GECO Evolutionary and Computational Genomics

Bioinformatics, Phylogeny and Evolutionary Genomics Group

Baobab Group

The main goal of the GECO department is to foster integration and synergies between theoretical and methodological research relevant for the analysis of genomes (computational genomics) and empirical analysis of genomic and multi-omic data (evolutionary and functional genomics). The department is structured in two teams, BAOBAB and BPGE:

BAOBAB is deeply rooted in computer science. Its strengths are in algorithms, models, and mathematical analysis of graphs and networks, with applications to transcriptomics and metabolic networks.

BPGE is oriented towards bioinformatics, phylogenetics and evolutionary genomics. Its research projects cover a broad range of subjects, such as methodological developments for phylogenetic inference, their applications to the reconstruction of the evolutionary history of bacteria and archaea, the role of mobile genetic elements in the evolution of bacteria and of antibioresistance, or the role of recombination, of genomic rearrangements and of transposable elements in the evolution of eukaryotic genomes.

As detailed on their pages, the research conducted in both teams integrates deep and long-ranging theoretical and methodological (algorithmic and computational) developments with data analysis driven by empirical questions. This integration is bi-directional: methodological developments are guided by empirical questions and then used in empirical applications, while theoretical modeling helps clarify the conceptual basis of subsequent empirical analyses.

Publications

Display of 271 to 300 publications on 1415 in total

Evidence of Austronesian Genetic Lineages in East Africa and South Arabia: Complex Dispersal from Madagascar and Southeast Asia

Nicolas Brucato, Verónica Fernandes, Pradiptajati Kusuma, Viktor Černý, Connie Mulligan, Pedro Soares...

Genome Biology and Evolution . 11 ( 3 ) : 748-758

DOI: 10.1093/gbe/evz028

Journal article

see the publication

The role of matrilineality in shaping patterns of Y chromosome and mtDNA sequence variation in southwestern Angola

Sandra Oliveira, Alexander Hübner, Anne-Maria Fehn, Teresa Aço, Fernanda Lages, Brigitte Pakendorf...

European Journal of Human Genetics . 27 ( 3 ) : 475-483

DOI: 10.1038/s41431-018-0304-2

Journal article

see the publication

A kinetic metabolic study of lipid production in Chlorella protothecoides under heterotrophic condition

Xiaojie Ren, Jean-Sébastien Deschênes, Réjean Tremblay, Sabine Pérès, Mario Jolicœur

Microbial Cell Factories . 18 ( 1 ) : 113

DOI: 10.1186/s12934-019-1163-4

Journal article

see the publication

Metabolic therapies inhibit tumor growth in vivo and in silico

Jorgelindo da Veiga Moreira, Minoo Hamraz, Mohammad Abolhassani, Laurent H Schwartz, Mario Jolicœur, Sabine Pérès

Scientific Reports . 9 ( 1 ) : 3153

DOI: 10.1038/s41598-019-39109-1

Journal article

see the publication

Modulating mitochondria horsepower for biotechnological applications

Jorgelindo da Veiga Moreira, Laurent Schwartz, Sabine S. Peres

Metabolic Pathway Analysis 2019 .

Conference paper

see the publication

Using a hybrid approach to model central carbon metabolism across the cell cycle

Cecile Moulin, Laurent Tournier, Sabine Pérès

International Workshop on Hybrid Systems Biology . 11705

DOI: 10.1007/978-3-030-28042-0_9

Conference paper

see the publication

Use of shotgun metagenomics for the identification of protozoa in the gut microbiota of healthy individuals from worldwide populations with various industrialization levels

Ana Lokmer, Amandine Cian, Alain Froment, Nausicaa Gantois, Eric Viscogliosi, Magali Chabé...

PLoS ONE . 14 ( 2 ) : e0211139

DOI: 10.1371/journal.pone.0211139

Journal article

see the publication

Exploring the Robustness of the Parsimonious Reconciliation Method in Host-Symbiont Cophylogeny

Laura Urbini, Blerina Sinaimeri, Catherine Matias, Marie-France Sagot

IEEE/ACM Transactions on Computational Biology and Bioinformatics . : 1-11

DOI: 10.1109/TCBB.2018.2838667

Journal article

see the publication

Global survey of mobile DNA horizontal transfer in arthropods reveals Lepidoptera as a prime hotspot

Daphné Reiss, Gladys Mialdea, Vincent Miele, Damien M. de Vienne, Jean Peccoud, Clément Gilbert...

PLoS Genetics . 15 ( 2 ) : e1007965

DOI: 10.1371/journal.pgen.1007965

Journal article

see the publication

A Distance-based block searching algorithm

M-F. Sagot, Alain Viari, H. Soldano

Third International Conference on Intelligent Systems for Molecular Biology (ISMB-95) . 3 : 322-331

Conference paper

see the publication

The Perfect Matching Reconfiguration Problem

Marthe Bonamy, Nicolas Bousquet, Marc Heinrich, Takehiro Ito, Yusuke Kobayashi, Arnaud Mary...

MFCS 2019 - 44th International Symposium on Mathematical Foundations of Computer Science . : 1-14

DOI: 10.4230/LIPIcs.MFCS.2019.80

Conference paper

see the publication

Article 22. Crise du stockage: conserver les molécules d'ADN ou les données informatiques de l'ADN ?

Dominique D. Joly, Guy Perriere

101 Secrets de l'ADN. CNRS Editions, Paris, pp 90-91 . : 90-91

Book chapter

see the publication

Taxonomic assignment of uncultured prokaryotes with long range PCR targeting the spectinomycin operon

Jean-Pierre Flandrois, Céline Brochier-Armanet, Jérôme Briolay, Danis Abrouk, Guillaume P Schwob, Philippe Normand...

Research in Microbiology . 170 ( 6-7 ) : 280-287

DOI: 10.1016/j.resmic.2019.06.005

Journal article

see the publication

Structure, Function, and Evolution of the Pseudomonas aeruginosa Lysine Decarboxylase LdcA

Eaazhisai Kandiah, Diego Carriel, Pierre Simon Garcia, Jan Felix, Manuel Banzhaf, George Kritikos...

Structure .

DOI: 10.1016/j.str.2019.10.003

Journal article

see the publication

The bacterial MrpORP is a novel Mrp/NBP35 protein involved in iron-sulfur biogenesis

Romain Pardoux, Anouchka Fiévet, Cíntia Carreira, Céline Brochier-Armanet, Odile Valette, Zorah Dermoun...

Scientific Reports . 9 ( 1 ) : 360-373

DOI: 10.1038/s41598-018-37021-8

Journal article

see the publication

Description Osteo-Oto-Hepato-Enteric (O2HE) syndrome, a new recessive autosomal syndrome secondary to loss of function mutations in the UNC45A gene

L. Faivre, Clothilde Esteve, L. Francescatto, P. L. Tan, A. Bourchany, C. Delafoulhouze...

European Journal of Human Genetics . 27 ( 1 ) : 795-796

Journal article

see the publication

On the Importance to Acknowledge Transposable Elements in Epigenomic Analyses

Emmanuelle Lerat, Josep Casacuberta, Cristian Chaparro, Cristina Vieira

Genes . 10 ( 4 ) : 258

DOI: 10.3390/genes10040258

Journal article

see the publication

Does the Presence of Transposable Elements Impact the Epigenetic Environment of Human Duplicated Genes?

Romain Lannes, Carène Rizzon, Emmanuelle Lerat

Genes . 10 ( 3 ) : 249

DOI: 10.3390/genes10030249

Journal article

see the publication

Homme/femme, mâle/femelle : la détermination du sexe dans l’espèce humaine et le reste du vivant

Gabriel Marais, Jos Käfer

Sexe & genre: De la biologie à la sociologie .

Book chapter

see the publication

Metapopulation ecology links antibiotic resistance, consumption and patient transfers in a network of hospital wards.

Julie Teresa Shapiro, Gilles Leboucher, Anne-Florence Myard-Dury, Pascale Girardo, Anatole Luzatti, Mélissa Mary...

DOI: 10.1101/771790

Preprint

see the publication

P2857 Quantifying drivers of antimicrobial resistance in a large network of hospital wards: a meta-population approach.

Julie Teresa Shapiro, Leboucher Gilles, Anatole Luzzati, Jean Francois Sauzon, Olivier Dauwalder, Pascale Girardo...

29TH ECCMID .

Conference paper

see the publication

GC-biased gene conversion conceals the prediction of the nearly neutral theory in avian genomes

Paulina Bolívar, Laurent Guéguen, Laurent Duret, Hans Ellegren, Carina Mugal

Genome Biology . 20 ( 1 )

DOI: 10.1186/s13059-018-1613-z

Journal article

see the publication

Evolution of replication origins in vertebrate genomes: rapid turnover despite selective constraints

Florian Massip, Marc Laurent, Caroline Brossas, José miguel Fernández-Justel, Maria Gomez, Marie-Noëlle Prioleau...

Nucleic Acids Research . 47 ( 10 ) : 5114-5125

DOI: 10.1093/nar/gkz182

Journal article

see the publication

On Bubble Generators in Directed Graphs

Vicente Acuña, Roberto Grossi, Giuseppe F. Italiano, Leandro Lima, Romeo Rizzi, Gustavo Sacomoto...

Algorithmica . : 1-19

DOI: 10.1007/s00453-019-00619-z

Journal article

see the publication

Efficient enumeration of solutions produced by closure operations

Arnaud Mary, Yann Strozecki

Discrete Mathematics and Theoretical Computer Science . : 1-30

DOI: 10.23638/DMTCS-21-3-22

Journal article

see the publication

The phytopathogenic nature of Dickeya aquatica 174/2 and the dynamic early evolution of Dickeya pathogenicity

Alexandre Duprey, Najwa Taïb, Simon Leonard, Tiffany Garin, Jean-Pierre Flandrois, William Nasser...

Environmental Microbiology . 21 ( 8 ) : 2809-2835

DOI: 10.1111/1462-2920.14627

Journal article

see the publication

New insights into minor splicing-a transcriptomic analysis of cells derived from TALS patients

Audric Cologne, Clara Benoit-Pilven, Alicia Besson, Audrey Putoux, Amandine Campan-Fournier, Michael B Bober...

RNA . : 1-21

DOI: 10.1261/rna.071423.119

Journal article

see the publication

Advances in Analyzing Virus-Induced Alterations of Host Cell Splicing

Usama Ashraf, Clara Benoit-Pilven, Vincent Lacroix, Vincent Navratil, Nadia Naffakh

Trends in Microbiology . 27 ( 3 ) : 268-281

DOI: 10.1016/j.tim.2018.11.004

Journal article

see the publication

Francisella tularensis: FupA mutation contributes tofluoroquinolone resistance by increasing vesicle secretion and biofilm formation

Claire Siebert, Helena Lindgren, Sabrina Ferré, Corinne Villers, Sandrine Boisset, Julien Pérard...

Emerging microbes & infections . 8 ( 1 ) : 808-822

DOI: 10.1080/22221751.2019.1615848

Journal article

see the publication

Comparative genomics and proteogenomics highlight key molecular players involved in Frankia sporulation

Lorine Bethencourt, Hasna Boubakri, Najwa Taïb, Philippe Normand, J. Armengaud, Pascale P Fournier...

Research in Microbiology . 170 ( 4-5 ) : 202-213

DOI: 10.1016/j.resmic.2019.04.002

Journal article

see the publication