Evaluation and Modeling with the Therapeutic Effects Group
Members
Stagiaire
UCBL
![](https://lbbe.univ-lyon1.fr/sites/default/files/styles/img__220x220__crop_main/public/media/directory_people/photo/AuffretM.jpg?itok=Zr4qlLT9)
Maîtresse de conférences - praticienne hospitalière
UCBL
Tel: 04 72 11 94 07
Maître de conférences - praticien hospitalier
UCBL
Tel: 33 04 72 32 34 87
![](https://lbbe.univ-lyon1.fr/sites/default/files/styles/img__220x220__crop_main/public/media/directory_people/photo/BoussageonR.jpg?itok=21ucFlrB)
Professeur des universités - médecin généraliste
UCBL
Tel: 04 78 74 18 18
![](https://lbbe.univ-lyon1.fr/sites/default/files/styles/img__220x220__crop_main/public/media/directory_people/photo/DronneM.jpg?itok=BZR0gKOI)
Maîtresse de conférences
UCBL
Tel: 33 04 78 78 57 83
![](https://lbbe.univ-lyon1.fr/sites/default/files/styles/img__220x220__crop_main/public/media/directory_people/photo/ErpeldingerS.jpg?itok=3nkzNVHc)
Professeure des universités - médecin généraliste
UCBL
Tel: 04 78 77 72 86
![](https://lbbe.univ-lyon1.fr/sites/default/files/styles/img__220x220__crop_main/public/media/directory_people/photo/FauvelJP.jpg?itok=y0KF0g8_)
Professeur d'université - praticien hospitalier
UCBL
Tel: 04 72 44 81 42
Doctorante
HCL
Assistant hospitalier universitaire
UCBL
Doctorant
UCBL
Tel: 04 72 44 81 42
![](https://lbbe.univ-lyon1.fr/sites/default/files/styles/img__220x220__crop_main/public/media/directory_people/photo/GoutelleS.jpg?itok=GUb-5E6b)
Professeur d'université - praticien hospitalier
UCBL
Tel: 33 04 72 16 80 99
![](https://lbbe.univ-lyon1.fr/sites/default/files/styles/img__220x220__crop_main/public/media/directory_people/photo/GranalM.jpg?itok=g5ZETgGh)
Doctorante
autre
Tel: 04 72 44 81 42
![](https://lbbe.univ-lyon1.fr/sites/default/files/styles/img__220x220__crop_main/public/media/directory_people/photo/GrenetG.jpg?itok=hSpPSEck)
Praticien hospitalier
HCL
Tel: 04 72 44 81 42
![](https://lbbe.univ-lyon1.fr/sites/default/files/styles/img__220x220__crop_main/public/media/directory_people/photo/GueyffierF.jpg?itok=hRKF_a_u)
Professeur d'université - praticien hospitalier émérite
UCBL
![](https://lbbe.univ-lyon1.fr/sites/default/files/styles/img__220x220__crop_main/public/media/directory_people/photo/KassaiB.jpg?itok=gKZkkwui)
Professeur d'université - praticien hospitalier
UCBL
Tel: 04 27 85 77 32
![](https://lbbe.univ-lyon1.fr/sites/default/files/styles/img__220x220__crop_main/public/media/directory_people/photo/LegaJC.jpg?itok=Lz-aSxrk)
Professeur d'université - praticien hospitalier
UCBL
Tel: 33 04 78 86 33 01
![](https://lbbe.univ-lyon1.fr/sites/default/files/styles/img__220x220__crop_main/public/media/directory_people/photo/MainbourgS.jpg?itok=RJQZ9Vw4)
Maîtresse de conférences - praticienne hospitalière
UCBL
![](https://lbbe.univ-lyon1.fr/sites/default/files/styles/img__220x220__crop_main/public/media/directory_people/photo/NguyenKA.jpg?itok=7RwYYTq4)
Maître de conférences - praticien hospitalier
UCBL
Tel: 04 72 11 94 20
Doctorant
HCL
Tel: 04 72 44 81 42
![](https://lbbe.univ-lyon1.fr/sites/default/files/styles/img__220x220__crop_main/public/media/directory_people/photo/PortefaixA.jpg?itok=Eglb_swq)
Doctorante
UCBL
![](https://lbbe.univ-lyon1.fr/sites/default/files/styles/img__220x220__crop_main/public/media/directory_people/photo/ReixP.jpg?itok=0K2cC0A3)
Professeur d'université - praticien hospitalier
UCBL
Tel: 33 04 72 12 94 37
Post-doc
UCBL
![](https://lbbe.univ-lyon1.fr/sites/default/files/styles/img__220x220__crop_main/public/media/directory_people/photo/TodM.jpg?itok=oEHgoOtD)
Professeur d'université - praticien hospitalier émérite
UCBL
Doctorante
UCBL
Tel: 04 72 44 81 42
Stagiaire
HCL
EMET presentation
The EMET team brings together doctors, pharmacists and research professors specializing in the evaluation and use of drug and non-drug therapies, around a single project built on two axes:
- the evaluation of therapies in clinical trials or observational studies;
- the construction of explanatory and predictive models, to better understand and therefore predict the effect of therapies, simulate their impacts at the individual and population level, and improve the innovation paradigm.
The EMET team is therefore part of two major dynamics in therapy: analysis of the level of evidence and precision medicine.
The fields of application are cardiovascular and metabolic diseases, primary care medicine, rare pediatric diseases (including genetic and autoimmune diseases), oncology and infectious diseases.
EMET members implement approaches using different mathematical models: direct comparison and network meta-analysis, pharmacokinetic/pharmacodynamic analysis, Bayesian networks and machine learning.
Education
The EMET team is specially involved in the teaching of pharmacology and therapeutics and the modeling of the treatment effect through the coordination of the Masters 2 Clinical Evaluation (EC) and Pharmacology modeling and clinical trials (PHAME), Interpretation of Therapeutic Trials (IET), Training of investigators in clinical drug trials (FIEC) and Training of clinical research assistants and clinical study technicians (FARCTEC). Teacher-researchers are also involved in the first (pharmacology), second (pharmacology / therapeutics, pharmacy) and third cycles (general medicine, pediatrics, internal medicine) in health training courses.
Society involvement
The members of the EMET team through their work and their interactions with the other components of the LBBE, National societies, governmental (HAS) or international (EMA) agencies, and the Hospices Civils de Lyon, are invested in current societal issues: rationalization of the use of health product resources, research ethics, gender equality, rationality of approaches in analyzing the diversity of human populations.
Publications
Display of 121 to 150 publications on 450 in total
Use of Topiramate in the Spectrum of Addictive and Eating Disorders: A Systematic Review Comparing Treatment Schemes, Efficacy, and Safety Features
CNS Drugs . 35 ( 2 ) : 177-213
Journal article
see the publicationImpact of vascular risk factors on clinical outcome in elderly patients with depression receiving electroconvulsive therapy
Journal of Affective Disorders . 279 : 308-315
Journal article
see the publicationUsing chest CT scan and unsupervised machine learning for predicting and evaluating response to lumacaftor-ivacaftor in people with cystic fibrosis
European Respiratory Journal . : 2101344
Journal article
see the publicationDiffuse alveolar haemorrhage in children: an international multicentre study
European Respiratory Society (ERS) Congress .
Conference paper
see the publicationReal-world assessment of LCI following lumacaftor-ivacaftor initiation in adolescents and adults with cystic fibrosis
Journal of Cystic Fibrosis .
Journal article
see the publicationChest physiotherapy enhances detection of Pseudomonas aeruginosa in nonexpectorating children with cystic fibrosis
ERJ Open Research . 7 ( 1 ) : 00513-2020
Journal article
see the publicationFactors Associated with Asthma Severity in Children: Data from the French COBRAPed Cohort
Journal of Allergy and Clinical Immunology: In Practice . 9 ( 5 ) : 1969-1979
Journal article
see the publicationImmune thrombocytopenia with clinical significance in systemic lupus erythematosus: a retrospective cohort study of 90 patients.
Rheumatology .
Journal article
see the publicationArterial and venous thromboembolism in COVID-19: a study-level meta-analysis
Thorax . 76 ( 10 ) : 970-979
Journal article
see the publicationAssessing the management of major bleeding events in patients treated by direct oral anticoagulant in an emergency department
Annales de Biologie Clinique . 79 ( 4 ) : 315-324
Journal article
see the publicationPopulation pharmacokinetics of daptomycin in patients with bone and joint infection: minimal effect of rifampicin co-administration and confirmation of a sex difference
Journal of Antimicrobial Chemotherapy . 76 ( 5 ) : 1250-1257
DOI: 10.1093/jac/dkab006
Journal article
see the publicationModel-Based Comparative Analysis of Rifampicin and Rifabutin Drug-Drug Interaction Profile
Antimicrobial Agents and Chemotherapy . 65 ( 9 ) : e0104321
DOI: 10.1128/AAC.01043-21
Journal article
see the publicationExpected Evolution of COVID-19 Epidemic in France for Several Combinations of Vaccination Strategies and Barrier Measures
Vaccines . 9 ( 12 ) : 1462
Journal article
see the publicationPopulation Pharmacokinetics and Dosing Simulation of Vancomycin Administered by Continuous Injection in Critically Ill Patient
Antibiotics . 10 ( 10 ) : 1228
Journal article
see the publicationRifampicin exposure reveals within-host Mycobacterium tuberculosis diversity in patients with delayed culture conversion
PLoS Pathogens . 17 ( 6 ) : e1009643
Journal article
see the publicationAnalysis of ncidence of hrombotic omplications in the resence of ompeting isks
Thrombosis Research . 191 : 152
Journal article
see the publicationOutpatient Subcutaneous Antimicrobial Therapy (OSCAT) as a Measure to Improve the Quality and Efficiency of Healthcare Delivery for Patients With Serious Bacterial Infections
Frontiers in Medicine . 7 : 585658
Journal article
see the publicationNonparametric Methods in Population Pharmacokinetics
Journal of Clinical Pharmacology . 62 ( 2 ) : 142-157
DOI: 10.1002/jcph.1650
Journal article
see the publicationDrug interactions between emergency contraceptive drugs and cytochrome inducers: literature review and quantitative prediction
Fundamental & Clinical Pharmacology . 35 ( 2 ) : 208-216
DOI: 10.1111/fcp.12601
Journal article
see the publicationAzithromycin for COVID-19: More Than Just an Antimicrobial?
Clinical Drug Investigation . 40 ( 8 ) : 683-686
Journal article
see the publicationIntra-individual Pharmacokinetic Variability of Intravenous Busulfan in Hematopoietic Stem Cell-Transplanted Children
Clinical Pharmacokinetics . 59 ( 8 ) : 1049-1061
Journal article
see the publicationAdverse events related to ibuprofen treatment for patent ductus arteriosus in premature neonates
Archives de Pédiatrie . 27 : 452 - 455
Journal article
see the publicationRole of ultrasonography in the assessment of correct endotracheal tube placement in neonates
Acta Paediatrica . 109 ( 5 ) : 1057-1059
DOI: 10.1111/apa.15097
Journal article
see the publicationA population pharmacokinetic model for escitalopram and its major metabolite in depressive patients during the perinatal period: Prediction of infant drug exposure through breast milk
British Journal of Clinical Pharmacology . 86 ( 8 ) : 1642-1653
DOI: 10.1111/bcp.14278
Journal article
see the publicationComparative analysis of predictive values of the kinetics of 11 circulating miRNAs and of CA125 in ovarian cancer during first line treatment (a GINECO study)
Gynecologic Oncology . 159 : 256 - 263
Journal article
see the publicationPotential drug-drug interactions associated with drugs currently proposed for COVID-19 treatment in patients receiving other treatments
Fundamental & Clinical Pharmacology . 34 ( 5 ) : 530-547
DOI: 10.1111/fcp.12586
Journal article
see the publicationEfficacy and safety of topiramate in binge eating disorder: a systematic review and meta-analysis
CNS Spectrums . 26 ( 5 ) : 459-467
Journal article
see the publicationDisparate regulatory status of methylphenidate for adults with ADHD across Europe
The Lancet. Psychiatry . 7 ( 1 ) : e1-e2
Journal article
see the publicationClinical response to lumacaftor-ivacaftor in patients with cystic fibrosis according to baseline lung function
Journal of Cystic Fibrosis .
Journal article
see the publicationReal-Life Safety and Effectiveness of Lumacaftor–Ivacaftor in Patients with Cystic Fibrosis
American Journal of Respiratory and Critical Care Medicine . 201 ( 2 ) : 188-197
Journal article
see the publication
You also, comment on this article