacology . 139 : 106882

DOI: 10.1016/j.vph.2021.106882

Journal article

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Assessing the management of major bleeding events in patients treated by direct oral anticoagulant in an emergency department

Julien Durand, Stéphanie Parat, Jean-Christophe Lega, Yessim Dargaud, Véronique Potinet, Laurent Jacquin...

Annales de Biologie Clinique . 79 ( 4 ) : 315-324

DOI: 10.1684/abc.2021.1658

Journal article

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Meta-regression of randomized control trials with antithrombotics: weak correlation between net clinical benefit and all cause-mortality

Roubi Kilo, Silvy Laporte, Rama Arab, Sabine Mainbourg, Steeve Provencher, Guillaume Grenet...

Scientific Reports . 11 ( 1 ) : 14728

DOI: 10.1038/s41598-021-94160-1

Journal article

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Meta-regression of randomized control trials with antithrombotics: weak correlation between net clinical benefit and all cause-mortality

Roubi Kilo, Silvy Laporte, Rama Arab, Sabine Mainbourg, Steeve Provencher, Guillaume Grenet...

Scientific Reports . 11 ( 1 ) : 14728

DOI: 10.1038/s41598-021-94160-1

Journal article

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Significant Major Bleeding in Hospitalized Patients with COVID-19 Receiving Thromboprophylaxis

Vicky Mai, Sabine Mainbourg, Boun Kim Tan, Jean-Christophe Lega, Steeve Provencher

Thrombosis and Haemostasis . 121 ( 12 ) : 1670-1673

DOI: 10.1055/a-1477-4027

Journal article

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Characteristics and risk factors for poor outcome in patients with systemic vasculitis involving the gastrointestinal tract

Ségolène Gendreau, Raphaël Porcher, Benjamin Thoreau, Romain Paule, François Maurier, Tiphaine Goulenok...

Seminars in Arthritis and Rheumatism . 51 ( 2 ) : 436-441

DOI: 10.1016/j.semarthrit.2021.03.002

Journal article

see the publication

Characteristics and risk factors for poor outcome in patients with systemic vasculitis involving the gastrointestinal tract

Ségolène Gendreau, Raphael Porcher, Benjamin Thoreau, Romain Paule, François Maurier, Tiphaine Goulenok...

Seminars in Arthritis and Rheumatism . 51 ( 2 ) : 436-441

DOI: 10.1016/j.semarthrit.2021.03.002

Journal article

see the publication

Paraneoplastic polyarteritis nodosa in a patient with cutaneous T-cell lymphoma

Inès Chircop, Amélie Boespflug, Antoine Cini, Jean Christophe Lega, Stéphane Dalle

The Lancet Haematology . 8 ( 3 ) : e240

DOI: 10.1016/S2352-3026(20)30393-8

Journal article

see the publication

Direct oral anticoagulants in the treatment of acute venous thromboembolism in patients with obesity: A systematic review with meta-analysis

V. Mai, E. Marceau-Ferron, L. Bertoletti, Y. Lacasse, S. Bonnet, J.C. Lega...

Pharmacological Research . 163 : 105317

DOI: 10.1016/j.phrs.2020.105317

Journal article

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DPP-4 Inhibitors and Respiratory Infection: A Systematic Review and Meta-analysis of the Cardiovascular Outcomes Trials

Guillaume Grenet, Samia Mekhaldi, Sabine Mainbourg, Marine Auffret, Catherine Cornu, Jean-Luc Cracowski...

Diabetes Care . 44 ( 3 ) : e36-e37

DOI: 10.2337/dc20-2018

Journal article

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Prevention of venous thromboembolism in nephrotic syndrome: the quest towards precision medicine

Hervé Lobbes, Sabine Mainbourg, Jean-Christophe Lega

Nephrology Dialysis Transplantation . 36 ( 7 ) : 1151-1154

DOI: 10.1093/ndt/gfaa337

Journal article

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Bladder endometriosis: Preoperative MRI analysis with assessment of extension to ureteral orifices

Pascal Rousset, Elodie Bischoff, Mathilde Charlot, Flavia Grangeon, Gil Dubernard, Philippe Paparel...

Diagnostic and Interventional Imaging . 102 ( 4 ) : 255-263

DOI: 10.1016/j.diii.2020.11.011

Journal article

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Splenectomy for primary immune thrombocytopenia revisited in the era of thrombopoietin receptor agonists: New insights for an old treatment

Arthur Mageau, Louis Terriou, Mikael Ebbo, Odile Souchaud-Debouverie, Corentin Orvain, Julie Graveleau...

American Journal of Hematology . 97 ( 1 ) : 10-17

DOI: 10.1002/ajh.26378

Journal article

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Arterial and venous thromboembolism in COVID-19: a study-level meta-analysis

Boun Kim Tan, Sabine Mainbourg, Arnaud Friggeri, Laurent Bertoletti, Marion Douplat, Yesim Dargaud...

Thorax . 76 ( 10 ) : 970-979

DOI: 10.1136/thoraxjnl-2020-215383

Journal article

see the publication

Population Pharmacokinetic Modeling and Dosing Simulations of Tobramycin in Pediatric Patients with Cystic Fibrosis

Antonin Praet, Laurent Bourguignon, Florence Vetele, Valentine Bréant, Charlotte Genestet, Oana Dumitrescu...

Antimicrobial Agents and Chemotherapy . 65 ( 10 ) : e0073721

DOI: 10.1128/AAC.00737-21

Journal article

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