Showing results 1281 to 1300 on 1839 in total
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Several protein isoforms can be produced from a single gene through alternative splicing. These isoforms have different protein sequences, and often diverse or even antagonistic functions. In the recent years,the use of high-throughput technologies has revealed that alternative splicing is massively deregulated in many experimental conditions. A proportion of the splicing events observed at the transcript level are also observed at the protein level. However, it is still difficult to decipher the functional consequences of these splicing variations because of the lack of functional information at the exon level. To circumvent that problem, we introduce a computational strategy that relies on the functional annotation of exons in order to predict the consequences of their inclusion or skipping.
Thèse de Pierre GARCIA le mardi 18 décembre 2018 à 14 h, amphithéâtre BU (La Doua)
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La méthode que je vais présenter résulte de 9 années de travaux et repose sur un modèle physiologique de pharmacocinétique au steady-state. Cette méthode est implémentée en grande partie dans un site académique en accès libre www.ddi-predictor dont je parlerai brièvement. Je décrirai le principe, les avantages et les limites, les approches concurrentes, les applications cliniques. -----Quantitative prediction of the variation in drug exposure, linked to the genetic polymorphism of cytochromes P450 and membrane transporters. The method I will present results from 9 years of work and is based on a physiological model of steady-state pharmacokinetics. This method is largely implemented in an open access academic site www.ddi-predictor which I will briefly discuss. I will describe the principle, the advantages and the limits, the competing approaches, the clinical applications.
Thèse de Maoulide Saindou - Mercredi 3 avril 2013 - 15h00 - Médiathèque (Faculté de Médecine Lyon Est)
Whole Genome Duplications (WGDs) can be difficult to detect when they are old and when synteny has been disrupted by genome rearrangements. To test the presence of WGDs on a species phylogeny, I will present two methods which do not require synteny information and build strength from the phylogenetic framework. They rely on a probability model for the evolution of gene families on a species tree with WGDs. Both methods use multiple gene families across multiple species. One method relies on aligned molecular sequences and the other simply uses information on gene counts. We assessed their performance with simulations and on a benchmark yeast dataset, where we recover strong evidence for a well-established WGD and a low retention rate of duplicated genes after this WGD.
Thèse de Nicolas Ferry le vendredi 6 avril 2018 à 14 h, salle de conférence de la BU (la Doua)