Predictive Modelling and Ecotoxicology Group
Members
Professeur des universités
UCBL
Tel: 33 04 72 43 29 00
Doctorante
CNRS
Ingénieure d'études CDD
UCBL
Maître de conférences
UCBL
Tel: 33 04 72 44 80 51
Research activities of team MEPS team aim at proposing integrated mathematical and statistical modelling approaches to predict the effects of environmental disturbances at different levels of biological organisation. We are also interested in their functional and evolutionary consequences whether on individual fitness, population, community and/or ecosystem dynamics. In order to build generic enough models with a high predictive power, team MEPS is particularly interested in understanding the functioning of the complex systems under consideration, and not only a very refined description of them. Thus, our models always respect the parsimony principl, ensuring that they remain sufficiently simple with limited "black box" effects. Particular attention is also paid to the robustness, and therefore the generalizability, of the knowledge produced through these models, with the final goal of improving the overall acceptability of modelling approaches in support of decision-making for environmental risk assessment.
Reducing the complexity of systems in order to produce relevant and generic enough models must not preclude having solid mathematical foundations, so that these models remain useful tools for understanding the mechanisms underlying disturbance processes and effects observed on tissues, organisms, populations, communities and/or ecosystems. Such mechanistic models must also include the temporal dimension, which is essential when we are talking about dynamic processes as for realistic exposure scenarios to several environmental pressures. At the same time, complementary criteria of short- and long-term effects must be taken into account to address issues such as remediation and restoration of some specific environments as well as the potential of providing a dynamical and integrative prediction of effects over several generations.
In this context, team MEPS is today focused on the following topics:
- The development of mechanistic models based on physiological, namely physiologically based toxicokinetic-toxicodynamic (PBTKTD) models, in the perspective of providing predictive and diagnostic tools for the environmental quality;
- The plasticity of individual responses to one (or a combination of) stress factor(s) (e.g. contamination and/or global warming) and the effects of adaptation phenomena on the long-term dynamics of populations;
- The prediction of the species sensitivity distribution within communities when exposed to chemical contaminants by integrating inter-species variability on various biological parameters of interest and not only on a critical effect concentration;
- The development and the maintenance of the MOSAIC web platform (MOdeling and StAtistical tools for ecotoxICology, http://mosaic.univ-lyon1.fr) which freely and in a user-friendly way provides a collection of tools for data analysis and modelling in the field of ecotoxicology.
Publications
Display of 1 to 30 publications on 226 in total
Advancing Maternal Transfer of Organic Pollutants across Reptiles for Conservation and Risk Assessment Purposes
Environmental Science and Technology . 58 ( 40 ) : 17567-17579
Journal article
see the publicationA brief review on models for birds exposed to chemicals
Environmental Science and Pollution Research .
Journal article
see the publicationAdvancing environmental monitoring across the water continuum combining biomarker analysis in multiple sentinel species: A case study in the Seine-Normandie Basin (France)
Journal of Environmental Management . 358 : 120784
Journal article
see the publicationQuantifying the relationship between observed variables that contain censored values using Bayesian error-in-variables regression
Preprint
see the publicationBioaccumulation, organotropism and fate of cadmium in Gammarus fossarum exposed through dietary pathway
Journal of Hazardous Materials . 480 : 135965
Journal article
see the publicationImpacts des néonicotinoïdes sur la biodiversité
Séminaire EcoScience .
Conference paper
see the publicationImpacts des néonicotinoïdes sur la biodiversité
52ème congrès du Groupe Français de recherche sur les Pesticides .
Conference paper
see the publicationHigh performance computing and neural network in support of toxicokinetic-toxicodynamic modelling for the understanding of mixture effects
SETAC Europe 34th Annual Meeting .
Poster
see the publicationAssessing viral freshwater hazard using a toxicokinetic model and Dreissena polymorpha
Environmental Pollution . 344 : 123420
Journal article
see the publicationAdvancing environmental monitoring across the water continuum combining biomarker analysis in multiple sentinel species: A case study in the Seine-Normandie Basin (France)
Journal of Environmental Management . 358 : 120784
Journal article
see the publicationAssimilation efficiencies and elimination rates of silver, cadmium and zinc accumulated by trophic pathway in Gammarus fossarum
Peer Community Journal . 4 : e51
Journal article
see the publicationMechanistic Analysis of the Sub Chronic Toxicity of La and Gd in Daphnia Magna Based on TKTD Modelling and Synchrotron X-Ray Fluorescence Imaging
DOI: 10.2139/ssrn.4570452
Preprint
see the publicationImpacts of neonicotinoids on biodiversity: a critical review
Environmental Science and Pollution Research . 31 : 90-108
Journal article
see the publicationEditorial trend: adverse outcome pathway (AOP) and computational strategy — towards new perspectives in ecotoxicology
Environmental Science and Pollution Research . 31 ( 5 ) : 6587-6596
Journal article
see the publicationModélisation mathématique et statistique pour l’évaluation du risque environnemental
Impacts des produits phytopharmaceutiques sur la biodiversité et les services écosystémiques
978-2-7592-3656-5 : 183 p.
Book
see the publicationA meta-analysis of ecotoxicological models used for plant protection product risk assessment before their placing on the market
11th European Modelling Workshop .
Conference paper
see the publicationApproches de modélisation pour évaluer les effets écotoxicologiques des pesticides : revue critique
51ème congrès du Groupe Français de recherche sur les Pesticides .
Poster
see the publicationStudy of host-symbionts coevolution in the whitefly Bemisia tabaci: an experimental evolution approach
13e Rencontre du Réseau Français de Biologie Adaptative des Pucerons et Organismes Associés (BAPOA) .
Conference paper
see the publicationAmphibians under scrutiny - When human-dominated landscape mosaics are not in full compliance with their ecological requirements
Peer Community In Ecology .
Journal article
see the publicationTowards model-guided organic farming expansion for crop pest management
Peer Community In Ecology .
Journal article
see the publicationThe use of new approach methodologies for the environmental risk assessment of food and feed chemicals
Current Opinion in Environmental Science & Health . 31 : 100416
Journal article
see the publicationUptake, distribution, and elimination of selenite in earthworm Eisenia fetida at sublethal concentrations based on toxicokinetic model
Science of the Total Environment . 858 : 159632
Journal article
see the publicationThe ATTAC guiding principles to openly and collaboratively share wildlife ecotoxicology data
MethodsX . 10 ( 1 ) : 101987
Journal article
see the publicationhb or not hb - When and why accounting for background mortality in toxicological survival models matters?
MethodsX . 10 : 102114
Journal article
see the publicationOneWater FAIR Data Platform : setting up a national FAIR water data platform and community
TERENO OZCAR 2023 - 2ème conférence internationale TERENO OZCAR . : 1-23
Conference paper
see the publicationInfluence of the exposure concentration of dissolved cadmium on its organotropism, toxicokinetic and fate in Gammarus fossarum
Environment International . 171 : 107673
Journal article
see the publicationMain conclusions and perspectives from the collective scientific assessment of the effects of plant protection products on biodiversity and ecosystem services along the land–sea continuum in France and French overseas territories
Environmental Science and Pollution Research .
Journal article
see the publicationIntegrative biomarker response - Threshold (IBR-T): Refinement of IBRv2 to consider the reference and threshold values of biomarkers
Journal of Environmental Management . 341 : 118049
Journal article
see the publication