Evaluation and Modeling with the Therapeutic Effects Group
Members
Stagiaire
UCBL
![](https://lbbe.univ-lyon1.fr/sites/default/files/styles/img__220x220__crop_main/public/media/directory_people/photo/AuffretM.jpg?itok=Zr4qlLT9)
Maîtresse de conférences - praticienne hospitalière
UCBL
Tel: 04 72 11 94 07
Maître de conférences - praticien hospitalier
UCBL
Tel: 33 04 72 32 34 87
![](https://lbbe.univ-lyon1.fr/sites/default/files/styles/img__220x220__crop_main/public/media/directory_people/photo/BoussageonR.jpg?itok=21ucFlrB)
Professeur des universités - médecin généraliste
UCBL
Tel: 04 78 74 18 18
![](https://lbbe.univ-lyon1.fr/sites/default/files/styles/img__220x220__crop_main/public/media/directory_people/photo/DronneM.jpg?itok=BZR0gKOI)
Maîtresse de conférences
UCBL
Tel: 33 04 78 78 57 83
![](https://lbbe.univ-lyon1.fr/sites/default/files/styles/img__220x220__crop_main/public/media/directory_people/photo/ErpeldingerS.jpg?itok=3nkzNVHc)
Professeure des universités - médecin généraliste
UCBL
Tel: 04 78 77 72 86
![](https://lbbe.univ-lyon1.fr/sites/default/files/styles/img__220x220__crop_main/public/media/directory_people/photo/FauvelJP.jpg?itok=y0KF0g8_)
Professeur d'université - praticien hospitalier
UCBL
Tel: 04 72 44 81 42
Doctorante
HCL
Assistant hospitalier universitaire
UCBL
Doctorant
UCBL
Tel: 04 72 44 81 42
![](https://lbbe.univ-lyon1.fr/sites/default/files/styles/img__220x220__crop_main/public/media/directory_people/photo/GoutelleS.jpg?itok=GUb-5E6b)
Professeur d'université - praticien hospitalier
UCBL
Tel: 33 04 72 16 80 99
![](https://lbbe.univ-lyon1.fr/sites/default/files/styles/img__220x220__crop_main/public/media/directory_people/photo/GranalM.jpg?itok=g5ZETgGh)
Doctorante
autre
Tel: 04 72 44 81 42
![](https://lbbe.univ-lyon1.fr/sites/default/files/styles/img__220x220__crop_main/public/media/directory_people/photo/GrenetG.jpg?itok=hSpPSEck)
Praticien hospitalier
HCL
Tel: 04 72 44 81 42
![](https://lbbe.univ-lyon1.fr/sites/default/files/styles/img__220x220__crop_main/public/media/directory_people/photo/GueyffierF.jpg?itok=hRKF_a_u)
Professeur d'université - praticien hospitalier émérite
UCBL
![](https://lbbe.univ-lyon1.fr/sites/default/files/styles/img__220x220__crop_main/public/media/directory_people/photo/KassaiB.jpg?itok=gKZkkwui)
Professeur d'université - praticien hospitalier
UCBL
Tel: 04 27 85 77 32
![](https://lbbe.univ-lyon1.fr/sites/default/files/styles/img__220x220__crop_main/public/media/directory_people/photo/LegaJC.jpg?itok=Lz-aSxrk)
Professeur d'université - praticien hospitalier
UCBL
Tel: 33 04 78 86 33 01
![](https://lbbe.univ-lyon1.fr/sites/default/files/styles/img__220x220__crop_main/public/media/directory_people/photo/MainbourgS.jpg?itok=RJQZ9Vw4)
Maîtresse de conférences - praticienne hospitalière
UCBL
![](https://lbbe.univ-lyon1.fr/sites/default/files/styles/img__220x220__crop_main/public/media/directory_people/photo/NguyenKA.jpg?itok=7RwYYTq4)
Maître de conférences - praticien hospitalier
UCBL
Tel: 04 72 11 94 20
Doctorant
HCL
Tel: 04 72 44 81 42
![](https://lbbe.univ-lyon1.fr/sites/default/files/styles/img__220x220__crop_main/public/media/directory_people/photo/PortefaixA.jpg?itok=Eglb_swq)
Doctorante
UCBL
![](https://lbbe.univ-lyon1.fr/sites/default/files/styles/img__220x220__crop_main/public/media/directory_people/photo/ReixP.jpg?itok=0K2cC0A3)
Professeur d'université - praticien hospitalier
UCBL
Tel: 33 04 72 12 94 37
Post-doc
UCBL
![](https://lbbe.univ-lyon1.fr/sites/default/files/styles/img__220x220__crop_main/public/media/directory_people/photo/TodM.jpg?itok=oEHgoOtD)
Professeur d'université - praticien hospitalier émérite
UCBL
Doctorante
UCBL
Tel: 04 72 44 81 42
Stagiaire
HCL
EMET presentation
The EMET team brings together doctors, pharmacists and research professors specializing in the evaluation and use of drug and non-drug therapies, around a single project built on two axes:
- the evaluation of therapies in clinical trials or observational studies;
- the construction of explanatory and predictive models, to better understand and therefore predict the effect of therapies, simulate their impacts at the individual and population level, and improve the innovation paradigm.
The EMET team is therefore part of two major dynamics in therapy: analysis of the level of evidence and precision medicine.
The fields of application are cardiovascular and metabolic diseases, primary care medicine, rare pediatric diseases (including genetic and autoimmune diseases), oncology and infectious diseases.
EMET members implement approaches using different mathematical models: direct comparison and network meta-analysis, pharmacokinetic/pharmacodynamic analysis, Bayesian networks and machine learning.
Education
The EMET team is specially involved in the teaching of pharmacology and therapeutics and the modeling of the treatment effect through the coordination of the Masters 2 Clinical Evaluation (EC) and Pharmacology modeling and clinical trials (PHAME), Interpretation of Therapeutic Trials (IET), Training of investigators in clinical drug trials (FIEC) and Training of clinical research assistants and clinical study technicians (FARCTEC). Teacher-researchers are also involved in the first (pharmacology), second (pharmacology / therapeutics, pharmacy) and third cycles (general medicine, pediatrics, internal medicine) in health training courses.
Society involvement
The members of the EMET team through their work and their interactions with the other components of the LBBE, National societies, governmental (HAS) or international (EMA) agencies, and the Hospices Civils de Lyon, are invested in current societal issues: rationalization of the use of health product resources, research ethics, gender equality, rationality of approaches in analyzing the diversity of human populations.
Publications
Display of 91 to 120 publications on 450 in total
Splenectomy for primary immune thrombocytopenia revisited in the era of thrombopoietin receptor agonists: New insights for an old treatment
American Journal of Hematology . 97 ( 1 ) : 10-17
DOI: 10.1002/ajh.26378
Journal article
see the publicationArterial and venous thromboembolism in COVID-19: a study-level meta-analysis
Thorax . 76 ( 10 ) : 970-979
Journal article
see the publicationParametric and Nonparametric Methods in Population Pharmacokinetics: Experts’ Discussion on Use, Strengths, and Limitations
Journal of Clinical Pharmacology . 62 ( 2 ) : 158-170
DOI: 10.1002/jcph.1993
Journal article
see the publicationEstimating renal function when adjusting the dosage of antibiotics: Facts and fables
Infectious Diseases Now . 51 ( 7 ) : 635-637
Journal article
see the publicationPopulation Pharmacokinetic Modeling and Dosing Simulations of Tobramycin in Pediatric Patients with Cystic Fibrosis
Antimicrobial Agents and Chemotherapy . 65 ( 10 ) : e0073721
DOI: 10.1128/AAC.00737-21
Journal article
see the publicationDrug-related problems among older patients: Analysis of 8 years of pharmacist's interventions
Annales Pharmaceutiques Françaises . 79 ( 5 ) : 511-521
Journal article
see the publicationPharmacokinetic/Pharmacodynamic Dosage Individualization of Cefepime in Critically Ill Patients: A Case Study
Therapeutic Drug Monitoring . 43 ( 4 ) : 451-454
Journal article
see the publicationTo Estimate or to Forecast? Lessons From a Comparative Analysis of Four Bayesian Fitting Methods Based on Nonparametric Models
Therapeutic Drug Monitoring . 43 ( 4 ) : 461-471
Journal article
see the publicationAdherence to oral antibiotic therapy in patients with bone and joint infection: A pilot study
Infectious Diseases Now . 51 ( 4 ) : 334-339
Journal article
see the publicationPharmacokinetic/Pharmacodynamic Dosage Individualization of Suppressive Beta-Lactam Therapy Administered by Subcutaneous Route in Patients With Prosthetic Joint Infection
Frontiers in Medicine . 8 : 583086
Journal article
see the publicationPharmacogenetic-guided glimepiride therapy in type-2 diabetes mellitus: a cost-effectiveness study
Pharmacogenomics Journal . 21 ( 5 ) : 559-565
Journal article
see the publicationEconomic impact of clinical pharmaceutical activities in hospital wards: A systematic review
Research in Social and Administrative Pharmacy . 17 ( 3 ) : 497-505
Journal article
see the publicationRelationship between adverse drug reactions and unlicensed/off-label drug use in hospitalized children (EREMI): A study protocol
Therapies . 76 ( 6 ) : 675-685
Journal article
see the publicationReference values for the external genitalia of full-term and pre-term female neonates
Archives of disease in childhood. Fetal and neonatal edition . 106 ( 1 ) : 39-44
Journal article
see the publicationDoes DDI-Predictor Help Pharmacists to Detect Drug-Drug Interactions and Resolve Medication Issues More Effectively?
Metabolites . 11 ( 3 ) : 173
Journal article
see the publicationAssociation between voriconazole exposure and Sequential Organ Failure Assessment (SOFA) score in critically ill patients
PLoS ONE . 16 ( 11 ) : e0260656
Journal article
see the publicationRelationship Between Scorpion Stings Events and Environmental Conditions in Mainland France
Journal of Medical Entomology . 58 ( 6 ) : 2146-2153
DOI: 10.1093/jme/tjab109
Journal article
see the publicationReappraisal of the efficacy of intensive glycaemic control on microvascular complications in patients with type 2 diabetes: A meta-analysis of randomised control-trials
Thérapie .
Journal article
see the publicationTobacco-induced sleep disturbances: A systematic review and meta-analysis
Sleep Medicine Reviews . 60 : 101544
Journal article
see the publicationEfficacy and safety of topiramate in binge eating disorder: a systematic review and meta-analysis
CNS Spectrums . 26 ( 5 ) : 459-467
Journal article
see the publicationGabapentinoid use in French most precarious populations: Insight from Lyon Permanent Access to Healthcare (PASS) units, 2016—1Q2021
Fundamental & Clinical Pharmacology . 36 ( 2 ) : 448-452
DOI: 10.1111/fcp.12726
Journal article
see the publicationEfficacy and safety of topiramate for reducing impulsivity: A transdiagnostic systematic review and meta‐analysis of a common clinical use
Fundamental & Clinical Pharmacology . 36 ( 1 ) : 4-15
DOI: 10.1111/fcp.12710
Journal article
see the publicationFcRn as a Transporter for Nasal Delivery of Biologics: A Systematic Review
International Journal of Molecular Sciences . 22 ( 12 ) : 6475
DOI: 10.3390/ijms22126475
Journal article
see the publicationFcRn as a Transporter for Nasal Delivery of Biologics: A Systematic Review
International Journal of Molecular Sciences . 22 ( 12 ) : 6475
DOI: 10.3390/ijms22126475
Journal article
see the publicationAssociation of Attention-Deficit/Hyperactivity Disorder in Childhood and Adolescence With the Risk of Subsequent Psychotic Disorder
JAMA Psychiatry . 78 ( 5 ) : 519
Journal article
see the publicationPharmacotherapy of substance use disorders in the neuroscience-based nomenclature (NbN)
Therapies . 76 ( 2 ) : 127-136
Journal article
see the publicationDeterminants of interest in extended-released buprenorphine: A survey among 366 French patients treated with buprenorphine or methadone
Drug and Alcohol Dependence . 220 : 108492
Journal article
see the publicationUse of Topiramate in the Spectrum of Addictive and Eating Disorders: A Systematic Review Comparing Treatment Schemes, Efficacy, and Safety Features
CNS Drugs . 35 ( 2 ) : 177-213
Journal article
see the publicationImpact of vascular risk factors on clinical outcome in elderly patients with depression receiving electroconvulsive therapy
Journal of Affective Disorders . 279 : 308 - 315
Journal article
see the publicationDeterminants of interest in extended-released buprenorphine: A survey among 366 French patients treated with buprenorphine or methadone
Drug and Alcohol Dependence . 220 : 108492
Journal article
see the publication
You also, comment on this article