Statistics and Modelling for Health Sciences

Evaluation and Modeling with the Therapeutic Effects Group

Lega Jean-Christophe

Professeur d'université - praticien hospitalier

UCBL

Address: Centre Hospitalier Lyon Sud
69003 LYON

Tel: 33 04 78 86 33 01

Email

My work focuses on estimating the benefit-risk balance and the level of evidence of the treatment effect of antithrombotics and immunosuppressants. This modeling is particularly based on conducting meta-analyses (baseline risk, risk stratification and interaction of treatment effect, effect on human subpopulations, and personalized medicine).

This activity has expanded to questions of meta-research, concerning the distortion of treatment effect measurement due to methodological biases and cognitive biases in treatment evaluation. This activity echoes my work within the transparency commission of the HAS.

I have been responsible for the Modeling and Therapeutic Effect Modeling Team since January 2021.

Publications

Display of 1 to 30 publications on 105 in total

Difficult‐to‐treat primary immune thrombocytopenia in adults: Prevalence and burden. Results from the CARMEN ‐France registry

Guillaume Moulis, Manuela Rueter, Aymeric Duvivier, Matthieu Mahévas, Jean‐françois Viallard, Thibault Comont...

British Journal of Haematology . 204 ( 4 ) : 1476-1482

DOI: 10.1111/bjh.19288

Journal article

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Taux de rémissions prolongées à l’arrêt d’un traitement par agoniste du récepteur de la thrombopoïétine au cours de la thrombopénie immunologique : suivi à long-terme de l’étude STOPAGO, cohorte prospective multicentrique

A. Cottu, S. Guillet, J.F. Viallard, E. Riviere, S. Cheze, D. Gobert...

La Revue de Médecine Interne . 45 : A109

DOI: 10.1016/j.revmed.2024.04.409

Journal article

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Risk of infections in psoriatic arthritis or axial spondyloarthritis patients treated with targeted therapies: A meta-analysis of randomized controlled trials

Milène Séauve, Mélanie Auréal, Soline Laplane, Jean-Christophe Lega, Natalia Cabrera, Fabienne Coury

Joint Bone Spine . 91 ( 3 ) : 105673

DOI: 10.1016/j.jbspin.2023.105673

Journal article

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Deaths induced by compassionate use of hydroxychloroquine during the first COVID-19 wave: an estimate

Alexiane Pradelle, Sabine Mainbourg, Steeve Provencher, Emmanuel Massy, Guillaume Grenet, Jean-Christophe Lega

Biomedicine and Pharmacotherapy . 171 : 116055

DOI: 10.1016/j.biopha.2023.116055

Journal article

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Comparison of daptomycin and glycopeptide efficacy and safety for the treatment of Gram-positive infections: a systematic review and meta-analysis

Abdelwahab Boulekbache, Fanny Maldonado, Raphael Kavafian, Tristan Ferry, Laurent Bourguignon, Sylvain Goutelle...

Journal of Antimicrobial Chemotherapy .

DOI: 10.1093/jac/dkae026

Journal article

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Patients’ perceptions on clinical trials outcomes in pulmonary arterial hypertension therapy

Vicky Mai, Camille Gosselin, Élodie Tremblay, Gabrielle Rompré, Annie Christine Lajoie, Jason Weatherald...

Thorax . 78 ( 7 ) : 721-725

DOI: 10.1136/thorax-2022-219490

Journal article

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Association between immune‐related adverse events and prognosis in patients treated with immune checkpoint inhibitors in melanoma: A surrogacy analysis

Romain Euvrard, Marie Robert, Sabine Mainbourg, Stéphane Dalle, Jean‐christophe Lega

Fundamental & Clinical Pharmacology . 38 ( 2 ) : 369-379

DOI: 10.1111/fcp.12966

Journal article

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Circulating microRNAs improve bacterial infection diagnosis and overall survival prediction in acute decompensation of liver cirrhosis

Yasmina Chouik, Fanny Lebossé, Marie‐laure Plissonnier, Jean-Christophe Lega, Pierre Pradat, Teresa Antonini...

iScience . 26 ( 8 ) : 107427

DOI: 10.1016/j.isci.2023.107427

Journal article

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Heart and systemic sclerosis—findings from a national cohort study

Alexis Guédon, Fabrice Carrat, Luc Mouthon, David Launay, Benjamin Chaigne, Grégory Pugnet...

Rheumatology .

DOI: 10.1093/rheumatology/kead599

Journal article

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Heart and systemic sclerosis—findings from a national cohort study

Alexis Guédon, Fabrice Carrat, Luc Mouthon, David Launay, Benjamin Chaigne, Grégory Pugnet...

Rheumatology .

DOI: 10.1093/rheumatology/kead599

Journal article

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L’aspirine a-t-elle une place dans la prévention cardiovasculaire primaire par la polypill ? Étude de simulation sur une population virtuelle réaliste

Mor Fall, Guillaume Grenet, Hai-Ha Le, Behrouz Kassaï, Jean-Christophe Lega, Rémy Boussageon...

Therapies . 78 ( 6 ) : 667-678

DOI: 10.1016/j.therap.2023.01.011

Journal article

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Incidence of infections in patients with psoriatic arthritis and axial spondyloarthritis treated with biological or targeted disease-modifying agents: a systematic review and meta-analysis of randomised controlled trials, open-label studies and observatio

Melanie Aureal, Milene Seauve, Soline Laplane, Jean-Christophe Lega, Natalia Cabrera, Fabienne Coury

RMD Open . 9 ( 3 ) : e003064

DOI: 10.1136/rmdopen-2023-003064

Journal article

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Circulating microRNAs improve bacterial infection diagnosis and overall survival prediction in acute decompensation of liver cirrhosis

Yasmina Chouik, Fanny Lebossé, Marie-Laure Plissonnier, Jean-Christophe Lega, Pierre Pradat, Teresa Antonini...

iScience . 26 ( 8 ) : 107427

DOI: 10.1016/j.isci.2023.107427

Journal article

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Platelet count threshold for hemorrhage in patients with immune thrombocytopenia treated with antiplatelet agents.

Natasha Ollier, Marie-Léa Piel-Julian, Matthieu Mahevas, Jean-François Viallard, Thibault Comont, Stephane Cheze...

Blood .

DOI: 10.1182/blood.2023020311

Journal article

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Treatment strategy for acquired pure red cell aplasia: a systematic review and meta-analysis

Hervé Lobbes, Jean-Christophe Lega, Guillaume Le Guenno, Marc Ruivard, Sabine Mainbourg

Blood Advances . 7 ( 21 ) : 6451-6465

DOI: 10.1182/bloodadvances.2023010587

Journal article

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Platelet count threshold for hemorrhage in patients with immune thrombocytopenia treated with antiplatelet agents

Natasha Ollier, Marie-Léa Piel-Julian, Matthieu Mahévas, Jean-François Viallard, Thibault Comont, Stéphane Chèze...

Blood . 142 ( 12 ) : 1099-1101

DOI: 10.1182/blood.2023020311

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Prolonged response after TPO-RA discontinuation in primary ITP: results of a prospective multicenter study

Stephanie Guillet, Etienne Crickx, Imane Azzaoui, Pascal Chappert, Emmanuelle Boutin, Jean-François Viallard...

Blood .

DOI: 10.1182/blood.2022018665

Journal article

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Immune thrombocytopenia and pregnancy: an exposed/nonexposed cohort study

Stéphanie Guillet, Valentine Loustau, Emmanuelle Boutin, Anissa Zarour, Thibault Comont, Odile Souchaud-Debouverie...

Blood . 141 ( 1 ) : 11-21

DOI: 10.1182/blood.2022017277

Journal article

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Prolonged response after TPO-RA discontinuation in primary ITP: results of a prospective multicenter study

Stephanie Guillet, Etienne Crickx, Imane Azzaoui, Pascal Chappert, Emmanuelle Boutin, Jean-François Viallard...

Blood .

DOI: 10.1182/blood.2022018665

Journal article

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Immune thrombocytopenia and pregnancy: an exposed/nonexposed cohort study

Stéphanie Guillet, Valentine Loustau, Emmanuelle Boutin, Anissa Zarour, Thibault Comont, Odile Souchaud-Debouverie...

Blood . 141 ( 1 ) : 11-21

DOI: 10.1182/blood.2022017277

Journal article

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Population designations in biomedical research: limitations and perspectives

Caroline Gombault, Guillaume Grenet, Laure Ségurel, Laurent Duret, François Gueyffier, Pascal Cathébras...

HLA: Immune Response Genetics . 101 ( 1 ) : 3-15

DOI: 10.1111/tan.14852

Journal article

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Effective Anti–SARS-CoV-2 Immune Response in Patients With Clonal Mast Cell Disorders

Julien Rossignol, Amani Ouedrani, Cristina Bulai Livideanu, Stéphane Barete, Louis Terriou, David Launay...

Journal of Allergy and Clinical Immunology: In Practice . 10 ( 5 ) : 1356-1364.e2

DOI: 10.1016/j.jaip.2021.12.038

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Cryoglobulinemia in systemic lupus erythematosus: a retrospective study of 213 patients

Yoann Roubertou, Sabine Mainbourg, Arnaud Hot, Denis Fouque, Cyrille Confavreux, Roland Chapurlat...

Arthritis Research and Therapy . 24 ( 1 ) : 167

DOI: 10.1186/s13075-022-02857-z

Journal article

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Nécessité d’améliorer nos connaissances sur les pneumopathies interstitielles diffuses associées aux connectivites

Vincent Cottin, Jean-Christophe Lega, Fabienne Coury, Mouhamad Nasser

Revue du Rhumatisme .

DOI: 10.1016/j.rhum.2022.03.006

Journal article

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Screening for hypertension-mediated organ damage and aetiology: still of value after 65 years of age?

Delphine Thiolliere, Brahim Harbaoui, Claire Falandry, Marc Bonnefoy, Jean-Christophe Lega, Pierre Lantelme...

Journal of Geriatric Cardiology . 19 ( 11 ) : 791-801

DOI: 10.11909/j.issn.1671-5411.2022.11.005

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The consequences of COVID-19 pandemic on patients with monoclonal gammopathy–associated systemic capillary leak syndrome (Clarkson disease)

Marc Pineton de Chambrun, Quentin Moyon, Stanislas Faguer, Geoffrey Urbanski, Alexis Mathian, Noémie Zucman...

Journal of Allergy and Clinical Immunology: In Practice . 10 ( 2 ) : 626-629

DOI: 10.1016/j.jaip.2021.11.023

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Intravenous Immunoglobulins Tapering and Withdrawal in Systemic Capillary Leak Syndrome (Clarkson Disease)

Quentin Moyon, Marc Pineton de Chambrun, Marie Gousseff, Alexis Mathian, Miguel Hie, Geoffrey Urbanski...

Journal of Allergy and Clinical Immunology: In Practice . 10 ( 11 ) : 2889-2895

DOI: 10.1016/j.jaip.2022.07.006

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Off-label use of biologics for the treatment of refractory and/or relapsing granulomatosis with polyangiitis

C. Mettler, Ca. Durel, P. Guilpain, B. Bonnotte, F. Cohen-Aubart, M. Hamidou...

European Journal of Internal Medicine . 96 : 97-101

DOI: 10.1016/j.ejim.2021.10.028

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SGLT2 inhibitors in type 2 diabetes: a systematic review and meta-analysis of cardiovascular outcome trials balancing their risks and benefits

Elisa Marilly, Judith Cottin, Natalia Cabrera, Catherine Cornu, Rémy Boussageon, Philippe Moulin...

Diabetologia . 65 : 2000-2010

DOI: 10.1007/s00125-022-05773-8

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Réponse sérologique après vaccination contre le coronavirus chez les patients atteints de rhumatisme inflammatoire chronique traités par DMARDs : étude de cohorte et revue systématique avec méta-analyse

Maxime Auroux, Benjamin Laurent, Baptiste Coste, Emmanuel Massy, Alexandre Mercier, Isabelle Durieu...

Revue du Rhumatisme . 89 ( 5 ) : 435-446

DOI: 10.1016/j.rhum.2022.07.002

Journal article

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