Statistics and Modelling for Health Sciences
Evaluation and Modeling with the Therapeutic Effects Group
Lega Jean-Christophe
Professeur d'université - praticien hospitalier
UCBL
Tel: 33 04 78 86 33 01
My work focuses on estimating the benefit-risk balance and the level of evidence of the treatment effect of antithrombotics and immunosuppressants. This modeling is particularly based on conducting meta-analyses (baseline risk, risk stratification and interaction of treatment effect, effect on human subpopulations, and personalized medicine).
This activity has expanded to questions of meta-research, concerning the distortion of treatment effect measurement due to methodological biases and cognitive biases in treatment evaluation. This activity echoes my work within the transparency commission of the HAS.
I have been responsible for the Modeling and Therapeutic Effect Modeling Team since January 2021.
Publications
Display of 31 to 60 publications on 108 in total
SGLT2 inhibitors in type 2 diabetes: a systematic review and meta-analysis of cardiovascular outcome trials balancing their risks and benefits
Diabetologia . 65 : 2000-2010
Journal article
see the publicationRéponse sérologique après vaccination contre le coronavirus chez les patients atteints de rhumatisme inflammatoire chronique traités par DMARDs : étude de cohorte et revue systématique avec méta-analyse
Revue du Rhumatisme . 89 ( 5 ) : 435-446
Journal article
see the publicationThe consequences of COVID-19 pandemic on patients with monoclonal gammopathy–associated systemic capillary leak syndrome (Clarkson disease)
The Journal of Allergy and Clinical Immunology: In Practice . 10 ( 2 ) : 626-629
Journal article
see the publicationIndirect Comparison of Glucocorticoid-Sparing Agents for Remission Maintenance in Giant Cell Arteritis: A Network Meta-analysis
Mayo Clinic Proceedings . 97 ( 10 ) : 1824-1835
Journal article
see the publicationVEXAS syndrome-related AA amyloidosis: a case report
Rheumatology . 61 ( 1 ) : e15-e16
Journal article
see the publicationImmune thrombocytopenia with clinical significance in systemic lupus erythematosus: a retrospective cohort study of 90 patients
Rheumatology . 61 ( 9 ) : 3627-3639
Journal article
see the publicationEpidemiology of major relapse in giant cell arteritis: A study-level meta-analysis
Autoimmunity Reviews . 21 ( 1 ) : 102930
Journal article
see the publicationInfection Risk in Patients with Dermatomyositis Associated with Anti-MDA5 Antibodies: A Historical Cohort Study
Biomedicines . 10 ( 12 ) : 3176
Journal article
see the publicationHuman Papilloma Virus Vaccination in Patients with Rheumatic Diseases in France: A Study of Vaccination Coverage and Drivers of Vaccination
Journal of Clinical Medicine . 11 ( 14 ) : 4137
DOI: 10.3390/jcm11144137
Journal article
see the publicationA call for evidence in connective tissue diseases-associated interstitial lung disease
Joint Bone Spine . 89 ( 1 ) : 105274
Journal article
see the publicationSplenectomy for primary immune thrombocytopenia revisited in the era of thrombopoietin receptor agonists: New insights for an old treatment
American Journal of Hematology . 97 ( 1 ) : 10-17
DOI: 10.1002/ajh.26378
Journal article
see the publicationManagement and Outcome of COVID-19 Positive and Negative Patients in French Emergency Departments During the First COVID-19 Outbreak: A Prospective Controlled Cohort Study
Western Journal of Emergency Medicine . 23 ( 6 ) : 897-906
Journal article
see the publicationHuman Papilloma Virus Vaccination in Patients with Rheumatic Diseases in France: A Study of Vaccination Coverage and Drivers of Vaccination
Journal of Clinical Medicine . 11 ( 14 ) : 4137
DOI: 10.3390/jcm11144137
Journal article
see the publicationSignificant Major Bleeding in Hospitalized Patients with COVID-19 Receiving Thromboprophylaxis
Thrombosis and Haemostasis . 121 ( 12 ) : 1670-1673
DOI: 10.1055/a-1477-4027
Journal article
see the publicationCharacteristics and risk factors for poor outcome in patients with systemic vasculitis involving the gastrointestinal tract
Seminars in Arthritis and Rheumatism . 51 ( 2 ) : 436-441
Journal article
see the publicationInflammation of Unknown Origin: Evaluation and Prognosis of 57 Cases
Journal of Clinical Medicine . 11 ( 1 ) : 32
DOI: 10.3390/jcm11010032
Journal article
see the publicationCharacteristics and risk factors for poor outcome in patients with systemic vasculitis involving the gastrointestinal tract
Seminars in Arthritis and Rheumatism . 51 ( 2 ) : 436-441
Journal article
see the publicationRisk Factors for Venous Thromboembolism in Severe COVID-19: A Study-Level Meta-Analysis of 21 Studies
International Journal of Environmental Research and Public Health . 18 ( 24 ) : 12944
Journal article
see the publicationParaneoplastic polyarteritis nodosa in a patient with cutaneous T-cell lymphoma
The Lancet Haematology . 8 ( 3 ) : e240
Journal article
see the publicationVenous thromboembolism in COVID-19 compared to non-COVID-19 cohorts: A systematic review with meta-analysis
Vascular Pharmacology . 139 : 106882
Journal article
see the publicationDirect oral anticoagulants in the treatment of acute venous thromboembolism in patients with obesity: A systematic review with meta-analysis
Pharmacological Research . 163 : 105317
Journal article
see the publicationAssessing the management of major bleeding events in patients treated by direct oral anticoagulant in an emergency department
Annales de Biologie Clinique . 79 ( 4 ) : 315-324
Journal article
see the publicationMeta-regression of randomized control trials with antithrombotics: weak correlation between net clinical benefit and all cause-mortality
Scientific Reports . 11 ( 1 ) : 14728
Journal article
see the publicationMeta-regression of randomized control trials with antithrombotics: weak correlation between net clinical benefit and all cause-mortality
Scientific Reports . 11 ( 1 ) : 14728
Journal article
see the publicationPrevention of venous thromboembolism in nephrotic syndrome: the quest towards precision medicine
Nephrology Dialysis Transplantation . 36 ( 7 ) : 1151-1154
DOI: 10.1093/ndt/gfaa337
Journal article
see the publicationBladder endometriosis: Preoperative MRI analysis with assessment of extension to ureteral orifices
Diagnostic and Interventional Imaging . 102 ( 4 ) : 255-263
Journal article
see the publicationDPP-4 Inhibitors and Respiratory Infection: A Systematic Review and Meta-analysis of the Cardiovascular Outcomes Trials
Diabetes Care . 44 ( 3 ) : e36-e37
DOI: 10.2337/dc20-2018
Journal article
see the publicationSplenectomy for primary immune thrombocytopenia revisited in the era of thrombopoietin receptor agonists: New insights for an old treatment
American Journal of Hematology . 97 ( 1 ) : 10-17
DOI: 10.1002/ajh.26378
Journal article
see the publicationArterial and venous thromboembolism in COVID-19: a study-level meta-analysis
Thorax . 76 ( 10 ) : 970-979
Journal article
see the publicationAssessing the management of major bleeding events in patients treated by direct oral anticoagulant in an emergency department
Annales de Biologie Clinique . 79 ( 4 ) : 315-324
Journal article
see the publication