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Statistics and Modelling for Health Sciences
Evaluation and Modeling with the Therapeutic Effects Group
Lega Jean-Christophe
Professeur d'université - praticien hospitalier
UCBL
Tel: 33 04 78 86 33 01
My work focuses on estimating the benefit-risk balance and the level of evidence of the treatment effect of antithrombotics and immunosuppressants. This modeling is particularly based on conducting meta-analyses (baseline risk, risk stratification and interaction of treatment effect, effect on human subpopulations, and personalized medicine).
This activity has expanded to questions of meta-research, concerning the distortion of treatment effect measurement due to methodological biases and cognitive biases in treatment evaluation. This activity echoes my work within the transparency commission of the HAS.
I have been responsible for the Modeling and Therapeutic Effect Modeling Team since January 2021.
Publications
Display of 61 to 90 publications on 108 in total
Arterial and venous thromboembolism in COVID-19: a study-level meta-analysis
Thorax . 76 ( 10 ) : 970-979
Journal article
see the publicationAssessing the management of major bleeding events in patients treated by direct oral anticoagulant in an emergency department
Annales de Biologie Clinique . 79 ( 4 ) : 315-324
Journal article
see the publicationL'acéruléoplasminémie héréditaire, une pathologie à ne pas méconnaître
La Revue de Médecine Interne . 41 : 769 - 775
Journal article
see the publicationRecurrent superficial vein thrombosis revealing relapsing polychondritis associated with myelodysplastic syndrome
Rheumatology . 59 ( 11 ) : 3581-3581
Journal article
see the publicationANCA-associated vasculitides: Recommendations of the French Vasculitis Study Group on the use of immunosuppressants and biotherapies for remission induction and maintenance
La Presse Médicale . 49 ( 3 ) : 104031
Journal article
see the publicationThe benefit–risk balance for biological agents in juvenile idiopathic arthritis: a meta-analysis of randomized clinical trials
Rheumatology . 59 ( 9 ) : 2226-2236
Journal article
see the publicationRectal endometriosis: predictive MRI signs for segmental bowel resection
European Radiology . 31 ( 2 ) : 884-894
Journal article
see the publicationPrevalence of Giant Cell Arteritis Relapse in Patients Treated With Glucocorticoids: A Meta‐Analysis
Arthritis Care & Research = Arthritis Care and Research . 72 ( 6 ) : 838-849
DOI: 10.1002/acr.23901
Journal article
see the publicationSevere infections in patients with anti-neutrophil cytoplasmic antibody-associated vasculitides receiving rituximab: A meta-analysis
Autoimmunity Reviews . 19 ( 5 ) : 102505
Journal article
see the publicationDosage de la tryptase : un guide d'utilisation pour le clinicien
La Revue de Médecine Interne . 41 : 748 - 755
Journal article
see the publicationEarly trajectories of skin thickening are associated with severity and mortality in systemic sclerosis
Arthritis Research & Therapy . 22 ( 1 ) : 30
Journal article
see the publicationAnalysis of ncidence of hrombotic omplications in the resence of ompeting isks
Thrombosis Research . 191 : 152
Journal article
see the publicationEarly trajectories of skin thickening are associated with severity and mortality in systemic sclerosis
Arthritis Research and Therapy . 22 ( 1 ) : 30
Journal article
see the publicationFrench recommendations for the management of systemic necrotizing vasculitides (polyarteritis nodosa and ANCA-associated vasculitides)
Orphanet Journal of Rare Diseases . 15 ( S2 ) : 351
Journal article
see the publicationEarly-onset autoimmunity associated with SOCS1 haploinsufficiency
Nature Communications . 11 ( 1 ) : 5341
Journal article
see the publicationContribution of rare and predicted pathogenic gene variants to childhood-onset lupus: a large, genetic panel analysis of British and French cohorts
The Lancet Rheumatology . 2 ( 2 ) : e99-e109
Journal article
see the publicationPredictive factors of renal involvement in cryoglobulinaemia: a retrospective study of 153 patients
Clinical Kidney Journal . 12 ( 3 ) : 365-372
DOI: 10.1093/ckj/sfy096
Journal article
see the publicationSafety of biological agents in paediatric rheumatic diseases: A real-life multicenter retrospective study using the JIRcohorte database
Joint Bone Spine . 86 ( 3 ) : 343-350
Journal article
see the publicationExtended anticoagulation for the secondary prevention of venous thromboembolic events: An updated network meta-analysis
PLoS ONE . 14 ( 4 ) : e0214134
Journal article
see the publicationTreatment of idiopathic inflammatory myositis associated interstitial lung disease: A systematic review and meta-analysis
Autoimmunity Reviews . 18 ( 2 ) : 113-122
Journal article
see the publicationTreatment of idiopathic inflammatory myositis associated interstitial lung disease: A systematic review and meta-analysis
Autoimmunity Reviews . 18 ( 2 ) : 113-122
Journal article
see the publicationTreatment of idiopathic inflammatory myositis associated interstitial lung disease: A systematic review and meta-analysis
Autoimmunity Reviews . 18 ( 2 ) : 113 - 122
Journal article
see the publicationSurvival and prognosis factors in systemic sclerosis data of a French multicenter cohort, systematic review, and meta-analysis of the literature
Arthritis Research and Therapy . 21 ( 1 ) : 86
Journal article
see the publicationMonogenic lupus: Dissecting heterogeneity
Autoimmunity Reviews . 18 ( 10 )
Journal article
see the publicationExtended anticoagulation for the secondary prevention of venous thromboembolic events: An updated network meta-analysis
PLoS ONE . 14 ( 4 ) : e0214134
Journal article
see the publicationRisk of thrombosis with anti-phospholipid syndrome in systemic lupus erythematosus treated with thrombopoietin-receptor agonists.
Rheumatology . 57 : 1432–1438
Journal article
see the publicationMortality in systemic necrotizing vasculitides: A retrospective analysis of the French Vasculitis Study Group registry
Autoimmunity Reviews . 17 ( 7 ) : 653--659
Journal article
see the publicationCauses and consequences of variation in offspring body mass: meta-analyses in birds and mammals
Biol. Rev . 93 : 1 - 27
DOI: 10.1111/brv.12329
Journal article
see the publication