Evaluation and Modeling with the Therapeutic Effects Group

Members

EMET  presentation

The EMET team brings together doctors, pharmacists and research professors specializing in the evaluation and use of drug and non-drug therapies, around a single project built on two axes:

  • the evaluation of therapies in clinical trials or observational studies;
  • the construction of explanatory and predictive models, to better understand and therefore predict the effect of therapies, simulate their impacts at the individual and population level, and improve the innovation paradigm.

The EMET team is therefore part of two major dynamics in therapy: analysis of the level of evidence and precision medicine.
The fields of application are cardiovascular and metabolic diseases, primary care medicine, rare pediatric diseases (including genetic and autoimmune diseases), oncology and infectious diseases.
EMET members implement approaches using different mathematical models: direct comparison and network meta-analysis, pharmacokinetic/pharmacodynamic analysis, Bayesian networks and machine learning.

Education

The EMET team is specially involved in the teaching of pharmacology and therapeutics and the modeling of the treatment effect through the coordination of the Masters 2 Clinical Evaluation (EC) and Pharmacology modeling and clinical trials (PHAME), Interpretation of Therapeutic Trials (IET), Training of investigators in clinical drug trials (FIEC) and Training of clinical research assistants and clinical study technicians (FARCTEC). Teacher-researchers are also involved in the first (pharmacology), second (pharmacology / therapeutics, pharmacy) and third cycles (general medicine, pediatrics, internal medicine) in health training courses.

Society involvement

The members of the EMET team through their work and their interactions with the other components of the LBBE, National societies, governmental (HAS) or international (EMA) agencies, and the Hospices Civils de Lyon, are invested in current societal issues: rationalization of the use of health product resources, research ethics, gender equality, rationality of approaches in analyzing the diversity of human populations.

Publications

Display of 151 to 180 publications on 628 in total

Meta-regression of randomized control trials with antithrombotics: weak correlation between net clinical benefit and all cause-mortality

Roubi Kilo, Silvy Laporte, Rama Arab, Sabine Mainbourg, Steeve Provencher, Guillaume Grenet...

Scientific Reports . 11 ( 1 ) : 14728

DOI: 10.1038/s41598-021-94160-1

Journal article

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Significant Major Bleeding in Hospitalized Patients with COVID-19 Receiving Thromboprophylaxis

Vicky Mai, Sabine Mainbourg, Boun Kim Tan, Jean-Christophe Lega, Steeve Provencher

Thrombosis and Haemostasis . 121 ( 12 ) : 1670-1673

DOI: 10.1055/a-1477-4027

Journal article

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Characteristics and risk factors for poor outcome in patients with systemic vasculitis involving the gastrointestinal tract

Ségolène Gendreau, Raphaël Porcher, Benjamin Thoreau, Romain Paule, François Maurier, Tiphaine Goulenok...

Seminars in Arthritis and Rheumatism . 51 ( 2 ) : 436-441

DOI: 10.1016/j.semarthrit.2021.03.002

Journal article

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Characteristics and risk factors for poor outcome in patients with systemic vasculitis involving the gastrointestinal tract

Ségolène Gendreau, Raphael Porcher, Benjamin Thoreau, Romain Paule, François Maurier, Tiphaine Goulenok...

Seminars in Arthritis and Rheumatism . 51 ( 2 ) : 436-441

DOI: 10.1016/j.semarthrit.2021.03.002

Journal article

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Paraneoplastic polyarteritis nodosa in a patient with cutaneous T-cell lymphoma

Inès Chircop, Amélie Boespflug, Antoine Cini, Jean Christophe Lega, Stéphane Dalle

The Lancet Haematology . 8 ( 3 ) : e240

DOI: 10.1016/S2352-3026(20)30393-8

Journal article

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Direct oral anticoagulants in the treatment of acute venous thromboembolism in patients with obesity: A systematic review with meta-analysis

V. Mai, E. Marceau-Ferron, L. Bertoletti, Y. Lacasse, S. Bonnet, J.C. Lega...

Pharmacological Research . 163 : 105317

DOI: 10.1016/j.phrs.2020.105317

Journal article

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DPP-4 Inhibitors and Respiratory Infection: A Systematic Review and Meta-analysis of the Cardiovascular Outcomes Trials

Guillaume Grenet, Samia Mekhaldi, Sabine Mainbourg, Marine Auffret, Catherine Cornu, Jean-Luc Cracowski...

Diabetes Care . 44 ( 3 ) : e36-e37

DOI: 10.2337/dc20-2018

Journal article

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Prevention of venous thromboembolism in nephrotic syndrome: the quest towards precision medicine

Hervé Lobbes, Sabine Mainbourg, Jean-Christophe Lega

Nephrology Dialysis Transplantation . 36 ( 7 ) : 1151-1154

DOI: 10.1093/ndt/gfaa337

Journal article

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Bladder endometriosis: Preoperative MRI analysis with assessment of extension to ureteral orifices

Pascal Rousset, Elodie Bischoff, Mathilde Charlot, Flavia Grangeon, Gil Dubernard, Philippe Paparel...

Diagnostic and Interventional Imaging . 102 ( 4 ) : 255-263

DOI: 10.1016/j.diii.2020.11.011

Journal article

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Splenectomy for primary immune thrombocytopenia revisited in the era of thrombopoietin receptor agonists: New insights for an old treatment

Arthur Mageau, Louis Terriou, Mikael Ebbo, Odile Souchaud-Debouverie, Corentin Orvain, Julie Graveleau...

American Journal of Hematology . 97 ( 1 ) : 10-17

DOI: 10.1002/ajh.26378

Journal article

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Arterial and venous thromboembolism in COVID-19: a study-level meta-analysis

Boun Kim Tan, Sabine Mainbourg, Arnaud Friggeri, Laurent Bertoletti, Marion Douplat, Yesim Dargaud...

Thorax . 76 ( 10 ) : 970-979

DOI: 10.1136/thoraxjnl-2020-215383

Journal article

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Population Pharmacokinetic Modeling and Dosing Simulations of Tobramycin in Pediatric Patients with Cystic Fibrosis

Antonin Praet, Laurent Bourguignon, Florence Vetele, Valentine Bréant, Charlotte Genestet, Oana Dumitrescu...

Antimicrobial Agents and Chemotherapy . 65 ( 10 ) : e0073721

DOI: 10.1128/AAC.00737-21

Journal article

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Parametric and Nonparametric Methods in Population Pharmacokinetics: Experts’ Discussion on Use, Strengths, and Limitations

Sylvain Goutelle, Jean-Baptiste Woillard, Thierry Buclin, Laurent Bourguignon, Walter Yamada, Chantal Csajka...

Journal of Clinical Pharmacology . 62 ( 2 ) : 158-170

DOI: 10.1002/jcph.1993

Journal article

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Estimating renal function when adjusting the dosage of antibiotics: Facts and fables

Sylvain Goutelle, N. Bleyzac, L. Mioux, B. de la Gastine, L. Bourguignon

Infectious Diseases Now . 51 ( 7 ) : 635-637

DOI: 10.1016/j.idnow.2021.01.012

Journal article

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Drug-related problems among older patients: Analysis of 8 years of pharmacist's interventions

F. Gervais, T. Novais, Sylvain Goutelle, M. Chappuy, S. Parat, D. Cabelguenne...

Annales Pharmaceutiques Françaises . 79 ( 5 ) : 511-521

DOI: 10.1016/j.pharma.2021.02.002

Journal article

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Pharmacokinetic/Pharmacodynamic Dosage Individualization of Cefepime in Critically Ill Patients: A Case Study

Sylvain Goutelle, Lucille Jay, Clément Boidin, Sabine Cohen, Laurent Bourguignon, Nathalie Bleyzac...

Therapeutic Drug Monitoring . 43 ( 4 ) : 451-454

DOI: 10.1097/FTD.0000000000000896

Journal article

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To Estimate or to Forecast? Lessons From a Comparative Analysis of Four Bayesian Fitting Methods Based on Nonparametric Models

Sylvain Goutelle, Céline Alloux, Laurent Bourguignon, Michael van Guilder, Michael Neely, Pascal Maire

Therapeutic Drug Monitoring . 43 ( 4 ) : 461-471

DOI: 10.1097/FTD.0000000000000879

Journal article

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Adherence to oral antibiotic therapy in patients with bone and joint infection: A pilot study

Laure Lalande, Constance Bretagnolle, Eugénie Mabrut, Tristan Ferry, Sylvain Goutelle

Infectious Diseases Now . 51 ( 4 ) : 334-339

DOI: 10.1016/j.idnow.2020.10.007

Journal article

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Pharmacokinetic/Pharmacodynamic Dosage Individualization of Suppressive Beta-Lactam Therapy Administered by Subcutaneous Route in Patients With Prosthetic Joint Infection

Sylvain Goutelle, Anne Conrad, Cécile Pouderoux, Evelyne Braun, Frédéric Laurent, Marie-Claude Gagnieu...

Frontiers in Medicine . 8 : 583086

DOI: 10.3389/fmed.2021.583086

Journal article

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Pharmacogenetic-guided glimepiride therapy in type-2 diabetes mellitus: a cost-effectiveness study

Cécile Fokoun, Hassan Serrier, Hugo Rabier, Sylvain Goutelle, Michel Tod, Laurent Bourguignon

Pharmacogenomics Journal . 21 ( 5 ) : 559-565

DOI: 10.1038/s41397-021-00232-w

Journal article

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Needs for re-intervention on restored teeth in adults: a practice-based study

Franck Decup, Emmanuelle Dantony, Charlène Chevalier, Alexandra David, Valentin Garyga, Marie Tohmé...

Clinical Oral Investigations . 26 ( 1 ) : 789-801

DOI: 10.1007/s00784-021-04058-5

Journal article

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Olaparib in recurrent IDH-mutant high-grade glioma (OLAGLI).

François Ducray, Marc Sanson, O. Chinot, Maxime Fontanilles, Romain Rivoirard, Laure Thomas-Maisonneuve...

57th Annual Meeting of the American Society of Clinical Oncology (2021 ASCO Annual Meeting) . 39 ( 15_suppl ) : 2007-2007

DOI: 10.1200/JCO.2021.39.15_suppl.2007

Conference paper

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Effect of periodontal treatment on the glomerular filtration rate, reduction of inflammatory markers and mortality in patients with chronic kidney disease: A systematic review

T. Delbove, F. Gueyffier, L. Juillard, E. Kalbacher, D. Maucort-Boulch, P. Nony...

PLoS ONE . 16 ( 1 ) : e0245619

DOI: 10.1371/journal.pone.0245619

Journal article

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Evaluation of High-Throughput SARS-CoV-2 Serological Assays in a Longitudinal Cohort of Patients with Mild COVID-19: Clinical Sensitivity, Specificity, and Association with Virus Neutralization Test

Antonin Bal, Bruno Pozzetto, Mary-Anne Trabaud, Vanessa Escuret, Muriel Rabilloud, Carole Langlois-Jacques...

Clinical Chemistry . 67 ( 5 ) : 742-752

DOI: 10.1093/clinchem/hvaa336

Journal article

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Clinical and laboratory characteristics of symptomatic healthcare workers with suspected COVID-19: a prospective cohort study

Antonin Bal, Karen Brengel-Pesce, Alexandre Gaymard, Grégory Quéromès, Nicolas Guibert, Emilie Frobert...

Scientific Reports . 11 ( 1 ) : 14977

DOI: 10.1038/s41598-021-93828-y

Journal article

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Economic impact of clinical pharmaceutical activities in hospital wards: A systematic review

Amandine Baudouin, Chloé Herledan, Nicolas Poletto, Marie-Delphine Guillemin, Ophélie Maison, Romain Garreau...

Research in Social and Administrative Pharmacy . 17 ( 3 ) : 497-505

DOI: 10.1016/j.sapharm.2020.07.016

Journal article

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Relationship between adverse drug reactions and unlicensed/off-label drug use in hospitalized children (EREMI): A study protocol

Kim An Nguyen, Yanis Mimouni, Elham Jaberi, Nathalie Paret, Inesse Boussaha, Thierry Vial...

Therapies . 76 ( 6 ) : 675-685

DOI: 10.1016/j.therap.2021.01.057

Journal article

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Reference values for the external genitalia of full-term and pre-term female neonates

Sarah Castets, Kim-An Nguyen, Franck Plaisant, Malika Baya Prudon, Ingrid Plotton, Behrouz Kassai...

Archives of disease in childhood. Fetal and neonatal edition . 106 ( 1 ) : 39-44

DOI: 10.1136/archdischild-2019-318090

Journal article

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Reappraisal of the efficacy of intensive glycaemic control on microvascular complications in patients with type 2 diabetes: A meta-analysis of randomised control-trials

Sophie Sun, Lucie Hisland, Guillaume Grenet, François Gueyffier, Catherine Cornu, Nemat Jaafari...

Thérapie .

DOI: 10.1016/j.therap.2021.10.002

Journal article

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Relationship Between Scorpion Stings Events and Environmental Conditions in Mainland France

Jules-Antoine Vaucel, Sébastien Larréché, Camille Paradis, Magali Labadie, Arnaud Courtois, Guillaume Grenet...

Journal of Medical Entomology . 58 ( 6 ) : 2146-2153

DOI: 10.1093/jme/tjab109

Journal article

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