Evaluation and Modeling with the Therapeutic Effects Group

Members

EMET  presentation

The EMET team brings together doctors, pharmacists and research professors specializing in the evaluation and use of drug and non-drug therapies, around a single project built on two axes:

  • the evaluation of therapies in clinical trials or observational studies;
  • the construction of explanatory and predictive models, to better understand and therefore predict the effect of therapies, simulate their impacts at the individual and population level, and improve the innovation paradigm.

The EMET team is therefore part of two major dynamics in therapy: analysis of the level of evidence and precision medicine.
The fields of application are cardiovascular and metabolic diseases, primary care medicine, rare pediatric diseases (including genetic and autoimmune diseases), oncology and infectious diseases.
EMET members implement approaches using different mathematical models: direct comparison and network meta-analysis, pharmacokinetic/pharmacodynamic analysis, Bayesian networks and machine learning.

Education

The EMET team is specially involved in the teaching of pharmacology and therapeutics and the modeling of the treatment effect through the coordination of the Masters 2 Clinical Evaluation (EC) and Pharmacology modeling and clinical trials (PHAME), Interpretation of Therapeutic Trials (IET), Training of investigators in clinical drug trials (FIEC) and Training of clinical research assistants and clinical study technicians (FARCTEC). Teacher-researchers are also involved in the first (pharmacology), second (pharmacology / therapeutics, pharmacy) and third cycles (general medicine, pediatrics, internal medicine) in health training courses.

Society involvement

The members of the EMET team through their work and their interactions with the other components of the LBBE, National societies, governmental (HAS) or international (EMA) agencies, and the Hospices Civils de Lyon, are invested in current societal issues: rationalization of the use of health product resources, research ethics, gender equality, rationality of approaches in analyzing the diversity of human populations.

Publications

Display of 91 to 120 publications on 653 in total

Outcomes of pregnancies with preterm premature rupture of membranes occurring before 24 weeks of gestation: An 11‐year observational study

Helene Gauthier-Moulinier, Daouda Ndour, Muriel Rabilloud, Kim‐an Nguyen

International Journal of Gynecology and Obstetrics . 162 ( 2 ) : 590-595

DOI: 10.1002/ijgo.14700

Journal article

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Defining standard and high dosages for β-lactam agents administered by intermittent, prolonged or continuous infusion: a PK/PD simulation study

Sylvain Goutelle, Vincent Jullien, Jean-Pierre Bru, Vincent Cattoir, Rémy Gauzit, Philippe Lesprit...

Journal of Antimicrobial Chemotherapy . 78 ( 11 ) : 2762–2769

DOI: 10.1093/jac/dkad300

Journal article

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A Knowledge-Based Approach for Evaluating Impact of Therapeutic Strategies

Nadia Abchiche-Mimouni, Mike Donald Tapi Nzali, François Gueyffier

ICAART 2023 - 15th International Conference on Agents and Artificial Intelligence . 3 : 1036-1046

DOI: 10.5220/0011894300003393

Conference paper

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Projet Rebuild the Evidence Base

Hélène Vaillant-Roussel, Clara Blanchard, Thibault Menini, Elodie Charuel, Bruno Pereira, Florian Naudet...

Exercer . 34 ( 190 ) : 81-88

DOI: 10.56746/EXERCER.2023.190.81

Journal article

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Population designations in biomedical research: limitations and perspectives

Caroline Gombault, Guillaume Grenet, Laure Ségurel, Laurent Duret, François Gueyffier, Pascal Cathébras...

HLA: Immune Response Genetics . 101 ( 1 ) : 3-15

DOI: 10.1111/tan.14852

Journal article

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The COVID-19 Pandemic Impacted Maternal Mental Health Differently Depending on Pregnancy Status and Trimester of Gestation

Anick Bérard, Jessica Gorgui, Vanina Tchuente, Anaïs Lacasse, Yessica-Haydee Gomez, Sylvana Côté...

International Journal of Environmental Research and Public Health . 19 ( 5 ) : 2926

DOI: 10.3390/ijerph19052926

Journal article

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Extreme Hyperferritinemia: Causes and Prognosis

Maxime Fauter, Sabine Mainbourg, Thomas El Jammal, Arthur Guerber, Sabine Zaepfel, Thomas Henry...

Journal of Clinical Medicine . 11 ( 18 ) : 5438

DOI: 10.3390/jcm11185438

Journal article

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Iron Deficiency in Cystic Fibrosis: A Cross-Sectional Single-Centre Study in a Referral Adult Centre

Hervé Lobbes, Stéphane Durupt, Sabine Mainbourg, Bruno Pereira, Raphaele Nove-Josserand, Isabelle Durieu...

Nutrients . 14 ( 3 ) : 673

DOI: 10.3390/nu14030673

Journal article

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A New Pathogenic Missense Variant in a Consanguineous North-African Family Responsible for a Highly Variable Aceruloplasminemia Phenotype: A Case-Report

Hervé Lobbes, Quitterie Reynaud, Sabine Mainbourg, Claire Savy-Stortz, Martine Ropert, Edouard Bardou-Jacquet...

Frontiers in Neuroscience . 16 : 906360

DOI: 10.3389/fnins.2022.906360

Journal article

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Epidemiology of major relapse in giant cell arteritis: A study-level meta-analysis

Marie Aussedat, Hervé Lobbes, Maxime Samson, Romain Euvrard, Jean-Christophe Lega, Sabine Mainbourg

Autoimmunity Reviews . 21 ( 1 ) : 102930

DOI: 10.1016/j.autrev.2021.102930

Journal article

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What place for intelligent automation and artificial intelligence to preserve and strengthen vigilance expertise in the face of increasing declarations?

Antoine Pariente, Joëlle Micallef, Amir Lahouegue, Mathieu Molimard, Marine Auffret, Laurent Chouchana...

Therapies . 78 ( 1 ) : 131-143

DOI: 10.1016/j.therap.2022.11.004

Journal article

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How do they add up? The interaction between the placebo and treatment effect: A systematic review

Rémy Boussageon, Jeremy Howick, Raphael Baron, Florian Naudet, Bruno Falissard, Ghina Harika-Germaneau...

British Journal of Clinical Pharmacology . 88 ( 8 ) : 3638-3656

DOI: 10.1111/bcp.15345

Journal article

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SGLT2 inhibitors in type 2 diabetes: a systematic review and meta-analysis of cardiovascular outcome trials balancing their risks and benefits

Elisa Marilly, Judith Cottin, Natalia Cabrera, Catherine Cornu, Remy Boussageon, Philippe Moulin...

Diabetologia . 65 ( 12 ) : 2000-2010

DOI: 10.1007/s00125-022-05773-8

Journal article

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Profiling the response to lumacaftor‐ivacaftor in children with cystic between fibrosis and new insight from a French‐Italian real‐life cohort

Matthieu Cornet, Geneviève Robin, Fabiana Ciciriello, Tiphaine Bihouee, Christophe Marguet, Valérie Roy...

Pediatric Pulmonology . 57 ( 12 ) : 2992-2999

DOI: 10.1002/ppul.26123

Journal article

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Replacing liquid with solid dosage forms in pediatric practice: Feasibility and economic impact from a hospital-based study

Rama Arab, Behrouz Kassai, Roubi Kilo, Catherine Cornu, Elisabete Gomes, Tristan Dagonneau...

Therapies . 77 ( 4 ) : 445-452

DOI: 10.1016/J.THERAP.2021.12.013

Journal article

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Nirsevimab for Prevention of RSV in Healthy Late-Preterm and Term Infants

Laura Hammitt, Ron Dagan, Yuan Yuan, Manuel Baca Cots, Miroslava Bosheva, Shabir Madhi...

New England Journal of Medicine . 386 ( 9 ) : 837-846

DOI: 10.1056/NEJMoa2110275

Journal article

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Immune thrombocytopenia with clinical significance in systemic lupus erythematosus: a retrospective cohort study of 90 patients

Mickaël Roussotte, Mathieu Gerfaud-Valentin, Arnaud Hot, Sylvain Audia, Bernard Bonnotte, Thomas Thibault...

Rheumatology . 61 ( 9 ) : 3627-3639

DOI: 10.1093/rheumatology/keab925

Journal article

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Intravenous Immunoglobulins Tapering and Withdrawal in Systemic Capillary Leak Syndrome (Clarkson Disease)

Quentin Moyon, Marc Pineton de Chambrun, Marie Gousseff, Alexis Mathian, Miguel Hie, Geoffrey Urbanski...

Journal of Allergy and Clinical Immunology: In Practice . 10 ( 11 ) : 2889-2895

DOI: 10.1016/j.jaip.2022.07.006

Journal article

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The consequences of COVID-19 pandemic on patients with monoclonal gammopathy–associated systemic capillary leak syndrome (Clarkson disease)

Marc Pineton de Chambrun, Quentin Moyon, Stanislas Faguer, Geoffrey Urbanski, Alexis Mathian, Noémie Zucman...

Journal of Allergy and Clinical Immunology: In Practice . 10 ( 2 ) : 626-629

DOI: 10.1016/j.jaip.2021.11.023

Journal article

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Quelle place pour l’automatisation intelligente et l’intelligence artificielle pour préserver et renforcer l’expertise en vigilance devant l’augmentation des déclarations ?

Antoine Pariente, Joëlle Micallef, Amir Lahouegue, Mathieu Molimard, Marine Auffret, Laurent Chouchana...

Therapies . 78 ( 1 ) : 115-129

DOI: 10.1016/j.therap.2022.11.003

Journal article

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Estimating individualized treatment effects using individual participant data meta-analysis

Florie Brion Bouvier, Anna Chaimani, François Gueyffier, Guillaume Grenet, Raphaël Porcher

Preprint

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A randomized controlled phase III study comparing hadrontherapy with carbon ions versus conventional radiotherapy – including photon and proton therapy – for the treatment of radioresistant tumors: the ETOILE trial

Jacques Balosso, Olivia Febvey-Combes, Annie Iung, Hélène Lozano, Abdoulkader Alloh, Catherine Cornu...

BMC Cancer . 22 ( 1 ) : 575

DOI: 10.1186/s12885-022-09564-7

Journal article

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Machine-Learning Exploration of Exposure-Effect Relationships of Cisplatin in Head and Neck Cancer Patients

Céleste Cauvin, Laurent Bourguignon, Laure Carriat, Abel Mence, Pauline Ghipponi, Sébastien Salas...

Pharmaceutics . 14 ( 11 ) : 2509

DOI: 10.3390/pharmaceutics14112509

Journal article

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SGLT2 inhibitors in type 2 diabetes: a systematic review and meta-analysis of cardiovascular outcome trials balancing their risks and benefits

Elisa Marilly, Judith Cottin, Natalia Cabrera, Catherine Cornu, Rémy Boussageon, Philippe Moulin...

Diabetologia . 65 : 2000-2010

DOI: 10.1007/s00125-022-05773-8

Journal article

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Indirect Comparison of Glucocorticoid-Sparing Agents for Remission Maintenance in Giant Cell Arteritis: A Network Meta-analysis

Sabine Mainbourg, Axel Tabary, Michel Cucherat, François Gueyffier, Hervé Lobbes, Marie Aussedat...

Mayo Clinic Proceedings . 97 ( 10 ) : 1824-1835

DOI: 10.1016/j.mayocp.2022.03.010

Journal article

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Screening for hypertension-mediated organ damage and aetiology: still of value after 65 years of age?

Delphine Thiolliere, Brahim Harbaoui, Claire Falandry, Marc Bonnefoy, Jean-Christophe Lega, Pierre Lantelme...

Journal of Geriatric Cardiology . 19 ( 11 ) : 791-801

DOI: 10.11909/j.issn.1671-5411.2022.11.005

Journal article

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Intravenous Immunoglobulins Tapering and Withdrawal in Systemic Capillary Leak Syndrome (Clarkson Disease)

Quentin Moyon, Marc Pineton de Chambrun, Marie Gousseff, Alexis Mathian, Miguel Hie, Geoffrey Urbanski...

Journal of Allergy and Clinical Immunology: In Practice . 10 ( 11 ) : 2889-2895

DOI: 10.1016/j.jaip.2022.07.006

Journal article

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Réponse sérologique après vaccination contre le coronavirus chez les patients atteints de rhumatisme inflammatoire chronique traités par DMARDs : étude de cohorte et revue systématique avec méta-analyse

Maxime Auroux, Benjamin Laurent, Baptiste Coste, Emmanuel Massy, Alexandre Mercier, Isabelle Durieu...

Revue du Rhumatisme . 89 ( 5 ) : 435-446

DOI: 10.1016/j.rhum.2022.07.002

Journal article

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Immune thrombocytopenia with clinical significance in systemic lupus erythematosus: a retrospective cohort study of 90 patients

Mickaël Roussotte, Mathieu Gerfaud-Valentin, Arnaud Hot, Sylvain Audia, Bernard Bonnotte, Thomas Thibault...

Rheumatology . 61 ( 9 ) : 3627-3639

DOI: 10.1093/rheumatology/keab925

Journal article

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Assessment of Clinical Worsening End Points as a Surrogate for Mortality in Pulmonary Arterial Hypertension: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Élodie Tremblay, Camille Gosselin, Vicky Mai, Annie Lajoie, Roubi Kilo, Jason Weatherald...

Circulation . 146 ( 8 ) : 597-612

DOI: 10.1161/CIRCULATIONAHA.121.058635

Journal article

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