Predictive Modelling and Ecotoxicology Group
Members

Professeur des universités
UCBL
Tel: 33 04 72 43 29 00

Ingénieure d'études CDD
UCBL

Maître de conférences
UCBL
Tel: 33 04 72 44 80 51
Research activities of team MEPS team aim at proposing integrated mathematical and statistical modelling approaches to predict the effects of environmental disturbances at different levels of biological organisation. We are also interested in their functional and evolutionary consequences whether on individual fitness, population, community and/or ecosystem dynamics. In order to build generic enough models with a high predictive power, team MEPS is particularly interested in understanding the functioning of the complex systems under consideration, and not only a very refined description of them. Thus, our models always respect the parsimony principl, ensuring that they remain sufficiently simple with limited "black box" effects. Particular attention is also paid to the robustness, and therefore the generalizability, of the knowledge produced through these models, with the final goal of improving the overall acceptability of modelling approaches in support of decision-making for environmental risk assessment.
Reducing the complexity of systems in order to produce relevant and generic enough models must not preclude having solid mathematical foundations, so that these models remain useful tools for understanding the mechanisms underlying disturbance processes and effects observed on tissues, organisms, populations, communities and/or ecosystems. Such mechanistic models must also include the temporal dimension, which is essential when we are talking about dynamic processes as for realistic exposure scenarios to several environmental pressures. At the same time, complementary criteria of short- and long-term effects must be taken into account to address issues such as remediation and restoration of some specific environments as well as the potential of providing a dynamical and integrative prediction of effects over several generations.
In this context, team MEPS is today focused on the following topics:
- The development of mechanistic models based on physiological, namely physiologically based toxicokinetic-toxicodynamic (PBTKTD) models, in the perspective of providing predictive and diagnostic tools for the environmental quality;
- The plasticity of individual responses to one (or a combination of) stress factor(s) (e.g. contamination and/or global warming) and the effects of adaptation phenomena on the long-term dynamics of populations;
- The prediction of the species sensitivity distribution within communities when exposed to chemical contaminants by integrating inter-species variability on various biological parameters of interest and not only on a critical effect concentration;
- The development and the maintenance of the MOSAIC web platform (MOdeling and StAtistical tools for ecotoxICology, http://mosaic.univ-lyon1.fr) which freely and in a user-friendly way provides a collection of tools for data analysis and modelling in the field of ecotoxicology.

Publications
Display of 1 to 30 publications on 116 in total
OneWater FAIR Data Platform : setting up a national FAIR water data platform and community
TERENO OZCAR 2023 - 2ème conférence internationale TERENO OZCAR . : 1-23
Conference paper
see the publicationEditorial trend: adverse outcome pathway (AOP) and computational strategy — towards new perspectives in ecotoxicology
Environmental Science and Pollution Research .
Journal article
see the publicationInfluence of the exposure concentration of dissolved cadmium on its organotropism, toxicokinetic and fate in Gammarus fossarum
Environment International . 171 : 107673
Journal article
see the publicationMain conclusions and perspectives from the collective scientific assessment of the effects of plant protection products on biodiversity and ecosystem services along the land–sea continuum in France and French overseas territories
Environmental Science and Pollution Research .
Journal article
see the publicationIntegrative biomarker response - Threshold (IBR-T): Refinement of IBRv2 to consider the reference and threshold values of biomarkers
Journal of Environmental Management . 341 : 118049
Journal article
see the publicationIn Vivo Mercury (De)Methylation Metabolism in Cephalopods under Different p CO 2 Scenarios
Environmental Science and Technology . 57 ( 14 ) : 5761-5770
Journal article
see the publicationImplementation of Model-Based Dose Adjustment of Tobramycin in Adult Patients with Cystic Fibrosis
Pharmaceutics . 14 ( 8 ) : 1750
Journal article
see the publicationOrgan-specific accumulation of cadmium and zinc in Gammarus fossarum exposed to environmentally relevant metal concentrations
Environmental Pollution . 308 : 119625
Journal article
see the publicationImprovements in Estimating Bioaccumulation Metrics in the Light of Toxicokinetic Models and Bayesian Inference
Archives of Environmental Contamination and Toxicology . 83 ( 4 ) : 339-348
Journal article
see the publicationA review of modelling approaches for ecological risk assessment of pesticides
SETAC Europe 32nd annual meeting .
Poster
see the publicationImpacts des produits phytopharmaceutiques sur la biodiversité et les services écosystémiques. Rapport de l’expertise scientifique collective
: 1408 p.
DOI: 10.17180/0gp2-cd65
Report
see the publicationImpacts des produits phytopharmaceutiques sur la biodiversité et les services écosystémiques. Synthèse de l’expertise scientifique collective
: 136 p.
DOI: 10.17180/gfkj-e861
Report
see the publicationNew perspectives on the calculation of bioaccumulation metrics for active substances in living organisms
Integrated Environmental Assessment and Management . 18 ( 1 ) : 10-18
DOI: 10.1002/ieam.4439
Journal article
see the publicationA critical review of effect modeling for ecological risk assessment of plant protection products
Environmental Science and Pollution Research . 29 : 43448-43500
Journal article
see the publicationRecent advances in the development of the comet assay on the hemocytes of zebra mussels and its application in field studies for evaluating environmental genotoxicity
International Comet Assay Workshop - 14th annual meeting .
Conference paper
see the publicationPredicting characterization factors of chemical substances from a set of molecular descriptors based on machine learning algorithms
Peer Community in Ecotoxicology and Environmental Chemistry . : 100001
Other publication
see the publicationTaking full advantage of modelling to better assess environmental risk due to xenobiotics
Environmental Science and Pollution Research .
Journal article
see the publicationGeneric Solving of One-compartment Toxicokinetic Models
Journal of Exploratory Research in Pharmacology .
Journal article
see the publicationKeeping modelling notebooks with TRACE: Good for you and good for environmental research and management support
Environmental Modelling & Software . 136 : 104932
Journal article
see the publicationOne and multi-compartments toxico-kinetic modeling to understand metals’ organotropism and fate in Gammarus fossarum
Environment International . 156 : 106625
Journal article
see the publicationThe added value of Bayesian inference for estimating biotransformation rates of organic contaminants in aquatic invertebrates
Aquatic Toxicology . 234 : 105811
Journal article
see the publicationAccumulation-depuration data collection in support of toxicokinetic modelling
Preprint
see the publicationHow to account for the uncertainty from standard toxicity tests in species sensitivity distributions: An example in non-target plants
PLoS ONE .
Journal article
see the publicationIn Situ Reproductive Bioassay with Caged Gammarus fossarum (Crustacea): Part 1—Gauging the Confounding Influence of Temperature and Water Hardness
Environmental Toxicology and Chemistry . 39 ( 3 ) : 667-677
DOI: 10.1002/etc.4655
Journal article
see the publicationIn Situ Reproductive Bioassay with Caged Gammarus fossarum (Crustacea): Part 2—Evaluating the Relevance of Using a Molt Cycle Temperature‐Dependent Model as a Reference to Assess Toxicity in Freshwater Monitoring
Environmental Toxicology and Chemistry . 39 ( 3 ) : 678-691
DOI: 10.1002/etc.4656
Journal article
see the publicationModèles de croissance des micro-organismes, in Micro-organismes & biodiversité
Textes et documents pour la classe . 1130 : 60-63
Journal article
see the publicationRecommendations to address uncertainties in environmental risk assessment using toxicokinetic-toxicodynamic models
Scientific Reports . 9 ( 1 )
Journal article
see the publicationA Bayesian framework for estimating parameters of a generic toxicokinetic model for the bioaccumulation of organic chemicals by benthic invertebrates: Proof of concept with PCB153 and two freshwater species
Ecotoxicology and Environmental Safety . 180 : 33-42
Journal article
see the publicationMOSAIC: a web-interface for statistical analyses in ecotoxicology
Environmental Science and Pollution Research . 25 ( 12 ) : 11295-11302
Journal article
see the publication