Research activities of team MEPS team aim at proposing integrated mathematical and statistical modelling approaches to predict the effects of environmental disturbances at different levels of biological organisation. We are also interested in their functional and evolutionary consequences whether on individual fitness, population, community and/or ecosystem dynamics. In order to build generic enough models with a high predictive power, team MEPS is particularly interested in understanding the functioning of the complex systems under consideration, and not only a very refined description of them. Thus, our models always respect the parsimony principl, ensuring that they remain sufficiently simple with limited "black box" effects. Particular attention is also paid to the robustness, and therefore the generalizability, of the knowledge produced through these models, with the final goal of improving the overall acceptability of modelling approaches in support of decision-making for environmental risk assessment.
Reducing the complexity of systems in order to produce relevant and generic enough models must not preclude having solid mathematical foundations, so that these models remain useful tools for understanding the mechanisms underlying disturbance processes and effects observed on tissues, organisms, populations, communities and/or ecosystems. Such mechanistic models must also include the temporal dimension, which is essential when we are talking about dynamic processes as for realistic exposure scenarios to several environmental pressures. At the same time, complementary criteria of short- and long-term effects must be taken into account to address issues such as remediation and restoration of some specific environments as well as the potential of providing a dynamical and integrative prediction of effects over several generations.
In this context, team MEPS is today focused on the following topics:
- The development of mechanistic models based on physiological, namely physiologically based toxicokinetic-toxicodynamic (PBTKTD) models, in the perspective of providing predictive and diagnostic tools for the environmental quality;
- The plasticity of individual responses to one (or a combination of) stress factor(s) (e.g. contamination and/or global warming) and the effects of adaptation phenomena on the long-term dynamics of populations;
- The prediction of the species sensitivity distribution within communities when exposed to chemical contaminants by integrating inter-species variability on various biological parameters of interest and not only on a critical effect concentration;
- The development and the maintenance of the MOSAIC web platform (MOdeling and StAtistical tools for ecotoxICology, http://mosaic.univ-lyon1.fr) which freely and in a user-friendly way provides a collection of tools for data analysis and modelling in the field of ecotoxicology.
Display of 1 to 30 publications on 98 in total
Accumulation-depuration data collection in support of toxicokinetic modelling
Generic Solving of One-compartment Toxicokinetic Models
Journal of Exploratory Research in Pharmacology .
How to account for the uncertainty from standard toxicity tests in species sensitivity distributions: An example in non-target plants
PLoS ONE .
The added value of Bayesian inference for estimating biotransformation rates of organic contaminants in aquatic invertebrates
Aquatic Toxicology . 234 : 105811
Keeping modelling notebooks with TRACE: Good for you and good for environmental research and management support
Environmental Modelling & Software . 136 : 104932
In Situ Reproductive Bioassay with Caged Gammarus fossarum (Crustacea): Part 2—Evaluating the Relevance of Using a Molt Cycle Temperature‐Dependent Model as a Reference to Assess Toxicity in Freshwater Monitoring
Environmental Toxicology and Chemistry . 39 ( 3 ) : 678-691
Impact of solvents on the in vitro genotoxicity of TMPTA in human HepG2 cells
Toxicology in Vitro . 69 : 105003
In Situ Reproductive Bioassay with Caged Gammarus fossarum (Crustacea): Part 1—Gauging the Confounding Influence of Temperature and Water Hardness
Environmental Toxicology and Chemistry . 39 ( 3 ) : 667-677
A Bayesian framework for estimating parameters of a generic toxicokinetic model for the bioaccumulation of organic chemicals by benthic invertebrates: Proof of concept with PCB153 and two freshwater species
Ecotoxicology and Environmental Safety . 180 : 33-42
Recommendations to address uncertainties in environmental risk assessment using toxicokinetic-toxicodynamic models
Scientific Reports . 9 ( 1 )
MOSAIC : une plate-forme web pour l’analyse statistique des données d’écotoxicologie. Fiche Thématique N°13
: 4 p.
tRophicPosition , an r package for the Bayesian estimation of trophic position from consumer stable isotope ratios
Methods in Ecology and Evolution . 9 ( 6 ) : 1592-1599
MOSAIC: a web-interface for statistical analyses in ecotoxicology
Environmental Science and Pollution Research . 25 ( 12 ) : 11295-11302
Assessment of the in vitro genotoxicity of TiO 2 nanoparticles in a regulatory context
Nanotoxicology . : 1 - 18
Combined effect of temperature and ammonia on molecular response and survival of the freshwater crustacean Gammarus pulex
Ecotoxicology and Environmental Safety . 137 : 42-48
Ecophysiological responses of Gammarus pulex to the combined effects of temperature and ammonia
26th Annual Meeting SETAC Europe .
Combined effect of temperature and ammonia on the freshwater crustacean Gammarus pulex
SETAC Europe 26th Annual Meeting .
Les PCB dans le Rhône
PCB, environnement et santé . 978-2-7430-2005-7
Modelling survival: exposure pattern, species sensitivity and uncertainty
Scientific Reports . 6 : 29178
Mechanistic modelling of daphnid-algae dynamics within a laboratory microcosm
Ecological Modelling . 320 : 213–230
Optimizing the design of a reproduction toxicity test with the pond snail Lymnaea stagnalis
Regulatory Toxicology and Pharmacology . 81 : 47-56
Modelling algae-duckweed interaction under chemical pressure within a laboratory microcosm
Ecotoxicology and Environmental Safety . 128 : 252-65
MOSAIC_SSD: A new web tool for species sensitivity distribution to include censored data by maximum likelihood
Ecotoxicology and Environmental Safety . 33 ( 9 ) : 2133 - 2139
Hierarchical modelling of species sensitivity distribution: development and application to the case of diatoms exposed to several herbicides
Ecotoxicology and Environmental Safety . 114 : 212-221
Cadmium sulfide quantum dots induce oxidative stress and behavioral impairments in the marine clam Scrobicularia plana
Environmental Toxicology and Chemistry . 34 : 1659-64
A Toolbox for Nonlinear Regression in R: The Package nistools
Journal of Statistical Software . 66 : 1-21
Constructing Time-Resolved Species Sensitivity Distributions Using a Hierarchical Toxico-Dynamic Model
Environmental Science and Technology . 49 ( 20 ) : 12465-12473
Biochemical and behavioural responses of the marine polychaete Hediste diversicolor to cadmium sulfide quantum dots (CdS QDs): waterborne and dietary exposure
Chemosphere . 100 : 63-70
Statistical handling of reproduction data for exposure-response modeling
Environmental Science and Technology . 48 : 7544-51