Predictive Modelling and Ecotoxicology Group

Members

Research activities of team MEPS team aim at proposing integrated mathematical and statistical modelling approaches to predict the effects of environmental disturbances at different levels of biological organisation. We are also interested in their functional and evolutionary consequences whether on individual fitness, population, community and/or ecosystem dynamics. In order to build generic enough models with a high predictive power, team MEPS is particularly interested in understanding the functioning of the complex systems under consideration, and not only a very refined description of them. Thus, our models always respect the parsimony principl, ensuring that they remain sufficiently simple with limited "black box" effects. Particular attention is also paid to the robustness, and therefore the generalizability, of the knowledge produced through these models, with the final goal of improving the overall acceptability of modelling approaches in support of decision-making for environmental risk assessment.

Reducing the complexity of systems in order to produce relevant and generic enough models must not preclude having solid mathematical foundations, so that these models remain useful tools for understanding the mechanisms underlying disturbance processes and effects observed on tissues, organisms, populations, communities and/or ecosystems. Such mechanistic models must also include the temporal dimension, which is essential when we are talking about dynamic processes as for realistic exposure scenarios to several environmental pressures. At the same time, complementary criteria of short- and long-term effects must be taken into account to address issues such as remediation and restoration of some specific environments as well as the potential of providing a dynamical and integrative prediction of effects over several generations.
In this context, team MEPS is today focused on the following topics:

  • The development of mechanistic models based on physiological, namely physiologically based toxicokinetic-toxicodynamic (PBTKTD) models, in the perspective of providing predictive and diagnostic tools for the environmental quality;
  • The plasticity of individual responses to one (or a combination of) stress factor(s) (e.g. contamination and/or global warming) and the effects of adaptation phenomena on the long-term dynamics of populations;
  • The prediction of the species sensitivity distribution within communities when exposed to chemical contaminants by integrating inter-species variability on various biological parameters of interest and not only on a critical effect concentration;
  • The development and the maintenance of the MOSAIC web platform (MOdeling and StAtistical tools for ecotoxICology, http://mosaic.univ-lyon1.fr) which freely and in a user-friendly way provides a collection of tools for data analysis and modelling in the field of ecotoxicology.

Publications

Display of 91 to 120 publications on 226 in total

MOSAIC_SSD: A new web tool for species sensitivity distribution to include censored data by maximum likelihood

Guillaume Kon Kam King, Philippe Veber, Sandrine Charles, Marie Laure Delignette-Muller

Ecotoxicology and Environmental Safety . 33 ( 9 ) : 2133 - 2139

DOI: 10.1002/etc.2644

Journal article

see the publication

Hierarchical modelling of species sensitivity distribution: development and application to the case of diatoms exposed to several herbicides

Guillaume Kon Kam King, Floriane Larras, Sandrine Charles, Marie Laure Delignette-Muller

Ecotoxicology and Environmental Safety . 114 : 212-221

DOI: 10.1016/j.ecoenv.2015.01.022

Journal article

see the publication

Développement d’une méthodologie pour l'amélioration du suivi chimique des eaux continentales. Rapport de synthèse de l’étude pilote : déploiement de l’outil gammare encagé au niveau national, résultats pour les métaux ciblés

Olivier Geffard, J.P. Besse, Arnaud Chaumot, A. Francois, J. Gahou, G. Grisot...

: 60

Report

see the publication

Développement d’une méthodologie pour l'amélioration du suivi chimique des eaux continentales

R. Recoura Massaquant, Olivier Geffard, Jean-Philippe Besse, Arnaud Chaumot, Adeline François, Christelle Lopes...

: 66

Report

see the publication

Approche méthodologique pour faire évoluer la pédagogie en TD vers un apprentissage actif soutenu par des TICE

Michel Ney, R. Nifle, Sandrine Charles, M. Macedo-Rouet, L. Humblot, C. Batier

Colloque annuel AIPU (Association Internationale de Pédagogie Universitaire) . : 157-165

Conference paper

see the publication

Statistical handling of reproduction data for exposure-response modeling

Marie Laure Delignette-Muller, Christelle Lopes, Philippe Veber, Sandrine Charles

Environmental Science and Technology . 48 : 7544-51

DOI: 10.1021/es502009r

Journal article

see the publication

Biochemical and behavioural responses of the marine polychaete Hediste diversicolor to cadmium sulfide quantum dots (CdS QDs): waterborne and dietary exposure

P. E. Buffet, L. Poirier, A. Zalouk-Vergnoux, Christelle Lopes, J. C. Amiard, P. Gaudin...

Chemosphere . 100 : 63-70

DOI: 10.1016/j.chemosphere.2013.12.069

Journal article

see the publication

Ecological Modeling for the Extrapolation of Ecotoxicological Effects Measured during in Situ Assays in Gammarus

Romain Coulaud, Olivier Geffard, A Coquillat, H. Quéau, Sandrine Charles, Arnaud Chaumot

Environmental Science and Technology . 48 ( 11 ) : 6428-6436

DOI: 10.1021/es501126g

Journal article

see the publication

Development and validation of an OECD reproductive toxicity test guideline with the pond snail Lymnaea stagnalis (Mollusca, Gastropoda)

Virginie Ducrot, Clare Askem, Didier Azam, Denise Brettschneider, Rebecca Brown, Sandrine Charles...

Regulatory Toxicology and Pharmacology . 70 ( 3 ) : 605-614

DOI: 10.1016/j.yrtph.2014.09.004

Journal article

see the publication

Caged gammarids for the characterization of contamination levels in continental waters

J.P. Besse, Marina Coquery, C. Lopes, Arnaud Chaumot, Olivier Geffard

Society for Environmental Geochemistry and Health 29th International Conference . : 25

Conference paper

see the publication

In situ reproductive bioassay with caged Gammarus fossarum (Crustacea): a tool to diagnose toxicity of wastewater effluents

C. Lopes, Olivier Geffard, B. Xuereb, Romain Coulaud, G. Jubeaux, H. Quéau...

23rd SETAC Europe . : 2

Conference paper

see the publication

Life-history phenology strongly influences the vulnerability of populations to toxicants: a case study with the mudsnail Potamopyrgus antipodarum

Romain Coulaud, S. Charles, Arnaud Chaumot

CREAM Open Conference: Mechanistic Effect Models for Ecological Risk Assessment of Chemicals . : 41

Conference paper

see the publication

The molecular signal for the adaptation to cold temperature during early life on Earth

Mathieu Groussin, Bastien Boussau, Sandrine Charles, Samuel Blanquart, Manolo Gouy

Biology Letters . 9 ( 5 ) : 20130608

DOI: 10.1098/rsbl.2013.0608

Journal article

see the publication

Caged Gammarus fossarum (crustacea) as a robust tool for the characterization of bioavailable contamination levels in continental waters. Toward the determination of threshold values

J.P. Besse, Marina Coquery, C. Lopes, Arnaud Chaumot, H. Budzinski, P. Labadie...

Water Research . 47 ( 2 ) : p. 650 - p. 660

DOI: 10.1016/j.watres.2012.10.024

Journal article

see the publication

Life-history phenology strongly influences population vulnerability to toxicants: a case study with the mudsnail Potamopyrgus antipodarum.

Romain Coulaud, Jacques Mouthon, Hervé Quéau, Sandrine Charles, Arnaud Chaumot

Environmental Toxicology and Chemistry . 32 ( 8 ) : 1727-36

DOI: 10.1002/etc.2235

Journal article

see the publication

Caractérisation de la contamination chimique des eaux continentales par une approche de biosurveillance active sur le macroinvertébéré Gammarus fossarum. Vers la détermination de valeurs seuil de contamination

J.P. Besse, Marina Coquery, C. Lopes, Arnaud Chaumot, Olivier Geffard

SEFA, Société d'écotoxicologie fondamentale et appliquée . : 16

Conference paper

see the publication

Caged Gammarus fossarum to improve the characterization of contamination levels in continental waters: toward the determination of threshold values

J.P. Besse, Marina Coquery, C. Lopes, Arnaud Chaumot, Olivier Geffard

Ecobim . : 1

Poster

see the publication

Vitellogenin-like protein measurement in caged Gammarus fossarum males as a biomarker of endocrine disruptor exposure: Inconclusive experience

G. Jubeaux, R. Simon, A. Salvador, C. Lopes, Emilie Lacaze, H. Quéau...

Aquatic Toxicology . 122-123 : 9-18

Journal article

see the publication

Développement d'une méthodologie pour l'amélioration du suivi chimique des eaux continentales. Approche de biosurveillance active sur Gammarus fossarum

J.P. Besse, Olivier Geffard, C. Lopes, Arnaud Chaumot, Marina Coquery

: 63

Report

see the publication

Réalisme environnemental des modèles de populations pour l'évaluation de l'impact démographique de la toxicité des contaminants : exemple de la prise en compte de la variabilité saisonnière chez les invertébrés aquatiques

Romain Coulaud, Olivier Geffard, H. Quéau, S. Charles, Arnaud Chaumot

SEFA . : 43

Conference paper

see the publication

Use of sensitivity analysis to identify influential and non-influential parameters within an aquatic ecosystem model

Catalina Ciric, P. Ciffroy, S. Charles

Ecological Modelling . 246 : 119--130

Journal article

see the publication

Use of sensitivity analysis to identify influential and non-influential parameters within an aquatic ecosystem model

C. Ciric, P. Ciffroy, Sandrine Charles

Ecological Modelling . 246 : 119-130

DOI: 10.1016/j.ecolmodel.2012.06.024

Journal article

see the publication

Population-Level Modeling to Account for Multigenerational Effects of Uranium in Daphnia magna

P-A. Biron, S. Massarin, F. Alonzo, L. Garcia-Sanchez, Sandrine Charles, Elise Billoir

Environmental Science and Technology . 46 : 1136--1143

DOI: 10.1021/es202658b

Journal article

see the publication

What to do with NOECS/NOELS - prohibition or innovation?

Dr Fox, Elise Billoir, S. Charles, Marie-Laure Delignette-Muller, C. Lopes

Integr Environ Assess Manag . 8 : 764--766

DOI: 10.1002/ieam.1350

Journal article

see the publication

Transfer of PCBs from bottom sediment to freshwater river fish: A food-web modelling approach in the Rhône River (France) in support of sediment management.

C. Lopes, H. Persat, M. Babut

Ecotoxicology and Environmental Safety . 81 : 17-26

DOI: 10.1016/j.ecoenv.2012.04.007

Journal article

see the publication

BSAFs for freshwater fish and derivation of a sediment quality guideline for PCBs in the Rhone basin, France

Marc Babut, Christelle Lopes, Sébastien Pradelle, Henri Persat, Pierre-Marie Badot

Journal of Soils and Sediments . 12 ( 2 ) : 241-251

DOI: 10.1007/s11368-011-0448-y

Journal article

see the publication

Vitellogenin-like protein measurement in caged Gammarus fossarum males as a biomarker of endocrine disruptor exposure: Inconclusive experience

Guillaume Jubeaux, Romain Simon, Arnaud Salvador, Christelle Lopes, Emilie Lacaze, Hervé Quéau...

Aquatic Toxicology . 122 : 9-18

DOI: 10.1016/j.aquatox.2012.05.007

Journal article

see the publication

Comparison of bioassays with different exposure time patterns: The added value of dynamic modelling in predictive ecotoxicology

Elise Billoir, Hélène Delhaye, Carole Forfait-Dubuc, Bernard Clément, Gaëlle Triffault-Bouchet, Sandrine Charles...

Ecotoxicology and Environmental Safety . 75 : 80-86

DOI: 10.1016/j.ecoenv.2011.08.006

Journal article

see the publication

Survival data analyses in ecotoxicology: critical effect concentrations, methods and models. What should we use?

Carole Forfait-Dubuc, Sandrine Charles, Elise Billoir, Marie-Laure Delignette-Muller

Ecotoxicology . 21 : 1072--1083

DOI: 10.1007/s10646-012-0860-0

Journal article

see the publication

Towards a renewed research agenda in ecotoxicology

Joan Artigas, Gertie Arts, Marc Babut, Anna Barra Caracciolo, Sandrine Charles, Arnaud Chaumot...

Environmental Pollution . 160 ( 1 ) : 201-206

DOI: 10.1016/j.envpol.2011.08.011

Journal article

see the publication