Statistics and Modelling for Health Sciences

Severity of post-partum hemorrhage after vaginal delivery is not predictable from clinical variables available at the time post-partum hemorrhage is diagnosed

Marion Cortet, Delphine Maucort-Boulch, Catherine Deneux-Tharaux, Corinne Dupont, René-Charles Rudigoz, Pascal Roy...

Journal of Obstetrics and Gynaecology Research . 41 ( 2 ) : 199-206

DOI: 10.1111/jog.12528

2015

Journal article

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Predicting Corneal Graft Rejection by Confocal Microscopy

V. Kocaba, C. Colica, Muriel Rabilloud, C. Burillon

Cornea . 34 : S61-4

2015

Journal article

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An enhancement of ROC curves made them clinically relevant for diagnostic-test comparison and optimal-threshold determination

Fabien Subtil, Muriel Rabilloud

Journal of Clinical Epidemiology . 68 : 752-9

DOI: 10.1016/j.jclinepi.2015.01.003

2015

Journal article

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Uptake of systematic reviews and meta-analyses based on individual participant data in clinical practice guidelines: descriptive study

C. Vale, L. Rydzewska, M. Rovers, J. Emberson, François Gueyffier, L. Stewart

British medical journal . 350 : h1088

DOI: 10.1136/bmj.h1088

2015

Journal article

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Subcutaneous administration of levetiracetam in geriatrics

O. Maison, B. de La Gastine, L. Peter-Derex, C. Berger, Sylvain Goutelle

Revue Neurologique . 171 : 398-399

2015

Journal article

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A pharmacometric pulmonary model predicting the extent and rate of distribution from plasma to epithelial lining fluid and alveolar cells-using rifampicin as an example

O. Clewe, Sylvain Goutelle, Jr. Conte, Ush. Simonsson

European Journal of Clinical Pharmacology . 71 ( 3 ) : 313-9

DOI: 10.1007/s00228-014-1798-3

2015

Journal article

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Quantitative methods for prediction of the effect of cytochrome P450 gene polymorphisms on substrate drug exposure

Sylvain Goutelle, M. Tod

Clinical Pharmacokinetics . 54 : 319-20

2015

Journal article

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Model-Based Determination of Effective Blood Concentrations of Cyclosporine for Neutrophil Response in the Treatment of Severe Aplastic Anemia in Children

M. Philippe, E. Henin, Y. Bertrand, D. Plantaz, Sylvain Goutelle, N. Bleyzac

AAPS Journal . 17 ( 5 ) : 1157-67

DOI: 10.1208/s12248-015-9779-8

2015

Journal article

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Population modeling and simulation study of the pharmacokinetics and antituberculosis pharmacodynamics of isoniazid in lungs

Laure Lalande, Laurent Bourguignon, S. Bihari, P. Maire, M. Neely, R. Jelliffe...

Antimicrobial Agents and Chemotherapy . 59 ( 9 ) : 5181-5189

DOI: 10.1128/AAC.00462-15

2015

Journal article

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The precision–recall curve overcame the optimism of the receiver operating characteristic curve in rare diseases

Brice Ozenne, Fabien Subtil, Delphine Maucort-Boulch

Journal of Clinical Epidemiology . 68 : 855-9

2015

Journal article

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Spatially regularized mixture model for lesion segmentation with application to stroke patients

B. Ozenne, Fabien Subtil, L. Ostergaard, Delphine Maucort-Boulch

Biostatistics . 16 ( 3 ) : 580-595

DOI: 10.1093/biostatistics/kxv004

2015

Journal article

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An original phylogenetic approach identified mitochondrial haplogroup T1a1 as inversely associated with breast cancer risk in BRCA2 mutation carriers

S. Blein, Claire Bardel, V. Danjean, L. Mcguffog, S. Healey, D. Barrowdale...

Breast Cancer Research . 17 : 61

DOI: 10.1186/s13058-015-0567-2

2015

Journal article

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Management of adolescents with very poorly controlled type 1 diabetes by nurses: a parallel group randomized controlled trial

B. Kassai, Muriel Rabilloud, D. Bernoux, C. Michal, B. Riche, T. Ginhoux...

Trials . 16 ( 1 ) : 399

DOI: 10.1186/s13063-015-0923-7

2015

Journal article

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Comparison of two next-generation sequencing kits for diagnosis of epileptic disorders with a user-friendly tool for displaying gene coverage, DeCovA

S. Dimassi, T. Simonet, A. Labalme, N. Boutry-Kryza, Amandine Campan-Fournier, R. Lamy...

Applied & Translational Genomics . 7 : 19-25

DOI: 10.1016/j.atg.2015.10.001

2015

Journal article

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Accuracy of different equations in estimating GFR in pediatric kidney transplant recipients

V. de Souza, P. Cochat, Muriel Rabilloud, L. Selistre, M. Wagner, A. Hadj-Aissa...

Clinical Journal of the American Society of Nephrology . 10 ( 3 ) : 463-70

DOI: 10.2215/CJN.06300614

2015

Journal article

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Clinical profile of patients with ATP1A3 mutations in Alternating Hemiplegia of Childhood-a study of 155 patients

E. Panagiotakaki, E. de Grandis, M. Stagnaro, E. L. Heinzen, C. Fons, S. Sisodiya...

Orphanet Journal of Rare Diseases . 10 : 123

DOI: 10.1186/s13023-015-0335-5

2015

Journal article

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Influence of renal function estimation on pharmacokinetic modeling of vancomycin in elderly patients

A. Glatard, Laurent Bourguignon, R. W. Jelliffe, P. Maire, M. N. Neely, Sylvain Goutelle

Antimicrobial Agents and Chemotherapy . 59 ( 6 ) : 2986-94

DOI: 10.1128/AAC.04132-14

2015

Journal article

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CSF IgA NMDAR antibodies are potential biomarkers for teratomas in anti-NMDAR encephalitis

V. Desestret, A. Chefdeville, A. Viaccoz, C. Bost, F. Ducray, G. Picard...

Neurology Neuroimmunology & Neuroinflammation . 2 ( 6 ) : e166

DOI: 10.1212/NXI.0000000000000166

2015

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An 18F-FDG-PET maximum standardized uptake value > 10 represents a novel valid marker for discerning Richter’s Syndrome

Anne-Sophie Michallet, Pierre Sesques, Kari Rabe, Emmanuel Itti, Jérémy Tordot, Christelle Tychyj-Pinel...

Leukemia & lymphoma . 57 ( 6 ) : 1474-1477

DOI: 10.3109/10428194.2015.1099643

2015

Journal article

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Different treatment benefits were estimated by clinical trials performed in adults compared with those performed in children

Perrine Janiaud, A. Lajoinie, F. Cour-Andlauer, Catherine Cornu, P. Cochat, Michel Cucherat...

Journal of Clinical Epidemiology . 68 : 1221-1231

2015

Journal article

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Is legacy a myth or a reality? We should know, and we do not

F. Gueyffier, Michel Cucherat

Journal of Hypertension . 33 : 2207-9

2015

Journal article

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Sequential combination of gemcitabine, vinorelbine, pegylated liposomal doxorubicin and Brentuximab as a bridge regimen to transplant in relapsed or refractory Hodgkin lymphoma

As. Michallet, Y. Guillermin, B. Deau, L. Lebras, S. Harel, S. Amorin...

Haematologica . 100 ( 7 ) : e269-e271

DOI: 10.3324/haematol.2015.124784

2015

Journal article

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High Risk versus Proportional Benefit: Modelling Equitable Strategies in Cardiovascular Prevention

I. Marchant, Jp. Boissel, Patrice Nony, F. Gueyffier

PLoS ONE . 10 ( 11 ) : e0140793

DOI: 10.1371/journal.pone.0140793

2015

Journal article

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A Prediction Model of Drug Exposure in Cirrhotic Patients According to Child-Pugh Classification

J. Steelandt, E. Jean-Bart, Sylvain Goutelle, M. Tod

Clinical Pharmacokinetics . 54 : 1245-58

DOI: 10.1007/s40262-015-0288-9

2015

Journal article

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Population pharmacokinetics of ciprofloxacin in neonates and young infants less than three months of age

W. Zhao, H. Hill, C. Le Guellec, T. Neal, S. Mahoney, S. Paulus...

Antimicrobial Agents and Chemotherapy . 58 ( 11 ) : 6572-80

DOI: 10.1128/AAC.03568-14

2014

Journal article

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Solid oral forms availability in children: a cost saving investigation

A. Lajoinie, E. Henin, Behrouz Kassai, D. Terry

British Journal of Clinical Pharmacology . 78 ( 5 ) : 1080-9

DOI: 10.1111/bcp.12442

2014

Journal article

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Practical interest of both skin prick test and specific IgE in the evaluation of tolerance acquisition in IgE mediated cow's milk allergy (CMA). A clinical retrospective study in a cohort of 184 children

F. Payot, J. Berthiller, Behrouz Kassai, A. S. Brunet, F. Villard-Truc, A. Lachaux

Allergologia et Immunopathologia . 42 : 395-401

2014

Journal article

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Which factors predict proposal and uptake of psychological counselling after BRCA1/2 test result disclosure?

Christine Maheu, Anne-Deborah Bouhnik, Catherine Noguès, Emmanuelle Mouret-Fourme, Dominique Stoppa-Lyonnet, Christine Lasset...

Psycho-Oncology . 23 ( 4 ) : 420-427

DOI: 10.1002/pon.3435

2014

Journal article

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Effects of a TAFI-Inhibitor Combined with a Suboptimal Dose of rtPA in a Murine Thromboembolic Model of Stroke

Anne Durand, Fabien Chauveau, Tae-Hee Cho, Christopher Kallus, Mickael Wagner, Florent Boutitie...

Cerebrovascular Diseases . 38 ( 4 ) : 268-275

DOI: 10.1159/000366266

2014

Journal article

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Pharmacokinetic Drug-Drug Interaction of Calcium Channel Blockers With Cyclosporine in Hematopoietic Stem Cell Transplant Children

Elodie Bernard, Sylvain Goutelle, Yves Bertrand, Nathalie Bleyzac

Annals of Pharmacotherapy . 48 ( 12 ) : 1580-1584

DOI: 10.1177/1060028014550644

2014

Journal article

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Statistics and Modelling for Health Sciences

Biostatistics Health Group

Evaluation and Modeling with the Therapeutic Effects Group

Publications

Severity of post-partum hemorrhage after vaginal delivery is not predictable from clinical variables available at the time post-partum hemorrhage is diagnosed

Predicting Corneal Graft Rejection by Confocal Microscopy

An enhancement of ROC curves made them clinically relevant for diagnostic-test comparison and optimal-threshold determination

Uptake of systematic reviews and meta-analyses based on individual participant data in clinical practice guidelines: descriptive study

Subcutaneous administration of levetiracetam in geriatrics

A pharmacometric pulmonary model predicting the extent and rate of distribution from plasma to epithelial lining fluid and alveolar cells-using rifampicin as an example

Quantitative methods for prediction of the effect of cytochrome P450 gene polymorphisms on substrate drug exposure

Model-Based Determination of Effective Blood Concentrations of Cyclosporine for Neutrophil Response in the Treatment of Severe Aplastic Anemia in Children

Population modeling and simulation study of the pharmacokinetics and antituberculosis pharmacodynamics of isoniazid in lungs

The precision–recall curve overcame the optimism of the receiver operating characteristic curve in rare diseases

Spatially regularized mixture model for lesion segmentation with application to stroke patients

An original phylogenetic approach identified mitochondrial haplogroup T1a1 as inversely associated with breast cancer risk in BRCA2 mutation carriers

Management of adolescents with very poorly controlled type 1 diabetes by nurses: a parallel group randomized controlled trial

Comparison of two next-generation sequencing kits for diagnosis of epileptic disorders with a user-friendly tool for displaying gene coverage, DeCovA

Accuracy of different equations in estimating GFR in pediatric kidney transplant recipients

Clinical profile of patients with ATP1A3 mutations in Alternating Hemiplegia of Childhood-a study of 155 patients

Influence of renal function estimation on pharmacokinetic modeling of vancomycin in elderly patients

CSF IgA NMDAR antibodies are potential biomarkers for teratomas in anti-NMDAR encephalitis

An 18F-FDG-PET maximum standardized uptake value > 10 represents a novel valid marker for discerning Richter’s Syndrome

Different treatment benefits were estimated by clinical trials performed in adults compared with those performed in children

Is legacy a myth or a reality? We should know, and we do not

Sequential combination of gemcitabine, vinorelbine, pegylated liposomal doxorubicin and Brentuximab as a bridge regimen to transplant in relapsed or refractory Hodgkin lymphoma

High Risk versus Proportional Benefit: Modelling Equitable Strategies in Cardiovascular Prevention

A Prediction Model of Drug Exposure in Cirrhotic Patients According to Child-Pugh Classification

Population pharmacokinetics of ciprofloxacin in neonates and young infants less than three months of age

Solid oral forms availability in children: a cost saving investigation

Practical interest of both skin prick test and specific IgE in the evaluation of tolerance acquisition in IgE mediated cow's milk allergy (CMA). A clinical retrospective study in a cohort of 184 children

Which factors predict proposal and uptake of psychological counselling after BRCA1/2 test result disclosure?

Effects of a TAFI-Inhibitor Combined with a Suboptimal Dose of rtPA in a Murine Thromboembolic Model of Stroke

Pharmacokinetic Drug-Drug Interaction of Calcium Channel Blockers With Cyclosporine in Hematopoietic Stem Cell Transplant Children

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