Evaluation and Modeling with the Therapeutic Effects Group

Members

EMET  presentation

The EMET team brings together doctors, pharmacists and research professors specializing in the evaluation and use of drug and non-drug therapies, around a single project built on two axes:

  • the evaluation of therapies in clinical trials or observational studies;
  • the construction of explanatory and predictive models, to better understand and therefore predict the effect of therapies, simulate their impacts at the individual and population level, and improve the innovation paradigm.

The EMET team is therefore part of two major dynamics in therapy: analysis of the level of evidence and precision medicine.
The fields of application are cardiovascular and metabolic diseases, primary care medicine, rare pediatric diseases (including genetic and autoimmune diseases), oncology and infectious diseases.
EMET members implement approaches using different mathematical models: direct comparison and network meta-analysis, pharmacokinetic/pharmacodynamic analysis, Bayesian networks and machine learning.

Education

The EMET team is specially involved in the teaching of pharmacology and therapeutics and the modeling of the treatment effect through the coordination of the Masters 2 Clinical Evaluation (EC) and Pharmacology modeling and clinical trials (PHAME), Interpretation of Therapeutic Trials (IET), Training of investigators in clinical drug trials (FIEC) and Training of clinical research assistants and clinical study technicians (FARCTEC). Teacher-researchers are also involved in the first (pharmacology), second (pharmacology / therapeutics, pharmacy) and third cycles (general medicine, pediatrics, internal medicine) in health training courses.

Society involvement

The members of the EMET team through their work and their interactions with the other components of the LBBE, National societies, governmental (HAS) or international (EMA) agencies, and the Hospices Civils de Lyon, are invested in current societal issues: rationalization of the use of health product resources, research ethics, gender equality, rationality of approaches in analyzing the diversity of human populations.

Publications

Display of 151 to 180 publications on 613 in total

Parametric and Nonparametric Methods in Population Pharmacokinetics: Experts’ Discussion on Use, Strengths, and Limitations

Sylvain Goutelle, Jean-Baptiste Woillard, Thierry Buclin, Laurent Bourguignon, Walter Yamada, Chantal Csajka...

Journal of Clinical Pharmacology . 62 ( 2 ) : 158-170

DOI: 10.1002/jcph.1993

Journal article

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Estimating renal function when adjusting the dosage of antibiotics: Facts and fables

Sylvain Goutelle, N. Bleyzac, L. Mioux, B. de la Gastine, L. Bourguignon

Infectious Diseases Now . 51 ( 7 ) : 635-637

DOI: 10.1016/j.idnow.2021.01.012

Journal article

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Drug-related problems among older patients: Analysis of 8 years of pharmacist's interventions

F. Gervais, T. Novais, Sylvain Goutelle, M. Chappuy, S. Parat, D. Cabelguenne...

Annales Pharmaceutiques Françaises . 79 ( 5 ) : 511-521

DOI: 10.1016/j.pharma.2021.02.002

Journal article

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Pharmacokinetic/Pharmacodynamic Dosage Individualization of Cefepime in Critically Ill Patients: A Case Study

Sylvain Goutelle, Lucille Jay, Clément Boidin, Sabine Cohen, Laurent Bourguignon, Nathalie Bleyzac...

Therapeutic Drug Monitoring . 43 ( 4 ) : 451-454

DOI: 10.1097/FTD.0000000000000896

Journal article

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To Estimate or to Forecast? Lessons From a Comparative Analysis of Four Bayesian Fitting Methods Based on Nonparametric Models

Sylvain Goutelle, Céline Alloux, Laurent Bourguignon, Michael van Guilder, Michael Neely, Pascal Maire

Therapeutic Drug Monitoring . 43 ( 4 ) : 461-471

DOI: 10.1097/FTD.0000000000000879

Journal article

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Adherence to oral antibiotic therapy in patients with bone and joint infection: A pilot study

Laure Lalande, Constance Bretagnolle, Eugénie Mabrut, Tristan Ferry, Sylvain Goutelle

Infectious Diseases Now . 51 ( 4 ) : 334-339

DOI: 10.1016/j.idnow.2020.10.007

Journal article

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Pharmacokinetic/Pharmacodynamic Dosage Individualization of Suppressive Beta-Lactam Therapy Administered by Subcutaneous Route in Patients With Prosthetic Joint Infection

Sylvain Goutelle, Anne Conrad, Cécile Pouderoux, Evelyne Braun, Frédéric Laurent, Marie-Claude Gagnieu...

Frontiers in Medicine . 8 : 583086

DOI: 10.3389/fmed.2021.583086

Journal article

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Pharmacogenetic-guided glimepiride therapy in type-2 diabetes mellitus: a cost-effectiveness study

Cécile Fokoun, Hassan Serrier, Hugo Rabier, Sylvain Goutelle, Michel Tod, Laurent Bourguignon

Pharmacogenomics Journal . 21 ( 5 ) : 559-565

DOI: 10.1038/s41397-021-00232-w

Journal article

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Needs for re-intervention on restored teeth in adults: a practice-based study

Franck Decup, Emmanuelle Dantony, Charlène Chevalier, Alexandra David, Valentin Garyga, Marie Tohmé...

Clinical Oral Investigations . 26 ( 1 ) : 789-801

DOI: 10.1007/s00784-021-04058-5

Journal article

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Olaparib in recurrent IDH-mutant high-grade glioma (OLAGLI).

François Ducray, Marc Sanson, O. Chinot, Maxime Fontanilles, Romain Rivoirard, Laure Thomas-Maisonneuve...

57th Annual Meeting of the American Society of Clinical Oncology (2021 ASCO Annual Meeting) . 39 ( 15_suppl ) : 2007-2007

DOI: 10.1200/JCO.2021.39.15_suppl.2007

Conference paper

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Effect of periodontal treatment on the glomerular filtration rate, reduction of inflammatory markers and mortality in patients with chronic kidney disease: A systematic review

T. Delbove, F. Gueyffier, L. Juillard, E. Kalbacher, D. Maucort-Boulch, P. Nony...

PLoS ONE . 16 ( 1 ) : e0245619

DOI: 10.1371/journal.pone.0245619

Journal article

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Clinical and laboratory characteristics of symptomatic healthcare workers with suspected COVID-19: a prospective cohort study

Antonin Bal, Karen Brengel-Pesce, Alexandre Gaymard, Grégory Quéromès, Nicolas Guibert, Emilie Frobert...

Scientific Reports . 11 ( 1 ) : 14977

DOI: 10.1038/s41598-021-93828-y

Journal article

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Evaluation of High-Throughput SARS-CoV-2 Serological Assays in a Longitudinal Cohort of Patients with Mild COVID-19: Clinical Sensitivity, Specificity, and Association with Virus Neutralization Test

Antonin Bal, Bruno Pozzetto, Mary-Anne Trabaud, Vanessa Escuret, Muriel Rabilloud, Carole Langlois-Jacques...

Clinical Chemistry . 67 ( 5 ) : 742-752

DOI: 10.1093/clinchem/hvaa336

Journal article

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Economic impact of clinical pharmaceutical activities in hospital wards: A systematic review

Amandine Baudouin, Chloé Herledan, Nicolas Poletto, Marie-Delphine Guillemin, Ophélie Maison, Romain Garreau...

Research in Social and Administrative Pharmacy . 17 ( 3 ) : 497-505

DOI: 10.1016/j.sapharm.2020.07.016

Journal article

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Relationship between adverse drug reactions and unlicensed/off-label drug use in hospitalized children (EREMI): A study protocol

Kim An Nguyen, Yanis Mimouni, Elham Jaberi, Nathalie Paret, Inesse Boussaha, Thierry Vial...

Therapies . 76 ( 6 ) : 675-685

DOI: 10.1016/j.therap.2021.01.057

Journal article

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Reference values for the external genitalia of full-term and pre-term female neonates

Sarah Castets, Kim-An Nguyen, Franck Plaisant, Malika Baya Prudon, Ingrid Plotton, Behrouz Kassai...

Archives of disease in childhood. Fetal and neonatal edition . 106 ( 1 ) : 39-44

DOI: 10.1136/archdischild-2019-318090

Journal article

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Reappraisal of the efficacy of intensive glycaemic control on microvascular complications in patients with type 2 diabetes: A meta-analysis of randomised control-trials

Sophie Sun, Lucie Hisland, Guillaume Grenet, François Gueyffier, Catherine Cornu, Nemat Jaafari...

Thérapie .

DOI: 10.1016/j.therap.2021.10.002

Journal article

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Relationship Between Scorpion Stings Events and Environmental Conditions in Mainland France

Jules-Antoine Vaucel, Sébastien Larréché, Camille Paradis, Magali Labadie, Arnaud Courtois, Guillaume Grenet...

Journal of Medical Entomology . 58 ( 6 ) : 2146-2153

DOI: 10.1093/jme/tjab109

Journal article

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Efficacy and safety of topiramate in binge eating disorder: a systematic review and meta-analysis

M. Nourredine, L. Jurek, M. Auffret, S. Iceta, G. Grenet, B. Kassai...

CNS Spectrums . 26 ( 5 ) : 459-467

DOI: 10.1017/s1092852920001613

Journal article

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Using chest CT scan and unsupervised machine learning for predicting and evaluating response to lumacaftor-ivacaftor in people with cystic fibrosis

Alienor Campredon, Enzo Battistella, Clémence Martin, Isabelle Durieu, Laurent Mely, Christophe Marguet...

European Respiratory Journal . : 2101344

DOI: 10.1183/13993003.01344-2021

Journal article

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Diffuse alveolar haemorrhage in children: an international multicentre study

Astrid Madsen Ring, Nural Kiper, Frederik Buchvald, Ayse Tana Aslan, Roser Ayats, Ines Azevedo...

European Respiratory Society (ERS) Congress .

Conference paper

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Real-world assessment of LCI following lumacaftor-ivacaftor initiation in adolescents and adults with cystic fibrosis

Philippe Reix, Aurélie Tatopoulos, Iulia Ioan, Muriel Le Bourgeois, Stéphanie Bui, Marie Luce Choukroun...

Journal of Cystic Fibrosis .

DOI: 10.1016/j.jcf.2021.06.002

Journal article

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Chest physiotherapy enhances detection of Pseudomonas aeruginosa in nonexpectorating children with cystic fibrosis

Christophe Marguet, Véronique Houdouin, Isabelle Pin, Philippe Reix, Frédéric Huet, Marie Mittaine...

ERJ Open Research . 7 ( 1 ) : 00513-2020

DOI: 10.1183/23120541.00513-2020

Journal article

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Factors Associated with Asthma Severity in Children: Data from the French COBRAPed Cohort

Guillaume Lezmi, Stéphanie Lejeune, Isabelle Pin, Sylvain Blanchon, Naïm Bouazza, Valérie Jolaine...

Journal of Allergy and Clinical Immunology: In Practice . 9 ( 5 ) : 1969-1979

DOI: 10.1016/j.jaip.2020.12.027

Journal article

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Immune thrombocytopenia with clinical significance in systemic lupus erythematosus: a retrospective cohort study of 90 patients.

Mickaël Roussotte, Mathieu Gerfaud-Valentin, Arnaud Hot, Sylvain Audia, Bernard Bonnotte, Thomas Thibault...

Rheumatology .

DOI: 10.1093/rheumatology/keab925

Journal article

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Arterial and venous thromboembolism in COVID-19: a study-level meta-analysis

Boun Kim Tan, Sabine Mainbourg, Arnaud Friggeri, Laurent Bertoletti, Marion Douplat, Yesim Dargaud...

Thorax . 76 ( 10 ) : 970-979

DOI: 10.1136/thoraxjnl-2020-215383

Journal article

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Assessing the management of major bleeding events in patients treated by direct oral anticoagulant in an emergency department

Julien Durand, Stéphanie Parat, Jean-Christophe Lega, Yessim Dargaud, Véronique Potinet, Laurent Jacquin...

Annales de Biologie Clinique . 79 ( 4 ) : 315-324

DOI: 10.1684/abc.2021.1658

Journal article

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Evaluation of High-Throughput SARS-CoV-2 Serological Assays in a Longitudinal Cohort of Patients with Mild COVID-19: Clinical Sensitivity, Specificity, and Association with Virus Neutralization Test

Antonin Bal, Bruno Pozzetto, Mary-Anne Trabaud, Vanessa Escuret, Muriel Rabilloud, Carole Langlois-Jacques...

Clinical Chemistry . 67 ( 5 ) : 742-752

DOI: 10.1093/clinchem/hvaa336

Journal article

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Population pharmacokinetics of daptomycin in patients with bone and joint infection: minimal effect of rifampicin co-administration and confirmation of a sex difference

Romain Garreau, Romain Bricca, Marie-Claude Gagnieu, Sandrine Roux, Anne Conrad, Laurent Bourguignon...

Journal of Antimicrobial Chemotherapy . 76 ( 5 ) : 1250-1257

DOI: 10.1093/jac/dkab006

Journal article

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Model-Based Comparative Analysis of Rifampicin and Rifabutin Drug-Drug Interaction Profile

Vianney Tuloup, Mathilde France, Romain Garreau, Nathalie Bleyzac, Laurent Bourguignon, Michel Tod...

Antimicrobial Agents and Chemotherapy . 65 ( 9 ) : e0104321

DOI: 10.1128/AAC.01043-21

Journal article

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