Predictive Modelling and Ecotoxicology Group

Members

Research activities of team MEPS team aim at proposing integrated mathematical and statistical modelling approaches to predict the effects of environmental disturbances at different levels of biological organisation. We are also interested in their functional and evolutionary consequences whether on individual fitness, population, community and/or ecosystem dynamics. In order to build generic enough models with a high predictive power, team MEPS is particularly interested in understanding the functioning of the complex systems under consideration, and not only a very refined description of them. Thus, our models always respect the parsimony principl, ensuring that they remain sufficiently simple with limited "black box" effects. Particular attention is also paid to the robustness, and therefore the generalizability, of the knowledge produced through these models, with the final goal of improving the overall acceptability of modelling approaches in support of decision-making for environmental risk assessment.

Reducing the complexity of systems in order to produce relevant and generic enough models must not preclude having solid mathematical foundations, so that these models remain useful tools for understanding the mechanisms underlying disturbance processes and effects observed on tissues, organisms, populations, communities and/or ecosystems. Such mechanistic models must also include the temporal dimension, which is essential when we are talking about dynamic processes as for realistic exposure scenarios to several environmental pressures. At the same time, complementary criteria of short- and long-term effects must be taken into account to address issues such as remediation and restoration of some specific environments as well as the potential of providing a dynamical and integrative prediction of effects over several generations.
In this context, team MEPS is today focused on the following topics:

  • The development of mechanistic models based on physiological, namely physiologically based toxicokinetic-toxicodynamic (PBTKTD) models, in the perspective of providing predictive and diagnostic tools for the environmental quality;
  • The plasticity of individual responses to one (or a combination of) stress factor(s) (e.g. contamination and/or global warming) and the effects of adaptation phenomena on the long-term dynamics of populations;
  • The prediction of the species sensitivity distribution within communities when exposed to chemical contaminants by integrating inter-species variability on various biological parameters of interest and not only on a critical effect concentration;
  • The development and the maintenance of the MOSAIC web platform (MOdeling and StAtistical tools for ecotoxICology, http://mosaic.univ-lyon1.fr) which freely and in a user-friendly way provides a collection of tools for data analysis and modelling in the field of ecotoxicology.

Publications

Display of 121 to 150 publications on 226 in total

Caged gammarids to improve the characterization of contamination levels in continental waters - toward the determination of threshold values

J.P. Besse, Marina Coquery, C. Lopes, Arnaud Chaumot, Olivier Geffard

EMEC ( European Meeting on Environmental Chemistry) 12th . : 1

Poster

see the publication

Transfer of PCB from sediment to biota: development of a bioaccumulation model in a risk assessment perspective

C. Lopes, A. Roy, H. Persat, M.E. Perga, Marc Babut

SETAC Europe 21st Annual Meeting . : 2

Conference paper

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Effet des substances chimiques sur les organismes aquatiques. Développement d’une batterie multi spécifique pour l’évaluation écotoxicologique de la qualité du milieu

C. Lopes, Jeanne Garric, Marina Coquery, B. Ferrari, Arnaud Chaumot, Olivier Geffard

: 93

Report

see the publication

Transferts de contaminants hydrophobes du sédiment au biote : construction de modèles dans une perspective de gestion

Marc Babut, Cecile Miege, A. Roy, C. Lopes, G. Roux, M. Desmet...

: 186

Report

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Contamination des poissons d'eau douce par les PCB et d'autres contaminants persistants dans le bassin Rhône-Méditerranée. Détermination de facteurs d'accumulation sédiments-poissons et d'une valeur seuil dans le sédiment au-delà de laquelle les po

Marc Babut, A. Roy, C. Lopes, S. Pradelle

: 84

Report

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Mesure du taux d'alimentation in situ avec Gammarus fossarum (Crustacé) : un outil écologiquement pertinent pour l'évaluation de la qualité chimique des milieux aquatiques

Romain Coulaud, Olivier Geffard, H. Quéau, Jeanne Garric, S. Charles, Arnaud Chaumot

Colloque de la SEFA . : 22

Conference paper

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Population models in Gammarus (Crustacean) and Potamopyrgus (Gastropod): depicting the seasonal variability in demographic sensitivities to toxic stress by sensitivity analysis

Romain Coulaud, Olivier Geffard, H. Quéau, Jeanne Garric, S. Charles, S. Chaumot

SETAC Europe 21st Annual Meeting . : 1

Poster

see the publication

In situ feeding assay with Gammarus fossarum: move forward to an ecologically relevant biomonitoring of water chemical quality

Romain Coulaud, Olivier Geffard, H. Quéau, Jeanne Garric, S. Charles, Arnaud Chaumot

SETAC Europe 21st Annual Meeting . : 21

Conference paper

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Les mathématiques au secours de la faune aquatique

Arnaud Chaumot, S. Charles, C. Schmidt Laine, B. Chocat

Rhône-Alpes et l'environnement : 100 questions pour la recherche . : 124-125

Book chapter

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In situ feeding assay with Gammarus fossarum (Crustacea): Modelling the influence of confounding factors to improve water quality biomonitoring

Romain Coulaud, Olivier Geffard, Benoît Xuereb, Emilie Lacaze, Herve Queau, Jeanne Garric...

Water Research . 45 ( 19 ) : 6417 - 6429

DOI: 10.1016/j.watres.2011.09.035

Journal article

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MODÉLISATION EN (ÉCO)TOXICOLOGIE :

Alexandre R.R. Pery, P. Hubert, Sandrine Charles, J. Devillers, P. Ciffroy, O. Perceval...

incollection . -- : 423-427

Journal article

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Bayesian modelling of daphnid responses to time-varying cadmium exposure in laboratory aquatic microcosms

Elise Billoir, Hélène Delhaye, Bernard Clément, Marie Laure Delignette-Muller, Sandrine Charles

Ecotoxicology and Environmental Safety . 74 ( 4 ) : 693-702

DOI: 10.1016/j.ecoenv.2010.10.023

Journal article

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The importance of incorporating age and sex when backcalculating length in bullhead Cottus gobio

J. Kielbassa, Sandrine Charles, Marie Laure Delignette-Muller

Journal of Fish Biology . 78 : 1492-1507

DOI: 10.1111/j.1095-8649.2011.02956.x

Journal article

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Is PCBs concentration variability between and within freshwater fish species explained by their contamination pathways?

C. Lopes, M.E. Perga, A. Peretti, M.C. Roger, H. Persat, M. Babut

Chemosphere . 85 ( 3 ) : p. 502 - p. 508

DOI: 10.1016/j.chemosphere.2011.08.011

Journal article

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A New Perspective on the Dunnett Procedure: Filling the Gap Between Noec/Loec and Ecx Concepts

Marie Laure Delignette-Muller, Carole Forfait-Dubuc, Elise Billoir, Sandrine Charles

Environmental Toxicology and Chemistry . 30 : 2888-2891

DOI: 10.1002/etc.686

Journal article

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Modeling Nosocomial Transmission of Rotavirus in Pediatric Wards

C.M. Kribs-Zaleta, J.F. Jusot, Philippe Vanhems, Sandrine Charles

Bulletin of Mathematical Biology . 73 ( 7 ) : 1413-1442

DOI: 10.1007/s11538-010-9570-z

Journal article

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How non-standard test methods and data analysis tools can benefit to ecological risk assessment of chemicals ?

Virginie Ducrot, Sandrine Charles, Alexandre R.R. Pery, Laurent Lagadic

21. SETAC Europe annual meeting "Ecosystem protection in a sustainable world : a challenge for science and regulation" .

Conference paper

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Transfer of hydrophobic contaminants in the Rhône River from the sediment to the biota: development of a bioaccumulation model in a management perspective

C. Lopes, A. Roy, H. Persat, M-E. Perga, Marc Babut

SETAC Europe . : 2

Poster

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Déterminisme de l’impact des pesticides en cours d’eau : influence de la dynamique de l’exposition sur les effets biologiques

Véronique Gouy, A. Berard, Agnes Bouchez, Nadia Carluer, S. Charles, Arnaud Chaumot...

Colloque de restitution du programme EC2CO . : 1

Poster

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Population level integration of individual effect measurements for in situ water quality assessment: a modelling approach with Gammarus fossarum

Romain Coulaud, Olivier Geffard, H. Quéau, S. Charles, Arnaud Chaumot

14th international colloquium on Amphipoda . : 1

Poster

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Coupler modèles de dynamique de population et encagements in situ pour appréhender les effets populationnels des contaminations : illustration de la démarche chez le crustacé Gammarus fossarum

Romain Coulaud, Olivier Geffard, O. Adam, H. Quéau, Jeanne Garric, S. Charles...

Ecologie 2010 . : 25

Conference paper

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A temperature-dependent Leslie model to describe the dynamics of a bullhead (Cottus gobio) population

J. Kielbassa, Arnaud Chaumot, M.L. Delignette-Müller, S. Charles

Conference on Computational and Mathematical Population Dynamics . : 1

Conference paper

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Modelling and in situ caging for a realistic extrapolation of ecotoxicological effects at the population level: a methodological approach with Gammarus fossarum (Crustacean) and Potamopyrgus antipodarum (Gastropod)

Romain Coulaud, O. Adam, Olivier Geffard, H. Quéau, Jeanne Garric, S. Charles...

20th SETAC annual meeting . : 24

Conference paper

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Population dynamics and integration of individual toxicological effects for in situ water quality assessment: a modelling approach with Gammarus fossarum and Potamopyrgus antipodarum

Arnaud Chaumot, Olivier Geffard, Romain Coulaud, O. Adam, H. Quéau, S. Charles...

Colloque de la SEFA . : 1

Poster

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Application of a temperature-dependent von Bertalanffy growth model to bullhead (Cottus gobio)

J. Kielbassa, M.L. Delignette-Müller, Didier Pont, S. Charles

Ecological Modelling . 221 ( 20 ) : 2475-2481

DOI: 10.1016/j.ecolmodel.2010.07.001

Journal article

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From individual to population level effects of toxicants in the tubicifid branchiura sowerbyi using threshold effect models in a bayesian framework

Virginie Ducrot, Elise Billoir, Alexandre R.R. Pery, Jeanne Garric, Sandrine Charles

Environmental Science and Technology . 44 ( 9 ) : 3566-3571

DOI: 10.1021/es903860w

Journal article

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Development of partial life-cycle experiments to assess the effects of endocrine disruptors on the freshwater gastropod Lymnaea stagnalis; a case-study with vinclozolin.

Virginie Ducrot, Mickaël Teixeira-Alves, Christelle Lopes, Marie Laure Delignette-Muller, Sandrine Charles, Laurent Lagadic

Ecotoxicology . 19 ( 7 ) : 1312-1321

DOI: 10.1007/s10646-010-0518-8

Journal article

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Identification of food webs for freshwater river fishes for food-web modelling purposes

C. Lopes, A. Roy, M.C. Roger, Marc Babut, H. Persat

International Symposium on Toxicity Assessment . : 1

Poster

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Population level integration of individual effect measurements for in situ water quality assessment: a modelling approach with Gammarus fossarum (Crustacean) and Potamopyrgus antipodarum (Gastropod)

Arnaud Chaumot, Olivier Geffard, Romain Coulaud, O. Adam, H. Quéau, S. Charles...

Final MODELKEY Conference . : 1

Poster

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Modeling and in situ caging for a realistic extrapolation of ecotoxicological effects at the population level: a methodological approach with Gammarus fossarum (Crustacean) and Potamopyrgus antipodarum (Gastropod)

Romain Coulaud, O. Adam, Olivier Geffard, H. Quéau, Jeanne Garric, S. Charles...

14th ISTA . : 1

Poster

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