Showing results 1101 to 1120 on 1601 in total
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La méthode que je vais présenter résulte de 9 années de travaux et repose sur un modèle physiologique de pharmacocinétique au steady-state. Cette méthode est implémentée en grande partie dans un site académique en accès libre www.ddi-predictor dont je parlerai brièvement. Je décrirai le principe, les avantages et les limites, les approches concurrentes, les applications cliniques. -----Quantitative prediction of the variation in drug exposure, linked to the genetic polymorphism of cytochromes P450 and membrane transporters. The method I will present results from 9 years of work and is based on a physiological model of steady-state pharmacokinetics. This method is largely implemented in an open access academic site www.ddi-predictor which I will briefly discuss. I will describe the principle, the advantages and the limits, the competing approaches, the clinical applications.
Thèse de Maoulide Saindou - Mercredi 3 avril 2013 - 15h00 - Médiathèque (Faculté de Médecine Lyon Est)
Whole Genome Duplications (WGDs) can be difficult to detect when they are old and when synteny has been disrupted by genome rearrangements. To test the presence of WGDs on a species phylogeny, I will present two methods which do not require synteny information and build strength from the phylogenetic framework. They rely on a probability model for the evolution of gene families on a species tree with WGDs. Both methods use multiple gene families across multiple species. One method relies on aligned molecular sequences and the other simply uses information on gene counts. We assessed their performance with simulations and on a benchmark yeast dataset, where we recover strong evidence for a well-established WGD and a low retention rate of duplicated genes after this WGD.
Thèse de Nicolas Ferry le vendredi 6 avril 2018 à 14 h, salle de conférence de la BU (la Doua)
"Governing the sex determination cascade in fish : regulatory coups d'état and ephemeral genetic dictators".
Constraints and opportunities in vertebrate genome evolution
un projet qui implique les quatre départements du laboratoire
Le LBBE, comme de nombreux laboratoires à travers le monde, est impliqué dans des projets de recherche autour de la Covid-19. Voici la liste des projets en cours (octobre 2020).
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