Evaluation and Modeling with the Therapeutic Effects Group

Members

EMET  presentation

The EMET team brings together doctors, pharmacists and research professors specializing in the evaluation and use of drug and non-drug therapies, around a single project built on two axes:

  • the evaluation of therapies in clinical trials or observational studies;
  • the construction of explanatory and predictive models, to better understand and therefore predict the effect of therapies, simulate their impacts at the individual and population level, and improve the innovation paradigm.

The EMET team is therefore part of two major dynamics in therapy: analysis of the level of evidence and precision medicine.
The fields of application are cardiovascular and metabolic diseases, primary care medicine, rare pediatric diseases (including genetic and autoimmune diseases), oncology and infectious diseases.
EMET members implement approaches using different mathematical models: direct comparison and network meta-analysis, pharmacokinetic/pharmacodynamic analysis, Bayesian networks and machine learning.

Education

The EMET team is specially involved in the teaching of pharmacology and therapeutics and the modeling of the treatment effect through the coordination of the Masters 2 Clinical Evaluation (EC) and Pharmacology modeling and clinical trials (PHAME), Interpretation of Therapeutic Trials (IET), Training of investigators in clinical drug trials (FIEC) and Training of clinical research assistants and clinical study technicians (FARCTEC). Teacher-researchers are also involved in the first (pharmacology), second (pharmacology / therapeutics, pharmacy) and third cycles (general medicine, pediatrics, internal medicine) in health training courses.

Society involvement

The members of the EMET team through their work and their interactions with the other components of the LBBE, National societies, governmental (HAS) or international (EMA) agencies, and the Hospices Civils de Lyon, are invested in current societal issues: rationalization of the use of health product resources, research ethics, gender equality, rationality of approaches in analyzing the diversity of human populations.

Publications

Display of 31 to 60 publications on 613 in total

Prolonged response after TPO-RA discontinuation in primary ITP: results of a prospective multicenter study

Stephanie Guillet, Etienne Crickx, Imane Azzaoui, Pascal Chappert, Emmanuelle Boutin, Jean-François Viallard...

Blood .

DOI: 10.1182/blood.2022018665

Journal article

see the publication

Immune thrombocytopenia and pregnancy: an exposed/nonexposed cohort study

Stéphanie Guillet, Valentine Loustau, Emmanuelle Boutin, Anissa Zarour, Thibault Comont, Odile Souchaud-Debouverie...

Blood . 141 ( 1 ) : 11-21

DOI: 10.1182/blood.2022017277

Journal article

see the publication

Granulocyte-macrophage colony-stimulating factor (GM-CSF) in patients presenting sepsis-induced immunosuppression: The GRID randomized controlled trial

Pierre-Yves Meunier, Camille Raynaud, Emmanuelle Guimaraes, François Gueyffier, Laurent Letrilliart

Journal of Critical Care . 78 ( 1 ) : 154330

DOI: 10.1370/afm.2908

Journal article

see the publication

[Does aspirin have a place in primary cardiovascular prevention by the polypill ? Simulation study on a realistic virtual population].

Mor Fall, Guillaume Grenet, Hai-Ha Le, Behrouz Kassaï, Jean-Christophe Lega, Rémy Boussageon...

Therapies . 78 ( 6 ) : 667-678

DOI: 10.1016/j.therap.2023.01.011

Journal article

see the publication

Implementation of a centralized pharmacovigilance system in academic pan‐European clinical trials: Experience from EU‐Response and conect4children consortia

Catherine Cornu, Anne Donche, Carine Coffre, Amélie Le Gouge, Boulkedid Rym, Isabelle Vaugier...

Therapies . 78 ( 5 ) : S11-S18

DOI: 10.2515/therapie/2015042

Journal article

see the publication

Pharmacokinetic/pharmacodynamic model of a methionine starvation based anti-cancer drug

N. Eymard, N. Bessonov, V. Volpert, P. Kurbatova, F. Gueyffier, P. Nony

Medical and Biological Engineering and Computing . 61 ( 7 ) : 1697-1722

DOI: 10.1007/s11517-023-02786-2

Journal article

see the publication

Diabetes, periodontitis, and cardiovascular disease: towards equity in diabetes care

Constanza Serón, Pablo Olivero, Nicolás Flores, Benjamín Cruzat, Francisca Ahumada, François Gueyffier...

Frontiers in Public Health . 11 ( 1 ) : 1270557

DOI: 10.3389/fpubh.2023.1270557

Journal article

see the publication

Pharmacokinetic/pharmacodynamic model of a methionine starvation based anti-cancer drug

N. Eymard, N. Bessonov, V. Volpert, P. Kurbatova, F. Gueyffier, P. Nony

Medical and Biological Engineering and Computing . 61 ( 7 ) : 1697-1722

DOI: 10.1007/s11517-023-02786-2

Journal article

see the publication

Project Rebuild the Evidence Base (REB): a method to interpret randomised clinical trials and their meta-analysis to present solid benefit-risk assessments to patients

Rémy Boussageon, Clara Blanchard, Elodie Charuel, Thibault Menini, Bruno Pereira, Florian Naudet...

Therapies . 78 ( 4 ) : 353-365

DOI: 10.1016/j.therap.2022.10.008

Journal article

see the publication

Editorial: New insights into caring for pediatric patients with cystic fibrosis

Stephanie Bui, Laurence Delhaes, Gael Dournes, Philippe Reix, Michael John Fayon

Frontiers in Pediatrics . 11

DOI: 10.3389/fped.2023.1243496

Journal article

see the publication

L’aspirine a-t-elle une place dans la prévention cardiovasculaire primaire par la polypill ? Étude de simulation sur une population virtuelle réaliste

Mor Fall, Guillaume Grenet, Hai-Ha Le, Behrouz Kassaï, Jean-Christophe Lega, Rémy Boussageon...

Therapies . 78 ( 6 ) : 667-678

DOI: 10.1016/j.therap.2023.01.011

Journal article

see the publication

Association between immune‐related adverse events and prognosis in patients treated with immune checkpoint inhibitors in melanoma: A surrogacy analysis

Romain Euvrard, Marie Robert, Sabine Mainbourg, Stéphane Dalle, Jean‐christophe Lega

Fundamental & Clinical Pharmacology . 38 ( 2 ) : 369-379

DOI: 10.1111/fcp.12966

Journal article

see the publication

Heart and systemic sclerosis—findings from a national cohort study

Alexis Guédon, Fabrice Carrat, Luc Mouthon, David Launay, Benjamin Chaigne, Grégory Pugnet...

Rheumatology .

DOI: 10.1093/rheumatology/kead599

Journal article

see the publication

Heart and systemic sclerosis—findings from a national cohort study

Alexis Guédon, Fabrice Carrat, Luc Mouthon, David Launay, Benjamin Chaigne, Grégory Pugnet...

Rheumatology .

DOI: 10.1093/rheumatology/kead599

Journal article

see the publication

Incidence of infections in patients with psoriatic arthritis and axial spondyloarthritis treated with biological or targeted disease-modifying agents: a systematic review and meta-analysis of randomised controlled trials, open-label studies and observatio

Melanie Aureal, Milene Seauve, Soline Laplane, Jean-Christophe Lega, Natalia Cabrera, Fabienne Coury

RMD Open . 9 ( 3 ) : e003064

DOI: 10.1136/rmdopen-2023-003064

Journal article

see the publication

Circulating microRNAs improve bacterial infection diagnosis and overall survival prediction in acute decompensation of liver cirrhosis

Yasmina Chouik, Fanny Lebossé, Marie-Laure Plissonnier, Jean-Christophe Lega, Pierre Pradat, Teresa Antonini...

iScience . 26 ( 8 ) : 107427

DOI: 10.1016/j.isci.2023.107427

Journal article

see the publication

Platelet count threshold for hemorrhage in patients with immune thrombocytopenia treated with antiplatelet agents.

Natasha Ollier, Marie-Léa Piel-Julian, Matthieu Mahevas, Jean-François Viallard, Thibault Comont, Stephane Cheze...

Blood .

DOI: 10.1182/blood.2023020311

Journal article

see the publication

Patients’ perceptions on clinical trials outcomes in pulmonary arterial hypertension therapy

Vicky Mai, Camille Gosselin, Élodie Tremblay, Gabrielle Rompré, Annie Christine Lajoie, Jason Weatherald...

Thorax . 78 ( 7 ) : 721-725

DOI: 10.1136/thorax-2022-219490

Journal article

see the publication

Circulating microRNAs improve bacterial infection diagnosis and overall survival prediction in acute decompensation of liver cirrhosis

Yasmina Chouik, Fanny Lebossé, Marie‐laure Plissonnier, Jean-Christophe Lega, Pierre Pradat, Teresa Antonini...

iScience . 26 ( 8 ) : 107427

DOI: 10.1016/j.isci.2023.107427

Journal article

see the publication

Treatment strategy for acquired pure red cell aplasia: a systematic review and meta-analysis

Hervé Lobbes, Jean-Christophe Lega, Guillaume Le Guenno, Marc Ruivard, Sabine Mainbourg

Blood Advances . 7 ( 21 ) : 6451-6465

DOI: 10.1182/bloodadvances.2023010587

Journal article

see the publication

Platelet count threshold for hemorrhage in patients with immune thrombocytopenia treated with antiplatelet agents

Natasha Ollier, Marie-Léa Piel-Julian, Matthieu Mahévas, Jean-François Viallard, Thibault Comont, Stéphane Chèze...

Blood . 142 ( 12 ) : 1099-1101

DOI: 10.1182/blood.2023020311

Journal article

see the publication

Prolonged response after TPO-RA discontinuation in primary ITP: results of a prospective multicenter study

Stephanie Guillet, Etienne Crickx, Imane Azzaoui, Pascal Chappert, Emmanuelle Boutin, Jean-François Viallard...

Blood .

DOI: 10.1182/blood.2022018665

Journal article

see the publication

Immune thrombocytopenia and pregnancy: an exposed/nonexposed cohort study

Stéphanie Guillet, Valentine Loustau, Emmanuelle Boutin, Anissa Zarour, Thibault Comont, Odile Souchaud-Debouverie...

Blood . 141 ( 1 ) : 11-21

DOI: 10.1182/blood.2022017277

Journal article

see the publication

AUC-based monitoring and model-informed precision dosing of vancomycin in critically ill patients: why and how?

Sylvain Goutelle, Florent Wallet, Yann Thoma, Jean-Rémi Peclard, Laurent Bourguignon, Sabine Cohen...

Anaesthesia Critical Care & Pain Medicine . 42 ( 6 ) : 101286

DOI: 10.1016/j.accpm.2023.101286

Journal article

see the publication

Population Pharmacokinetics of Vancomycin in Patients Receiving Hemodialysis in a Malian and a French Center and Simulation of the Optimal Loading Dose

Balla Coulibaly, Pascal Maire, Jêrome Guitton, Solenne Pelletier, Moustapha Tangara, Gilles Aulagner...

Therapeutic Drug Monitoring . 45 ( 5 ) : 637-643

DOI: 10.1097/FTD.0000000000001065

Journal article

see the publication

Evaluation of Limited Sampling Strategies for Bayesian Estimation of Daptomycin Area Under the Concentration–Time Curve: A Short Communication

Vianney Tuloup, Aurélien Millet, Alessandra Taricco, François Parant, Tristan Ferry, Sylvain Goutelle

Therapeutic Drug Monitoring . 45 ( 4 ) : 562-565

DOI: 10.1097/FTD.0000000000001070

Journal article

see the publication

From Personalized to Precision Medicine in Oncology: A Model-Based Dosing Approach to Optimize Achievement of Imatinib Target Exposure

Sylvain Goutelle, Monia Guidi, Verena Gotta, Chantal Csajka, Thierry Buclin, Nicolas Widmer

Pharmaceutics . 15 ( 4 ) : 1081

DOI: 10.3390/pharmaceutics15041081

Journal article

see the publication

Suboptimal exposure to fluconazole in critically ill patients: Pharmacokinetic analysis and determinants

A.L. Bienvenu, P. Pradat, E. Matusik, V. Piriou, T. Rimmelé, F. Parant...

Infectious Diseases Now . 53 ( 2 ) : 104630

DOI: 10.1016/j.idnow.2022.10.002

Journal article

see the publication

Evaluation of Renal Impairment Influence on Metabolic Drug Clearance using a Modelling Approach

Vianney Tuloup, Sylvain Goutelle, Michel Tod, Laurent Bourguignon

Clinical Pharmacokinetics . 62 ( 2 ) : 307-319

DOI: 10.1007/s40262-022-01205-3

Journal article

see the publication

Granulocyte-macrophage colony-stimulating factor (GM-CSF) in patients presenting sepsis-induced immunosuppression: The GRID randomized controlled trial

Charles-Hervé Vacheron, Alain Lepape, Fabienne Venet, Guillaume Monneret, Francois Gueyffier, Florent Boutitie...

Journal of Critical Care . 78 : 154330

DOI: 10.1016/j.jcrc.2023.154330

Journal article

see the publication

You also, comment on this article

Choose an avatar
(Will not be posted on the site)
(Will not be posted on the site)