Evaluation and Modeling with the Therapeutic Effects Group
Members
Stagiaire
UCBL
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Maîtresse de conférences - praticienne hospitalière
UCBL
Tel: 04 72 11 94 07
Maître de conférences - praticien hospitalier
UCBL
Tel: 33 04 72 32 34 87
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Professeur des universités - médecin généraliste
UCBL
Tel: 04 78 74 18 18
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Maîtresse de conférences
UCBL
Tel: 33 04 78 78 57 83
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Professeure des universités - médecin généraliste
UCBL
Tel: 04 78 77 72 86
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Professeur d'université - praticien hospitalier
UCBL
Tel: 04 72 44 81 42
Doctorante
HCL
Assistant hospitalier universitaire
UCBL
Doctorant
UCBL
Tel: 04 72 44 81 42
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Professeur d'université - praticien hospitalier
UCBL
Tel: 33 04 72 16 80 99
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Doctorante
autre
Tel: 04 72 44 81 42
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Praticien hospitalier
HCL
Tel: 04 72 44 81 42
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Professeur d'université - praticien hospitalier émérite
UCBL
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Professeur d'université - praticien hospitalier
UCBL
Tel: 04 27 85 77 32
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Professeur d'université - praticien hospitalier
UCBL
Tel: 33 04 78 86 33 01
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Maîtresse de conférences - praticienne hospitalière
UCBL
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Maître de conférences - praticien hospitalier
UCBL
Tel: 04 72 11 94 20
Doctorant
HCL
Tel: 04 72 44 81 42
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Doctorante
UCBL
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Professeur d'université - praticien hospitalier
UCBL
Tel: 33 04 72 12 94 37
Post-doc
UCBL
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Professeur d'université - praticien hospitalier émérite
UCBL
Doctorante
UCBL
Tel: 04 72 44 81 42
Stagiaire
HCL
EMET presentation
The EMET team brings together doctors, pharmacists and research professors specializing in the evaluation and use of drug and non-drug therapies, around a single project built on two axes:
- the evaluation of therapies in clinical trials or observational studies;
- the construction of explanatory and predictive models, to better understand and therefore predict the effect of therapies, simulate their impacts at the individual and population level, and improve the innovation paradigm.
The EMET team is therefore part of two major dynamics in therapy: analysis of the level of evidence and precision medicine.
The fields of application are cardiovascular and metabolic diseases, primary care medicine, rare pediatric diseases (including genetic and autoimmune diseases), oncology and infectious diseases.
EMET members implement approaches using different mathematical models: direct comparison and network meta-analysis, pharmacokinetic/pharmacodynamic analysis, Bayesian networks and machine learning.
Education
The EMET team is specially involved in the teaching of pharmacology and therapeutics and the modeling of the treatment effect through the coordination of the Masters 2 Clinical Evaluation (EC) and Pharmacology modeling and clinical trials (PHAME), Interpretation of Therapeutic Trials (IET), Training of investigators in clinical drug trials (FIEC) and Training of clinical research assistants and clinical study technicians (FARCTEC). Teacher-researchers are also involved in the first (pharmacology), second (pharmacology / therapeutics, pharmacy) and third cycles (general medicine, pediatrics, internal medicine) in health training courses.
Society involvement
The members of the EMET team through their work and their interactions with the other components of the LBBE, National societies, governmental (HAS) or international (EMA) agencies, and the Hospices Civils de Lyon, are invested in current societal issues: rationalization of the use of health product resources, research ethics, gender equality, rationality of approaches in analyzing the diversity of human populations.
Publications
Display of 31 to 60 publications on 519 in total
Suboptimal exposure to fluconazole in critically ill patients: Pharmacokinetic analysis and determinants
Infectious Diseases Now . 53 ( 2 ) : 104630
Journal article
see the publicationEvaluation of Renal Impairment Influence on Metabolic Drug Clearance using a Modelling Approach
Clinical Pharmacokinetics . 62 ( 2 ) : 307-319
Journal article
see the publicationDaptomycin Exposure as a Risk Factor for Daptomycin-Induced Eosinophilic Pneumonia and Muscular Toxicity
Clinical Infectious Diseases . 77 ( 10 ) : 1372-1380
DOI: 10.1093/cid/ciad386
Journal article
see the publicationStrengthening Reporting of Neonatal Trials
Pediatrics . 152 ( 3 )
Journal article
see the publicationHeterogeneity and Gaps in Reporting Primary Outcomes From Neonatal Trials
Pediatrics . 152 ( 3 )
Journal article
see the publicationSafety of Re-dosing Nirsevimab Prior to RSV Season 2 in Children With Heart or Lung Disease
Journal of the Pediatric Infectious Diseases Society . 12 ( 8 ) : 477-480
Journal article
see the publicationEfficacy of nirsevimab against respiratory syncytial virus lower respiratory tract infections in preterm and term infants, and pharmacokinetic extrapolation to infants with congenital heart disease and chronic lung disease: a pooled analysis of randomised
The Lancet Child & Adolescent Health . 7 ( 3 ) : 180-189
Journal article
see the publicationTherapeutic Drug Monitoring and Pharmacogenetic Testing as Guides to Psychotropic Drug Dose Adjustment: An Observational Study
Pharmaceuticals . 17 ( 1 ) : 21
DOI: 10.3390/ph17010021
Journal article
see the publicationAvis de l'Anses relatif à l’évaluation du triphénylphosphate (TPP) (EC No 204-112-2 ; CAS No 115-86-6) dans le cadre de l’évaluation des substances sous REACH
: 12 p.
Report
see the publicationOptions chirurgicales et instrumentales pour la rhinite chronique : une revue systématique avec méta-analyse PRISMA
Annales françaises d'Oto-rhino-laryngologie et de Pathologie Cervico-faciale . 140 ( 6 ) : 279-289
Journal article
see the publicationSurgical and instrumental options for chronic rhinitis: A systematic review and PRISMA meta-analysis
European Annals of Otorhinolaryngology, Head and Neck Diseases . 140 ( 6 ) : 279-287
Journal article
see the publicationSurgical and instrumental options for chronic rhinitis: A systematic review and PRISMA meta-analysis
European Annals of Otorhinolaryngology, Head and Neck Diseases . 140 ( 6 ) : 279-287
Journal article
see the publicationA cross-sectional study to evaluate hypovitaminosis C prevalence and risk factors in an acute geriatric unit in Lyon, France: the HYPO-VIT-C protocol
BMJ Open . 13 ( 8 ) : e075924
Journal article
see the publicationPost‐prostatectomy anastomotic stenosis: systematic review and meta‐analysis of endoscopic treatment
BJU International . 133 ( 3 ) : 237-245
DOI: 10.1111/bju.16141
Journal article
see the publicationValue of Chest X-Ray and Chest Computed Tomography for Systemic Sarcoidosis Diagnosis in Undifferentiated Uveitis
Ocular Immunology and Inflammation . : 1-7
Journal article
see the publicationRisk of drug use during pregnancy: master protocol for living systematic reviews and meta-analyses performed in the metaPreg project
Systematic Reviews . 12 ( 1 ) : 101
Journal article
see the publicationAssociation between cannabis use and symptom dimensions in schizophrenia spectrum disorders: an individual participant data meta-analysis on 3053 individuals
EClinicalMedicine . 64 ( 6 ) : 102199
Journal article
see the publicationEfficacy and safety of clonidine for the treatment of impulse control disorder in Parkinson’s disease: a multicenter, parallel, randomised, double-blind, Phase 2b Clinical trial
Journal of Neurology . 270 ( 10 ) : 4851-4859
Journal article
see the publicationSuccessful thrombectomy is beneficial in patients with pre-stroke disability: Results from an international multicenter cohort study
Journal de Neuroradiologie / Journal of Neuroradiology . 50 ( 1 ) : 59-64
Journal article
see the publicationEfficacy and safety of clonidine for the treatment of impulse control disorder in Parkinson’s disease: a multicenter, parallel, randomised, double-blind, Phase 2b Clinical trial
Journal of Neurology . 270 : 4851 - 4859
Journal article
see the publicationA cross-sectional study to evaluate hypovitaminosis C prevalence and risk factors in an acute geriatric unit in Lyon, France: the HYPO-VIT-C protocol
BMJ Open . 13 ( 8 ) : e075924
Journal article
see the publicationValue of Chest X-Ray and Chest Computed Tomography for Systemic Sarcoidosis Diagnosis in Undifferentiated Uveitis
Ocular Immunology and Inflammation . 32 ( 2 ) : 161-167
Journal article
see the publicationLung Transplantation under a Janus Kinase Inhibitor in Three Patients with SAVI Syndrome
Journal of Clinical Immunology . 43 ( 8 ) : 2156-2164
Journal article
see the publicationMethotrexate does not affect lung function in children with juvenile idiopathic arthritis
Pediatric Pulmonology . 58 ( 12 ) : 3630-3636
DOI: 10.1002/ppul.26681
Journal article
see the publicationTheratyping cystic fibrosis patients to guide elexacaftor/tezacaftor/ivacaftor out-of-label prescription
European Respiratory Journal . 62 ( 4 ) : 2300110
Journal article
see the publicationClinical problems in rare interstitial lung diseases
European Respiratory Society .
Poster
see the publicationProlonged response after TPO-RA discontinuation in primary ITP: results of a prospective multicenter study
Blood .
Journal article
see the publicationImmune thrombocytopenia and pregnancy: an exposed/nonexposed cohort study
Blood . 141 ( 1 ) : 11-21
Journal article
see the publicationPreuves de bénéfice et décision thérapeutique : enquête auprès de médecins généralistes sur la prescription d’hydroxychloroquine pour traiter la Covid-19
Exercer . 34 ( 195 ) : 298-304
Journal article
see the publicationOutcomes of pregnancies with preterm premature rupture of membranes occurring before 24 weeks of gestation: An 11‐year observational study
International Journal of Gynecology and Obstetrics . 162 ( 2 ) : 590-595
DOI: 10.1002/ijgo.14700
Journal article
see the publication
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