Statistics and Modelling for Health Sciences
Evaluation and Modeling with the Therapeutic Effects Group
Lega Jean-Christophe
Professeur d'université - praticien hospitalier
UCBL
Tel: 33 04 78 86 33 01
My work focuses on estimating the benefit-risk balance and the level of evidence of the treatment effect of antithrombotics and immunosuppressants. This modeling is particularly based on conducting meta-analyses (baseline risk, risk stratification and interaction of treatment effect, effect on human subpopulations, and personalized medicine).
This activity has expanded to questions of meta-research, concerning the distortion of treatment effect measurement due to methodological biases and cognitive biases in treatment evaluation. This activity echoes my work within the transparency commission of the HAS.
I have been responsible for the Modeling and Therapeutic Effect Modeling Team since January 2021.
Publications
Display of 1 to 30 publications on 105 in total
Difficult‐to‐treat primary immune thrombocytopenia in adults: Prevalence and burden. Results from the CARMEN ‐France registry
British Journal of Haematology . 204 ( 4 ) : 1476-1482
DOI: 10.1111/bjh.19288
Journal article
see the publicationTaux de rémissions prolongées à l’arrêt d’un traitement par agoniste du récepteur de la thrombopoïétine au cours de la thrombopénie immunologique : suivi à long-terme de l’étude STOPAGO, cohorte prospective multicentrique
La Revue de Médecine Interne . 45 : A109
Journal article
see the publicationRisk of infections in psoriatic arthritis or axial spondyloarthritis patients treated with targeted therapies: A meta-analysis of randomized controlled trials
Joint Bone Spine . 91 ( 3 ) : 105673
Journal article
see the publicationDeaths induced by compassionate use of hydroxychloroquine during the first COVID-19 wave: an estimate
Biomedicine and Pharmacotherapy . 171 : 116055
Journal article
see the publicationComparison of daptomycin and glycopeptide efficacy and safety for the treatment of Gram-positive infections: a systematic review and meta-analysis
Journal of Antimicrobial Chemotherapy .
DOI: 10.1093/jac/dkae026
Journal article
see the publicationPatients’ perceptions on clinical trials outcomes in pulmonary arterial hypertension therapy
Thorax . 78 ( 7 ) : 721-725
Journal article
see the publicationAssociation between immune‐related adverse events and prognosis in patients treated with immune checkpoint inhibitors in melanoma: A surrogacy analysis
Fundamental & Clinical Pharmacology . 38 ( 2 ) : 369-379
DOI: 10.1111/fcp.12966
Journal article
see the publicationCirculating microRNAs improve bacterial infection diagnosis and overall survival prediction in acute decompensation of liver cirrhosis
iScience . 26 ( 8 ) : 107427
Journal article
see the publicationHeart and systemic sclerosis—findings from a national cohort study
Rheumatology .
Journal article
see the publicationHeart and systemic sclerosis—findings from a national cohort study
Rheumatology .
Journal article
see the publicationL’aspirine a-t-elle une place dans la prévention cardiovasculaire primaire par la polypill ? Étude de simulation sur une population virtuelle réaliste
Therapies . 78 ( 6 ) : 667-678
Journal article
see the publicationIncidence of infections in patients with psoriatic arthritis and axial spondyloarthritis treated with biological or targeted disease-modifying agents: a systematic review and meta-analysis of randomised controlled trials, open-label studies and observatio
RMD Open . 9 ( 3 ) : e003064
Journal article
see the publicationCirculating microRNAs improve bacterial infection diagnosis and overall survival prediction in acute decompensation of liver cirrhosis
iScience . 26 ( 8 ) : 107427
Journal article
see the publicationPlatelet count threshold for hemorrhage in patients with immune thrombocytopenia treated with antiplatelet agents.
Blood .
Journal article
see the publicationTreatment strategy for acquired pure red cell aplasia: a systematic review and meta-analysis
Blood Advances . 7 ( 21 ) : 6451-6465
Journal article
see the publicationPlatelet count threshold for hemorrhage in patients with immune thrombocytopenia treated with antiplatelet agents
Blood . 142 ( 12 ) : 1099-1101
Journal article
see the publicationProlonged response after TPO-RA discontinuation in primary ITP: results of a prospective multicenter study
Blood .
Journal article
see the publicationImmune thrombocytopenia and pregnancy: an exposed/nonexposed cohort study
Blood . 141 ( 1 ) : 11-21
Journal article
see the publicationProlonged response after TPO-RA discontinuation in primary ITP: results of a prospective multicenter study
Blood .
Journal article
see the publicationImmune thrombocytopenia and pregnancy: an exposed/nonexposed cohort study
Blood . 141 ( 1 ) : 11-21
Journal article
see the publicationPopulation designations in biomedical research: limitations and perspectives
HLA: Immune Response Genetics . 101 ( 1 ) : 3-15
DOI: 10.1111/tan.14852
Journal article
see the publicationEffective Anti–SARS-CoV-2 Immune Response in Patients With Clonal Mast Cell Disorders
Journal of Allergy and Clinical Immunology: In Practice . 10 ( 5 ) : 1356-1364.e2
Journal article
see the publicationCryoglobulinemia in systemic lupus erythematosus: a retrospective study of 213 patients
Arthritis Research and Therapy . 24 ( 1 ) : 167
Journal article
see the publicationNécessité d’améliorer nos connaissances sur les pneumopathies interstitielles diffuses associées aux connectivites
Revue du Rhumatisme .
Journal article
see the publicationScreening for hypertension-mediated organ damage and aetiology: still of value after 65 years of age?
Journal of Geriatric Cardiology . 19 ( 11 ) : 791-801
Journal article
see the publicationThe consequences of COVID-19 pandemic on patients with monoclonal gammopathy–associated systemic capillary leak syndrome (Clarkson disease)
Journal of Allergy and Clinical Immunology: In Practice . 10 ( 2 ) : 626-629
Journal article
see the publicationIntravenous Immunoglobulins Tapering and Withdrawal in Systemic Capillary Leak Syndrome (Clarkson Disease)
Journal of Allergy and Clinical Immunology: In Practice . 10 ( 11 ) : 2889-2895
Journal article
see the publicationOff-label use of biologics for the treatment of refractory and/or relapsing granulomatosis with polyangiitis
European Journal of Internal Medicine . 96 : 97-101
Journal article
see the publicationSGLT2 inhibitors in type 2 diabetes: a systematic review and meta-analysis of cardiovascular outcome trials balancing their risks and benefits
Diabetologia . 65 : 2000-2010
Journal article
see the publicationRéponse sérologique après vaccination contre le coronavirus chez les patients atteints de rhumatisme inflammatoire chronique traités par DMARDs : étude de cohorte et revue systématique avec méta-analyse
Revue du Rhumatisme . 89 ( 5 ) : 435-446
Journal article
see the publication