Evaluation and Modeling with the Therapeutic Effects Group
Members
Stagiaire
UCBL
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Maîtresse de conférences - praticienne hospitalière
UCBL
Tel: 04 72 11 94 07
Maître de conférences - praticien hospitalier
UCBL
Tel: 33 04 72 32 34 87
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Professeur des universités - médecin généraliste
UCBL
Tel: 04 78 74 18 18
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Maîtresse de conférences
UCBL
Tel: 33 04 78 78 57 83
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Professeure des universités - médecin généraliste
UCBL
Tel: 04 78 77 72 86
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Professeur d'université - praticien hospitalier
UCBL
Tel: 04 72 44 81 42
Doctorante
HCL
Assistant hospitalier universitaire
UCBL
Doctorant
UCBL
Tel: 04 72 44 81 42
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Professeur d'université - praticien hospitalier
UCBL
Tel: 33 04 72 16 80 99
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Doctorante
autre
Tel: 04 72 44 81 42
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Praticien hospitalier
HCL
Tel: 04 72 44 81 42
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Professeur d'université - praticien hospitalier émérite
UCBL
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Professeur d'université - praticien hospitalier
UCBL
Tel: 04 27 85 77 32
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Professeur d'université - praticien hospitalier
UCBL
Tel: 33 04 78 86 33 01
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Maîtresse de conférences - praticienne hospitalière
UCBL
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Maître de conférences - praticien hospitalier
UCBL
Tel: 04 72 11 94 20
Doctorant
HCL
Tel: 04 72 44 81 42
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Doctorante
UCBL
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Professeur d'université - praticien hospitalier
UCBL
Tel: 33 04 72 12 94 37
Post-doc
UCBL
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Professeur d'université - praticien hospitalier émérite
UCBL
Doctorante
UCBL
Tel: 04 72 44 81 42
Stagiaire
HCL
EMET presentation
The EMET team brings together doctors, pharmacists and research professors specializing in the evaluation and use of drug and non-drug therapies, around a single project built on two axes:
- the evaluation of therapies in clinical trials or observational studies;
- the construction of explanatory and predictive models, to better understand and therefore predict the effect of therapies, simulate their impacts at the individual and population level, and improve the innovation paradigm.
The EMET team is therefore part of two major dynamics in therapy: analysis of the level of evidence and precision medicine.
The fields of application are cardiovascular and metabolic diseases, primary care medicine, rare pediatric diseases (including genetic and autoimmune diseases), oncology and infectious diseases.
EMET members implement approaches using different mathematical models: direct comparison and network meta-analysis, pharmacokinetic/pharmacodynamic analysis, Bayesian networks and machine learning.
Education
The EMET team is specially involved in the teaching of pharmacology and therapeutics and the modeling of the treatment effect through the coordination of the Masters 2 Clinical Evaluation (EC) and Pharmacology modeling and clinical trials (PHAME), Interpretation of Therapeutic Trials (IET), Training of investigators in clinical drug trials (FIEC) and Training of clinical research assistants and clinical study technicians (FARCTEC). Teacher-researchers are also involved in the first (pharmacology), second (pharmacology / therapeutics, pharmacy) and third cycles (general medicine, pediatrics, internal medicine) in health training courses.
Society involvement
The members of the EMET team through their work and their interactions with the other components of the LBBE, National societies, governmental (HAS) or international (EMA) agencies, and the Hospices Civils de Lyon, are invested in current societal issues: rationalization of the use of health product resources, research ethics, gender equality, rationality of approaches in analyzing the diversity of human populations.
Publications
Display of 151 to 180 publications on 450 in total
Impact of Coexistence Phenotype Between Staphylococcus aureus and Pseudomonas aeruginosa Isolates on Clinical Outcomes Among Cystic Fibrosis Patients
Frontiers in Cellular and Infection Microbiology . 10 : 105996
Journal article
see the publicationEarly trajectories of skin thickening are associated with severity and mortality in systemic sclerosis
Arthritis Research and Therapy . 22 ( 1 ) : 30
Journal article
see the publicationFrench recommendations for the management of systemic necrotizing vasculitides (polyarteritis nodosa and ANCA-associated vasculitides)
Orphanet Journal of Rare Diseases . 15 ( S2 ) : 351
Journal article
see the publicationEarly-onset autoimmunity associated with SOCS1 haploinsufficiency
Nature Communications . 11 ( 1 )
Journal article
see the publicationImpact of interleukin‐6 on drug transporters and permeability in the hCMEC/D3 blood–brain barrier model
Fundamental & Clinical Pharmacology . 35 ( 2 ) : 397-409
DOI: 10.1111/fcp.12596
Journal article
see the publicationInconclusive efficacy of intervention on upper-limb function after tetraplegia: A systematic review and meta-analysis
Annals of physical and rehabilitation medicine . 63 ( 3 ) : 230-240
Journal article
see the publicationContribution of rare and predicted pathogenic gene variants to childhood-onset lupus: a large, genetic panel analysis of British and French cohorts
The Lancet Rheumatology . 2 ( 2 ) : e99-e109
Journal article
see the publicationPublication language and the estimate of treatment effects of physical therapy on balance and postural control after stroke in meta-analyses of randomised controlled trials
PLoS ONE . 15 ( 3 ) : e0229822
Journal article
see the publicationQuantitative Prediction of Interactions Mediated by Transporters and Cytochromes: Application to Organic Anion Transporting Polypeptides, Breast Cancer Resistance Protein and Cytochrome 2C8
Clinical Pharmacokinetics . 59 ( 6 ) : 757-770
Journal article
see the publicationErratum à l’article : « Pancréatite aiguë en lien avec la migration d’une sonde de gastrostomie (Acute pancreatitis caused by gastrostomy tube migration: Case report and literature review) [Presse Med. 2019;48:563–581]
La Presse Médicale . 48 ( 11 ) : 1360
Journal article
see the publication[Acute pancreatitis caused by gastrostomy tube migration: Case report and literature review].
La Presse Médicale . 48 ( 5 ) : 563-567
Journal article
see the publicationParameters influencing the pharmacokinetics/pharmacodynamics of piperacillin/tazobactam in patients with febrile neutropenia and haematological malignancy: a prospective study
Journal of Antimicrobial Chemotherapy . 74 ( 9 ) : 2676-2680
DOI: 10.1093/jac/dkz248
Journal article
see the publicationPostsurgery analgesic and sedative drug use in a French neonatal intensive care unit: A single-center retrospective cohort study
Archives de Pédiatrie . 26 : 145 - 150
Journal article
see the publicationPostsurgery analgesic and sedative drug use in a French neonatal intensive care unit: A single-center retrospective cohort study
Archives de Pédiatrie . 26 ( 3 ) : 145-150
Journal article
see the publicationSystematic review of artesunate pharmacokinetics: Implication for treatment of resistant malaria
International Journal of Infectious Diseases . 89 : 30 - 44
Journal article
see the publicationClinical efficacy of the optimal biological dose in early-phase trials of anti-cancer targeted therapies
European Journal of Cancer . 120 : 40 - 46
Journal article
see the publicationThesaurus for off-label indications for systemic antifungal agents
Médecine et Maladies Infectieuses . 49 : 275 - 280
Journal article
see the publicationChallenges in personalized evidence-based medicine, applications in type 2 diabetes
Thesis
see the publicationTherapeutic Prospects of Cannabidiol for Alcohol Use Disorder and Alcohol-Related Damages on the Liver and the Brain
Frontiers in Pharmacology . 10 : 627
Journal article
see the publicationLe syndrome sérotoninergique : une revue actualisée de la littérature
La Revue de Médecine Interne . 40 ( 2 ) : 98-104
Journal article
see the publicationLe syndrome sérotoninergique : une revue actualisée de la littérature
La Revue de Médecine Interne . 40 ( 2 ) : 98-104
Journal article
see the publicationA Patient-Tailored Evidence-Based Approach for Developing Early Neuropsychological Training Programs in Addiction Settings
Neuropsychology Review . 29 ( 1 ) : 103-115
Journal article
see the publicationTherapeutic prospects of cannabidiol for alcohol use disorder and alcohol-related damages on the liver and the brain
Frontiers in Pharmacology . 10 : 627
Journal article
see the publicationUsefulness of bronchoalveolar lavage in a French pediatric cohort with hypersensitivity pneumonitis
Pediatric Pulmonology . 55 ( 1 ) : 136-140
DOI: 10.1002/ppul.24546
Journal article
see the publicationHealth-related quality of life in children interstitial lung disease.
European Respiratory Society (ERS) Congress .
Conference paper
see the publicationHealth‐related quality of life in infants and children with interstitial lung disease
Pediatric Pulmonology . 54 ( 6 ) : 828-836
DOI: 10.1002/ppul.24308
Journal article
see the publicationViral respiratory tract infections in young children with cystic fibrosis: a prospective full-year seasonal study
Virology Journal . 16 ( 1 ) : 111
Journal article
see the publicationSurvival and prognosis factors in systemic sclerosis data of a French multicenter cohort, systematic review, and meta-analysis of the literature
Arthritis Research and Therapy . 21 ( 1 ) : 86
Journal article
see the publicationMonogenic lupus: Dissecting heterogeneity
Autoimmunity Reviews . 18 ( 10 )
Journal article
see the publicationTreatment of idiopathic inflammatory myositis associated interstitial lung disease: A systematic review and meta-analysis
Autoimmunity Reviews . 18 ( 2 ) : 113 - 122
Journal article
see the publication
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