GECO Evolutionary and Computational Genomics

The main goal of the GECO department is to foster integration and synergies between theoretical and methodological research relevant for the analysis of genomes (computational genomics) and empirical analysis of genomic and multi-omic data (evolutionary and functional genomics). The department is structured in two teams, BAOBAB and BPGE:

BAOBAB is deeply rooted in computer science. Its strengths are in algorithms, models, and mathematical analysis of graphs and networks, with applications to transcriptomics and metabolic networks.

BPGE is oriented towards bioinformatics, phylogenetics and evolutionary genomics. Its research projects cover a broad range of subjects, such as methodological developments for phylogenetic inference, their applications to the reconstruction of the evolutionary history of bacteria and archaea, the role of mobile genetic elements in the evolution of bacteria and of antibioresistance, or the role of recombination, of genomic rearrangements and of transposable elements in the evolution of eukaryotic genomes.

As detailed on their pages, the research conducted in both teams integrates deep and long-ranging theoretical and methodological (algorithmic and computational) developments with data analysis driven by empirical questions. This integration is bi-directional: methodological developments are guided by empirical questions and then used in empirical applications, while theoretical modeling helps clarify the conceptual basis of subsequent empirical analyses.

Publications

Display of 361 to 390 publications on 1402 in total

Microbiome intestinal ancien et problématiques médicales contemporaines

Philippe Charlier, Anaïs Augias, Philippe Sansonetti, Céline Bon, Sean Kennedy, Laure Ségurel

Médecine/Sciences . 33 : 984-990

DOI: 10.1051/medsci/20173311016

2017

Other publication

see the publication

On the Evolution of Lactase Persistence in Humans

Laure Ségurel, Céline Bon

Annual Review of Genomics and Human Genetics . 18 ( 1 ) : 297-319

DOI: 10.1146/annurev-genom-091416-035340

2017

Journal article

see the publication

Sex-specific genetic diversity is shaped by cultural factors in Inner Asian human populations

Nina Marchi, Tatyana Hegay, Philippe Mennecier, Myriam Georges, Romain Laurent, Mark Whitten...

American Journal of Physical Anthropology . 162 ( 4 ) : 627-640

DOI: 10.1002/ajpa.23151

2017

Journal article

see the publication

Latitude as a co-driver of human gut microbial diversity?

Emma Dikongué, Laure Ségurel

BioEssays . 39 ( 3 ) : 1600145

DOI: 10.1002/bies.201600145

2017

Journal article

see the publication

MareyMap online: A user-friendly web application and database service for estimating recombination rates using physical and genetic maps

Aurélie Siberchicot, Adrien Bessy, Laurent Gueguen, Gabriel A. B. Marais

Genome Biology and Evolution . 9 ( 10 ) : 2506-2509

DOI: 10.1093/gbe/evx178

2017

Journal article

see the publication

The global impact of Wolbachia on mitochondrial diversity and evolution

Marie Cariou, Laurent Duret, Sylvain Charlat

Journal of Evolutionary Biology . 30 ( 12 ) : 2204-2210

DOI: 10.1111/jeb.13186

2017

Journal article

see the publication

The Red Queen model of recombination hot-spot evolution: a theoretical investigation

Thibault Latrille, L. Duret, Nicolas Lartillot

Philosophical Transactions of the Royal Society B: Biological Sciences .

DOI: 10.1098/rstb.2016.0463

2017

Journal article

see the publication

BacHBerry: BACterial Hosts for production of Bioactive phenolics from bERRY fruits

Alexey Dudnik, Filipa Almeida, Ricardo Andrade, Barbara Avila, Pilar Bañados, Barbay Diane...

Phytochemistry Reviews . : 1-36

DOI: 10.1007/s11101-017-9532-2

2017

Journal article

see the publication

Algorithms for k-meet-semidistributive lattices

Laurent Beaudou, Arnaud Mary, Lhouari Nourine

Theoretical Computer Science . 658 : 391 - 398

DOI: 10.1016/j.tcs.2015.10.029

2017

Journal article

see the publication

d18O-Derived incubation temperatures of oviraptorosaur eggs.

Romain Amiot, Xu Wang, Shuo Wang, Christophe Lécuyer, Jean-Michel Mazin, Jinyou Mo...

Palaeontology . : 1-15

DOI: 10.1111/pala.12311

2017

Journal article

see the publication

Annotation and differential analysis of alternative splicing using de novo assembly of RNAseq data

Clara Benoit-Pilven, Camille Marchet, Emilie Chautard, Leandro Lima, Marie-Pierre Lambert, Gustavo Sacomoto...

DOI: 10.1101/074807

2017

Preprint

see the publication

The growing tree of Archaea: new perspectives on their diversity, evolution and ecology

Panagiotis S Adam, Guillaume Borrel, Céline Brochier-Armanet, Simonetta Gribaldo

The International Society of Microbiologial Ecology Journal . 11 ( 11 ) : 2407-2425

DOI: 10.1038/ismej.2017.122

2017

Journal article

see the publication

Improved Modeling of Compositional Heterogeneity Supports Sponges as Sister to All Other Animals

Roberto Feuda, Martin Dohrmann, Walker Pett, Herve Philippe, Omar Rota-Stabelli, Nicolas Lartillot...

Current Biology . 27 ( 24 ) : 3864-3870.e4

DOI: 10.1016/j.cub.2017.11.008

2017

Journal article

see the publication

Evolutionary strata on young mating-type chromosomes despite the lack of sexual antagonism

Sara E Branco, Hélène E Badouin, Ricardo E Rodríguez de La Vega, Jerome Gouzy, Fantin E Carpentier, Gabriela E Aguileta...

Proceedings of the National Academy of Sciences of the United States of America . 114 ( 27 ) : 7067-7072

DOI: 10.1073/pnas.1701658114

2017

Journal article

see the publication

Widespread selective sweeps throughout the genome of model plant pathogenic fungi and identification of effector candidates

Helene Badouin, Pierre Gladieux, Jerome Gouzy, Sophie Siguenza, Gabriela Aguileta, Alodie Snirc...

Molecular Ecology . 26 ( 7 )

DOI: 10.1111/mec.13976

2017

Journal article

see the publication

TEtools facilitates big data expression analysis of transposable elements and reveals an antagonism between their activity and that of piRNA genes

Emmanuelle Lerat, Marie Fablet, Laurent Modolo, Hélène Lopez-Maestre, Cristina Vieira

Nucleic Acids Research . 45 : 13

DOI: 10.1093/nar/gkw953

2017

Journal article

see the publication

On the rarity of dioecy in flowering plants

Jos Käfer, Gabriel Marais, Jr. Pannell

Molecular Ecology . 26 : 1225-1241

DOI: 10.1111/mec.14020

2017

Journal article

see the publication

In vivo binding of PRDM9 reveals interactions with noncanonical genomic sites

C Grey, Julie a J Clément, J Buard, B Leblanc, I Gut, M Gut...

Genome Research . 27 ( 4 ) : 580-590

DOI: 10.1101/gr.217240.116

2017

Journal article

see the publication

Recombination, meiotic expression and human codon usage

F. Pouyet, Dominique Mouchiroud, L. Duret, M. Sémon

eLife . 6 : e27344

DOI: 10.7554/eLife.27344.001

2017

Journal article

see the publication

Playing hide and seek with repeats in local and global de novo transcriptome assembly of short RNA-seq reads

Leandro Lima, Blerina Sinaimeri, Gustavo Sacomoto, Helene Lopez-Maestre, Camille Marchet, Vincent Miele...

Algorithms for Molecular Biology . 12 ( 1 ) : 2

DOI: 10.1186/s13015-017-0091-2

2017

Journal article

see the publication

OptPipe - a pipeline for optimizing metabolic engineering targets

András Hartmann, Ana Vila-Santa, Nicolai Kallscheuer, Michael Vogt, Alice Julien-Laferrière, Marie-France Sagot...

BMC Systems Biology . 11 : 1-9

DOI: 10.1186/s12918-017-0515-0

2017

Journal article

see the publication

On Bubble Generators in Directed Graphs

Vicente Acuna, Roberto Grossi, Giuseppe F Italiano, Leandro Lima, Romeo Rizzi, Gustavo Sacomoto...

WG 2017 - 43rd International Workshop on Graph-Theoretic Concepts in Computer Science . 10520 : 18-31

DOI: 10.1007/978-3-319-68705-6_2

2017

Conference paper

see the publication

IsoSel: Protein Isoform Selector for phylogenetic reconstructions

H. Philippon, A. Souvane, Céline Brochier-Armanet, G. Perriere

PLoS ONE . 12 : e0174250

DOI: 10.1371/journal.pone.0174250

2017

Journal article

see the publication

Record of Nile seasonality in Nubian neonates.

Céline Martin, Bruno Maureille, Romain Amiot, Alexandra Touzeau, Aurélien Royer, François Fourel...

Isotopes in Environmental and Health Studies . 53 ( 3 ) : 223-242

DOI: 10.1080/10256016.2016.1229667

2017

Journal article

see the publication

Strain-specific estimation of epidemic success provides insights into the transmission dynamics of tuberculosis

Jean-Philippe Rasigade, Maxime Barbier, Oana Dumitrescu, Catherine Pichat, Gérard Carret, Anne-Sophie Ronnaux-Baron...

Scientific Reports . 7 : 45326

DOI: 10.1038/srep45326

2017

Journal article

see the publication

The CO dehydrogenase accessory protein CooT is a novel nickel-binding protein.

J. Timm, C. Brochier-Armanet, J. Pérard, B. Zambelli, S. Ollagnier de Choudens, S. Ciurli...

Metallomics . 9 ( 5 ) : 575-583

DOI: 10.1039/c7mt00063d

2017

Journal article

see the publication

Evolutionary history of LTR-retrotransposons among 20 Drosophila species

N. Bargues, Emmanuelle Lerat

Mobile DNA . 8 : 7

DOI: 10.1186/s13100-017-0090-3

2017

Journal article

see the publication

A newly evolved W(olbachia) sex chromosome in pillbug!

Gabriel Marais, Sylvain Charlat

Peer Community In Evolutionary Biology .

DOI: 10.24072/pci.evolbiol.100016

2017

Journal article

see the publication

Continental-level population differentiation and environmental adaptation in the mushroom Suillus brevipes

Sara Branco, Ke Bi, Hui-Ling Liao, Pierre Gladieux, Helene Badouin, Christopher E Ellison...

Molecular Ecology . 26 ( 7 ) : 2063-2076

DOI: 10.1111/mec.13892

2017

Journal article

see the publication

The sunflower genome provides insights into oil metabolism, flowering and Asterid evolution

Hélène Badouin, Jerome Gouzy, Christopher Grassa, Florent Murat, S Evan Staton, Ludovic Cottret...

Nature . 546 ( 7656 ) : 148-152

DOI: 10.1038/nature22380

2017

Journal article

see the publication

GECO Evolutionary and Computational Genomics

Bioinformatics, Phylogeny and Evolutionary Genomics Group

Baobab Group

Publications

Microbiome intestinal ancien et problématiques médicales contemporaines

On the Evolution of Lactase Persistence in Humans

Sex-specific genetic diversity is shaped by cultural factors in Inner Asian human populations

Latitude as a co-driver of human gut microbial diversity?

MareyMap online: A user-friendly web application and database service for estimating recombination rates using physical and genetic maps

The global impact of Wolbachia on mitochondrial diversity and evolution

The Red Queen model of recombination hot-spot evolution: a theoretical investigation

BacHBerry: BACterial Hosts for production of Bioactive phenolics from bERRY fruits

Algorithms for k-meet-semidistributive lattices

d18O-Derived incubation temperatures of oviraptorosaur eggs.

Annotation and differential analysis of alternative splicing using de novo assembly of RNAseq data

The growing tree of Archaea: new perspectives on their diversity, evolution and ecology

Improved Modeling of Compositional Heterogeneity Supports Sponges as Sister to All Other Animals

Evolutionary strata on young mating-type chromosomes despite the lack of sexual antagonism

Widespread selective sweeps throughout the genome of model plant pathogenic fungi and identification of effector candidates

TEtools facilitates big data expression analysis of transposable elements and reveals an antagonism between their activity and that of piRNA genes

On the rarity of dioecy in flowering plants

In vivo binding of PRDM9 reveals interactions with noncanonical genomic sites

Recombination, meiotic expression and human codon usage

Playing hide and seek with repeats in local and global de novo transcriptome assembly of short RNA-seq reads

OptPipe - a pipeline for optimizing metabolic engineering targets

On Bubble Generators in Directed Graphs

IsoSel: Protein Isoform Selector for phylogenetic reconstructions

Record of Nile seasonality in Nubian neonates.

Strain-specific estimation of epidemic success provides insights into the transmission dynamics of tuberculosis

The CO dehydrogenase accessory protein CooT is a novel nickel-binding protein.

Evolutionary history of LTR-retrotransposons among 20 Drosophila species

A newly evolved W(olbachia) sex chromosome in pillbug!

Continental-level population differentiation and environmental adaptation in the mushroom Suillus brevipes

The sunflower genome provides insights into oil metabolism, flowering and Asterid evolution