Predictive Modelling and Ecotoxicology Group

Members

Research activities of team MEPS team aim at proposing integrated mathematical and statistical modelling approaches to predict the effects of environmental disturbances at different levels of biological organisation. We are also interested in their functional and evolutionary consequences whether on individual fitness, population, community and/or ecosystem dynamics. In order to build generic enough models with a high predictive power, team MEPS is particularly interested in understanding the functioning of the complex systems under consideration, and not only a very refined description of them. Thus, our models always respect the parsimony principl, ensuring that they remain sufficiently simple with limited "black box" effects. Particular attention is also paid to the robustness, and therefore the generalizability, of the knowledge produced through these models, with the final goal of improving the overall acceptability of modelling approaches in support of decision-making for environmental risk assessment.

Reducing the complexity of systems in order to produce relevant and generic enough models must not preclude having solid mathematical foundations, so that these models remain useful tools for understanding the mechanisms underlying disturbance processes and effects observed on tissues, organisms, populations, communities and/or ecosystems. Such mechanistic models must also include the temporal dimension, which is essential when we are talking about dynamic processes as for realistic exposure scenarios to several environmental pressures. At the same time, complementary criteria of short- and long-term effects must be taken into account to address issues such as remediation and restoration of some specific environments as well as the potential of providing a dynamical and integrative prediction of effects over several generations.
In this context, team MEPS is today focused on the following topics:

  • The development of mechanistic models based on physiological, namely physiologically based toxicokinetic-toxicodynamic (PBTKTD) models, in the perspective of providing predictive and diagnostic tools for the environmental quality;
  • The plasticity of individual responses to one (or a combination of) stress factor(s) (e.g. contamination and/or global warming) and the effects of adaptation phenomena on the long-term dynamics of populations;
  • The prediction of the species sensitivity distribution within communities when exposed to chemical contaminants by integrating inter-species variability on various biological parameters of interest and not only on a critical effect concentration;
  • The development and the maintenance of the MOSAIC web platform (MOdeling and StAtistical tools for ecotoxICology, http://mosaic.univ-lyon1.fr) which freely and in a user-friendly way provides a collection of tools for data analysis and modelling in the field of ecotoxicology.

Publications

Display of 1 to 30 publications on 116 in total

OneWater FAIR Data Platform : setting up a national FAIR water data platform and community

Sylvain Grellet, Isabelle Braud, Fanny Arnaud, Kenneth Maussang, Anne Laurent, Frédéric Huynh...

TERENO OZCAR 2023 - 2ème conférence internationale TERENO OZCAR . : 1-23

Conference paper

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Editorial trend: adverse outcome pathway (AOP) and computational strategy — towards new perspectives in ecotoxicology

Damien Baudiffier, Karine Audouze, Olivier Armant, Sandrine Frelon, Sandrine Charles, Rémy Beaudouin...

Environmental Science and Pollution Research .

DOI: 10.1007/s11356-023-30647-w

Journal article

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Influence of the exposure concentration of dissolved cadmium on its organotropism, toxicokinetic and fate in Gammarus fossarum

Ophélia Gestin, Thomas Lacoue-Labarthe, Nicolas Delorme, Laura Garnero, Olivier Geffard, Christelle Lopes

Environment International . 171 : 107673

DOI: 10.1016/j.envint.2022.107673

Journal article

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Main conclusions and perspectives from the collective scientific assessment of the effects of plant protection products on biodiversity and ecosystem services along the land–sea continuum in France and French overseas territories

Stéphane Pesce, Laure Mamy, Wilfried Sanchez, Marcel Amichot, Joan Artigas, Stéphanie Aviron...

Environmental Science and Pollution Research .

DOI: 10.1007/s11356-023-26952-z

Journal article

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Integrative biomarker response - Threshold (IBR-T): Refinement of IBRv2 to consider the reference and threshold values of biomarkers

Audrey Catteau, Antoine Le Guernic, Mélissa Palos Ladeiro, Odile Dedourge-Geffard, Marc Bonnard, Isabelle Bonnard...

Journal of Environmental Management . 341 : 118049

DOI: 10.1016/j.jenvman.2023.118049

Journal article

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In Vivo Mercury (De)Methylation Metabolism in Cephalopods under Different p CO 2 Scenarios

Sophie Gentès, Antoine Minet, Christelle Lopes, Emmanuel Tessier, Claire Gassie, Remy Guyoneaud...

Environmental Science and Technology . 57 ( 14 ) : 5761-5770

DOI: 10.1021/acs.est.2c08513

Journal article

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Implementation of Model-Based Dose Adjustment of Tobramycin in Adult Patients with Cystic Fibrosis

Jérémy Reverchon, Vianney Tuloup, Romain Garreau, Viviane Nave, Sabine Cohen, Philippe Reix...

Pharmaceutics . 14 ( 8 ) : 1750

DOI: 10.3390/pharmaceutics14081750

Journal article

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Organ-specific accumulation of cadmium and zinc in Gammarus fossarum exposed to environmentally relevant metal concentrations

Ophélia Gestin, Christelle Lopes, Nicolas Delorme, Laura Garnero, Olivier Geffard, Thomas Lacoue-Labarthe

Environmental Pollution . 308 : 119625

DOI: 10.1016/j.envpol.2022.119625

Journal article

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Improvements in Estimating Bioaccumulation Metrics in the Light of Toxicokinetic Models and Bayesian Inference

Aude Ratier, Christelle Lopes, Sandrine Charles

Archives of Environmental Contamination and Toxicology . 83 ( 4 ) : 339-348

DOI: 10.1007/s00244-022-00947-2

Journal article

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A review of modelling approaches for ecological risk assessment of pesticides

Floriane Larras, Sandrine Charles, Arnaud Chaumot, Céline Pélosi, Morgane Le Gall, Laure Mamy...

SETAC Europe 32nd annual meeting .

Poster

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Impacts des produits phytopharmaceutiques sur la biodiversité et les services écosystémiques. Rapport de l’expertise scientifique collective

Laure Mamy, Stéphane Pesce, Wilfried Sanchez, Marcel Amichot, Joan Artigas, Stéphanie Aviron...

: 1408 p.

DOI: 10.17180/0gp2-cd65

Report

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Impacts des produits phytopharmaceutiques sur la biodiversité et les services écosystémiques. Synthèse de l’expertise scientifique collective

Sophie Leenhardt, Laure Mamy, Stéphane Pesce, Wilfried Sanchez, Anne Laure Achard, Marcel Amichot...

: 136 p.

DOI: 10.17180/gfkj-e861

Report

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New perspectives on the calculation of bioaccumulation metrics for active substances in living organisms

Aude Ratier, Gauthier Multari, Vanessa Mazerolles, Patrice Carpentier, Sandrine Charles, Christelle Lopes

Integrated Environmental Assessment and Management . 18 ( 1 ) : 10-18

DOI: 10.1002/ieam.4439

Journal article

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A critical review of effect modeling for ecological risk assessment of plant protection products

Floriane Larras, Sandrine Charles, Arnaud Chaumot, Céline Pélosi, Morgane Le Gall, Laure Mamy...

Environmental Science and Pollution Research . 29 : 43448-43500

DOI: 10.1007/s11356-022-19111-3

Journal article

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Recent advances in the development of the comet assay on the hemocytes of zebra mussels and its application in field studies for evaluating environmental genotoxicity

Marc Bonnard, Delahaut Laurence, Isabelle Bonnard, Maxime Louzon, Damien Rioult, Véronique Gaillet...

International Comet Assay Workshop - 14th annual meeting .

Conference paper

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Predicting characterization factors of chemical substances from a set of molecular descriptors based on machine learning algorithms

Sandrine Charles

Peer Community in Ecotoxicology and Environmental Chemistry . : 100001

DOI: 10.24072/pci.ecotoxenvchem.100001

Other publication

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Taking full advantage of modelling to better assess environmental risk due to xenobiotics

Sandrine Charles, Aude Ratier, Virgile Baudrot, Gauthier Multari, Aurélie Siberchicot, Dan Wu...

Environmental Science and Pollution Research .

DOI: 10.1007/s11356-021-15042-7

Journal article

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Generic Solving of One-compartment Toxicokinetic Models

Sandrine Charles, Aude Ratier, Christelle Lopes

Journal of Exploratory Research in Pharmacology .

DOI: 10.14218/JERP.2021.00024

Journal article

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Keeping modelling notebooks with TRACE: Good for you and good for environmental research and management support

Daniel Ayllón, Steven Railsback, Cara Gallagher, Jacqueline Augusiak, Hans Baveco, Uta Berger...

Environmental Modelling & Software . 136 : 104932

DOI: 10.1016/j.envsoft.2020.104932

Journal article

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One and multi-compartments toxico-kinetic modeling to understand metals’ organotropism and fate in Gammarus fossarum

Ophélia Gestin, Thomas Lacoue-Labarthe, Marina Coquery, Nicolas Delorme, Laura Garnero, Lysiane Dherret...

Environment International . 156 : 106625

DOI: 10.1016/j.envint.2021.106625

Journal article

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The added value of Bayesian inference for estimating biotransformation rates of organic contaminants in aquatic invertebrates

Aude Ratier, Christelle Lopes, Olivier Geffard, Marc Babut

Aquatic Toxicology . 234 : 105811

DOI: 10.1016/j.aquatox.2021.105811

Journal article

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How to account for the uncertainty from standard toxicity tests in species sensitivity distributions: An example in non-target plants

Sandrine Charles, Dan Wu, Virginie Ducrot

PLoS ONE .

DOI: 10.1371/journal.pone.0245071

Journal article

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In Situ Reproductive Bioassay with Caged Gammarus fossarum (Crustacea): Part 1—Gauging the Confounding Influence of Temperature and Water Hardness

Arnaud Chaumot, Romain Coulaud Coulaud, Olivier Adam, Herve Queau, Christelle Lopes, Olivier Geffard

Environmental Toxicology and Chemistry . 39 ( 3 ) : 667-677

DOI: 10.1002/etc.4655

Journal article

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In Situ Reproductive Bioassay with Caged Gammarus fossarum (Crustacea): Part 2—Evaluating the Relevance of Using a Molt Cycle Temperature‐Dependent Model as a Reference to Assess Toxicity in Freshwater Monitoring

Christelle Lopes, Arnaud Chaumot, Benoit Xuereb, Romain Coulaud, Guillaume Jubeaux, Hervé Quéau...

Environmental Toxicology and Chemistry . 39 ( 3 ) : 678-691

DOI: 10.1002/etc.4656

Journal article

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Modèles de croissance des micro-organismes, in Micro-organismes & biodiversité

Sandrine Charles, Hubert Charles

Textes et documents pour la classe . 1130 : 60-63

Journal article

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Recommendations to address uncertainties in environmental risk assessment using toxicokinetic-toxicodynamic models

Virgile Baudrot, Sandrine Charles

Scientific Reports . 9 ( 1 )

DOI: 10.1038/s41598-019-47698-0

Journal article

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A Bayesian framework for estimating parameters of a generic toxicokinetic model for the bioaccumulation of organic chemicals by benthic invertebrates: Proof of concept with PCB153 and two freshwater species

Aude Ratier, Christelle Lopes, Pierre Labadie, Hélène Budzinski, Nicolas Delorme, Herve Queau...

Ecotoxicology and Environmental Safety . 180 : 33-42

DOI: 10.1016/j.ecoenv.2019.04.080

Journal article

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MOSAIC: a web-interface for statistical analyses in ecotoxicology

Sandrine Charles, Philippe Veber, Marie Laure Delignette-Muller

Environmental Science and Pollution Research . 25 ( 12 ) : 11295-11302

DOI: 10.1007/s11356-017-9809-4

Journal article

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